Incidental Mutation 'R4680:Chil5'
ID349976
Institutional Source Beutler Lab
Gene Symbol Chil5
Ensembl Gene ENSMUSG00000043873
Gene Namechitinase-like 5
SynonymsChi3l7, Bclp1, Bclp2
MMRRC Submission 041933-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #R4680 (G1)
Quality Score225
Status Validated
Chromosome3
Chromosomal Location106016919-106032814 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 106034875 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000200146]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170669
Predicted Effect probably benign
Transcript: ENSMUST00000200146
SMART Domains Protein: ENSMUSP00000142477
Gene: ENSMUSG00000043873

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Glyco_18 22 365 2.1e-133 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A T 2: 151,473,470 L96Q probably damaging Het
4930430F08Rik T C 10: 100,578,381 I139V probably benign Het
4931414P19Rik T C 14: 54,585,076 Y368C probably damaging Het
Acin1 T C 14: 54,686,758 N8S probably benign Het
Aspm T C 1: 139,480,671 V2432A probably benign Het
Atf2 A T 2: 73,828,681 probably null Het
B3gnt2 A G 11: 22,837,105 S28P probably damaging Het
Crybg2 CTTCCAGAGCCATGGACCCATCTTTTCCA CTTCCA 4: 134,072,718 probably null Het
Dennd3 A T 15: 73,533,376 H326L possibly damaging Het
Dysf C A 6: 84,097,715 D499E probably damaging Het
Eprs T C 1: 185,386,278 V461A possibly damaging Het
Fhad1 G A 4: 142,011,547 Q31* probably null Het
Gpr26 A G 7: 131,974,353 T249A probably benign Het
Gtf2ird1 T A 5: 134,357,881 M958L probably damaging Het
Kat2b-ps A G 5: 93,391,440 noncoding transcript Het
Kdm2b A T 5: 122,934,786 V343E probably damaging Het
Lipi A G 16: 75,565,529 probably null Het
Ltb4r1 T C 14: 55,767,468 F76S probably damaging Het
Msantd2 A G 9: 37,523,091 Y209C probably damaging Het
Nid1 G A 13: 13,472,852 C401Y probably damaging Het
Obox1 A T 7: 15,556,164 N144I probably damaging Het
Olfr1051 T A 2: 86,276,173 I105F possibly damaging Het
Olfr1099 T C 2: 86,959,321 I46V possibly damaging Het
Olfr128 T C 17: 37,923,922 S119P probably damaging Het
Plec T C 15: 76,180,575 E1630G unknown Het
Ppp2r5e C T 12: 75,469,759 R218Q probably damaging Het
Prkdc A G 16: 15,772,030 T2586A probably benign Het
Ptprj T C 2: 90,460,496 N633S probably benign Het
Rab11fip2 T C 19: 59,936,020 N284S probably benign Het
Ropn1 A G 16: 34,677,305 Q189R possibly damaging Het
Rwdd2b A G 16: 87,437,062 probably null Het
Ryr2 A T 13: 11,595,233 S4236T probably benign Het
Sigmar1 A G 4: 41,741,251 M1T probably null Het
Sncg T A 14: 34,373,311 N79I probably benign Het
Traf3ip2 C T 10: 39,639,260 P345S possibly damaging Het
Ttn C T 2: 76,932,677 G3213S probably damaging Het
Uqcrc1 G A 9: 108,947,861 R77H probably damaging Het
Vps13d A C 4: 145,108,510 L2756R possibly damaging Het
Other mutations in Chil5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01812:Chil5 APN 3 106017152 missense possibly damaging 0.73
IGL02959:Chil5 APN 3 106019590 missense probably damaging 1.00
R0255:Chil5 UTSW 3 106019267 missense probably damaging 1.00
R0409:Chil5 UTSW 3 106034966 unclassified probably benign
R0635:Chil5 UTSW 3 106017203 missense possibly damaging 0.50
R1403:Chil5 UTSW 3 106018093 missense probably benign 0.06
R1403:Chil5 UTSW 3 106018093 missense probably benign 0.06
R3500:Chil5 UTSW 3 106018220 missense probably damaging 1.00
R4426:Chil5 UTSW 3 106019627 missense probably damaging 0.96
R4998:Chil5 UTSW 3 106019932 missense probably damaging 0.99
R5045:Chil5 UTSW 3 106024140 missense possibly damaging 0.61
R5113:Chil5 UTSW 3 106017978 missense possibly damaging 0.91
R5274:Chil5 UTSW 3 106028853 missense probably damaging 1.00
R5627:Chil5 UTSW 3 106019635 missense probably damaging 1.00
R6910:Chil5 UTSW 3 106019661 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGTTATTGGTGGATGGCGTC -3'
(R):5'- AAACATTGACTTTATTGATCTTTGGGG -3'

Sequencing Primer
(F):5'- CCGCGTGAACTTTGACAATG -3'
(R):5'- GGGGGAATGTGATGCACTATC -3'
Posted On2015-10-08