Incidental Mutation 'R4654:Wdr17'
| ID |
351549 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
041914-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4654 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 55134434 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Arginine
at position 349
(G349R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122326
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000144482]
[ENSMUST00000144711]
[ENSMUST00000150488]
[ENSMUST00000175915]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126316
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000127511
AA Change: G373R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: G373R
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000144482
AA Change: G60R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134950
Gene: ENSMUSG00000039375
AA Change: G60R
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
16 |
65 |
2e-24 |
BLAST |
|
WD40
|
70 |
109 |
1.59e-7 |
SMART |
|
WD40
|
112 |
152 |
2.39e0 |
SMART |
|
WD40
|
155 |
196 |
5.52e-2 |
SMART |
|
WD40
|
198 |
237 |
4.14e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000144711
AA Change: G356R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: G356R
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000150488
AA Change: G349R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: G349R
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175915
AA Change: G349R
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: G349R
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.3416 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
| Validation Efficiency |
97% (98/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam3 |
A |
T |
8: 25,193,819 (GRCm39) |
C398S |
probably damaging |
Het |
| Adamts10 |
A |
G |
17: 33,756,304 (GRCm39) |
K316E |
possibly damaging |
Het |
| Ap1m1 |
T |
C |
8: 73,006,717 (GRCm39) |
F238L |
possibly damaging |
Het |
| Aph1a |
T |
A |
3: 95,803,088 (GRCm39) |
D180E |
probably benign |
Het |
| Atp9b |
A |
G |
18: 80,935,093 (GRCm39) |
F201L |
probably benign |
Het |
| Btbd9 |
A |
C |
17: 30,704,561 (GRCm39) |
|
probably benign |
Het |
| C2cd5 |
T |
C |
6: 142,975,910 (GRCm39) |
T768A |
probably benign |
Het |
| Casq1 |
C |
T |
1: 172,037,965 (GRCm39) |
|
probably benign |
Het |
| Cimap2 |
C |
A |
4: 106,467,612 (GRCm39) |
M341I |
probably benign |
Het |
| Cltc |
A |
T |
11: 86,617,196 (GRCm39) |
M351K |
probably benign |
Het |
| Cnp |
A |
G |
11: 100,469,877 (GRCm39) |
E271G |
possibly damaging |
Het |
| Col22a1 |
T |
C |
15: 71,845,544 (GRCm39) |
D406G |
possibly damaging |
Het |
| Cylc2 |
T |
C |
4: 51,228,279 (GRCm39) |
S117P |
probably benign |
Het |
| Cyp2b13 |
T |
C |
7: 25,761,072 (GRCm39) |
L43P |
probably damaging |
Het |
| Cyp3a16 |
A |
G |
5: 145,373,267 (GRCm39) |
V500A |
probably benign |
Het |
| Dclk2 |
T |
C |
3: 86,743,683 (GRCm39) |
D262G |
probably damaging |
Het |
| Dcun1d3 |
A |
C |
7: 119,458,742 (GRCm39) |
Y98D |
probably damaging |
Het |
| Ddx39b |
A |
G |
17: 35,472,464 (GRCm39) |
*429W |
probably null |
Het |
| Dennd5b |
T |
C |
6: 148,908,335 (GRCm39) |
N986S |
probably damaging |
Het |
| Dipk1a |
T |
C |
5: 108,057,982 (GRCm39) |
|
probably null |
Het |
| Dusp9 |
G |
A |
X: 72,684,378 (GRCm39) |
R182Q |
probably benign |
Het |
| Ecpas |
A |
T |
4: 58,834,523 (GRCm39) |
I785N |
possibly damaging |
Het |
| Edil3 |
A |
G |
13: 89,437,589 (GRCm39) |
K397E |
probably damaging |
Het |
| Ehd1 |
T |
C |
19: 6,326,994 (GRCm39) |
|
probably benign |
Het |
| Fam13a |
A |
T |
6: 58,964,152 (GRCm39) |
H93Q |
probably benign |
Het |
| Farp1 |
T |
C |
14: 121,513,716 (GRCm39) |
I837T |
possibly damaging |
Het |
| Fbxl5 |
T |
A |
5: 43,922,771 (GRCm39) |
I216F |
probably damaging |
Het |
| Gadl1 |
G |
A |
9: 115,770,408 (GRCm39) |
E74K |
probably damaging |
Het |
| Gnpnat1 |
A |
G |
14: 45,618,436 (GRCm39) |
V122A |
probably damaging |
Het |
| Hdac10 |
C |
T |
15: 89,011,036 (GRCm39) |
|
probably benign |
Het |
| Heatr5b |
T |
C |
17: 79,128,130 (GRCm39) |
S502G |
possibly damaging |
Het |
| Hr |
C |
A |
14: 70,801,013 (GRCm39) |
A695E |
probably damaging |
Het |
| Ift80 |
A |
T |
3: 68,825,870 (GRCm39) |
I490N |
possibly damaging |
Het |
| Ipo11 |
A |
G |
13: 106,970,692 (GRCm39) |
|
probably benign |
Het |
| Iqch |
T |
G |
9: 63,432,195 (GRCm39) |
Y400S |
probably damaging |
Het |
| Jag2 |
C |
T |
12: 112,877,266 (GRCm39) |
D702N |
probably benign |
Het |
| Kiss1r |
T |
A |
10: 79,757,624 (GRCm39) |
L326Q |
probably damaging |
Het |
| Lrrc42 |
A |
T |
4: 107,104,746 (GRCm39) |
I73N |
probably damaging |
Het |
| Lrrc55 |
C |
T |
2: 85,026,880 (GRCm39) |
G48D |
possibly damaging |
Het |
| Lrrk2 |
T |
C |
15: 91,649,884 (GRCm39) |
S1674P |
probably damaging |
Het |
| Mctp2 |
A |
G |
7: 71,739,942 (GRCm39) |
L816P |
probably damaging |
Het |
| Mipol1 |
A |
T |
12: 57,352,918 (GRCm39) |
T86S |
probably benign |
Het |
| Mkrn3 |
C |
T |
7: 62,069,452 (GRCm39) |
R113H |
probably damaging |
Het |
| Mmp1b |
A |
G |
9: 7,370,849 (GRCm39) |
V302A |
probably benign |
Het |
| Msc |
A |
T |
1: 14,826,053 (GRCm39) |
|
probably null |
Het |
| Msmo1 |
C |
A |
8: 65,180,888 (GRCm39) |
V9L |
probably benign |
Het |
| Nbeal2 |
G |
A |
9: 110,461,072 (GRCm39) |
R1630C |
probably damaging |
Het |
| Nlgn1 |
C |
T |
3: 26,187,850 (GRCm39) |
V12I |
possibly damaging |
Het |
| Npas3 |
T |
C |
12: 54,108,915 (GRCm39) |
|
probably null |
Het |
| Nr2e3 |
A |
G |
9: 59,856,355 (GRCm39) |
|
probably benign |
Het |
| Oca2 |
C |
T |
7: 55,978,560 (GRCm39) |
A576V |
probably benign |
Het |
| Or5b21 |
T |
A |
19: 12,839,596 (GRCm39) |
C152* |
probably null |
Het |
| Or6d12 |
T |
C |
6: 116,493,409 (GRCm39) |
Y224H |
probably damaging |
Het |
| Or6z7 |
T |
C |
7: 6,484,045 (GRCm39) |
T37A |
probably benign |
Het |
| Parp6 |
A |
G |
9: 59,548,383 (GRCm39) |
|
probably null |
Het |
| Pate13 |
T |
A |
9: 35,820,287 (GRCm39) |
C4S |
probably damaging |
Het |
| Phlpp1 |
A |
T |
1: 106,267,231 (GRCm39) |
M715L |
probably benign |
Het |
| Pi4k2a |
G |
A |
19: 42,101,544 (GRCm39) |
|
probably null |
Het |
| Pik3ap1 |
A |
G |
19: 41,316,348 (GRCm39) |
S305P |
probably damaging |
Het |
| Plcg2 |
G |
A |
8: 118,231,054 (GRCm39) |
M45I |
probably benign |
Het |
| Ppm1m |
A |
T |
9: 106,073,601 (GRCm39) |
L317H |
probably damaging |
Het |
| Ppp1r21 |
T |
G |
17: 88,866,227 (GRCm39) |
M341R |
probably benign |
Het |
| Prdx3 |
A |
G |
19: 60,853,674 (GRCm39) |
V217A |
possibly damaging |
Het |
| Ptk2b |
A |
G |
14: 66,400,496 (GRCm39) |
V773A |
possibly damaging |
Het |
| Raly |
T |
C |
2: 154,699,376 (GRCm39) |
V60A |
probably damaging |
Het |
| Reps1 |
A |
G |
10: 17,990,148 (GRCm39) |
D420G |
probably damaging |
Het |
| Rev1 |
A |
T |
1: 38,118,337 (GRCm39) |
|
probably benign |
Het |
| Rgs2 |
T |
G |
1: 143,878,650 (GRCm39) |
|
probably benign |
Het |
| Rlf |
G |
T |
4: 121,007,798 (GRCm39) |
T394K |
probably benign |
Het |
| Rptn |
A |
T |
3: 93,304,792 (GRCm39) |
R708S |
possibly damaging |
Het |
| Sec23b |
T |
A |
2: 144,414,494 (GRCm39) |
M402K |
probably benign |
Het |
| Skic2 |
A |
G |
17: 35,068,922 (GRCm39) |
C26R |
probably damaging |
Het |
| Slx9 |
T |
C |
10: 77,325,860 (GRCm39) |
M170V |
possibly damaging |
Het |
| Smpd4 |
A |
G |
16: 17,459,992 (GRCm39) |
|
probably benign |
Het |
| Synj2 |
A |
G |
17: 6,063,813 (GRCm39) |
E434G |
probably damaging |
Het |
| Tatdn2 |
T |
A |
6: 113,684,326 (GRCm39) |
F64I |
probably benign |
Het |
| Tex21 |
A |
C |
12: 76,263,860 (GRCm39) |
H177Q |
probably benign |
Het |
| Tln1 |
T |
A |
4: 43,535,954 (GRCm39) |
Q2077L |
probably null |
Het |
| Tnrc6c |
T |
C |
11: 117,611,797 (GRCm39) |
V145A |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,616,936 (GRCm39) |
|
probably benign |
Het |
| Uggt2 |
A |
G |
14: 119,269,670 (GRCm39) |
F954S |
possibly damaging |
Het |
| Ugt2a1 |
A |
G |
5: 87,634,083 (GRCm39) |
S175P |
probably damaging |
Het |
| Vcl |
A |
G |
14: 21,035,820 (GRCm39) |
|
probably null |
Het |
| Vegfa |
A |
T |
17: 46,336,176 (GRCm39) |
|
probably benign |
Het |
| Vmn2r68 |
G |
A |
7: 84,882,769 (GRCm39) |
Q328* |
probably null |
Het |
| Vmn2r7 |
A |
G |
3: 64,626,864 (GRCm39) |
Y142H |
probably benign |
Het |
| Ybx3 |
G |
T |
6: 131,347,290 (GRCm39) |
R282S |
probably damaging |
Het |
| Zfp566 |
T |
C |
7: 29,777,194 (GRCm39) |
H329R |
probably damaging |
Het |
| Zfp786 |
T |
C |
6: 47,797,868 (GRCm39) |
I357V |
probably benign |
Het |
| Zfr2 |
C |
A |
10: 81,087,083 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGCTACCTAGTTGAGTTACTTAG -3'
(R):5'- AAGTCCTGCCTAATTTTCAGCCAC -3'
Sequencing Primer
(F):5'- ACCTAGTTGAGTTACTTAGATGAGC -3'
(R):5'- ACACTGAGTTTTATGCTCATTTTTGG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation