Incidental Mutation 'R3981:Mras'
ID 351176
Institutional Source Beutler Lab
Gene Symbol Mras
Ensembl Gene ENSMUSG00000032470
Gene Name muscle and microspikes RAS
Synonyms 2900078C09Rik
MMRRC Submission 040943-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R3981 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 99267473-99319434 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99293469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 57 (D57G)
Ref Sequence ENSEMBL: ENSMUSP00000121307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035045] [ENSMUST00000119472] [ENSMUST00000122384] [ENSMUST00000123771]
AlphaFold O08989
Predicted Effect probably damaging
Transcript: ENSMUST00000035045
AA Change: D57G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035045
Gene: ENSMUSG00000032470
AA Change: D57G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119472
AA Change: D57G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112407
Gene: ENSMUSG00000032470
AA Change: D57G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000122384
AA Change: D57G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113275
Gene: ENSMUSG00000032470
AA Change: D57G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000123771
AA Change: D57G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121307
Gene: ENSMUSG00000032470
AA Change: D57G

DomainStartEndE-ValueType
RAS 11 130 1.06e-68 SMART
Meta Mutation Damage Score 0.7221 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,482,407 (GRCm39) C4313G probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Bckdk C A 7: 127,504,590 (GRCm39) R105S probably damaging Het
Bhlhe22 G T 3: 18,109,058 (GRCm39) R36L probably damaging Het
Cacnb2 A G 2: 14,609,314 (GRCm39) E18G probably benign Het
Cct2 G A 10: 116,890,040 (GRCm39) P10L probably damaging Het
Cep295 G T 9: 15,228,363 (GRCm39) probably benign Het
Cep89 A G 7: 35,137,808 (GRCm39) R731G probably damaging Het
Chrnb3 C T 8: 27,884,034 (GRCm39) T257M probably damaging Het
Clca3a1 T A 3: 144,461,070 (GRCm39) T194S probably benign Het
Clca4b T C 3: 144,631,797 (GRCm39) K236R probably benign Het
Col18a1 C A 10: 76,924,721 (GRCm39) D23Y probably damaging Het
Cry1 A T 10: 84,982,456 (GRCm39) Y297N probably damaging Het
Defb38 A G 8: 19,076,483 (GRCm39) probably null Het
Dlgap1 A G 17: 70,823,780 (GRCm39) K255R probably damaging Het
Erich6 T C 3: 58,544,125 (GRCm39) E154G probably benign Het
Esf1 G A 2: 140,000,476 (GRCm39) P437S probably benign Het
Fkbp7 A C 2: 76,493,601 (GRCm39) N197K probably damaging Het
Fsip2 T A 2: 82,789,006 (GRCm39) D342E probably benign Het
Gbx1 T C 5: 24,731,213 (GRCm39) D201G probably benign Het
Gm15056 T A 8: 21,390,957 (GRCm39) K25N possibly damaging Het
Grb7 T G 11: 98,345,391 (GRCm39) probably benign Het
H2-M3 C T 17: 37,582,021 (GRCm39) A159V probably damaging Het
Hcar1 T C 5: 124,016,683 (GRCm39) N336S probably benign Het
Ift122 T C 6: 115,890,882 (GRCm39) V807A probably benign Het
Maml2 T C 9: 13,532,364 (GRCm39) V526A possibly damaging Het
Map3k20 C T 2: 72,268,571 (GRCm39) T526I probably damaging Het
Mfap2 A G 4: 140,741,554 (GRCm39) Q71R possibly damaging Het
Mmd2 T C 5: 142,550,554 (GRCm39) Y228C probably damaging Het
Mme T A 3: 63,235,485 (GRCm39) Y178N probably damaging Het
Muc5ac T C 7: 141,367,512 (GRCm39) C2274R possibly damaging Het
Or8j3c T A 2: 86,253,186 (GRCm39) Y278F probably damaging Het
Palmd T C 3: 116,717,472 (GRCm39) T342A probably benign Het
Prb1b G A 6: 132,289,657 (GRCm39) P56S unknown Het
Rdh19 A G 10: 127,686,017 (GRCm39) N43S probably benign Het
Ros1 G A 10: 51,996,974 (GRCm39) H1233Y possibly damaging Het
Samd8 A G 14: 21,830,248 (GRCm39) R225G probably null Het
Slc7a11 C A 3: 50,382,223 (GRCm39) V175L probably benign Het
Spata31d1c A G 13: 65,182,925 (GRCm39) T156A possibly damaging Het
Spata31g1 C T 4: 42,971,534 (GRCm39) T289I probably damaging Het
Spmip9 T C 6: 70,890,283 (GRCm39) N170D possibly damaging Het
Stxbp5 T C 10: 9,665,060 (GRCm39) probably benign Het
Tec T A 5: 72,980,942 (GRCm39) probably benign Het
Vps16 T C 2: 130,284,514 (GRCm39) W728R possibly damaging Het
Xirp1 T C 9: 119,846,810 (GRCm39) E691G probably damaging Het
Zfp605 T C 5: 110,275,604 (GRCm39) S241P probably damaging Het
Zfp839 G A 12: 110,832,765 (GRCm39) G561D probably damaging Het
Other mutations in Mras
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01759:Mras APN 9 99,293,548 (GRCm39) missense probably damaging 1.00
R3918:Mras UTSW 9 99,293,473 (GRCm39) missense probably damaging 1.00
R3919:Mras UTSW 9 99,293,473 (GRCm39) missense probably damaging 1.00
R4950:Mras UTSW 9 99,276,537 (GRCm39) missense probably damaging 1.00
R5375:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R5501:Mras UTSW 9 99,293,599 (GRCm39) missense probably damaging 1.00
R5624:Mras UTSW 9 99,293,538 (GRCm39) missense probably damaging 0.99
R6349:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R6350:Mras UTSW 9 99,293,560 (GRCm39) missense probably damaging 1.00
R7453:Mras UTSW 9 99,271,793 (GRCm39) missense probably benign 0.01
R8351:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R8451:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R9622:Mras UTSW 9 99,275,054 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCACTTTCGTTGCCACTAAG -3'
(R):5'- TGACTACCAGAAACATGGCGAC -3'

Sequencing Primer
(F):5'- CGTTGCCACTAAGATCATTAAGCAG -3'
(R):5'- ACCAGCGCTGTTCCAAGTG -3'
Posted On 2015-10-08