Mutagenetix > Incidental Mutation

Incidental Mutation 'R4647:Apbb1'

350372

Institutional Source

Beutler Lab

Gene Symbol

Apbb1

Ensembl Gene

ENSMUSG00000037032

Gene Name

amyloid beta precursor protein binding family B member 1

Synonyms

Fe65, Rir

MMRRC Submission

041908-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4647 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105207690-105230860 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 105214745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 500 (S500A)

Ref Sequence

ENSEMBL: ENSMUSP00000140116 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081165] [ENSMUST00000186814] [ENSMUST00000186868] [ENSMUST00000187051] [ENSMUST00000187057] [ENSMUST00000187683] [ENSMUST00000187721] [ENSMUST00000189265] [ENSMUST00000191601] [ENSMUST00000189378] [ENSMUST00000189072] [ENSMUST00000191011] [ENSMUST00000190369] [ENSMUST00000188368] [ENSMUST00000188001] [ENSMUST00000210079] [ENSMUST00000188440]

AlphaFold

Q9QXJ1

Predicted Effect

probably benign
Transcript: ENSMUST00000081165
AA Change: S500A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000079932
Gene: ENSMUSG00000037032
AA Change: S500A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	512	4.16e-38	SMART
PTB	538	667	1.76e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186814

Predicted Effect

probably benign
Transcript: ENSMUST00000186868

SMART Domains

Protein: ENSMUSP00000140052
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	1.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000187051

SMART Domains

Protein: ENSMUSP00000139755
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	1.4e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
SCOP:d1shca_	74	120	9e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187057
AA Change: S275A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000139899
Gene: ENSMUSG00000037032
AA Change: S275A

Domain	Start	End	E-Value	Type
WW	31	62	3.7e-7	SMART
low complexity region	64	76	N/A	INTRINSIC
PTB	142	287	3.8e-41	SMART
PTB	313	442	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187683

SMART Domains

Protein: ENSMUSP00000139426
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	2.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
Pfam:PID	111	158	5.9e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000187721

SMART Domains

Protein: ENSMUSP00000140192
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
low complexity region	2	15	N/A	INTRINSIC
WW	54	85	3.7e-7	SMART
low complexity region	87	99	N/A	INTRINSIC
Pfam:PID	170	242	1.5e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000189265
AA Change: S25A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000140137
Gene: ENSMUSG00000037032
AA Change: S25A

Domain	Start	End	E-Value	Type
Pfam:PID	1	34	2.3e-6	PFAM
PTB	63	192	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191601
AA Change: S500A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000140116
Gene: ENSMUSG00000037032
AA Change: S500A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	3.7e-7	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	512	1.8e-40	SMART
PTB	538	667	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189378
AA Change: S498A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000140979
Gene: ENSMUSG00000037032
AA Change: S498A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	510	6.86e-39	SMART
PTB	536	665	1.76e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189072
AA Change: S241A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000139575
Gene: ENSMUSG00000037032
AA Change: S241A

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	8.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	253	1.8e-40	SMART
PTB	279	408	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191011
AA Change: S498A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000140973
Gene: ENSMUSG00000037032
AA Change: S498A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	510	6.86e-39	SMART
PTB	536	665	1.76e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000190369
AA Change: S241A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000140486
Gene: ENSMUSG00000037032
AA Change: S241A

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	8.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	253	1.8e-40	SMART
PTB	279	408	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000188368
AA Change: S277A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000139788
Gene: ENSMUSG00000037032
AA Change: S277A

Domain	Start	End	E-Value	Type
WW	31	62	3.7e-7	SMART
low complexity region	64	76	N/A	INTRINSIC
PTB	142	289	1.8e-40	SMART
PTB	315	444	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000188001

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190961

Predicted Effect

probably benign
Transcript: ENSMUST00000210079

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191250

Predicted Effect

probably benign
Transcript: ENSMUST00000211614

Predicted Effect

probably benign
Transcript: ENSMUST00000188440

SMART Domains

Protein: ENSMUSP00000140715
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	3.4e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	223	1.4e-14	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
PHENOTYPE: Homozygotes for a null allele are hypersensitive to ionizing radiation while mouse embryonic fibroblasts are hypersensitive to DNA damaging agents. Homozygotes for a second null allele display impaired performance in learning and memory tasks, with a striking deficit in reversal spatial learning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 139 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700031F05Rik	G	T	X: 101,904,515 (GRCm39)	N132K	possibly damaging	Het
Aatf	T	C	11: 84,362,023 (GRCm39)	D313G	possibly damaging	Het
Abcb11	T	G	2: 69,115,615 (GRCm39)	D583A	probably damaging	Het
Adgrv1	A	T	13: 81,676,914 (GRCm39)	Y1252*	probably null	Het
Aim2	T	C	1: 173,283,090 (GRCm39)		silent	Het
Angpt1	T	A	15: 42,539,580 (GRCm39)	Y93F	probably benign	Het
Ankrd27	C	T	7: 35,337,659 (GRCm39)	P991L	probably benign	Het
Ap1s3	C	T	1: 79,591,920 (GRCm39)		probably null	Het
Arc	G	A	15: 74,543,374 (GRCm39)	A283V	probably damaging	Het
Bbs10	A	G	10: 111,136,995 (GRCm39)	K703E	probably benign	Het
C1galt1c1	A	T	X: 37,720,349 (GRCm39)	S216T	probably benign	Het
C1qtnf4	T	A	2: 90,719,996 (GRCm39)	S90T	probably damaging	Het
Cachd1	A	T	4: 100,810,327 (GRCm39)	K310*	probably null	Het
Calhm1	A	G	19: 47,132,240 (GRCm39)	L125P	probably damaging	Het
Carmil1	G	A	13: 24,321,162 (GRCm39)	L278F	probably damaging	Het
Ccar1	A	T	10: 62,583,196 (GRCm39)	Y972*	probably null	Het
Cd163	C	T	6: 124,297,580 (GRCm39)	P909S	probably damaging	Het
Cd44	T	A	2: 102,668,274 (GRCm39)	H268L	possibly damaging	Het
Cdkl2	A	T	5: 92,165,072 (GRCm39)	L517Q	probably damaging	Het
Cep68	G	T	11: 20,189,349 (GRCm39)	N554K	probably benign	Het
Ces1d	A	G	8: 93,893,038 (GRCm39)	W515R	probably damaging	Het
Clca4b	A	C	3: 144,634,286 (GRCm39)	H102Q	probably benign	Het
Cldn15	T	A	5: 137,003,337 (GRCm39)	I142N	probably damaging	Het
Cmklr1	T	A	5: 113,752,701 (GRCm39)	D100V	probably damaging	Het
Crocc2	G	A	1: 93,096,516 (GRCm39)	V24M	possibly damaging	Het
D430041D05Rik	G	A	2: 104,088,788 (GRCm39)	P63S	probably damaging	Het
Ddx39a	A	T	8: 84,448,902 (GRCm39)	H259L	probably benign	Het
Dhx16	C	G	17: 36,196,527 (GRCm39)	A565G	probably benign	Het
Dimt1	A	T	13: 107,084,163 (GRCm39)	D50V	probably benign	Het
Dock9	A	T	14: 121,823,658 (GRCm39)	L1428H	probably damaging	Het
Dpp4	G	T	2: 62,164,949 (GRCm39)	T700K	probably damaging	Het
E030030I06Rik	T	A	10: 22,024,744 (GRCm39)	R56S	unknown	Het
Eea1	A	G	10: 95,864,255 (GRCm39)	T925A	probably benign	Het
Ext1	A	G	15: 52,953,383 (GRCm39)	S494P	possibly damaging	Het
Fam171a1	G	A	2: 3,221,328 (GRCm39)	E140K	probably damaging	Het
Fgfr3	C	T	5: 33,892,330 (GRCm39)		probably benign	Het
Gabra6	A	G	11: 42,198,199 (GRCm39)	I407T	probably damaging	Het
Gm16223	C	A	5: 42,371,954 (GRCm39)	L115M	unknown	Het
Gm4781	G	T	10: 100,232,862 (GRCm39)		noncoding transcript	Het
Gm9772	T	A	17: 22,226,013 (GRCm39)	I70F	possibly damaging	Het
Gpr107	T	A	2: 31,100,513 (GRCm39)	F497Y	probably damaging	Het
Grm7	T	A	6: 110,891,344 (GRCm39)	Y192*	probably null	Het
Gtf2ird2	G	A	5: 134,245,034 (GRCm39)	A431T	probably damaging	Het
H2-K2	T	A	17: 34,194,989 (GRCm39)		noncoding transcript	Het
H2-M11	T	A	17: 36,858,883 (GRCm39)	V141D	probably benign	Het
Hmcn1	A	G	1: 150,551,262 (GRCm39)		probably null	Het
Hmcn2	A	T	2: 31,289,031 (GRCm39)	Q2280L	possibly damaging	Het
Hmg20b	T	A	10: 81,184,416 (GRCm39)	Q129L	probably damaging	Het
Igfbp7	T	A	5: 77,499,143 (GRCm39)	Q285L	possibly damaging	Het
Igkv13-85	T	A	6: 68,907,720 (GRCm39)		probably benign	Het
Inpp5e	A	T	2: 26,297,926 (GRCm39)	L225H	probably benign	Het
Inpp5f	T	A	7: 128,260,833 (GRCm39)	V91E	possibly damaging	Het
Khdc3	A	G	9: 73,009,868 (GRCm39)	E26G	possibly damaging	Het
Klra5	T	A	6: 129,876,339 (GRCm39)	D156V	probably damaging	Het
Kmo	C	A	1: 175,487,340 (GRCm39)	Y430*	probably null	Het
Lbx2	A	G	6: 83,065,027 (GRCm39)	D188G	probably damaging	Het
Lcorl	A	T	5: 45,890,931 (GRCm39)	L474*	probably null	Het
Lnx1	C	T	5: 74,771,457 (GRCm39)	V350I	probably benign	Het
Lrrc45	T	A	11: 120,609,947 (GRCm39)	S464T	probably benign	Het
Ltc4s	T	A	11: 50,128,052 (GRCm39)	T61S	probably benign	Het
Luc7l3	A	C	11: 94,200,467 (GRCm39)	N50K	probably damaging	Het
Ly75	G	A	2: 60,138,622 (GRCm39)	T1415M	probably damaging	Het
Macf1	T	C	4: 123,367,420 (GRCm39)	E2447G	probably benign	Het
Map3k21	A	G	8: 126,668,850 (GRCm39)	D812G	probably benign	Het
Mbtd1	C	T	11: 93,815,437 (GRCm39)	H342Y	probably damaging	Het
Mest	C	T	6: 30,745,109 (GRCm39)	R226*	probably null	Het
Mindy1	A	T	3: 95,190,054 (GRCm39)		probably benign	Het
Mmp13	A	T	9: 7,274,233 (GRCm39)	D180V	probably damaging	Het
Mn1	A	G	5: 111,567,949 (GRCm39)	T640A	probably benign	Het
Msi2	T	C	11: 88,608,864 (GRCm39)	H18R	possibly damaging	Het
Myo18a	T	A	11: 77,708,776 (GRCm39)	V61E	probably damaging	Het
Myo19	T	G	11: 84,785,468 (GRCm39)	I237S	probably damaging	Het
Ncaph2	T	A	15: 89,254,635 (GRCm39)	L416Q	probably damaging	Het
Nlrp1a	T	A	11: 70,987,952 (GRCm39)		probably null	Het
Or1n1b	A	G	2: 36,780,663 (GRCm39)	F66L	probably benign	Het
Or2d4	A	T	7: 106,543,547 (GRCm39)	N220K	probably benign	Het
Or51a25	A	G	7: 102,373,299 (GRCm39)	S133P	probably damaging	Het
Or5b98	A	G	19: 12,931,441 (GRCm39)	I163V	probably benign	Het
Or8s10	G	T	15: 98,335,457 (GRCm39)	V36F	probably benign	Het
Padi2	T	C	4: 140,671,757 (GRCm39)	F495S	probably damaging	Het
Pan3	G	T	5: 147,464,013 (GRCm39)	D535Y	probably damaging	Het
Paqr3	T	A	5: 97,256,069 (GRCm39)	R102*	probably null	Het
Patl1	T	A	19: 11,891,798 (GRCm39)	D34E	probably damaging	Het
Pcdha6	A	T	18: 37,102,189 (GRCm39)	T461S	probably damaging	Het
Pcnt	T	C	10: 76,190,047 (GRCm39)	S2830G	probably benign	Het
Pdgfa	G	A	5: 138,964,939 (GRCm39)	T181I	probably benign	Het
Pds5a	C	A	5: 65,813,661 (GRCm39)	D275Y	probably damaging	Het
Plod2	T	A	9: 92,487,503 (GRCm39)	Y607*	probably null	Het
Pomt2	G	T	12: 87,164,857 (GRCm39)	T517K	possibly damaging	Het
Pramel23	T	C	4: 143,425,914 (GRCm39)	M10V	probably benign	Het
Prdm1	T	C	10: 44,315,686 (GRCm39)	T817A	probably damaging	Het
Prdm2	T	C	4: 142,859,525 (GRCm39)	D1255G	possibly damaging	Het
Prex2	T	A	1: 11,232,509 (GRCm39)	C859S	probably damaging	Het
Ralgapa2	A	T	2: 146,229,549 (GRCm39)	M1077K	possibly damaging	Het
Ralgds	T	C	2: 28,435,532 (GRCm39)		probably null	Het
Rasa3	T	C	8: 13,638,865 (GRCm39)	E314G	probably null	Het
Rasa4	T	A	5: 136,130,217 (GRCm39)	D324E	probably damaging	Het
Rbm46	A	T	3: 82,771,765 (GRCm39)	D283E	probably benign	Het
Rnf139	A	T	15: 58,771,836 (GRCm39)	L620F	probably benign	Het
Rptor	T	A	11: 119,781,989 (GRCm39)	N1105K	probably benign	Het
Scaf11	A	T	15: 96,317,981 (GRCm39)		probably null	Het
Sectm1b	A	T	11: 120,946,760 (GRCm39)	V45E	probably damaging	Het
Selenon	A	G	4: 134,272,968 (GRCm39)	W157R	probably damaging	Het
Sema3b	C	A	9: 107,476,250 (GRCm39)	R657L	possibly damaging	Het
Setd1b	C	T	5: 123,286,175 (GRCm39)	A407V	unknown	Het
Sh3tc1	C	T	5: 35,863,662 (GRCm39)	A842T	probably damaging	Het
Shank2	A	G	7: 143,965,566 (GRCm39)	E1268G	probably damaging	Het
Shmt1	G	A	11: 60,692,291 (GRCm39)	S155F	probably damaging	Het
Sim2	A	G	16: 93,924,385 (GRCm39)	E510G	possibly damaging	Het
Slc25a46	A	T	18: 31,733,245 (GRCm39)	I168N	probably damaging	Het
Slc26a4	T	G	12: 31,590,525 (GRCm39)	D376A	possibly damaging	Het
Slfn14	G	T	11: 83,167,484 (GRCm39)	A677E	probably benign	Het
Slk	G	T	19: 47,608,713 (GRCm39)	Q555H	possibly damaging	Het
Synj1	A	T	16: 90,770,877 (GRCm39)	D517E	probably damaging	Het
Syvn1	G	A	19: 6,101,504 (GRCm39)	R440Q	probably benign	Het
Tafa5	T	G	15: 87,604,783 (GRCm39)	S115A	probably damaging	Het
Tas2r118	A	T	6: 23,969,467 (GRCm39)	I198N	probably damaging	Het
Tdh	A	G	14: 63,731,205 (GRCm39)	L323P	possibly damaging	Het
Tet2	A	T	3: 133,193,843 (GRCm39)	M197K	probably benign	Het
Timeless	A	G	10: 128,075,825 (GRCm39)	Y19C	possibly damaging	Het
Tnn	T	C	1: 159,973,612 (GRCm39)	M252V	probably benign	Het
Trdn	G	T	10: 33,071,977 (GRCm39)	E215*	probably null	Het
Trmt1l	G	T	1: 151,333,632 (GRCm39)	V712F	possibly damaging	Het
Tti1	T	C	2: 157,848,940 (GRCm39)		probably benign	Het
Ulk4	T	C	9: 120,970,918 (GRCm39)	H1018R	probably benign	Het
Vim	A	T	2: 13,587,306 (GRCm39)	H461L	probably benign	Het
Vmn2r118	T	A	17: 55,917,665 (GRCm39)	E282D	probably damaging	Het
Vmn2r31	T	A	7: 7,387,367 (GRCm39)	I735F	probably damaging	Het
Vmn2r88	A	G	14: 51,656,250 (GRCm39)	M829V	probably benign	Het
Washc4	T	A	10: 83,410,407 (GRCm39)	M665K	possibly damaging	Het
Wbp2	T	A	11: 115,973,207 (GRCm39)	M67L	probably benign	Het
Wdr81	T	A	11: 75,336,814 (GRCm39)	E1525V	probably damaging	Het
Xbp1	A	G	11: 5,472,006 (GRCm39)	D44G	probably damaging	Het
Zfhx4	T	G	3: 5,464,341 (GRCm39)	F1500V	probably damaging	Het
Zfp286	A	C	11: 62,674,559 (GRCm39)	Y95*	probably null	Het
Zfp872	A	G	9: 22,111,057 (GRCm39)	T178A	possibly damaging	Het
Zkscan5	A	G	5: 145,155,640 (GRCm39)	H364R	possibly damaging	Het
Zp3r	A	T	1: 130,505,697 (GRCm39)	Y422N	probably damaging	Het
Zscan10	C	T	17: 23,829,314 (GRCm39)	R542C	probably benign	Het

Other mutations in Apbb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02171:Apbb1	APN	7	105,208,333 (GRCm39)	splice site	probably benign
athena	UTSW	7	105,215,902 (GRCm39)	missense	probably benign
R0092:Apbb1	UTSW	7	105,208,361 (GRCm39)	missense	probably damaging	1.00
R0348:Apbb1	UTSW	7	105,214,510 (GRCm39)	missense	probably damaging	0.98
R0633:Apbb1	UTSW	7	105,208,170 (GRCm39)	missense	probably damaging	1.00
R0946:Apbb1	UTSW	7	105,223,062 (GRCm39)	missense	probably benign	0.09
R1076:Apbb1	UTSW	7	105,223,062 (GRCm39)	missense	probably benign	0.09
R1332:Apbb1	UTSW	7	105,214,750 (GRCm39)	missense	possibly damaging	0.74
R1658:Apbb1	UTSW	7	105,223,291 (GRCm39)	missense	probably damaging	1.00
R1739:Apbb1	UTSW	7	105,223,434 (GRCm39)	missense	probably benign
R4230:Apbb1	UTSW	7	105,216,891 (GRCm39)	missense	probably damaging	1.00
R4296:Apbb1	UTSW	7	105,223,033 (GRCm39)	missense	probably benign	0.16
R4385:Apbb1	UTSW	7	105,216,483 (GRCm39)	missense	probably benign	0.00
R4571:Apbb1	UTSW	7	105,222,969 (GRCm39)	missense	probably damaging	1.00
R4812:Apbb1	UTSW	7	105,223,232 (GRCm39)	missense	probably damaging	0.99
R5044:Apbb1	UTSW	7	105,214,889 (GRCm39)	intron	probably benign
R5109:Apbb1	UTSW	7	105,214,242 (GRCm39)	missense	probably damaging	1.00
R5479:Apbb1	UTSW	7	105,214,232 (GRCm39)	missense	probably damaging	0.97
R5611:Apbb1	UTSW	7	105,208,690 (GRCm39)	missense	probably damaging	1.00
R5677:Apbb1	UTSW	7	105,208,453 (GRCm39)	missense	probably damaging	1.00
R5785:Apbb1	UTSW	7	105,216,922 (GRCm39)	missense	probably damaging	1.00
R5850:Apbb1	UTSW	7	105,216,790 (GRCm39)	missense	probably damaging	1.00
R5896:Apbb1	UTSW	7	105,223,432 (GRCm39)	missense	probably damaging	1.00
R6151:Apbb1	UTSW	7	105,223,459 (GRCm39)	nonsense	probably null
R6186:Apbb1	UTSW	7	105,216,933 (GRCm39)	missense	probably damaging	1.00
R6229:Apbb1	UTSW	7	105,222,938 (GRCm39)	missense	probably damaging	0.98
R6229:Apbb1	UTSW	7	105,222,937 (GRCm39)	missense	probably damaging	0.98
R6288:Apbb1	UTSW	7	105,208,434 (GRCm39)	missense	probably damaging	1.00
R6295:Apbb1	UTSW	7	105,215,902 (GRCm39)	missense	probably benign
R6443:Apbb1	UTSW	7	105,222,970 (GRCm39)	missense	probably damaging	1.00
R6729:Apbb1	UTSW	7	105,214,588 (GRCm39)	missense	probably damaging	1.00
R7130:Apbb1	UTSW	7	105,214,538 (GRCm39)	missense	probably damaging	0.98
R7209:Apbb1	UTSW	7	105,215,292 (GRCm39)	missense	probably damaging	1.00
R7467:Apbb1	UTSW	7	105,215,339 (GRCm39)	missense	probably benign	0.04
R7489:Apbb1	UTSW	7	105,216,687 (GRCm39)	missense	probably benign	0.30
R7588:Apbb1	UTSW	7	105,223,173 (GRCm39)	missense	probably benign	0.29
R7754:Apbb1	UTSW	7	105,208,509 (GRCm39)	missense	probably damaging	0.97
R7768:Apbb1	UTSW	7	105,216,295 (GRCm39)	missense	probably benign
R7785:Apbb1	UTSW	7	105,216,630 (GRCm39)	missense	probably benign	0.00
R7804:Apbb1	UTSW	7	105,215,807 (GRCm39)	missense	probably damaging	1.00
R7809:Apbb1	UTSW	7	105,223,014 (GRCm39)	missense	probably benign	0.04
R7995:Apbb1	UTSW	7	105,214,852 (GRCm39)	missense	probably benign	0.09
R9206:Apbb1	UTSW	7	105,208,727 (GRCm39)	missense	probably damaging	0.97
R9208:Apbb1	UTSW	7	105,208,727 (GRCm39)	missense	probably damaging	0.97
R9225:Apbb1	UTSW	7	105,218,063 (GRCm39)	missense
Z1088:Apbb1	UTSW	7	105,208,343 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCATTGACCAAGCAGCGAG -3'
(R):5'- AAACCCTGTAGGCTGTCATGG -3'

Sequencing Primer
(F):5'- AGCATTGCGCCGTTCAGAC -3'
(R):5'- CATGGACAGGGAGGTTGTG -3'

Posted On

2015-10-08