Incidental Mutation 'R4639:Rgs16'
ID 350815
Institutional Source Beutler Lab
Gene Symbol Rgs16
Ensembl Gene ENSMUSG00000026475
Gene Name regulator of G-protein signaling 16
Synonyms Rgsr
MMRRC Submission 041901-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R4639 (G1)
Quality Score 130
Status Validated
Chromosome 1
Chromosomal Location 153616099-153621212 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 153617781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 97 (C97F)
Ref Sequence ENSEMBL: ENSMUSP00000027748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027748]
AlphaFold P97428
PDB Structure Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000027748
AA Change: C97F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027748
Gene: ENSMUSG00000026475
AA Change: C97F

DomainStartEndE-ValueType
RGS 64 180 3.69e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190663
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191474
Meta Mutation Damage Score 0.9436 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (37/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility toparasitic infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Atad2b A C 12: 5,068,053 (GRCm39) H1017P probably damaging Het
Atp8a1 A T 5: 67,813,317 (GRCm39) V943D probably benign Het
Babam1 C T 8: 71,856,951 (GRCm39) A304V probably damaging Het
Cdk5rap2 G T 4: 70,220,413 (GRCm39) A584D probably damaging Het
Ddx21 A T 10: 62,427,616 (GRCm39) L429* probably null Het
Dsp T C 13: 38,380,760 (GRCm39) Y2502H probably damaging Het
Eaf1 G A 14: 31,226,333 (GRCm39) D206N probably benign Het
Fam43b T A 4: 138,123,278 (GRCm39) D14V possibly damaging Het
Fanca T A 8: 124,044,889 (GRCm39) K34I probably damaging Het
Fzd4 T C 7: 89,056,525 (GRCm39) Y191H probably benign Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm10479 A G 12: 20,483,343 (GRCm39) T55A probably damaging Het
Gsr T G 8: 34,187,284 (GRCm39) I488M probably damaging Het
Mrs2 A G 13: 25,185,767 (GRCm39) I135T probably damaging Het
Myh13 T C 11: 67,232,377 (GRCm39) M517T possibly damaging Het
Naip1 C G 13: 100,580,791 (GRCm39) G152A probably benign Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nat10 G A 2: 103,565,234 (GRCm39) T449I probably benign Het
Nin A G 12: 70,085,375 (GRCm39) S1619P probably damaging Het
Or14c45 G A 7: 86,175,969 (GRCm39) M1I probably null Het
Or5m9b A G 2: 85,905,923 (GRCm39) I280V probably benign Het
Pcdh15 A G 10: 74,479,439 (GRCm39) T448A probably benign Het
Pcolce2 A G 9: 95,519,930 (GRCm39) probably null Het
Pnp C T 14: 51,188,380 (GRCm39) R207* probably null Het
Ppl A G 16: 4,907,310 (GRCm39) V995A probably damaging Het
Ppp2r2a G A 14: 67,276,406 (GRCm39) T33I probably damaging Het
Pramel20 C T 4: 143,298,467 (GRCm39) R137C probably benign Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Sacs T A 14: 61,444,717 (GRCm39) D2254E probably benign Het
Slc6a17 T C 3: 107,381,597 (GRCm39) M495V probably benign Het
Svep1 T C 4: 58,082,724 (GRCm39) I1967V probably benign Het
Sympk G T 7: 18,777,385 (GRCm39) R545L possibly damaging Het
Tcp11l2 A G 10: 84,420,800 (GRCm39) D13G probably damaging Het
Vmn1r167 T C 7: 23,205,011 (GRCm39) I2V probably benign Het
Vwa5a T C 9: 38,638,410 (GRCm39) probably null Het
Wdr95 T C 5: 149,505,279 (GRCm39) probably benign Het
Other mutations in Rgs16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01919:Rgs16 APN 1 153,617,804 (GRCm39) missense probably damaging 0.99
IGL02319:Rgs16 APN 1 153,617,852 (GRCm39) missense probably damaging 1.00
LCD18:Rgs16 UTSW 1 153,619,976 (GRCm39) utr 3 prime probably benign
R0295:Rgs16 UTSW 1 153,619,483 (GRCm39) missense probably damaging 1.00
R1355:Rgs16 UTSW 1 153,619,414 (GRCm39) missense probably damaging 0.99
R5398:Rgs16 UTSW 1 153,616,246 (GRCm39) missense probably benign 0.01
R6566:Rgs16 UTSW 1 153,619,546 (GRCm39) missense unknown
R6629:Rgs16 UTSW 1 153,619,420 (GRCm39) missense probably damaging 0.98
R7208:Rgs16 UTSW 1 153,617,416 (GRCm39) missense probably damaging 1.00
R8195:Rgs16 UTSW 1 153,616,689 (GRCm39) missense probably benign 0.00
R9125:Rgs16 UTSW 1 153,617,874 (GRCm39) missense probably null 1.00
R9140:Rgs16 UTSW 1 153,619,381 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACAAAGACAGAGCCTTGTTC -3'
(R):5'- CTGCACTGCAAAGCTAACTC -3'

Sequencing Primer
(F):5'- GAGCCATTAACGCCAATT -3'
(R):5'- ATTGACCTCGGTTTTCAGTTGGAAAG -3'
Posted On 2015-10-08