Incidental Mutation 'R4639:Or14c45'
ID 350829
Institutional Source Beutler Lab
Gene Symbol Or14c45
Ensembl Gene ENSMUSG00000057067
Gene Name olfactory receptor family 14 subfamily C member 45
Synonyms Olfr297, GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
MMRRC Submission 041901-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R4639 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 86175967-86176899 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) G to A at 86175969 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000134371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071112] [ENSMUST00000172965]
AlphaFold Q7TS07
Predicted Effect probably null
Transcript: ENSMUST00000071112
AA Change: M1I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132942
Gene: ENSMUSG00000057067
AA Change: M1I

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.9e-45 PFAM
Pfam:7tm_1 39 288 1.4e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000172965
AA Change: M1I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: M1I

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Meta Mutation Damage Score 0.7983 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (37/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Atad2b A C 12: 5,068,053 (GRCm39) H1017P probably damaging Het
Atp8a1 A T 5: 67,813,317 (GRCm39) V943D probably benign Het
Babam1 C T 8: 71,856,951 (GRCm39) A304V probably damaging Het
Cdk5rap2 G T 4: 70,220,413 (GRCm39) A584D probably damaging Het
Ddx21 A T 10: 62,427,616 (GRCm39) L429* probably null Het
Dsp T C 13: 38,380,760 (GRCm39) Y2502H probably damaging Het
Eaf1 G A 14: 31,226,333 (GRCm39) D206N probably benign Het
Fam43b T A 4: 138,123,278 (GRCm39) D14V possibly damaging Het
Fanca T A 8: 124,044,889 (GRCm39) K34I probably damaging Het
Fzd4 T C 7: 89,056,525 (GRCm39) Y191H probably benign Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm10479 A G 12: 20,483,343 (GRCm39) T55A probably damaging Het
Gsr T G 8: 34,187,284 (GRCm39) I488M probably damaging Het
Mrs2 A G 13: 25,185,767 (GRCm39) I135T probably damaging Het
Myh13 T C 11: 67,232,377 (GRCm39) M517T possibly damaging Het
Naip1 C G 13: 100,580,791 (GRCm39) G152A probably benign Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nat10 G A 2: 103,565,234 (GRCm39) T449I probably benign Het
Nin A G 12: 70,085,375 (GRCm39) S1619P probably damaging Het
Or5m9b A G 2: 85,905,923 (GRCm39) I280V probably benign Het
Pcdh15 A G 10: 74,479,439 (GRCm39) T448A probably benign Het
Pcolce2 A G 9: 95,519,930 (GRCm39) probably null Het
Pnp C T 14: 51,188,380 (GRCm39) R207* probably null Het
Ppl A G 16: 4,907,310 (GRCm39) V995A probably damaging Het
Ppp2r2a G A 14: 67,276,406 (GRCm39) T33I probably damaging Het
Pramel20 C T 4: 143,298,467 (GRCm39) R137C probably benign Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Rgs16 G T 1: 153,617,781 (GRCm39) C97F probably damaging Het
Sacs T A 14: 61,444,717 (GRCm39) D2254E probably benign Het
Slc6a17 T C 3: 107,381,597 (GRCm39) M495V probably benign Het
Svep1 T C 4: 58,082,724 (GRCm39) I1967V probably benign Het
Sympk G T 7: 18,777,385 (GRCm39) R545L possibly damaging Het
Tcp11l2 A G 10: 84,420,800 (GRCm39) D13G probably damaging Het
Vmn1r167 T C 7: 23,205,011 (GRCm39) I2V probably benign Het
Vwa5a T C 9: 38,638,410 (GRCm39) probably null Het
Wdr95 T C 5: 149,505,279 (GRCm39) probably benign Het
Other mutations in Or14c45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Or14c45 APN 7 86,175,986 (GRCm39) missense probably benign 0.10
IGL01823:Or14c45 APN 7 86,176,249 (GRCm39) missense probably damaging 1.00
PIT4378001:Or14c45 UTSW 7 86,176,306 (GRCm39) missense possibly damaging 0.50
R0304:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R0737:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R2177:Or14c45 UTSW 7 86,176,870 (GRCm39) missense probably benign 0.01
R2436:Or14c45 UTSW 7 86,176,591 (GRCm39) missense probably damaging 0.99
R4289:Or14c45 UTSW 7 86,176,262 (GRCm39) missense probably damaging 1.00
R5202:Or14c45 UTSW 7 86,176,324 (GRCm39) missense probably damaging 1.00
R5782:Or14c45 UTSW 7 86,176,421 (GRCm39) missense probably damaging 0.98
R6446:Or14c45 UTSW 7 86,176,310 (GRCm39) missense possibly damaging 0.90
R6615:Or14c45 UTSW 7 86,176,120 (GRCm39) missense probably benign 0.06
R6920:Or14c45 UTSW 7 86,176,522 (GRCm39) missense probably benign 0.00
R7150:Or14c45 UTSW 7 86,176,322 (GRCm39) missense probably damaging 1.00
R7309:Or14c45 UTSW 7 86,176,349 (GRCm39) missense probably damaging 1.00
R7621:Or14c45 UTSW 7 86,176,280 (GRCm39) missense probably benign 0.37
R8257:Or14c45 UTSW 7 86,176,678 (GRCm39) missense possibly damaging 0.95
R9349:Or14c45 UTSW 7 86,176,373 (GRCm39) missense probably benign 0.01
R9466:Or14c45 UTSW 7 86,176,080 (GRCm39) missense probably benign
R9479:Or14c45 UTSW 7 86,176,285 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- ATCAGACCATTTGACAGACAGC -3'
(R):5'- TTCCTGAGGAAGAAGTACATGG -3'

Sequencing Primer
(F):5'- CATTTGACAGACAGCCACATATATG -3'
(R):5'- AGAAGTACATGGGTGTGTTCAG -3'
Posted On 2015-10-08