Mutagenetix > Incidental Mutation

Incidental Mutation 'R4662:Prkdc'

352957

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DNA-PK, XRCC7, DNAPDcs, DOXNPH, dxnph, DNA-PKcs

MMRRC Submission

042011-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R4662 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

15455730-15660099 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 15551916 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 2041 (D2041N)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000023352
AA Change: D2041N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: D2041N

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	A	T	6: 91,891,939 (GRCm39)	Q67L	probably benign	Het
Adam34l	T	A	8: 44,080,116 (GRCm39)	Y36F	probably benign	Het
Adrb1	A	G	19: 56,711,206 (GRCm39)	T135A	probably damaging	Het
Ark2n	T	A	18: 77,762,186 (GRCm39)	Q42L	probably benign	Het
Asxl2	G	T	12: 3,477,193 (GRCm39)	W13L	probably damaging	Het
Atp4a	G	A	7: 30,419,650 (GRCm39)	R671Q	probably benign	Het
Brsk1	T	C	7: 4,710,298 (GRCm39)	S436P	possibly damaging	Het
Calb2	A	G	8: 110,894,709 (GRCm39)	F21L	probably benign	Het
Camk2a	T	C	18: 61,074,411 (GRCm39)	Y39H	probably damaging	Het
Cavin2	T	C	1: 51,340,510 (GRCm39)	S396P	probably benign	Het
Cfdp1	A	G	8: 112,557,577 (GRCm39)	F188S	probably benign	Het
Chek2	T	A	5: 111,014,908 (GRCm39)	V459D	probably damaging	Het
Cldn8	G	A	16: 88,359,296 (GRCm39)	H210Y	probably benign	Het
Cobl	A	G	11: 12,203,672 (GRCm39)	V1003A	probably benign	Het
Ctsll3	A	G	13: 60,947,416 (GRCm39)	F257L	possibly damaging	Het
Dnajc13	A	C	9: 104,084,957 (GRCm39)	F819V	probably damaging	Het
Dram1	C	A	10: 88,161,246 (GRCm39)	V208L	probably damaging	Het
Dynlt1b	A	G	17: 6,699,279 (GRCm39)	T10A	probably benign	Het
Eml6	A	T	11: 29,727,390 (GRCm39)	V1244E	probably damaging	Het
Ethe1	G	A	7: 24,293,405 (GRCm39)	S17N	probably benign	Het
Foxi1	T	C	11: 34,157,578 (GRCm39)	D149G	probably damaging	Het
Fzd9	T	C	5: 135,278,475 (GRCm39)	E470G	probably damaging	Het
Ggnbp2	A	G	11: 84,753,072 (GRCm39)	F56L	probably damaging	Het
Hao1	G	A	2: 134,364,947 (GRCm39)	R227*	probably null	Het
Hyal1	G	A	9: 107,456,420 (GRCm39)	R369H	probably damaging	Het
Jam2	G	A	16: 84,609,840 (GRCm39)	V151M	probably damaging	Het
Kcna2	T	A	3: 107,012,733 (GRCm39)	I438N	probably benign	Het
Lrp1	A	T	10: 127,388,054 (GRCm39)	C3331*	probably null	Het
Mcm9	T	C	10: 53,424,623 (GRCm39)	I656V	probably benign	Het
Mroh9	C	T	1: 162,883,162 (GRCm39)	C439Y	probably damaging	Het
N4bp2l2	T	C	5: 150,574,160 (GRCm39)	D85G	probably damaging	Het
Nr1h2	A	G	7: 44,199,855 (GRCm39)	Y355H	probably damaging	Het
Nr5a2	T	C	1: 136,868,167 (GRCm39)	I322V	probably benign	Het
Nup153	A	C	13: 46,840,750 (GRCm39)	L273V	possibly damaging	Het
Obscn	A	G	11: 58,890,422 (GRCm39)	L7370P	unknown	Het
Or1a1	T	C	11: 74,086,542 (GRCm39)	I71T	probably damaging	Het
Or4b1	T	A	2: 89,980,222 (GRCm39)	I43F	probably damaging	Het
Or5k15	A	G	16: 58,710,287 (GRCm39)	C99R	probably damaging	Het
Ptdss1	A	G	13: 67,081,675 (GRCm39)	D35G	possibly damaging	Het
Ptprs	G	T	17: 56,724,666 (GRCm39)	T1118K	probably damaging	Het
Pygb	C	T	2: 150,657,036 (GRCm39)	T329I	probably benign	Het
Rhoh	T	A	5: 66,050,157 (GRCm39)	D142E	probably benign	Het
Saraf	C	A	8: 34,635,616 (GRCm39)	A306E	probably damaging	Het
Scn1a	T	C	2: 66,181,332 (GRCm39)	I64V	probably benign	Het
Sec16a	A	G	2: 26,320,582 (GRCm39)	W1333R	probably damaging	Het
Shroom1	A	T	11: 53,357,289 (GRCm39)	T651S	possibly damaging	Het
Skint3	C	A	4: 112,134,863 (GRCm39)	Y345*	probably null	Het
Slc1a7	T	A	4: 107,864,751 (GRCm39)	N263K	probably damaging	Het
Sptbn2	C	T	19: 4,789,267 (GRCm39)	R1236C	probably damaging	Het
Tbx21	T	C	11: 96,992,393 (GRCm39)	N226S	probably benign	Het
Thada	A	G	17: 84,743,078 (GRCm39)	L782P	probably damaging	Het
Tle1	T	G	4: 72,055,335 (GRCm39)	I446L	possibly damaging	Het
Trgv1	T	A	13: 19,524,503 (GRCm39)	L76I	possibly damaging	Het
Triobp	A	G	15: 78,877,469 (GRCm39)	D1621G	probably damaging	Het
Trpm2	G	C	10: 77,773,972 (GRCm39)	A481G	probably benign	Het
Unc80	A	T	1: 66,685,595 (GRCm39)	M2240L	probably benign	Het
Usp9x	A	G	X: 12,989,747 (GRCm39)	R776G	possibly damaging	Homo
Vangl1	T	C	3: 102,074,238 (GRCm39)	T290A	probably benign	Het
Vmn1r233	T	A	17: 21,214,393 (GRCm39)	I186F	probably benign	Het
Vmn2r102	G	A	17: 19,901,424 (GRCm39)	C517Y	probably damaging	Het
Vrk2	G	A	11: 26,421,611 (GRCm39)	T449M	possibly damaging	Het
Zfp518a	A	G	19: 40,900,304 (GRCm39)	S78G	probably benign	Het
Zscan25	T	C	5: 145,223,120 (GRCm39)	S131P	unknown	Het
Zscan29	G	A	2: 120,997,096 (GRCm39)	T140I	probably benign	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,515,090 (GRCm39)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,627,508 (GRCm39)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,608,330 (GRCm39)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,593,711 (GRCm39)	splice site	probably null
IGL00489:Prkdc	APN	16	15,617,790 (GRCm39)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,482,103 (GRCm39)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,470,222 (GRCm39)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,554,699 (GRCm39)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,605,022 (GRCm39)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,597,290 (GRCm39)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,634,503 (GRCm39)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,577,618 (GRCm39)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,557,428 (GRCm39)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,519,979 (GRCm39)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,487,185 (GRCm39)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,544,568 (GRCm39)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,647,556 (GRCm39)	missense	probably benign
IGL01335:Prkdc	APN	16	15,634,760 (GRCm39)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,653,030 (GRCm39)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,531,451 (GRCm39)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,470,166 (GRCm39)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,485,609 (GRCm39)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,552,858 (GRCm39)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,516,751 (GRCm39)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,526,643 (GRCm39)	missense	probably benign
IGL02121:Prkdc	APN	16	15,535,048 (GRCm39)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,487,149 (GRCm39)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,627,623 (GRCm39)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,603,843 (GRCm39)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,603,842 (GRCm39)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,634,622 (GRCm39)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,488,399 (GRCm39)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,532,146 (GRCm39)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,544,406 (GRCm39)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,488,465 (GRCm39)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,587,689 (GRCm39)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,653,907 (GRCm39)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,570,590 (GRCm39)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,651,530 (GRCm39)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,649,191 (GRCm39)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,469,383 (GRCm39)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,617,880 (GRCm39)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,617,848 (GRCm39)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,523,174 (GRCm39)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,531,499 (GRCm39)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,518,608 (GRCm39)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,587,665 (GRCm39)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,488,490 (GRCm39)	nonsense	probably null
anhimid	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
anhinga	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
Bushtit	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
clover	UTSW	16	15,520,020 (GRCm39)	splice site	probably benign
crackle	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
Daffy	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
darter	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
envenomation	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
hobgoblin	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
Incubus	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
liming	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
newt	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
primitive	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
roadrunner	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
Schreier	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
screamer	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
Screamer10	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
screamer2	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
screamer3	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
screamer4	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
screamer5	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
screamer6	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
screamer7	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
Screamer8	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
Screamer9	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
Tweetie	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
updock	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,526,565 (GRCm39)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,544,368 (GRCm39)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,516,871 (GRCm39)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,554,663 (GRCm39)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,609,791 (GRCm39)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,651,604 (GRCm39)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,651,652 (GRCm39)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,625,952 (GRCm39)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,589,921 (GRCm39)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,508,271 (GRCm39)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,628,665 (GRCm39)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,603,835 (GRCm39)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,647,580 (GRCm39)	missense	probably benign
R1027:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,472,613 (GRCm39)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,585,815 (GRCm39)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,570,646 (GRCm39)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,577,610 (GRCm39)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,508,146 (GRCm39)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,577,587 (GRCm39)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,482,091 (GRCm39)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,485,564 (GRCm39)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,549,430 (GRCm39)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
R1531:Prkdc	UTSW	16	15,589,970 (GRCm39)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,493,192 (GRCm39)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,551,922 (GRCm39)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,494,853 (GRCm39)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
R1762:Prkdc	UTSW	16	15,455,825 (GRCm39)	missense	probably benign
R1789:Prkdc	UTSW	16	15,557,388 (GRCm39)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,647,499 (GRCm39)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,543,300 (GRCm39)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,532,079 (GRCm39)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,532,130 (GRCm39)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R1939:Prkdc	UTSW	16	15,653,777 (GRCm39)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,494,873 (GRCm39)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,505,216 (GRCm39)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,533,827 (GRCm39)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,505,254 (GRCm39)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,523,071 (GRCm39)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,516,688 (GRCm39)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2271:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2272:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2356:Prkdc	UTSW	16	15,502,068 (GRCm39)	missense	probably benign
R2852:Prkdc	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,617,831 (GRCm39)	missense	probably benign
R3834:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,647,475 (GRCm39)	splice site	probably null
R4151:Prkdc	UTSW	16	15,634,637 (GRCm39)	missense	probably benign
R4233:Prkdc	UTSW	16	15,653,783 (GRCm39)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,623,963 (GRCm39)	splice site	probably null
R4296:Prkdc	UTSW	16	15,555,769 (GRCm39)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,585,886 (GRCm39)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,591,603 (GRCm39)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,518,517 (GRCm39)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,554,734 (GRCm39)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,585,830 (GRCm39)	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15,628,688 (GRCm39)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,480,938 (GRCm39)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,634,638 (GRCm39)	missense	probably benign	0.05
R4680:Prkdc	UTSW	16	15,589,894 (GRCm39)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,519,976 (GRCm39)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,628,701 (GRCm39)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,485,579 (GRCm39)	missense	probably benign
R4785:Prkdc	UTSW	16	15,466,840 (GRCm39)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,519,939 (GRCm39)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,496,173 (GRCm39)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,655,882 (GRCm39)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,589,912 (GRCm39)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,608,444 (GRCm39)	missense	probably benign
R5151:Prkdc	UTSW	16	15,533,899 (GRCm39)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,589,985 (GRCm39)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,552,819 (GRCm39)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,532,838 (GRCm39)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,649,176 (GRCm39)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,623,814 (GRCm39)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,612,961 (GRCm39)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,587,739 (GRCm39)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,496,172 (GRCm39)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,469,333 (GRCm39)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,524,655 (GRCm39)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,627,476 (GRCm39)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,647,633 (GRCm39)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,628,634 (GRCm39)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,482,097 (GRCm39)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,597,252 (GRCm39)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,634,616 (GRCm39)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,555,698 (GRCm39)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,551,962 (GRCm39)	missense	probably benign
R5883:Prkdc	UTSW	16	15,533,778 (GRCm39)	missense	probably benign
R5895:Prkdc	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,601,021 (GRCm39)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,557,335 (GRCm39)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,589,937 (GRCm39)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,608,456 (GRCm39)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,605,019 (GRCm39)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,532,783 (GRCm39)	missense	probably benign
R6376:Prkdc	UTSW	16	15,587,749 (GRCm39)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,516,679 (GRCm39)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,612,939 (GRCm39)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,469,402 (GRCm39)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,594,936 (GRCm39)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,626,020 (GRCm39)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,601,127 (GRCm39)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,617,853 (GRCm39)	missense	probably benign
R6950:Prkdc	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,587,830 (GRCm39)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,608,317 (GRCm39)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,507,207 (GRCm39)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,516,667 (GRCm39)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,532,127 (GRCm39)	missense	probably benign
R7283:Prkdc	UTSW	16	15,535,628 (GRCm39)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,466,602 (GRCm39)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,555,807 (GRCm39)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,649,183 (GRCm39)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,623,960 (GRCm39)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,507,141 (GRCm39)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,532,870 (GRCm39)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,526,767 (GRCm39)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,597,315 (GRCm39)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,634,749 (GRCm39)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,482,108 (GRCm39)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,523,117 (GRCm39)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,532,005 (GRCm39)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,608,540 (GRCm39)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,469,400 (GRCm39)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,466,788 (GRCm39)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,482,232 (GRCm39)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,480,899 (GRCm39)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,626,068 (GRCm39)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,601,029 (GRCm39)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,545,523 (GRCm39)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,491,624 (GRCm39)	intron	probably benign
R8971:Prkdc	UTSW	16	15,493,229 (GRCm39)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,617,726 (GRCm39)	splice site	probably null
R9052:Prkdc	UTSW	16	15,508,160 (GRCm39)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,523,153 (GRCm39)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,526,792 (GRCm39)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,485,465 (GRCm39)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,657,079 (GRCm39)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,548,335 (GRCm39)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,548,334 (GRCm39)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,548,341 (GRCm39)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,617,818 (GRCm39)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,533,819 (GRCm39)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,657,044 (GRCm39)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,558,142 (GRCm39)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,505,286 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CAGGATTGGTGAAAGCTTTAGC -3'
(R):5'- TGCTTAGATCTTGGAAAGTCTCC -3'

Sequencing Primer
(F):5'- CTGCTTATTTTTCAGGCAG -3'
(R):5'- GCTACTGAGACCAACAGA -3'

Posted On

2015-10-08