Incidental Mutation 'R4656:Mroh9'
| ID |
352403 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh9
|
| Ensembl Gene |
ENSMUSG00000071890 |
| Gene Name |
maestro heat-like repeat family member 9 |
| Synonyms |
4921528O07Rik, Armc11 |
| MMRRC Submission |
041916-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4656 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
162851871-162913239 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 162893593 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 194
(M194K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096608]
|
| AlphaFold |
G5E8L9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096608
AA Change: M194K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: M194K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5b_
|
231 |
716 |
2e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195132
|
| Meta Mutation Damage Score |
0.5679 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
96% (80/83) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310003L06Rik |
G |
A |
5: 88,112,534 (GRCm39) |
|
probably benign |
Het |
| 4931406B18Rik |
T |
A |
7: 43,150,565 (GRCm39) |
H69L |
probably benign |
Het |
| Ace2 |
T |
C |
X: 162,936,110 (GRCm39) |
S84P |
probably benign |
Het |
| Adgb |
A |
C |
10: 10,281,050 (GRCm39) |
N656K |
probably damaging |
Het |
| Ago3 |
G |
T |
4: 126,257,545 (GRCm39) |
Y495* |
probably null |
Het |
| Ahnak |
G |
A |
19: 8,982,219 (GRCm39) |
V1168M |
possibly damaging |
Het |
| Armc10 |
A |
G |
5: 21,866,548 (GRCm39) |
R271G |
probably benign |
Het |
| Atp4a |
T |
G |
7: 30,419,373 (GRCm39) |
|
probably benign |
Het |
| Casp1 |
C |
T |
9: 5,304,324 (GRCm39) |
P333S |
probably damaging |
Het |
| Ceacam9 |
C |
T |
7: 16,457,574 (GRCm39) |
A34V |
probably benign |
Het |
| Ces1b |
C |
G |
8: 93,784,042 (GRCm39) |
E488Q |
probably damaging |
Het |
| Ces2h |
A |
T |
8: 105,741,271 (GRCm39) |
T88S |
possibly damaging |
Het |
| Cfap410 |
G |
A |
10: 77,817,450 (GRCm39) |
R59H |
probably benign |
Het |
| Col2a1 |
C |
T |
15: 97,874,057 (GRCm39) |
G1375D |
unknown |
Het |
| Cyp1a1 |
T |
C |
9: 57,609,893 (GRCm39) |
F436L |
probably damaging |
Het |
| Dcaf7 |
T |
C |
11: 105,944,624 (GRCm39) |
V269A |
probably damaging |
Het |
| Disp2 |
T |
C |
2: 118,621,044 (GRCm39) |
L592P |
probably damaging |
Het |
| Eda2r |
T |
A |
X: 96,385,239 (GRCm39) |
Q171L |
probably damaging |
Het |
| Egln2 |
A |
G |
7: 26,858,618 (GRCm39) |
V408A |
probably benign |
Het |
| Gabpb2 |
A |
G |
3: 95,096,252 (GRCm39) |
L325P |
probably damaging |
Het |
| Gigyf1 |
C |
A |
5: 137,523,477 (GRCm39) |
Y936* |
probably null |
Het |
| Gm14149 |
A |
T |
2: 151,072,684 (GRCm39) |
|
noncoding transcript |
Het |
| Gnl2 |
C |
T |
4: 124,934,790 (GRCm39) |
Q149* |
probably null |
Het |
| Gpr107 |
C |
T |
2: 31,104,261 (GRCm39) |
T522M |
probably damaging |
Het |
| Grpr |
T |
A |
X: 162,297,992 (GRCm39) |
S351C |
probably damaging |
Het |
| Gsdma |
T |
C |
11: 98,563,907 (GRCm39) |
L287P |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,301,993 (GRCm39) |
T652A |
probably damaging |
Het |
| Ifi204 |
C |
A |
1: 173,587,927 (GRCm39) |
|
probably benign |
Het |
| Irx2 |
T |
C |
13: 72,779,417 (GRCm39) |
S234P |
probably damaging |
Het |
| Itgal |
T |
A |
7: 126,921,725 (GRCm39) |
D808E |
probably damaging |
Het |
| Krt13 |
C |
A |
11: 100,010,189 (GRCm39) |
R264L |
probably damaging |
Het |
| Marchf1 |
T |
A |
8: 66,839,071 (GRCm39) |
L38I |
probably benign |
Het |
| Megf9 |
T |
C |
4: 70,367,004 (GRCm39) |
H326R |
probably damaging |
Het |
| Mif4gd |
G |
T |
11: 115,499,163 (GRCm39) |
|
probably benign |
Het |
| Nhlrc3 |
A |
G |
3: 53,370,501 (GRCm39) |
S22P |
probably damaging |
Het |
| Nipal2 |
A |
T |
15: 34,577,714 (GRCm39) |
|
probably null |
Het |
| Nr1h4 |
A |
G |
10: 89,334,115 (GRCm39) |
S78P |
probably benign |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Olfr908 |
A |
T |
9: 38,427,852 (GRCm39) |
N175Y |
probably damaging |
Het |
| Or1e30 |
A |
T |
11: 73,678,337 (GRCm39) |
D191V |
probably damaging |
Het |
| Or52d13 |
C |
T |
7: 103,109,695 (GRCm39) |
R235Q |
probably benign |
Het |
| Pdzd2 |
A |
G |
15: 12,385,797 (GRCm39) |
V991A |
probably benign |
Het |
| Pex1 |
G |
A |
5: 3,654,880 (GRCm39) |
|
probably null |
Het |
| Plch1 |
G |
T |
3: 63,611,598 (GRCm39) |
A859E |
probably damaging |
Het |
| Pramel32 |
T |
C |
4: 88,548,202 (GRCm39) |
T68A |
probably benign |
Het |
| Ranbp2 |
A |
G |
10: 58,289,244 (GRCm39) |
K84R |
possibly damaging |
Het |
| Rbm14 |
T |
C |
19: 4,861,463 (GRCm39) |
Y25C |
probably damaging |
Het |
| Rmi2 |
A |
G |
16: 10,653,186 (GRCm39) |
D78G |
probably damaging |
Het |
| Serpina3k |
C |
A |
12: 104,311,532 (GRCm39) |
T370K |
probably damaging |
Het |
| Shc2 |
A |
T |
10: 79,457,003 (GRCm39) |
L538M |
probably damaging |
Het |
| Skint1 |
A |
G |
4: 111,878,674 (GRCm39) |
K202R |
probably damaging |
Het |
| Slc22a29 |
C |
A |
19: 8,195,664 (GRCm39) |
S125I |
possibly damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Slco4c1 |
A |
T |
1: 96,768,970 (GRCm39) |
D297E |
probably benign |
Het |
| Slco6d1 |
T |
C |
1: 98,350,928 (GRCm39) |
F136S |
probably benign |
Het |
| Smg1 |
A |
T |
7: 117,812,174 (GRCm39) |
V39E |
probably benign |
Het |
| Spns1 |
G |
T |
7: 125,973,474 (GRCm39) |
|
probably benign |
Het |
| Spsb1 |
A |
G |
4: 149,990,867 (GRCm39) |
|
probably null |
Het |
| Sspo |
T |
G |
6: 48,431,010 (GRCm39) |
I631S |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,078,147 (GRCm39) |
L4694P |
probably damaging |
Het |
| Taf5l |
T |
C |
8: 124,724,844 (GRCm39) |
E325G |
probably benign |
Het |
| Tars1 |
A |
T |
15: 11,394,350 (GRCm39) |
S96T |
probably damaging |
Het |
| Tdrd12 |
T |
C |
7: 35,184,679 (GRCm39) |
K745E |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,746,761 (GRCm39) |
Y1015H |
probably damaging |
Het |
| Trpv3 |
T |
A |
11: 73,186,240 (GRCm39) |
M677K |
probably damaging |
Het |
| Txlnb |
A |
T |
10: 17,691,024 (GRCm39) |
K191N |
probably damaging |
Het |
| Ubr1 |
A |
G |
2: 120,756,494 (GRCm39) |
V711A |
probably benign |
Het |
| Uqcrb |
T |
C |
13: 67,049,603 (GRCm39) |
T41A |
probably benign |
Het |
| Usp6nl |
A |
G |
2: 6,445,973 (GRCm39) |
Y627C |
probably damaging |
Het |
| Vezf1 |
A |
G |
11: 87,965,493 (GRCm39) |
D245G |
probably damaging |
Het |
| Vmn2r66 |
A |
G |
7: 84,661,204 (GRCm39) |
W9R |
possibly damaging |
Het |
| Wdr17 |
C |
T |
8: 55,134,434 (GRCm39) |
G349R |
probably damaging |
Het |
| Wdr35 |
T |
A |
12: 9,066,619 (GRCm39) |
M749K |
probably benign |
Het |
| Wrn |
A |
T |
8: 33,826,019 (GRCm39) |
|
probably null |
Het |
| Zfy1 |
T |
G |
Y: 729,626 (GRCm39) |
T339P |
unknown |
Het |
|
| Other mutations in Mroh9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Mroh9
|
APN |
1 |
162,873,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00705:Mroh9
|
APN |
1 |
162,907,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00788:Mroh9
|
APN |
1 |
162,852,227 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00795:Mroh9
|
APN |
1 |
162,888,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00815:Mroh9
|
APN |
1 |
162,866,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01025:Mroh9
|
APN |
1 |
162,875,435 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01303:Mroh9
|
APN |
1 |
162,908,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01526:Mroh9
|
APN |
1 |
162,883,172 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01680:Mroh9
|
APN |
1 |
162,875,551 (GRCm39) |
splice site |
probably null |
|
|
IGL01823:Mroh9
|
APN |
1 |
162,883,178 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02024:Mroh9
|
APN |
1 |
162,890,071 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02213:Mroh9
|
APN |
1 |
162,885,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Mroh9
|
APN |
1 |
162,903,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02546:Mroh9
|
APN |
1 |
162,908,145 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03059:Mroh9
|
APN |
1 |
162,852,205 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03061:Mroh9
|
APN |
1 |
162,854,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Mroh9
|
APN |
1 |
162,866,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0441:Mroh9
|
UTSW |
1 |
162,888,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0629:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0751:Mroh9
|
UTSW |
1 |
162,893,693 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1301:Mroh9
|
UTSW |
1 |
162,871,552 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1481:Mroh9
|
UTSW |
1 |
162,854,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Mroh9
|
UTSW |
1 |
162,852,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1647:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Mroh9
|
UTSW |
1 |
162,852,161 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1795:Mroh9
|
UTSW |
1 |
162,884,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1796:Mroh9
|
UTSW |
1 |
162,873,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1857:Mroh9
|
UTSW |
1 |
162,866,714 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1869:Mroh9
|
UTSW |
1 |
162,854,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1923:Mroh9
|
UTSW |
1 |
162,903,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Mroh9
|
UTSW |
1 |
162,854,099 (GRCm39) |
splice site |
probably null |
|
|
R2511:Mroh9
|
UTSW |
1 |
162,866,514 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2912:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Mroh9
|
UTSW |
1 |
162,884,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Mroh9
|
UTSW |
1 |
162,884,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Mroh9
|
UTSW |
1 |
162,893,638 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4034:Mroh9
|
UTSW |
1 |
162,908,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4551:Mroh9
|
UTSW |
1 |
162,871,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4662:Mroh9
|
UTSW |
1 |
162,883,162 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4743:Mroh9
|
UTSW |
1 |
162,852,061 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4890:Mroh9
|
UTSW |
1 |
162,854,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5128:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5147:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5157:Mroh9
|
UTSW |
1 |
162,871,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5324:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5340:Mroh9
|
UTSW |
1 |
162,908,156 (GRCm39) |
start gained |
probably benign |
|
|
R6005:Mroh9
|
UTSW |
1 |
162,903,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6182:Mroh9
|
UTSW |
1 |
162,893,612 (GRCm39) |
nonsense |
probably null |
|
|
R6414:Mroh9
|
UTSW |
1 |
162,902,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Mroh9
|
UTSW |
1 |
162,903,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6540:Mroh9
|
UTSW |
1 |
162,866,541 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6541:Mroh9
|
UTSW |
1 |
162,885,607 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6643:Mroh9
|
UTSW |
1 |
162,903,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Mroh9
|
UTSW |
1 |
162,873,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6830:Mroh9
|
UTSW |
1 |
162,903,935 (GRCm39) |
missense |
probably benign |
|
|
R7026:Mroh9
|
UTSW |
1 |
162,888,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Mroh9
|
UTSW |
1 |
162,866,525 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7068:Mroh9
|
UTSW |
1 |
162,866,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Mroh9
|
UTSW |
1 |
162,903,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7545:Mroh9
|
UTSW |
1 |
162,902,277 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7615:Mroh9
|
UTSW |
1 |
162,873,601 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7743:Mroh9
|
UTSW |
1 |
162,852,122 (GRCm39) |
missense |
probably benign |
|
|
R7808:Mroh9
|
UTSW |
1 |
162,866,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Mroh9
|
UTSW |
1 |
162,866,802 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8062:Mroh9
|
UTSW |
1 |
162,866,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Mroh9
|
UTSW |
1 |
162,890,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8426:Mroh9
|
UTSW |
1 |
162,852,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8458:Mroh9
|
UTSW |
1 |
162,883,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Mroh9
|
UTSW |
1 |
162,899,595 (GRCm39) |
splice site |
probably null |
|
|
R8960:Mroh9
|
UTSW |
1 |
162,883,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9040:Mroh9
|
UTSW |
1 |
162,890,069 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9125:Mroh9
|
UTSW |
1 |
162,875,412 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9154:Mroh9
|
UTSW |
1 |
162,890,030 (GRCm39) |
missense |
|
|
|
R9596:Mroh9
|
UTSW |
1 |
162,893,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9612:Mroh9
|
UTSW |
1 |
162,866,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF003:Mroh9
|
UTSW |
1 |
162,885,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAACAGTAACCAAAGAAGTGTAGC -3'
(R):5'- GGATCCAGTGCAAACTTGTAC -3'
Sequencing Primer
(F):5'- GAAGTGTAGCTATATCTTGAAGCTG -3'
(R):5'- GATCCAGTGCAAACTTGTACCGTTG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation