Incidental Mutation 'R4652:Ano10'
ID 351408
Institutional Source Beutler Lab
Gene Symbol Ano10
Ensembl Gene ENSMUSG00000037949
Gene Name anoctamin 10
Synonyms Tmem16k
MMRRC Submission 041912-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R4652 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 122004940-122123489 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 122090181 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 377 (Y377*)
Ref Sequence ENSEMBL: ENSMUSP00000150161 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042546] [ENSMUST00000214283] [ENSMUST00000214409] [ENSMUST00000214507] [ENSMUST00000216081] [ENSMUST00000216670]
AlphaFold Q8BH79
Predicted Effect probably null
Transcript: ENSMUST00000042546
AA Change: Y377*
SMART Domains Protein: ENSMUSP00000045214
Gene: ENSMUSG00000037949
AA Change: Y377*

DomainStartEndE-ValueType
Pfam:Anoctamin 200 628 2.2e-115 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214283
AA Change: Y377*
Predicted Effect probably null
Transcript: ENSMUST00000214409
AA Change: Y319*
Predicted Effect probably null
Transcript: ENSMUST00000214507
AA Change: Y185*
Predicted Effect probably benign
Transcript: ENSMUST00000216081
Predicted Effect probably null
Transcript: ENSMUST00000216670
AA Change: Y377*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 95% (111/117)
MGI Phenotype FUNCTION: This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 105 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik T A 8: 125,366,350 (GRCm39) Q131L probably damaging Het
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
4933409G03Rik G A 2: 68,436,559 (GRCm39) E168K unknown Het
A830018L16Rik C A 1: 11,607,566 (GRCm39) probably benign Het
Adam26b A G 8: 43,974,375 (GRCm39) V209A possibly damaging Het
Adh6a T A 3: 138,031,876 (GRCm39) M256K probably benign Het
Ahnak2 T G 12: 112,741,271 (GRCm39) S128R possibly damaging Het
Angptl2 G T 2: 33,133,895 (GRCm39) D406Y probably damaging Het
Arfgef1 C T 1: 10,243,487 (GRCm39) D1021N probably damaging Het
Arhgap17 G A 7: 122,885,841 (GRCm39) probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp10b G A 11: 43,085,472 (GRCm39) G284S probably damaging Het
Atp13a4 A T 16: 29,271,421 (GRCm39) D498E probably damaging Het
C4a T A 17: 35,029,108 (GRCm39) noncoding transcript Het
Cacna1d C T 14: 29,817,365 (GRCm39) M1232I probably benign Het
Camsap3 A C 8: 3,650,689 (GRCm39) K223T possibly damaging Het
Cast A G 13: 74,894,133 (GRCm39) S171P probably benign Het
Cdh8 T A 8: 99,751,491 (GRCm39) D742V probably benign Het
Ceacam12 A G 7: 17,801,359 (GRCm39) T113A probably damaging Het
Cers3 G A 7: 66,431,604 (GRCm39) probably null Het
Cipc T C 12: 87,008,864 (GRCm39) V241A probably benign Het
Cntn5 C A 9: 9,704,917 (GRCm39) K832N possibly damaging Het
Col12a1 A T 9: 79,520,228 (GRCm39) D2815E probably damaging Het
Ctf2 T C 7: 127,318,556 (GRCm39) T148A probably benign Het
Cttnbp2 A G 6: 18,434,037 (GRCm39) I607T possibly damaging Het
Cux1 A T 5: 136,596,083 (GRCm39) N4K probably damaging Het
Dhx36 A T 3: 62,408,419 (GRCm39) L140M probably benign Het
Dhx58 T A 11: 100,592,185 (GRCm39) N288Y probably damaging Het
Dlgap1 T A 17: 71,068,090 (GRCm39) Y554N probably damaging Het
Dnah10 T C 5: 124,806,207 (GRCm39) Y127H probably benign Het
Dnah6 T C 6: 73,047,580 (GRCm39) M3140V probably benign Het
Dnd1 G A 18: 36,898,114 (GRCm39) probably benign Het
Dpy19l1 A C 9: 24,393,350 (GRCm39) S140A possibly damaging Het
Dyrk1a C T 16: 94,492,924 (GRCm39) T719I probably benign Het
Erlin1 T A 19: 44,029,231 (GRCm39) K234* probably null Het
Fndc7 T C 3: 108,770,135 (GRCm39) N597S probably benign Het
Folh1 C A 7: 86,393,633 (GRCm39) G360* probably null Het
Frmd4b T C 6: 97,272,716 (GRCm39) H846R probably benign Het
Gm10375 C A 14: 43,844,326 (GRCm39) probably null Het
Gm27047 T C 6: 130,607,479 (GRCm39) noncoding transcript Het
Gm7168 A G 17: 14,170,069 (GRCm39) R479G possibly damaging Het
Gm9996 T A 10: 29,019,754 (GRCm39) probably benign Het
Gnat3 T A 5: 18,220,568 (GRCm39) L247H probably damaging Het
H2-D1 T G 17: 35,485,492 (GRCm39) probably null Het
Hpf1 T G 8: 61,346,764 (GRCm39) S26R possibly damaging Het
Ift80 T A 3: 68,822,273 (GRCm39) N627I probably benign Het
Inpp5d A G 1: 87,593,173 (GRCm39) K91R probably benign Het
Irgc C A 7: 24,132,238 (GRCm39) R193L probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lamc1 T G 1: 153,104,523 (GRCm39) S59R probably damaging Het
Lrrc9 T C 12: 72,524,160 (GRCm39) W790R probably damaging Het
Man1a2 A G 3: 100,539,877 (GRCm39) L188P probably damaging Het
Med8 A T 4: 118,268,089 (GRCm39) E5V probably damaging Het
Mefv A G 16: 3,535,682 (GRCm39) L82P probably damaging Het
Mettl25 A T 10: 105,615,509 (GRCm39) C498* probably null Het
Mettl3 T A 14: 52,532,549 (GRCm39) I545F probably damaging Het
Mvp T A 7: 126,592,721 (GRCm39) I397F probably damaging Het
Nlrp14 A T 7: 106,781,024 (GRCm39) I74F probably benign Het
Nudt5 G A 2: 5,860,876 (GRCm39) probably benign Het
Nyap2 T A 1: 81,314,444 (GRCm39) D713E probably damaging Het
Obscn G A 11: 58,929,703 (GRCm39) R5824C probably damaging Het
Or4f6 G T 2: 111,838,595 (GRCm39) S312Y probably damaging Het
Or6c214 T C 10: 129,591,287 (GRCm39) I11V probably benign Het
Orc4 A T 2: 48,826,762 (GRCm39) probably benign Het
Pde10a T A 17: 8,975,885 (GRCm39) N3K possibly damaging Het
Pgm3 T A 9: 86,440,523 (GRCm39) R389S probably benign Het
Piwil4 G A 9: 14,623,604 (GRCm39) R529* probably null Het
Pkd2l2 A T 18: 34,542,889 (GRCm39) R20* probably null Het
Ppp4r3a T A 12: 101,049,170 (GRCm39) probably benign Het
Prkcq T C 2: 11,284,333 (GRCm39) V501A possibly damaging Het
Prkg1 T C 19: 30,572,412 (GRCm39) T400A probably damaging Het
Prps2 T C X: 166,135,288 (GRCm39) D183G probably damaging Het
Prrc2c A T 1: 162,550,843 (GRCm39) H40Q probably damaging Het
Ptcd1 A T 5: 145,091,985 (GRCm39) H371Q probably benign Het
Ptprk T C 10: 28,139,686 (GRCm39) I137T probably damaging Het
R3hdm1 T C 1: 128,112,181 (GRCm39) S422P probably damaging Het
Rapgef5 G A 12: 117,677,863 (GRCm39) G366E probably damaging Het
Rsf1 GCGGCGGCG GCGGCGGCGTCGGCGGCG 7: 97,229,126 (GRCm39) probably benign Het
Setd2 A G 9: 110,423,200 (GRCm39) D2085G possibly damaging Het
Sfxn3 A G 19: 45,039,313 (GRCm39) probably null Het
Sgce T C 6: 4,689,560 (GRCm39) probably benign Het
Sipa1l1 T A 12: 82,469,245 (GRCm39) L1248* probably null Het
Skint7 T G 4: 111,839,309 (GRCm39) M201R probably damaging Het
Slc18a1 A G 8: 69,496,583 (GRCm39) M360T possibly damaging Het
Srp68 A T 11: 116,164,840 (GRCm39) S31R probably benign Het
Stag1 T A 9: 100,678,769 (GRCm39) M230K probably damaging Het
Strc A T 2: 121,204,829 (GRCm39) D985E possibly damaging Het
Tars3 T A 7: 65,339,717 (GRCm39) V704E probably damaging Het
Tbc1d2b A G 9: 90,089,940 (GRCm39) F863S probably damaging Het
Tek T C 4: 94,669,121 (GRCm39) S41P probably damaging Het
Top1 T C 2: 160,554,637 (GRCm39) Y463H probably damaging Het
Trim24 T G 6: 37,934,774 (GRCm39) probably null Het
Ttn A G 2: 76,576,979 (GRCm39) V24638A possibly damaging Het
Ttn A G 2: 76,701,213 (GRCm39) probably benign Het
Txndc11 A G 16: 10,892,986 (GRCm39) S915P probably benign Het
Tyro3 G C 2: 119,647,349 (GRCm39) G826A probably benign Het
Ubxn4 T A 1: 128,202,587 (GRCm39) W410R probably benign Het
Vmn1r193 C T 13: 22,403,695 (GRCm39) G99D probably damaging Het
Vmn2r109 T A 17: 20,761,656 (GRCm39) K567M probably damaging Het
Vmn2r23 T C 6: 123,718,689 (GRCm39) F681L probably damaging Het
Vrk2 T C 11: 26,439,803 (GRCm39) D256G probably damaging Het
Vwa3a T A 7: 120,378,138 (GRCm39) I476N probably damaging Het
Wdr81 A G 11: 75,342,066 (GRCm39) V1067A probably damaging Het
Zcwpw2 A G 9: 117,843,119 (GRCm39) noncoding transcript Het
Other mutations in Ano10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Ano10 APN 9 122,090,422 (GRCm39) missense possibly damaging 0.96
IGL00886:Ano10 APN 9 122,100,390 (GRCm39) missense probably benign 0.01
IGL00932:Ano10 APN 9 122,080,297 (GRCm39) nonsense probably null
IGL01613:Ano10 APN 9 122,088,606 (GRCm39) missense possibly damaging 0.75
IGL02109:Ano10 APN 9 122,090,408 (GRCm39) missense probably damaging 1.00
IGL02397:Ano10 APN 9 122,090,458 (GRCm39) missense probably damaging 1.00
IGL02512:Ano10 APN 9 122,101,540 (GRCm39) missense possibly damaging 0.50
IGL03216:Ano10 APN 9 122,086,127 (GRCm39) missense probably damaging 1.00
arna UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R0624:Ano10 UTSW 9 122,088,661 (GRCm39) splice site probably benign
R1669:Ano10 UTSW 9 122,086,249 (GRCm39) missense possibly damaging 0.94
R1801:Ano10 UTSW 9 122,082,096 (GRCm39) missense probably damaging 1.00
R2511:Ano10 UTSW 9 122,088,011 (GRCm39) missense probably damaging 0.99
R3836:Ano10 UTSW 9 122,092,829 (GRCm39) missense possibly damaging 0.58
R4027:Ano10 UTSW 9 122,081,994 (GRCm39) splice site probably benign
R4151:Ano10 UTSW 9 122,090,601 (GRCm39) nonsense probably null
R4590:Ano10 UTSW 9 122,086,231 (GRCm39) missense probably benign 0.22
R4651:Ano10 UTSW 9 122,090,181 (GRCm39) nonsense probably null
R4676:Ano10 UTSW 9 122,092,853 (GRCm39) missense probably damaging 0.98
R5026:Ano10 UTSW 9 122,101,625 (GRCm39) nonsense probably null
R5281:Ano10 UTSW 9 122,090,552 (GRCm39) missense probably damaging 1.00
R5401:Ano10 UTSW 9 122,090,356 (GRCm39) missense probably damaging 1.00
R6269:Ano10 UTSW 9 122,090,308 (GRCm39) missense probably damaging 0.99
R6449:Ano10 UTSW 9 122,030,754 (GRCm39) intron probably benign
R6702:Ano10 UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R7010:Ano10 UTSW 9 122,082,190 (GRCm39) missense probably damaging 1.00
R7384:Ano10 UTSW 9 122,005,409 (GRCm39) missense unknown
R7584:Ano10 UTSW 9 122,104,597 (GRCm39) missense probably benign
R8849:Ano10 UTSW 9 122,090,510 (GRCm39) missense probably benign 0.00
R8980:Ano10 UTSW 9 122,090,558 (GRCm39) missense probably benign 0.00
R9328:Ano10 UTSW 9 122,090,168 (GRCm39) missense possibly damaging 0.66
R9653:Ano10 UTSW 9 122,080,221 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- TCAGTTGTGTGAGCCCAAAC -3'
(R):5'- CAACTGCGCATCTACCTAGTC -3'

Sequencing Primer
(F):5'- GTTGTGTGAGCCCAAACATCTAAGC -3'
(R):5'- AGTCTCTCTGCCATTTGTGTG -3'
Posted On 2015-10-08