Mutagenetix > Incidental Mutation

Incidental Mutation 'R4617:Cdh26'

351096

Institutional Source

Beutler Lab

Gene Symbol

Cdh26

Ensembl Gene

ENSMUSG00000039155

Gene Name

cadherin-like 26

Synonyms

LOC381409

MMRRC Submission

041828-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4617 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

178072324-178129159 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

G to A at 178102435 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104540 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042092] [ENSMUST00000108912]

AlphaFold

P59862

Predicted Effect

probably benign
Transcript: ENSMUST00000042092

SMART Domains

Protein: ENSMUSP00000048829
Gene: ENSMUSG00000039155

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CA	36	138	5.06e-2	SMART
CA	162	248	1.23e-19	SMART
CA	271	370	1.01e-6	SMART
CA	393	476	2.86e-20	SMART
transmembrane domain	592	614	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108912

SMART Domains

Protein: ENSMUSP00000104540
Gene: ENSMUSG00000039155

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CA	36	138	5.06e-2	SMART
CA	162	248	1.23e-19	SMART
CA	271	370	1.01e-6	SMART
CA	393	476	2.86e-20	SMART
transmembrane domain	592	614	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176869

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

96% (66/69)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,369,493 (GRCm39)	I363V	probably benign	Het
Acaa1a	T	A	9: 119,178,006 (GRCm39)	S279R	probably damaging	Het
Akr1cl	A	G	1: 65,060,550 (GRCm39)	C156R	probably damaging	Het
Arhgap11a	G	A	2: 113,664,423 (GRCm39)	T620M	probably benign	Het
Brinp1	A	G	4: 68,681,198 (GRCm39)	I444T	possibly damaging	Het
Ccdc150	A	G	1: 54,394,913 (GRCm39)	I760V	probably benign	Het
Cpd	A	G	11: 76,731,441 (GRCm39)	L255P	probably damaging	Het
Cyfip2	A	G	11: 46,144,845 (GRCm39)	Y670H	probably damaging	Het
Disp2	G	A	2: 118,620,643 (GRCm39)	M458I	probably benign	Het
Dot1l	T	C	10: 80,620,918 (GRCm39)	I563T	probably damaging	Het
Egf	A	T	3: 129,484,442 (GRCm39)	S1001T	probably benign	Het
Elfn1	A	G	5: 139,957,764 (GRCm39)	Y256C	probably damaging	Het
Exoc4	C	T	6: 33,839,139 (GRCm39)	T725I	probably benign	Het
Fam168b	A	G	1: 34,859,063 (GRCm39)	V72A	possibly damaging	Het
Fbxw20	C	T	9: 109,046,631 (GRCm39)	S443N	probably damaging	Het
Flacc1	A	T	1: 58,700,601 (GRCm39)	D301E	probably benign	Het
Flrt2	T	C	12: 95,747,003 (GRCm39)	V447A	possibly damaging	Het
Gm4846	A	G	1: 166,323,550 (GRCm39)	S58P	probably damaging	Het
Gpr20	T	C	15: 73,567,585 (GRCm39)	N268S	probably benign	Het
Lpcat2b	T	C	5: 107,581,865 (GRCm39)	L398P	possibly damaging	Het
Mapk8ip3	G	A	17: 25,123,761 (GRCm39)	P587L	probably damaging	Het
Mfap4	C	A	11: 61,376,335 (GRCm39)		probably benign	Het
Mplkipl1	C	T	19: 61,164,364 (GRCm39)	G24R	unknown	Het
Mrpl38	T	C	11: 116,023,278 (GRCm39)	D325G	probably damaging	Het
Mtmr12	A	G	15: 12,270,132 (GRCm39)	E430G	probably damaging	Het
Mup18	T	A	4: 61,590,154 (GRCm39)	I125F	possibly damaging	Het
Ogdhl	A	G	14: 32,047,842 (GRCm39)	R31G	probably benign	Het
Or13f5	A	T	4: 52,825,399 (GRCm39)	M1L	probably benign	Het
Pcdh1	C	A	18: 38,330,913 (GRCm39)	V697L	probably benign	Het
Pcdhga9	T	C	18: 37,871,553 (GRCm39)	Y461H	probably damaging	Het
Pdzrn4	A	G	15: 92,667,723 (GRCm39)	Y625C	probably damaging	Het
Pkd2l1	C	A	19: 44,142,573 (GRCm39)	A490S	probably damaging	Het
Poglut2	A	C	1: 44,149,180 (GRCm39)	F453V	probably damaging	Het
Ptprn	T	A	1: 75,228,931 (GRCm39)	D828V	possibly damaging	Het
Rgs12	T	A	5: 35,177,700 (GRCm39)	W97R	probably damaging	Het
Rnf10	T	A	5: 115,386,762 (GRCm39)	Q508L	probably damaging	Het
Rufy4	T	C	1: 74,186,822 (GRCm39)	C537R	probably damaging	Het
Sec24b	A	T	3: 129,834,413 (GRCm39)	S126T	possibly damaging	Het
Slc6a5	A	G	7: 49,561,768 (GRCm39)	N100S	probably benign	Het
Speer1j	T	C	5: 11,553,798 (GRCm39)	S7P	probably benign	Het
Stam2	A	T	2: 52,605,716 (GRCm39)	D167E	probably benign	Het
Stambp	G	A	6: 83,538,960 (GRCm39)	Q147*	probably null	Het
Tbc1d32	A	G	10: 56,047,000 (GRCm39)	V556A	possibly damaging	Het
Tll2	T	C	19: 41,087,075 (GRCm39)	D592G	probably benign	Het
Tmem199	A	T	11: 78,400,508 (GRCm39)		probably benign	Het
Traip	T	A	9: 107,847,218 (GRCm39)	N352K	probably benign	Het
Trmt1l	C	T	1: 151,329,799 (GRCm39)	Q581*	probably null	Het
Usp54	C	A	14: 20,600,406 (GRCm39)	A1444S	probably benign	Het
Vsig1	G	T	X: 139,827,135 (GRCm39)	A95S	probably benign	Het
Xdh	G	A	17: 74,225,389 (GRCm39)	T471I	probably damaging	Het
Zdhhc19	A	G	16: 32,316,494 (GRCm39)	D83G	probably damaging	Het
Zfp352	A	G	4: 90,113,318 (GRCm39)	K486R	probably benign	Het
Zfp451	A	G	1: 33,841,752 (GRCm39)		probably benign	Het
Zfp963	A	T	8: 70,195,944 (GRCm39)	S170T	probably benign	Het
Zfp970	A	G	2: 177,167,961 (GRCm39)	I512V	probably benign	Het
Zfp990	A	G	4: 145,263,616 (GRCm39)	I205V	possibly damaging	Het

Other mutations in Cdh26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00846:Cdh26	APN	2	178,123,417 (GRCm39)	missense	possibly damaging	0.86
IGL01341:Cdh26	APN	2	178,099,240 (GRCm39)	missense	probably damaging	0.99
IGL02636:Cdh26	APN	2	178,091,755 (GRCm39)	missense	probably damaging	1.00
IGL03144:Cdh26	APN	2	178,109,967 (GRCm39)	missense	probably damaging	0.99
R0244:Cdh26	UTSW	2	178,123,425 (GRCm39)	missense	possibly damaging	0.88
R0245:Cdh26	UTSW	2	178,123,425 (GRCm39)	missense	possibly damaging	0.88
R0466:Cdh26	UTSW	2	178,123,425 (GRCm39)	missense	possibly damaging	0.88
R0467:Cdh26	UTSW	2	178,123,425 (GRCm39)	missense	possibly damaging	0.88
R0514:Cdh26	UTSW	2	178,108,621 (GRCm39)	critical splice donor site	probably null
R0610:Cdh26	UTSW	2	178,091,691 (GRCm39)	missense	probably damaging	1.00
R0733:Cdh26	UTSW	2	178,128,724 (GRCm39)	missense	probably damaging	1.00
R1592:Cdh26	UTSW	2	178,091,684 (GRCm39)	missense	probably damaging	1.00
R2483:Cdh26	UTSW	2	178,108,382 (GRCm39)	missense	probably damaging	1.00
R3756:Cdh26	UTSW	2	178,111,794 (GRCm39)	splice site	probably benign
R4914:Cdh26	UTSW	2	178,091,614 (GRCm39)	missense	probably benign	0.02
R4915:Cdh26	UTSW	2	178,091,614 (GRCm39)	missense	probably benign	0.02
R4917:Cdh26	UTSW	2	178,091,614 (GRCm39)	missense	probably benign	0.02
R4918:Cdh26	UTSW	2	178,091,614 (GRCm39)	missense	probably benign	0.02
R5086:Cdh26	UTSW	2	178,083,210 (GRCm39)	nonsense	probably null
R5573:Cdh26	UTSW	2	178,108,482 (GRCm39)	missense	probably damaging	0.96
R5809:Cdh26	UTSW	2	178,101,919 (GRCm39)	nonsense	probably null
R5941:Cdh26	UTSW	2	178,123,443 (GRCm39)	nonsense	probably null
R6284:Cdh26	UTSW	2	178,091,677 (GRCm39)	missense	probably damaging	1.00
R6341:Cdh26	UTSW	2	178,113,366 (GRCm39)	splice site	probably null
R6496:Cdh26	UTSW	2	178,091,654 (GRCm39)	missense	probably damaging	1.00
R7132:Cdh26	UTSW	2	178,128,555 (GRCm39)	missense	possibly damaging	0.56
R7664:Cdh26	UTSW	2	178,111,835 (GRCm39)	missense	probably benign	0.02
R7694:Cdh26	UTSW	2	178,101,896 (GRCm39)	missense	probably damaging	0.96
R7814:Cdh26	UTSW	2	178,111,828 (GRCm39)	missense	probably damaging	0.98
R8089:Cdh26	UTSW	2	178,099,370 (GRCm39)	critical splice donor site	probably null
R8103:Cdh26	UTSW	2	178,110,006 (GRCm39)	missense	probably damaging	1.00
R8412:Cdh26	UTSW	2	178,104,517 (GRCm39)	missense	probably damaging	0.98
R8413:Cdh26	UTSW	2	178,110,022 (GRCm39)	missense	probably damaging	0.99
R9025:Cdh26	UTSW	2	178,104,409 (GRCm39)	missense	probably benign	0.01
R9621:Cdh26	UTSW	2	178,111,983 (GRCm39)	missense	probably damaging	1.00
R9628:Cdh26	UTSW	2	178,083,213 (GRCm39)	missense
RF002:Cdh26	UTSW	2	178,108,424 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GAGCTACTGAAAGCCACAGATC -3'
(R):5'- GCAGCATATGACTTACACGGTC -3'

Sequencing Primer
(F):5'- GATCTAGAGTGCTCCCAGACAG -3'
(R):5'- ACACGGTCTTCCATAAATGTGGG -3'

Posted On

2015-10-08