Incidental Mutation 'R4650:Myb'
ID 351228
Institutional Source Beutler Lab
Gene Symbol Myb
Ensembl Gene ENSMUSG00000019982
Gene Name myeloblastosis oncogene
Synonyms c-myb
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4650 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 21000834-21036883 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21028840 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 86 (L86P)
Ref Sequence ENSEMBL: ENSMUSP00000139699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020158] [ENSMUST00000188495]
AlphaFold P06876
Predicted Effect probably damaging
Transcript: ENSMUST00000020158
AA Change: L86P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000020158
Gene: ENSMUSG00000019982
AA Change: L86P

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 267 313 4e-29 PFAM
Pfam:Cmyb_C 399 559 1.5e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186446
Predicted Effect probably damaging
Transcript: ENSMUST00000188495
AA Change: L86P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139699
Gene: ENSMUSG00000019982
AA Change: L86P

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 266 313 3.6e-32 PFAM
low complexity region 409 421 N/A INTRINSIC
Pfam:Cmyb_C 516 682 8.5e-66 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216751
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110025L11Rik T A 16: 88,860,603 (GRCm39) Y77F unknown Het
4933409G03Rik G A 2: 68,436,559 (GRCm39) E168K unknown Het
Aldoa A G 7: 126,396,879 (GRCm39) S71P possibly damaging Het
Arhgef12 A G 9: 42,893,266 (GRCm39) V979A probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Brd8 T C 18: 34,739,752 (GRCm39) T674A probably benign Het
Cacna1d C T 14: 29,817,365 (GRCm39) M1232I probably benign Het
Capza1 A G 3: 104,752,296 (GRCm39) V14A probably damaging Het
Cdk2 A T 10: 128,538,364 (GRCm39) I135N probably damaging Het
Celf4 A T 18: 25,629,302 (GRCm39) M407K possibly damaging Het
Cenpf A T 1: 189,392,235 (GRCm39) D532E probably benign Het
Cideb A G 14: 55,992,688 (GRCm39) V76A possibly damaging Het
Dbpht2 C G 12: 74,345,933 (GRCm39) noncoding transcript Het
Dis3l2 A G 1: 86,918,043 (GRCm39) D550G possibly damaging Het
Dnah1 A T 14: 31,006,844 (GRCm39) probably null Het
Edc4 T A 8: 106,619,307 (GRCm39) L1293* probably null Het
Elp5 A G 11: 69,860,398 (GRCm39) V203A possibly damaging Het
Fndc7 T C 3: 108,770,135 (GRCm39) N597S probably benign Het
Gjb3 T C 4: 127,220,484 (GRCm39) Y16C probably damaging Het
Gm5773 A G 3: 93,680,712 (GRCm39) D128G probably benign Het
Gnb1l T C 16: 18,363,025 (GRCm39) probably null Het
Gon4l G A 3: 88,770,859 (GRCm39) D514N possibly damaging Het
Grhl3 T A 4: 135,276,547 (GRCm39) probably null Het
Hoxc10 T C 15: 102,875,698 (GRCm39) S136P probably benign Het
Ift22 G A 5: 136,940,655 (GRCm39) V107I probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lamc1 T G 1: 153,104,523 (GRCm39) S59R probably damaging Het
Lgi4 G A 7: 30,768,554 (GRCm39) A518T probably benign Het
Lhx2 T A 2: 38,250,052 (GRCm39) N290K probably damaging Het
Ltbp4 A T 7: 27,013,734 (GRCm39) C1092S probably damaging Het
Macf1 T C 4: 123,367,412 (GRCm39) I2450V probably benign Het
Mefv A G 16: 3,535,682 (GRCm39) L82P probably damaging Het
Myh3 C T 11: 66,977,270 (GRCm39) T333M probably damaging Het
Nek11 T C 9: 105,225,279 (GRCm39) N78D possibly damaging Het
Nmi C A 2: 51,838,646 (GRCm39) C296F probably benign Het
Nphs1 A T 7: 30,181,895 (GRCm39) T1163S probably benign Het
Npy4r C T 14: 33,868,181 (GRCm39) G369D possibly damaging Het
Ola1 T C 2: 72,972,309 (GRCm39) T221A probably damaging Het
Or51d1 A G 7: 102,348,027 (GRCm39) D194G probably damaging Het
Or8c11 T C 9: 38,289,699 (GRCm39) F168S probably damaging Het
Pfkfb2 A T 1: 130,633,200 (GRCm39) N184K possibly damaging Het
Plce1 T C 19: 38,513,088 (GRCm39) V129A probably benign Het
Prps2 T C X: 166,135,288 (GRCm39) D183G probably damaging Het
Pth A T 7: 112,985,026 (GRCm39) *116K probably null Het
R3hdm1 T C 1: 128,112,181 (GRCm39) S422P probably damaging Het
Rhox2a G C X: 36,508,962 (GRCm39) R43P probably benign Het
Rwdd3 A G 3: 120,952,826 (GRCm39) F55S probably damaging Het
Serpinb9d A T 13: 33,386,836 (GRCm39) L301F probably benign Het
Slc35e4 A G 11: 3,862,677 (GRCm39) C171R probably damaging Het
Slco1a4 A T 6: 141,758,424 (GRCm39) I529K possibly damaging Het
Styk1 A T 6: 131,277,532 (GRCm39) W370R probably damaging Het
Tmprss11e C A 5: 86,875,212 (GRCm39) W18L probably damaging Het
Trpv1 A C 11: 73,129,089 (GRCm39) E2A probably benign Het
Unc13b T A 4: 43,261,035 (GRCm39) I1799N probably damaging Het
Vmn1r213 G A 13: 23,196,422 (GRCm39) C335Y possibly damaging Het
Vps37c C T 19: 10,690,273 (GRCm39) S245L probably benign Het
Wrn T C 8: 33,745,537 (GRCm39) T1191A probably benign Het
Zfp13 A G 17: 23,799,112 (GRCm39) L153P probably damaging Het
Zfp472 T G 17: 33,196,631 (GRCm39) S235R possibly damaging Het
Other mutations in Myb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00654:Myb APN 10 21,017,725 (GRCm39) missense probably damaging 0.99
IGL00707:Myb APN 10 21,024,283 (GRCm39) missense probably damaging 1.00
IGL00796:Myb APN 10 21,017,698 (GRCm39) missense probably benign 0.00
IGL01012:Myb APN 10 21,022,159 (GRCm39) missense probably benign 0.03
IGL01082:Myb APN 10 21,028,843 (GRCm39) missense probably damaging 1.00
IGL01365:Myb APN 10 21,028,401 (GRCm39) missense probably benign 0.31
IGL01906:Myb APN 10 21,028,533 (GRCm39) missense probably damaging 1.00
IGL02560:Myb APN 10 21,028,347 (GRCm39) missense probably damaging 1.00
Huang_river UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
PIT4495001:Myb UTSW 10 21,028,521 (GRCm39) missense probably damaging 0.98
R0385:Myb UTSW 10 21,030,611 (GRCm39) missense possibly damaging 0.73
R0442:Myb UTSW 10 21,002,095 (GRCm39) missense probably benign 0.05
R0759:Myb UTSW 10 21,020,927 (GRCm39) missense probably benign 0.01
R0882:Myb UTSW 10 21,032,259 (GRCm39) missense possibly damaging 0.75
R0920:Myb UTSW 10 21,002,133 (GRCm39) missense possibly damaging 0.80
R1401:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R1651:Myb UTSW 10 21,002,097 (GRCm39) missense probably damaging 1.00
R1752:Myb UTSW 10 21,032,336 (GRCm39) missense possibly damaging 0.89
R1879:Myb UTSW 10 21,017,876 (GRCm39) missense probably benign 0.24
R1971:Myb UTSW 10 21,016,555 (GRCm39) missense probably benign 0.00
R4355:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R4611:Myb UTSW 10 21,021,223 (GRCm39) missense probably damaging 1.00
R4888:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5121:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5922:Myb UTSW 10 21,028,826 (GRCm39) missense probably damaging 1.00
R5955:Myb UTSW 10 21,028,398 (GRCm39) missense probably damaging 1.00
R6116:Myb UTSW 10 21,030,653 (GRCm39) missense probably damaging 1.00
R6150:Myb UTSW 10 21,017,668 (GRCm39) missense probably damaging 1.00
R6207:Myb UTSW 10 21,021,221 (GRCm39) missense probably benign
R6656:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R6801:Myb UTSW 10 21,020,865 (GRCm39) splice site probably null
R6824:Myb UTSW 10 21,021,019 (GRCm39) missense probably benign 0.00
R6884:Myb UTSW 10 21,028,431 (GRCm39) missense probably damaging 1.00
R6977:Myb UTSW 10 21,028,551 (GRCm39) missense probably damaging 0.96
R7562:Myb UTSW 10 21,017,653 (GRCm39) splice site probably null
R7651:Myb UTSW 10 21,032,273 (GRCm39) missense probably damaging 1.00
R7747:Myb UTSW 10 21,032,324 (GRCm39) missense possibly damaging 0.89
R8346:Myb UTSW 10 21,002,136 (GRCm39) missense probably benign 0.00
R8683:Myb UTSW 10 21,026,405 (GRCm39) missense possibly damaging 0.53
R8829:Myb UTSW 10 21,021,130 (GRCm39) missense probably damaging 0.96
R9227:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9228:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9240:Myb UTSW 10 21,016,500 (GRCm39) missense probably damaging 1.00
R9304:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R9408:Myb UTSW 10 21,026,275 (GRCm39) missense probably benign 0.21
R9517:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9576:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9577:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9610:Myb UTSW 10 21,030,627 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATAATCTGCTTTCATCCACTGGAC -3'
(R):5'- TCTCTAGTCCGTGAGCAGTG -3'

Sequencing Primer
(F):5'- TTTCATCCACTGGACATGCAGGAG -3'
(R):5'- GATAGGTGGGCTCTCTGTACAG -3'
Posted On 2015-10-08