Incidental Mutation 'R4641:Tmem273'
ID 351659
Institutional Source Beutler Lab
Gene Symbol Tmem273
Ensembl Gene ENSMUSG00000041707
Gene Name transmembrane protein 273
Synonyms 1810011H11Rik
MMRRC Submission 041903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R4641 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 32507920-32539941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32528839 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 68 (D68G)
Ref Sequence ENSEMBL: ENSMUSP00000153805 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039191] [ENSMUST00000227060] [ENSMUST00000227871]
AlphaFold E9PVZ2
Predicted Effect probably damaging
Transcript: ENSMUST00000039191
AA Change: D68G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000132997
Gene: ENSMUSG00000041707
AA Change: D68G

DomainStartEndE-ValueType
Pfam:DUF4514 16 75 3.6e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227060
Predicted Effect probably damaging
Transcript: ENSMUST00000227871
AA Change: D68G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000228481
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228955
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 79,841,615 (GRCm39) probably null Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Dsg3 T A 18: 20,653,615 (GRCm39) F54I probably benign Het
Ehbp1 G A 11: 22,045,892 (GRCm39) S619L probably benign Het
Eif1ad3 A G 12: 87,843,446 (GRCm39) Y31C probably damaging Het
Eif1ad5 A G 12: 87,946,852 (GRCm39) D98G probably benign Het
Erlec1 G A 11: 30,898,442 (GRCm39) Q10* probably null Het
Fbxw14 A G 9: 109,107,750 (GRCm39) probably null Het
Fhod1 C T 8: 106,056,224 (GRCm39) R1163H probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm4846 G A 1: 166,311,462 (GRCm39) P466S probably damaging Het
Ift122 A T 6: 115,865,726 (GRCm39) K339* probably null Het
Il6st T C 13: 112,625,064 (GRCm39) S227P probably damaging Het
Letmd1 A G 15: 100,375,708 (GRCm39) Y198C probably damaging Het
Map3k4 A T 17: 12,482,932 (GRCm39) L595Q probably damaging Het
Mdc1 C G 17: 36,168,361 (GRCm39) R1656G probably benign Het
Megf11 C T 9: 64,597,407 (GRCm39) S662L possibly damaging Het
Mrps25 T C 6: 92,160,881 (GRCm39) E25G probably benign Het
Myh2 G T 11: 67,085,520 (GRCm39) G1815C probably damaging Het
Myo15a A G 11: 60,393,867 (GRCm39) D2353G probably damaging Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
P2rx5 A T 11: 73,058,390 (GRCm39) H275L possibly damaging Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Rnf123 T C 9: 107,935,786 (GRCm39) D920G probably damaging Het
Slc44a2 A G 9: 21,258,178 (GRCm39) Y474C probably damaging Het
Slc9a4 T A 1: 40,646,285 (GRCm39) F439I probably damaging Het
Snap91 A G 9: 86,761,528 (GRCm39) V26A probably damaging Het
Spata31d1c C A 13: 65,182,862 (GRCm39) Q135K probably benign Het
Stard8 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA X: 98,110,114 (GRCm39) probably benign Het
Tlk2 T C 11: 105,166,809 (GRCm39) I669T probably benign Het
Ttc38 T C 15: 85,728,659 (GRCm39) S204P possibly damaging Het
Ttn T A 2: 76,617,155 (GRCm39) Y16403F probably damaging Het
Ttyh2 G T 11: 114,592,609 (GRCm39) W213L probably damaging Het
Ugt2a2 A T 5: 87,610,755 (GRCm39) D360E probably damaging Het
Vwa5b2 A T 16: 20,423,393 (GRCm39) H1102L probably damaging Het
Zbtb41 A T 1: 139,370,557 (GRCm39) T665S probably damaging Het
Zfp292 T C 4: 34,807,828 (GRCm39) I1739V probably damaging Het
Other mutations in Tmem273
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01930:Tmem273 APN 14 32,538,814 (GRCm39) missense probably benign 0.12
IGL03225:Tmem273 APN 14 32,527,133 (GRCm39) missense probably damaging 0.97
R0060:Tmem273 UTSW 14 32,528,726 (GRCm39) intron probably benign
R0255:Tmem273 UTSW 14 32,530,320 (GRCm39) missense possibly damaging 0.91
R1520:Tmem273 UTSW 14 32,527,083 (GRCm39) intron probably benign
R5218:Tmem273 UTSW 14 32,538,793 (GRCm39) splice site probably null
R6111:Tmem273 UTSW 14 32,528,755 (GRCm39) missense possibly damaging 0.93
R6793:Tmem273 UTSW 14 32,528,778 (GRCm39) missense probably benign
R7714:Tmem273 UTSW 14 32,527,129 (GRCm39) missense possibly damaging 0.63
R8087:Tmem273 UTSW 14 32,507,926 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- AGAACTCTGGAAGGTCCCTG -3'
(R):5'- ATTGTAGAGCCCCAGTTTCTTC -3'

Sequencing Primer
(F):5'- CTGGAGGCTGACAGCTGAATC -3'
(R):5'- TCTTCTCTCTGAGAGGAAACAGC -3'
Posted On 2015-10-08