Incidental Mutation 'R4641:Gas2l3'
ID 351648
Institutional Source Beutler Lab
Gene Symbol Gas2l3
Ensembl Gene ENSMUSG00000074802
Gene Name growth arrest-specific 2 like 3
Synonyms LOC237436, 8430435B07Rik
MMRRC Submission 041903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R4641 (G1)
Quality Score 217
Status Not validated
Chromosome 10
Chromosomal Location 89244685-89279829 bp(-) (GRCm39)
Type of Mutation small deletion (3 aa in frame mutation)
DNA Base Change (assembly) CACTCGTCATACT to CACT at 89266820 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099374] [ENSMUST00000105298] [ENSMUST00000218764] [ENSMUST00000219351] [ENSMUST00000220071] [ENSMUST00000220128] [ENSMUST00000220234]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000099374
SMART Domains Protein: ENSMUSP00000096973
Gene: ENSMUSG00000074802

DomainStartEndE-ValueType
CH 52 166 1.71e-9 SMART
low complexity region 179 194 N/A INTRINSIC
Pfam:GAS2 215 284 1.8e-29 PFAM
low complexity region 446 460 N/A INTRINSIC
low complexity region 630 643 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105298
SMART Domains Protein: ENSMUSP00000100935
Gene: ENSMUSG00000074802

DomainStartEndE-ValueType
CH 52 166 1.71e-9 SMART
low complexity region 179 194 N/A INTRINSIC
Pfam:GAS2 213 286 1.5e-31 PFAM
low complexity region 446 460 N/A INTRINSIC
low complexity region 630 643 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218764
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219073
Predicted Effect probably benign
Transcript: ENSMUST00000219351
Predicted Effect probably benign
Transcript: ENSMUST00000220071
Predicted Effect probably benign
Transcript: ENSMUST00000220128
Predicted Effect probably benign
Transcript: ENSMUST00000220234
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display partial postnatal lethality with none surviving past 4 months, dilated cardiomyopathy, cardiac interstitial fibrosis, and premature binucleation of cardiomyocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 79,841,615 (GRCm39) probably null Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Dsg3 T A 18: 20,653,615 (GRCm39) F54I probably benign Het
Ehbp1 G A 11: 22,045,892 (GRCm39) S619L probably benign Het
Eif1ad3 A G 12: 87,843,446 (GRCm39) Y31C probably damaging Het
Eif1ad5 A G 12: 87,946,852 (GRCm39) D98G probably benign Het
Erlec1 G A 11: 30,898,442 (GRCm39) Q10* probably null Het
Fbxw14 A G 9: 109,107,750 (GRCm39) probably null Het
Fhod1 C T 8: 106,056,224 (GRCm39) R1163H probably damaging Het
Gm4846 G A 1: 166,311,462 (GRCm39) P466S probably damaging Het
Ift122 A T 6: 115,865,726 (GRCm39) K339* probably null Het
Il6st T C 13: 112,625,064 (GRCm39) S227P probably damaging Het
Letmd1 A G 15: 100,375,708 (GRCm39) Y198C probably damaging Het
Map3k4 A T 17: 12,482,932 (GRCm39) L595Q probably damaging Het
Mdc1 C G 17: 36,168,361 (GRCm39) R1656G probably benign Het
Megf11 C T 9: 64,597,407 (GRCm39) S662L possibly damaging Het
Mrps25 T C 6: 92,160,881 (GRCm39) E25G probably benign Het
Myh2 G T 11: 67,085,520 (GRCm39) G1815C probably damaging Het
Myo15a A G 11: 60,393,867 (GRCm39) D2353G probably damaging Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
P2rx5 A T 11: 73,058,390 (GRCm39) H275L possibly damaging Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Rnf123 T C 9: 107,935,786 (GRCm39) D920G probably damaging Het
Slc44a2 A G 9: 21,258,178 (GRCm39) Y474C probably damaging Het
Slc9a4 T A 1: 40,646,285 (GRCm39) F439I probably damaging Het
Snap91 A G 9: 86,761,528 (GRCm39) V26A probably damaging Het
Spata31d1c C A 13: 65,182,862 (GRCm39) Q135K probably benign Het
Stard8 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA X: 98,110,114 (GRCm39) probably benign Het
Tlk2 T C 11: 105,166,809 (GRCm39) I669T probably benign Het
Tmem273 A G 14: 32,528,839 (GRCm39) D68G probably damaging Het
Ttc38 T C 15: 85,728,659 (GRCm39) S204P possibly damaging Het
Ttn T A 2: 76,617,155 (GRCm39) Y16403F probably damaging Het
Ttyh2 G T 11: 114,592,609 (GRCm39) W213L probably damaging Het
Ugt2a2 A T 5: 87,610,755 (GRCm39) D360E probably damaging Het
Vwa5b2 A T 16: 20,423,393 (GRCm39) H1102L probably damaging Het
Zbtb41 A T 1: 139,370,557 (GRCm39) T665S probably damaging Het
Zfp292 T C 4: 34,807,828 (GRCm39) I1739V probably damaging Het
Other mutations in Gas2l3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Gas2l3 APN 10 89,249,489 (GRCm39) missense probably benign 0.00
IGL01148:Gas2l3 APN 10 89,249,366 (GRCm39) missense probably benign 0.25
R0472:Gas2l3 UTSW 10 89,262,339 (GRCm39) missense probably damaging 1.00
R0578:Gas2l3 UTSW 10 89,252,937 (GRCm39) missense probably damaging 1.00
R0720:Gas2l3 UTSW 10 89,249,805 (GRCm39) missense probably benign 0.00
R1386:Gas2l3 UTSW 10 89,250,215 (GRCm39) missense possibly damaging 0.77
R1470:Gas2l3 UTSW 10 89,249,796 (GRCm39) missense probably benign
R1470:Gas2l3 UTSW 10 89,249,796 (GRCm39) missense probably benign
R1530:Gas2l3 UTSW 10 89,269,631 (GRCm39) missense probably benign 0.02
R1733:Gas2l3 UTSW 10 89,250,127 (GRCm39) missense probably damaging 1.00
R1772:Gas2l3 UTSW 10 89,252,876 (GRCm39) unclassified probably benign
R1840:Gas2l3 UTSW 10 89,258,113 (GRCm39) missense possibly damaging 0.79
R2168:Gas2l3 UTSW 10 89,249,960 (GRCm39) missense probably benign 0.01
R3082:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R3083:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4639:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4642:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4643:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4644:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4645:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4809:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4810:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4820:Gas2l3 UTSW 10 89,252,907 (GRCm39) missense probably damaging 1.00
R4852:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4853:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4855:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4865:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4900:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4906:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4926:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4946:Gas2l3 UTSW 10 89,249,634 (GRCm39) missense probably benign
R5072:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5073:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5074:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5137:Gas2l3 UTSW 10 89,249,837 (GRCm39) missense probably damaging 1.00
R5579:Gas2l3 UTSW 10 89,249,928 (GRCm39) missense probably benign
R5919:Gas2l3 UTSW 10 89,252,917 (GRCm39) missense probably damaging 1.00
R6573:Gas2l3 UTSW 10 89,258,072 (GRCm39) splice site probably null
R6763:Gas2l3 UTSW 10 89,249,231 (GRCm39) missense probably benign 0.00
R6961:Gas2l3 UTSW 10 89,249,153 (GRCm39) missense probably benign 0.00
R7491:Gas2l3 UTSW 10 89,249,763 (GRCm39) missense probably benign 0.02
R7707:Gas2l3 UTSW 10 89,250,220 (GRCm39) missense probably damaging 1.00
R7806:Gas2l3 UTSW 10 89,249,232 (GRCm39) missense probably benign 0.00
R8167:Gas2l3 UTSW 10 89,262,342 (GRCm39) missense probably damaging 1.00
R8781:Gas2l3 UTSW 10 89,266,841 (GRCm39) missense probably damaging 0.99
R8862:Gas2l3 UTSW 10 89,250,282 (GRCm39) missense probably damaging 0.97
R9063:Gas2l3 UTSW 10 89,249,558 (GRCm39) missense probably benign
R9119:Gas2l3 UTSW 10 89,249,319 (GRCm39) missense possibly damaging 0.87
R9258:Gas2l3 UTSW 10 89,262,315 (GRCm39) missense probably benign 0.18
R9574:Gas2l3 UTSW 10 89,258,135 (GRCm39) missense probably damaging 1.00
R9634:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
R9640:Gas2l3 UTSW 10 89,266,774 (GRCm39) missense probably damaging 1.00
R9702:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
R9703:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGCCTGACTCTGACATTCACTG -3'
(R):5'- GACATCAACCACTGTATTCAATGC -3'

Sequencing Primer
(F):5'- ACTGAGTATCCCTGGCATCTGG -3'
(R):5'- ACAATTTTGCTTATTCTGGATGGTC -3'
Posted On 2015-10-08