Incidental Mutation 'R4666:Duox1'
| ID |
351886 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
041924-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4666 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 122149956 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 116
(P116S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099461
AA Change: P116S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: P116S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Meta Mutation Damage Score |
0.0740 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410137M14Rik |
G |
A |
17: 37,289,794 (GRCm39) |
S12L |
probably benign |
Het |
| Abce1 |
A |
G |
8: 80,414,115 (GRCm39) |
V532A |
probably damaging |
Het |
| Adamts12 |
T |
A |
15: 11,311,578 (GRCm39) |
N1278K |
probably benign |
Het |
| Adipor1 |
T |
A |
1: 134,352,643 (GRCm39) |
I138N |
probably damaging |
Het |
| Aox1 |
C |
T |
1: 58,343,756 (GRCm39) |
Q480* |
probably null |
Het |
| Arhgef38 |
C |
T |
3: 132,846,533 (GRCm39) |
|
probably null |
Het |
| Atmin |
A |
G |
8: 117,684,698 (GRCm39) |
D786G |
probably damaging |
Het |
| Bltp3a |
G |
T |
17: 28,112,477 (GRCm39) |
W1222L |
possibly damaging |
Het |
| Capn1 |
A |
T |
19: 6,061,045 (GRCm39) |
N253K |
probably benign |
Het |
| Cdh8 |
T |
C |
8: 99,751,534 (GRCm39) |
T728A |
possibly damaging |
Het |
| Celsr1 |
A |
G |
15: 85,914,695 (GRCm39) |
S1093P |
probably damaging |
Het |
| Cep135 |
C |
A |
5: 76,764,701 (GRCm39) |
P560T |
probably benign |
Het |
| Chfr |
C |
T |
5: 110,292,733 (GRCm39) |
Q167* |
probably null |
Het |
| Chrna4 |
A |
G |
2: 180,679,286 (GRCm39) |
S54P |
probably damaging |
Het |
| Cntln |
A |
G |
4: 84,889,453 (GRCm39) |
N312S |
probably benign |
Het |
| Cntn6 |
A |
G |
6: 104,705,245 (GRCm39) |
E154G |
probably benign |
Het |
| Col6a6 |
T |
A |
9: 105,644,541 (GRCm39) |
Y1249F |
possibly damaging |
Het |
| Cpsf2 |
T |
C |
12: 101,949,466 (GRCm39) |
S61P |
probably damaging |
Het |
| Cpvl |
C |
T |
6: 53,908,918 (GRCm39) |
E282K |
probably benign |
Het |
| Cryba2 |
C |
T |
1: 74,929,207 (GRCm39) |
D179N |
probably benign |
Het |
| Daglb |
A |
T |
5: 143,489,104 (GRCm39) |
R654W |
probably damaging |
Het |
| Dennd3 |
A |
G |
15: 73,442,709 (GRCm39) |
D1244G |
probably damaging |
Het |
| Dhx57 |
T |
C |
17: 80,582,390 (GRCm39) |
E405G |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,905,536 (GRCm39) |
M4060T |
possibly damaging |
Het |
| Dph1 |
A |
G |
11: 75,072,156 (GRCm39) |
S238P |
probably damaging |
Het |
| Ebf1 |
A |
G |
11: 44,882,384 (GRCm39) |
N447D |
probably damaging |
Het |
| Epg5 |
A |
G |
18: 78,056,079 (GRCm39) |
N1751S |
probably benign |
Het |
| Exoc6 |
A |
G |
19: 37,558,953 (GRCm39) |
D75G |
probably damaging |
Het |
| Extl2 |
T |
A |
3: 115,817,856 (GRCm39) |
I70N |
probably damaging |
Het |
| Fanca |
T |
C |
8: 123,995,711 (GRCm39) |
T1364A |
probably damaging |
Het |
| Fbln7 |
T |
A |
2: 128,736,830 (GRCm39) |
|
probably null |
Het |
| Foxa3 |
G |
T |
7: 18,748,297 (GRCm39) |
C275* |
probably null |
Het |
| Foxred1 |
C |
T |
9: 35,122,151 (GRCm39) |
|
probably benign |
Het |
| Galr2 |
A |
G |
11: 116,174,455 (GRCm39) |
T362A |
probably benign |
Het |
| Garem2 |
C |
A |
5: 30,319,665 (GRCm39) |
R376S |
probably damaging |
Het |
| Garre1 |
T |
C |
7: 33,984,198 (GRCm39) |
M142V |
probably damaging |
Het |
| Gatc |
T |
A |
5: 115,473,606 (GRCm39) |
N111I |
probably benign |
Het |
| Gjb4 |
C |
A |
4: 127,245,571 (GRCm39) |
K123N |
probably damaging |
Het |
| Gm9894 |
T |
C |
13: 67,913,213 (GRCm39) |
|
noncoding transcript |
Het |
| Gtdc1 |
T |
C |
2: 44,481,937 (GRCm39) |
N301S |
probably benign |
Het |
| Gtf2ird1 |
T |
A |
5: 134,412,756 (GRCm39) |
E55V |
probably damaging |
Het |
| Gtsf1 |
T |
C |
15: 103,329,632 (GRCm39) |
I96V |
probably benign |
Het |
| Homer1 |
T |
A |
13: 93,538,667 (GRCm39) |
I170N |
probably damaging |
Het |
| Homer3 |
G |
A |
8: 70,742,793 (GRCm39) |
|
probably null |
Het |
| Hoxb9 |
A |
G |
11: 96,165,657 (GRCm39) |
K242R |
possibly damaging |
Het |
| Ifna14 |
T |
C |
4: 88,489,573 (GRCm39) |
R155G |
probably benign |
Het |
| Lrrc7 |
GAAGTTGTTTGGAGATTCTTATCTTA |
GA |
3: 158,024,045 (GRCm39) |
|
probably benign |
Het |
| Lsm11 |
A |
G |
11: 45,824,640 (GRCm39) |
S296P |
probably damaging |
Het |
| Macrod2 |
T |
C |
2: 142,059,519 (GRCm39) |
L265P |
probably damaging |
Het |
| Mcu |
G |
A |
10: 59,292,521 (GRCm39) |
L53F |
probably damaging |
Het |
| Mpv17l2 |
A |
G |
8: 71,213,061 (GRCm39) |
V104A |
possibly damaging |
Het |
| Myh10 |
G |
A |
11: 68,692,556 (GRCm39) |
|
probably null |
Het |
| Nemf |
T |
C |
12: 69,359,054 (GRCm39) |
E1031G |
probably damaging |
Het |
| Nhsl1 |
G |
A |
10: 18,407,153 (GRCm39) |
S1395N |
probably damaging |
Het |
| Niban3 |
G |
T |
8: 72,056,469 (GRCm39) |
E390* |
probably null |
Het |
| Nlrp2 |
T |
A |
7: 5,322,188 (GRCm39) |
I82F |
probably benign |
Het |
| Nlrp4e |
T |
A |
7: 23,036,205 (GRCm39) |
L686* |
probably null |
Het |
| Nudt12os |
T |
A |
17: 59,331,546 (GRCm39) |
|
noncoding transcript |
Het |
| Or10ag57 |
T |
A |
2: 87,218,220 (GRCm39) |
I57K |
probably damaging |
Het |
| Or10j5 |
G |
A |
1: 172,785,157 (GRCm39) |
S265N |
probably benign |
Het |
| Or2h1b |
A |
T |
17: 37,462,270 (GRCm39) |
S44T |
possibly damaging |
Het |
| Or5ac23 |
A |
G |
16: 59,149,573 (GRCm39) |
Y100H |
possibly damaging |
Het |
| Or5k16 |
T |
C |
16: 58,736,947 (GRCm39) |
D19G |
probably benign |
Het |
| Or8g27 |
T |
A |
9: 39,129,142 (GRCm39) |
M163K |
probably damaging |
Het |
| Pde7a |
T |
C |
3: 19,314,420 (GRCm39) |
T59A |
probably damaging |
Het |
| Pde7b |
A |
C |
10: 20,314,496 (GRCm39) |
D203E |
probably damaging |
Het |
| Phkg2 |
T |
A |
7: 127,177,156 (GRCm39) |
I94N |
possibly damaging |
Het |
| Pik3r2 |
G |
A |
8: 71,221,503 (GRCm39) |
T667I |
possibly damaging |
Het |
| Pitx3 |
T |
A |
19: 46,125,540 (GRCm39) |
H68L |
possibly damaging |
Het |
| Prcd |
A |
G |
11: 116,558,990 (GRCm39) |
|
probably benign |
Het |
| Prune2 |
C |
T |
19: 17,097,552 (GRCm39) |
R1019* |
probably null |
Het |
| Psap |
A |
G |
10: 60,136,324 (GRCm39) |
D486G |
probably benign |
Het |
| Purb |
A |
T |
11: 6,425,615 (GRCm39) |
V91E |
probably damaging |
Het |
| Recql |
C |
A |
6: 142,322,567 (GRCm39) |
V112F |
probably damaging |
Het |
| Rptor |
A |
T |
11: 119,634,708 (GRCm39) |
I175F |
probably damaging |
Het |
| Sbf1 |
C |
T |
15: 89,179,449 (GRCm39) |
V1385M |
probably damaging |
Het |
| Serpinb13 |
C |
T |
1: 106,910,574 (GRCm39) |
S66L |
probably damaging |
Het |
| Slc35f6 |
T |
C |
5: 30,812,957 (GRCm39) |
L37P |
probably damaging |
Het |
| Slc6a3 |
T |
A |
13: 73,686,700 (GRCm39) |
N22K |
possibly damaging |
Het |
| Sorl1 |
A |
T |
9: 41,915,347 (GRCm39) |
M1294K |
probably damaging |
Het |
| Sp6 |
C |
A |
11: 96,912,701 (GRCm39) |
A138E |
probably benign |
Het |
| Spag8 |
G |
T |
4: 43,653,408 (GRCm39) |
|
probably benign |
Het |
| Spmip4 |
G |
T |
6: 50,572,808 (GRCm39) |
T35K |
possibly damaging |
Het |
| Spon1 |
T |
A |
7: 113,628,204 (GRCm39) |
M320K |
probably benign |
Het |
| Tceanc2 |
A |
T |
4: 107,022,757 (GRCm39) |
S77T |
probably damaging |
Het |
| Thsd7a |
T |
A |
6: 12,337,313 (GRCm39) |
T1235S |
possibly damaging |
Het |
| Thsd7a |
T |
A |
6: 12,504,012 (GRCm39) |
I381F |
possibly damaging |
Het |
| Tmc4 |
T |
C |
7: 3,674,270 (GRCm39) |
|
probably null |
Het |
| Tmprss11d |
T |
C |
5: 86,457,260 (GRCm39) |
D133G |
probably damaging |
Het |
| Trav13n-3 |
T |
A |
14: 53,574,953 (GRCm39) |
V65D |
probably damaging |
Het |
| Trpm1 |
G |
T |
7: 63,852,782 (GRCm39) |
L65F |
probably damaging |
Het |
| Tyk2 |
C |
T |
9: 21,025,503 (GRCm39) |
A741T |
probably damaging |
Het |
| Ube2v1 |
T |
A |
2: 167,452,297 (GRCm39) |
Y102F |
probably damaging |
Het |
| Uckl1 |
A |
T |
2: 181,216,661 (GRCm39) |
S95T |
possibly damaging |
Het |
| Vcan |
C |
A |
13: 89,828,053 (GRCm39) |
W2171L |
probably damaging |
Het |
| Vinac1 |
T |
C |
2: 128,880,150 (GRCm39) |
H592R |
probably benign |
Het |
| Vmn1r64 |
T |
C |
7: 5,887,357 (GRCm39) |
N62S |
probably damaging |
Het |
| Vmn2r67 |
T |
C |
7: 84,799,831 (GRCm39) |
D469G |
probably benign |
Het |
| Vps13b |
A |
G |
15: 35,640,690 (GRCm39) |
S1352G |
probably benign |
Het |
| Zbtb38 |
C |
T |
9: 96,570,436 (GRCm39) |
R216H |
probably damaging |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTGGATTTGCCCATAATAGG -3'
(R):5'- GTGTCACTCCAGGAATGAGAGG -3'
Sequencing Primer
(F):5'- GAAATGACTGTTCTGAAGCTTCGAG -3'
(R):5'- TAGGGAGAGCCTCATCGTGTC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation