Incidental Mutation 'R4608:Or2t1'
ID 350908
Institutional Source Beutler Lab
Gene Symbol Or2t1
Ensembl Gene ENSMUSG00000072707
Gene Name olfactory receptor family 2 subfamily T member 1
Synonyms MTPCR53, GA_x6K02T2PLTE-6714644-6715597, Olfr31, MOR274-1
MMRRC Submission 041819-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.238) question?
Stock # R4608 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 8140697-8141650 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 14328887 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 259 (M259V)
Ref Sequence ENSEMBL: ENSMUSP00000149019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100872] [ENSMUST00000206009] [ENSMUST00000217035]
AlphaFold E9Q3K2
Predicted Effect probably benign
Transcript: ENSMUST00000100872
AA Change: M259V

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000098434
Gene: ENSMUSG00000072707
AA Change: M259V

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5.7e-50 PFAM
Pfam:7tm_1 40 289 3.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206009
AA Change: M259V

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000217035
AA Change: M259V

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224991
Meta Mutation Damage Score 0.0811 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (80/80)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930022D16Rik A G 11: 109,308,855 (GRCm39) I74V unknown Het
Acss3 T A 10: 106,802,890 (GRCm39) I452F possibly damaging Het
Adam10 T C 9: 70,651,173 (GRCm39) L66P probably damaging Het
Adamts18 A T 8: 114,464,245 (GRCm39) C738S probably damaging Het
Adamts7 T G 9: 90,056,593 (GRCm39) S221A probably damaging Het
Adrm1 A G 2: 179,816,648 (GRCm39) probably benign Het
Aqp1 T C 6: 55,313,624 (GRCm39) V50A possibly damaging Het
Aqp4 T C 18: 15,531,183 (GRCm39) I193V probably benign Het
B130006D01Rik A T 11: 95,617,066 (GRCm39) probably benign Het
Bbs10 T G 10: 111,136,681 (GRCm39) I598S probably damaging Het
Bbs10 A G 10: 111,136,995 (GRCm39) K703E probably benign Het
Ccdc121rt2 A G 5: 112,597,764 (GRCm39) S104G possibly damaging Het
Ccnl1 C T 3: 65,854,131 (GRCm39) probably benign Het
Crocc2 G A 1: 93,096,516 (GRCm39) V24M possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dcdc2a T A 13: 25,245,223 (GRCm39) L100* probably null Het
Eif4g3 G T 4: 137,853,769 (GRCm39) R618L probably benign Het
F5 C T 1: 164,036,598 (GRCm39) P1920S probably benign Het
Fam187b T A 7: 30,677,170 (GRCm39) N226K probably benign Het
Fancc C A 13: 63,479,637 (GRCm39) probably benign Het
Fastk G T 5: 24,648,117 (GRCm39) P233H probably damaging Het
Fbn1 A C 2: 125,148,420 (GRCm39) D2609E probably benign Het
Fes G A 7: 80,036,959 (GRCm39) R42W probably damaging Het
Fmnl2 T A 2: 52,993,728 (GRCm39) N374K possibly damaging Het
Fpgt G A 3: 154,792,333 (GRCm39) Q565* probably null Het
Gckr A G 5: 31,465,141 (GRCm39) D370G probably damaging Het
Ggt6 T C 11: 72,328,769 (GRCm39) M385T probably benign Het
Gm26657 C A 4: 56,741,114 (GRCm39) H100N probably benign Het
Gsg1l T A 7: 125,557,721 (GRCm39) I136F probably damaging Het
Hhip C T 8: 80,724,192 (GRCm39) R350Q probably damaging Het
Ints1 C T 5: 139,745,599 (GRCm39) S1353N probably benign Het
Ints10 G A 8: 69,263,271 (GRCm39) R394Q probably damaging Het
Ints6 T G 14: 62,940,678 (GRCm39) R557S probably damaging Het
Ints9 T A 14: 65,269,729 (GRCm39) I473N possibly damaging Het
Itih4 G A 14: 30,623,626 (GRCm39) G915R probably damaging Het
Kif1a C A 1: 92,952,368 (GRCm39) A1304S possibly damaging Het
Kif21b C T 1: 136,075,924 (GRCm39) probably benign Het
Klk13 C A 7: 43,363,284 (GRCm39) C10* probably null Het
Krtap4-8 C T 11: 99,671,321 (GRCm39) probably benign Het
Lef1 T C 3: 130,978,382 (GRCm39) S167P probably benign Het
Leng8 T A 7: 4,147,796 (GRCm39) I607N probably damaging Het
Lrch4 T A 5: 137,637,408 (GRCm39) L526* probably null Het
Memo1 G A 17: 74,565,456 (GRCm39) Q36* probably null Het
Nod1 C A 6: 54,920,741 (GRCm39) A526S probably damaging Het
Nostrin G A 2: 69,014,243 (GRCm39) V400M possibly damaging Het
Nrip1 T C 16: 76,089,920 (GRCm39) T546A probably benign Het
Nxf1 A G 19: 8,740,127 (GRCm39) D98G probably benign Het
Or13a24 A G 7: 140,154,554 (GRCm39) M163V probably benign Het
Or1l4 T A 2: 37,092,094 (GRCm39) Y280* probably null Het
Or2h2b-ps1 A T 17: 37,481,173 (GRCm39) V20E probably damaging Het
Or4c114 G T 2: 88,904,656 (GRCm39) P260T probably benign Het
Or6aa1 A T 7: 86,043,718 (GRCm39) probably null Het
Osgep T C 14: 51,155,378 (GRCm39) Y60C probably damaging Het
P2ry6 A G 7: 100,587,511 (GRCm39) Y283H probably damaging Het
Pcdha7 A T 18: 37,108,870 (GRCm39) S632C possibly damaging Het
Pms1 T A 1: 53,234,097 (GRCm39) R806S possibly damaging Het
Qars1 T A 9: 108,386,625 (GRCm39) probably null Het
Rxfp1 T C 3: 79,594,196 (GRCm39) N66S probably damaging Het
Slc12a5 A T 2: 164,815,685 (GRCm39) N67I probably damaging Het
Slc1a4 G T 11: 20,254,348 (GRCm39) T506K probably damaging Het
Stimate C A 14: 30,594,490 (GRCm39) probably benign Het
Tlr9 T A 9: 106,102,173 (GRCm39) I488N probably damaging Het
Tmem74 G T 15: 43,730,554 (GRCm39) T163K probably damaging Het
Uba2 T C 7: 33,854,021 (GRCm39) D307G probably damaging Het
Uty C T Y: 1,131,134 (GRCm39) R924Q probably damaging Het
Wdr7 C T 18: 63,910,651 (GRCm39) T681I probably benign Het
Xab2 A G 8: 3,668,105 (GRCm39) S158P probably benign Het
Ythdc1 T C 5: 86,970,667 (GRCm39) S418P probably damaging Het
Zfand4 T A 6: 116,305,195 (GRCm39) C207* probably null Het
Zfp367 C T 13: 64,283,238 (GRCm39) D305N probably damaging Het
Zfp804b C T 5: 6,822,584 (GRCm39) V160I probably benign Het
Other mutations in Or2t1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02550:Or2t1 APN 14 14,328,423 (GRCm38) missense possibly damaging 0.91
IGL02566:Or2t1 APN 14 14,328,138 (GRCm38) missense probably benign 0.05
IGL02902:Or2t1 APN 14 14,328,789 (GRCm38) missense probably benign
IGL03106:Or2t1 APN 14 14,328,851 (GRCm38) missense probably damaging 0.97
IGL03214:Or2t1 APN 14 14,328,284 (GRCm38) missense probably damaging 0.98
R0333:Or2t1 UTSW 14 14,328,498 (GRCm38) missense probably damaging 1.00
R0828:Or2t1 UTSW 14 14,328,800 (GRCm38) missense probably benign 0.00
R1231:Or2t1 UTSW 14 14,328,515 (GRCm38) missense probably benign 0.00
R1725:Or2t1 UTSW 14 14,328,977 (GRCm38) missense probably damaging 1.00
R1823:Or2t1 UTSW 14 14,328,774 (GRCm38) missense probably damaging 1.00
R1824:Or2t1 UTSW 14 14,328,774 (GRCm38) missense probably damaging 1.00
R2026:Or2t1 UTSW 14 14,328,891 (GRCm38) missense probably benign 0.10
R3891:Or2t1 UTSW 14 14,328,114 (GRCm38) start codon destroyed probably null 0.99
R4327:Or2t1 UTSW 14 14,328,193 (GRCm38) missense probably damaging 1.00
R4328:Or2t1 UTSW 14 14,328,193 (GRCm38) missense probably damaging 1.00
R4893:Or2t1 UTSW 14 14,328,852 (GRCm38) missense probably damaging 1.00
R5197:Or2t1 UTSW 14 14,328,462 (GRCm38) missense probably damaging 1.00
R5402:Or2t1 UTSW 14 14,328,878 (GRCm38) missense probably damaging 1.00
R5787:Or2t1 UTSW 14 14,328,725 (GRCm38) missense probably damaging 0.98
R5897:Or2t1 UTSW 14 14,328,120 (GRCm38) missense probably benign 0.00
R7340:Or2t1 UTSW 14 14,328,401 (GRCm38) missense possibly damaging 0.90
R7709:Or2t1 UTSW 14 14,328,384 (GRCm38) missense probably damaging 1.00
R8284:Or2t1 UTSW 14 14,329,011 (GRCm38) missense possibly damaging 0.91
R9166:Or2t1 UTSW 14 14,329,059 (GRCm38) missense probably benign 0.14
R9427:Or2t1 UTSW 14 14,328,456 (GRCm38) missense probably damaging 1.00
R9481:Or2t1 UTSW 14 14,328,756 (GRCm38) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- CTGAAGTTGGCATGTGCAGAC -3'
(R):5'- AGTCTTTGGACACTCGCTGAG -3'

Sequencing Primer
(F):5'- AGCCCTCTATGAGACGGTGATG -3'
(R):5'- TTGGACACTCGCTGAGAACTC -3'
Posted On 2015-10-08