Incidental Mutation 'R0268:Dlg1'
| ID |
35103 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlg1
|
| Ensembl Gene |
ENSMUSG00000022770 |
| Gene Name |
discs large MAGUK scaffold protein 1 |
| Synonyms |
B130052P05Rik, SAP97, Dlgh1 |
| MMRRC Submission |
038494-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0268 (G1)
|
| Quality Score |
183 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
31482261-31692174 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 31503011 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 73
(C73R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138782
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023454]
[ENSMUST00000064477]
[ENSMUST00000100001]
[ENSMUST00000115201]
[ENSMUST00000115205]
[ENSMUST00000132176]
|
| AlphaFold |
Q811D0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023454
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000023454
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
441 |
514 |
1.84e-22 |
SMART |
|
low complexity region
|
534 |
542 |
N/A |
INTRINSIC |
|
SH3
|
551 |
617 |
1.27e-9 |
SMART |
|
GuKc
|
681 |
860 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064477
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000064280
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
736 |
915 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100001
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000097581
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115201
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110855
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
721 |
900 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115205
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110859
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132176
AA Change: C73R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138782
Gene: ENSMUSG00000022770
AA Change: C73R
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
426 |
499 |
1.84e-22 |
SMART |
|
low complexity region
|
519 |
527 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155958
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232316
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.7%
- 10x: 95.9%
- 20x: 93.0%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
T |
A |
7: 29,274,027 (GRCm39) |
|
noncoding transcript |
Het |
| Aadacl4 |
A |
T |
4: 144,349,565 (GRCm39) |
H274L |
probably benign |
Het |
| Aldh1a7 |
T |
A |
19: 20,686,866 (GRCm39) |
|
probably null |
Het |
| Ap3m1 |
A |
C |
14: 21,087,170 (GRCm39) |
|
probably benign |
Het |
| Atp5f1a |
C |
A |
18: 77,867,895 (GRCm39) |
N356K |
probably damaging |
Het |
| AU021092 |
A |
T |
16: 5,040,031 (GRCm39) |
M31K |
possibly damaging |
Het |
| Avpr1a |
T |
C |
10: 122,285,614 (GRCm39) |
V302A |
probably damaging |
Het |
| Bicral |
A |
G |
17: 47,124,978 (GRCm39) |
|
probably benign |
Het |
| Btbd9 |
C |
T |
17: 30,493,916 (GRCm39) |
D492N |
possibly damaging |
Het |
| Casp8ap2 |
A |
T |
4: 32,644,079 (GRCm39) |
I1051F |
probably damaging |
Het |
| Cd209e |
T |
C |
8: 3,899,125 (GRCm39) |
I196V |
probably benign |
Het |
| Cdc42bpa |
G |
T |
1: 179,983,347 (GRCm39) |
|
probably benign |
Het |
| Cdcp3 |
A |
G |
7: 130,839,905 (GRCm39) |
D609G |
probably damaging |
Het |
| Clec16a |
T |
A |
16: 10,462,692 (GRCm39) |
L670* |
probably null |
Het |
| Cmtm2b |
A |
G |
8: 105,049,066 (GRCm39) |
E27G |
probably damaging |
Het |
| Col4a1 |
T |
A |
8: 11,317,588 (GRCm39) |
|
probably benign |
Het |
| Cyp26b1 |
A |
T |
6: 84,551,554 (GRCm39) |
F221I |
probably damaging |
Het |
| D430041D05Rik |
G |
C |
2: 103,998,295 (GRCm39) |
P1836R |
probably damaging |
Het |
| Dennd6b |
T |
C |
15: 89,080,432 (GRCm39) |
Q56R |
probably benign |
Het |
| Dip2c |
G |
A |
13: 9,687,186 (GRCm39) |
R1270H |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,988,681 (GRCm39) |
D3217G |
probably damaging |
Het |
| Dtx1 |
T |
C |
5: 120,819,356 (GRCm39) |
E614G |
probably damaging |
Het |
| Dut |
C |
A |
2: 125,099,011 (GRCm39) |
A166E |
probably damaging |
Het |
| Ebf1 |
C |
A |
11: 44,534,240 (GRCm39) |
D166E |
probably damaging |
Het |
| Egln2 |
A |
T |
7: 26,864,672 (GRCm39) |
D84E |
possibly damaging |
Het |
| Exosc7 |
T |
A |
9: 122,948,025 (GRCm39) |
S65T |
probably benign |
Het |
| Fam83e |
G |
A |
7: 45,376,334 (GRCm39) |
R349Q |
probably benign |
Het |
| Fbxl17 |
G |
A |
17: 63,692,062 (GRCm39) |
|
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,884,868 (GRCm39) |
N2582S |
probably damaging |
Het |
| Fubp1 |
T |
C |
3: 151,925,350 (GRCm39) |
V164A |
probably damaging |
Het |
| Gfral |
A |
T |
9: 76,104,383 (GRCm39) |
C210S |
probably damaging |
Het |
| Gls |
GGCTGCTGCTGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTGCTGCTGCTG |
1: 52,271,853 (GRCm39) |
|
probably benign |
Het |
| Hcn4 |
A |
C |
9: 58,767,445 (GRCm39) |
E1002A |
unknown |
Het |
| Hcrtr2 |
A |
G |
9: 76,135,470 (GRCm39) |
V449A |
probably benign |
Het |
| Hectd1 |
T |
C |
12: 51,815,891 (GRCm39) |
S1394G |
possibly damaging |
Het |
| Hectd1 |
C |
A |
12: 51,815,890 (GRCm39) |
S1394I |
probably damaging |
Het |
| Hecw2 |
A |
G |
1: 53,965,857 (GRCm39) |
|
probably benign |
Het |
| Herc3 |
A |
G |
6: 58,845,613 (GRCm39) |
|
probably benign |
Het |
| Ipo4 |
T |
C |
14: 55,863,399 (GRCm39) |
Q1073R |
possibly damaging |
Het |
| Itsn2 |
G |
A |
12: 4,750,333 (GRCm39) |
R1199Q |
probably benign |
Het |
| Kcnj3 |
C |
A |
2: 55,484,971 (GRCm39) |
Y356* |
probably null |
Het |
| Klb |
T |
A |
5: 65,506,180 (GRCm39) |
D142E |
probably benign |
Het |
| Klhl35 |
T |
A |
7: 99,120,958 (GRCm39) |
S409T |
probably benign |
Het |
| Krt16 |
T |
A |
11: 100,137,351 (GRCm39) |
|
probably benign |
Het |
| Krt82 |
C |
A |
15: 101,450,148 (GRCm39) |
R516L |
probably benign |
Het |
| Lce3a |
A |
T |
3: 92,833,038 (GRCm39) |
C21S |
unknown |
Het |
| Lims2 |
A |
G |
18: 32,077,573 (GRCm39) |
E103G |
probably benign |
Het |
| Map2 |
A |
T |
1: 66,419,881 (GRCm39) |
K71* |
probably null |
Het |
| Mthfr |
C |
G |
4: 148,139,885 (GRCm39) |
S618W |
probably damaging |
Het |
| Mycbp2 |
T |
A |
14: 103,551,761 (GRCm39) |
R157* |
probably null |
Het |
| Nat10 |
C |
A |
2: 103,558,262 (GRCm39) |
|
probably benign |
Het |
| Obscn |
G |
A |
11: 58,958,098 (GRCm39) |
T3810M |
possibly damaging |
Het |
| Or13a19 |
G |
A |
7: 139,903,068 (GRCm39) |
S152N |
possibly damaging |
Het |
| Or1x6 |
T |
A |
11: 50,939,768 (GRCm39) |
M278K |
probably damaging |
Het |
| Or5d35 |
A |
T |
2: 87,855,812 (GRCm39) |
I249F |
probably damaging |
Het |
| Or5g29 |
A |
G |
2: 85,421,645 (GRCm39) |
T254A |
possibly damaging |
Het |
| Or6c209 |
A |
T |
10: 129,483,045 (GRCm39) |
D16V |
possibly damaging |
Het |
| Or7a38 |
C |
T |
10: 78,753,439 (GRCm39) |
T255I |
probably damaging |
Het |
| Park7 |
A |
G |
4: 150,992,806 (GRCm39) |
V20A |
possibly damaging |
Het |
| Pgm2 |
T |
A |
5: 64,263,151 (GRCm39) |
V266E |
probably damaging |
Het |
| Phip |
G |
A |
9: 82,753,341 (GRCm39) |
T1801I |
probably damaging |
Het |
| Pkhd1l1 |
C |
A |
15: 44,460,407 (GRCm39) |
H4205Q |
probably benign |
Het |
| Ppp1r12a |
T |
A |
10: 108,109,242 (GRCm39) |
|
probably benign |
Het |
| Pramel26 |
A |
T |
4: 143,537,338 (GRCm39) |
I331N |
probably damaging |
Het |
| Ptprq |
A |
T |
10: 107,541,409 (GRCm39) |
D372E |
probably benign |
Het |
| Ptprr |
G |
A |
10: 116,088,868 (GRCm39) |
V340I |
possibly damaging |
Het |
| Qki |
A |
G |
17: 10,428,575 (GRCm39) |
|
probably benign |
Het |
| Qpct |
T |
A |
17: 79,385,081 (GRCm39) |
D240E |
probably benign |
Het |
| Ren1 |
A |
G |
1: 133,283,349 (GRCm39) |
T162A |
possibly damaging |
Het |
| Rif1 |
T |
C |
2: 51,980,298 (GRCm39) |
|
probably null |
Het |
| Sart3 |
A |
G |
5: 113,890,460 (GRCm39) |
V461A |
probably damaging |
Het |
| Saxo4 |
A |
G |
19: 10,454,449 (GRCm39) |
V329A |
possibly damaging |
Het |
| Scgb1b24 |
G |
A |
7: 33,443,278 (GRCm39) |
G19R |
probably null |
Het |
| Spen |
A |
T |
4: 141,204,868 (GRCm39) |
I1253N |
unknown |
Het |
| Sspo |
C |
A |
6: 48,442,489 (GRCm39) |
H1995N |
probably benign |
Het |
| Tfap2c |
A |
G |
2: 172,393,423 (GRCm39) |
T113A |
probably benign |
Het |
| Togaram2 |
T |
C |
17: 72,004,993 (GRCm39) |
|
probably null |
Het |
| Trim65 |
T |
A |
11: 116,017,470 (GRCm39) |
|
probably benign |
Het |
| Trpm3 |
T |
A |
19: 22,874,885 (GRCm39) |
|
probably null |
Het |
| Ubxn7 |
T |
C |
16: 32,178,864 (GRCm39) |
I87T |
probably benign |
Het |
| Vav1 |
T |
C |
17: 57,603,090 (GRCm39) |
F81L |
probably damaging |
Het |
| Vmn2r102 |
A |
G |
17: 19,898,112 (GRCm39) |
T376A |
probably benign |
Het |
| Vmn2r105 |
A |
T |
17: 20,428,938 (GRCm39) |
C713S |
probably benign |
Het |
| Zbtb45 |
C |
T |
7: 12,742,254 (GRCm39) |
M1I |
probably null |
Het |
| Zfp229 |
A |
T |
17: 21,964,822 (GRCm39) |
M351L |
probably benign |
Het |
| Zfp932 |
T |
C |
5: 110,156,929 (GRCm39) |
I176T |
probably benign |
Het |
| Zswim1 |
G |
A |
2: 164,668,046 (GRCm39) |
E433K |
probably damaging |
Het |
|
| Other mutations in Dlg1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01604:Dlg1
|
APN |
16 |
31,675,256 (GRCm39) |
splice site |
probably benign |
|
|
IGL02277:Dlg1
|
APN |
16 |
31,609,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02897:Dlg1
|
APN |
16 |
31,590,674 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03025:Dlg1
|
APN |
16 |
31,624,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03271:Dlg1
|
APN |
16 |
31,676,710 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4812001:Dlg1
|
UTSW |
16 |
31,665,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0068:Dlg1
|
UTSW |
16 |
31,655,018 (GRCm39) |
unclassified |
probably benign |
|
|
R0115:Dlg1
|
UTSW |
16 |
31,624,508 (GRCm39) |
nonsense |
probably null |
|
|
R0128:Dlg1
|
UTSW |
16 |
31,676,883 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0257:Dlg1
|
UTSW |
16 |
31,661,671 (GRCm39) |
splice site |
probably benign |
|
|
R0312:Dlg1
|
UTSW |
16 |
31,609,085 (GRCm39) |
missense |
probably benign |
|
|
R0321:Dlg1
|
UTSW |
16 |
31,676,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0355:Dlg1
|
UTSW |
16 |
31,502,992 (GRCm39) |
nonsense |
probably null |
|
|
R0538:Dlg1
|
UTSW |
16 |
31,615,682 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0540:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,484,398 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0894:Dlg1
|
UTSW |
16 |
31,561,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1107:Dlg1
|
UTSW |
16 |
31,665,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1349:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1372:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1696:Dlg1
|
UTSW |
16 |
31,600,616 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1772:Dlg1
|
UTSW |
16 |
31,484,485 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1795:Dlg1
|
UTSW |
16 |
31,561,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2106:Dlg1
|
UTSW |
16 |
31,631,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2207:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2846:Dlg1
|
UTSW |
16 |
31,682,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3954:Dlg1
|
UTSW |
16 |
31,676,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Dlg1
|
UTSW |
16 |
31,609,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Dlg1
|
UTSW |
16 |
31,610,570 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4898:Dlg1
|
UTSW |
16 |
31,676,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4966:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4985:Dlg1
|
UTSW |
16 |
31,606,953 (GRCm39) |
splice site |
probably null |
|
|
R5068:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5069:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5078:Dlg1
|
UTSW |
16 |
31,675,287 (GRCm39) |
nonsense |
probably null |
|
|
R5090:Dlg1
|
UTSW |
16 |
31,656,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5225:Dlg1
|
UTSW |
16 |
31,655,085 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5888:Dlg1
|
UTSW |
16 |
31,610,704 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5950:Dlg1
|
UTSW |
16 |
31,484,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Dlg1
|
UTSW |
16 |
31,612,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6132:Dlg1
|
UTSW |
16 |
31,655,059 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6246:Dlg1
|
UTSW |
16 |
31,484,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6294:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6322:Dlg1
|
UTSW |
16 |
31,675,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7147:Dlg1
|
UTSW |
16 |
31,610,672 (GRCm39) |
missense |
probably benign |
|
|
R7216:Dlg1
|
UTSW |
16 |
31,615,736 (GRCm39) |
frame shift |
probably null |
|
|
R7963:Dlg1
|
UTSW |
16 |
31,609,119 (GRCm39) |
missense |
probably null |
0.92 |
|
R7985:Dlg1
|
UTSW |
16 |
31,606,923 (GRCm39) |
nonsense |
probably null |
|
|
R8041:Dlg1
|
UTSW |
16 |
31,656,885 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8111:Dlg1
|
UTSW |
16 |
31,661,620 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8751:Dlg1
|
UTSW |
16 |
31,600,648 (GRCm39) |
missense |
probably benign |
|
|
R9052:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9674:Dlg1
|
UTSW |
16 |
31,610,580 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9725:Dlg1
|
UTSW |
16 |
31,665,683 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9741:Dlg1
|
UTSW |
16 |
31,676,735 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Dlg1
|
UTSW |
16 |
31,484,526 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCACCGTCACTGTTTACATTTGA -3'
(R):5'- GCTTTCTGAGATCTACCACCAAGACAC -3'
Sequencing Primer
(F):5'- gcaagagcagggggcag -3'
(R):5'- AGACAGAATCAAGATTCTTGACAC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation