Incidental Mutation 'R4664:Dock3'
| ID |
353115 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
041922-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.616)
|
| Stock # |
R4664 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 106870743 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 557
(N557I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044532
AA Change: N557I
PolyPhen 2
Score 0.708 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: N557I
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0813 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
| Validation Efficiency |
96% (110/115) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano2 |
A |
G |
6: 125,840,501 (GRCm39) |
I391V |
probably benign |
Het |
| Apc |
T |
A |
18: 34,431,647 (GRCm39) |
L349M |
probably damaging |
Het |
| Atmin |
A |
G |
8: 117,684,698 (GRCm39) |
D786G |
probably damaging |
Het |
| Atp8a1 |
T |
A |
5: 67,919,929 (GRCm39) |
D379V |
possibly damaging |
Het |
| Aurkb |
A |
G |
11: 68,939,435 (GRCm39) |
K173E |
probably damaging |
Het |
| Bak1 |
T |
C |
17: 27,241,510 (GRCm39) |
I83V |
possibly damaging |
Het |
| Btbd17 |
A |
C |
11: 114,684,832 (GRCm39) |
V69G |
probably damaging |
Het |
| Cacna1a |
T |
A |
8: 85,328,396 (GRCm39) |
Y1597* |
probably null |
Het |
| Camk2a |
C |
A |
18: 61,088,696 (GRCm39) |
Q167K |
possibly damaging |
Het |
| Capn1 |
A |
T |
19: 6,061,045 (GRCm39) |
N253K |
probably benign |
Het |
| Ccer2 |
A |
G |
7: 28,455,928 (GRCm39) |
E40G |
probably benign |
Het |
| Cdc42bpa |
A |
G |
1: 179,972,130 (GRCm39) |
T527A |
probably damaging |
Het |
| Cdkl2 |
T |
C |
5: 92,185,124 (GRCm39) |
D89G |
probably damaging |
Het |
| Cep128 |
G |
T |
12: 91,263,027 (GRCm39) |
R291S |
probably damaging |
Het |
| Cert1 |
T |
C |
13: 96,735,965 (GRCm39) |
V175A |
probably benign |
Het |
| Chd4 |
A |
G |
6: 125,078,465 (GRCm39) |
M203V |
possibly damaging |
Het |
| Chrna4 |
A |
G |
2: 180,679,286 (GRCm39) |
S54P |
probably damaging |
Het |
| Cic |
TGTTGCCCTC |
T |
7: 24,990,099 (GRCm39) |
|
probably benign |
Het |
| Cntn5 |
T |
A |
9: 10,144,214 (GRCm39) |
I152L |
possibly damaging |
Het |
| Cntn6 |
A |
G |
6: 104,705,245 (GRCm39) |
E154G |
probably benign |
Het |
| Col16a1 |
A |
C |
4: 129,955,883 (GRCm39) |
|
probably benign |
Het |
| Cpvl |
C |
T |
6: 53,908,918 (GRCm39) |
E282K |
probably benign |
Het |
| Cyth2 |
T |
C |
7: 45,460,143 (GRCm39) |
D183G |
probably damaging |
Het |
| Ddx47 |
A |
T |
6: 134,989,319 (GRCm39) |
T48S |
possibly damaging |
Het |
| Dgkk |
A |
G |
X: 6,794,751 (GRCm39) |
D685G |
probably benign |
Het |
| Dis3l |
C |
T |
9: 64,238,080 (GRCm39) |
S29N |
unknown |
Het |
| Dlg5 |
T |
C |
14: 24,187,249 (GRCm39) |
H1834R |
possibly damaging |
Het |
| Dnah10 |
T |
C |
5: 124,905,536 (GRCm39) |
M4060T |
possibly damaging |
Het |
| Dync2i1 |
T |
C |
12: 116,219,831 (GRCm39) |
E37G |
probably damaging |
Het |
| Eprs1 |
A |
T |
1: 185,105,273 (GRCm39) |
|
probably benign |
Het |
| Faim2 |
C |
A |
15: 99,422,581 (GRCm39) |
|
probably null |
Het |
| Faim2 |
T |
G |
15: 99,422,582 (GRCm39) |
S72R |
probably benign |
Het |
| Fanca |
T |
C |
8: 123,995,711 (GRCm39) |
T1364A |
probably damaging |
Het |
| Fance |
T |
C |
17: 28,534,636 (GRCm39) |
|
probably benign |
Het |
| Farsb |
A |
T |
1: 78,420,402 (GRCm39) |
H496Q |
possibly damaging |
Het |
| Fryl |
C |
T |
5: 73,248,022 (GRCm39) |
E1032K |
possibly damaging |
Het |
| Galnt14 |
A |
T |
17: 73,814,808 (GRCm39) |
|
probably benign |
Het |
| Gba2 |
A |
T |
4: 43,568,619 (GRCm39) |
|
probably benign |
Het |
| Gjb4 |
C |
A |
4: 127,245,571 (GRCm39) |
K123N |
probably damaging |
Het |
| Gmcl1 |
G |
A |
6: 86,709,980 (GRCm39) |
T56I |
probably benign |
Het |
| Gtf2ird1 |
T |
A |
5: 134,412,756 (GRCm39) |
E55V |
probably damaging |
Het |
| Gtpbp2 |
T |
C |
17: 46,472,080 (GRCm39) |
V5A |
probably benign |
Het |
| Hnrnpr |
A |
G |
4: 136,044,486 (GRCm39) |
|
probably benign |
Het |
| Homer3 |
G |
A |
8: 70,742,793 (GRCm39) |
|
probably null |
Het |
| Hsd3b3 |
T |
C |
3: 98,649,532 (GRCm39) |
S264G |
probably damaging |
Het |
| Ints8 |
T |
C |
4: 11,227,152 (GRCm39) |
M574V |
probably benign |
Het |
| Kif4-ps |
G |
A |
12: 101,115,477 (GRCm39) |
|
noncoding transcript |
Het |
| Klhl14 |
A |
T |
18: 21,687,765 (GRCm39) |
N552K |
probably benign |
Het |
| Klhl40 |
A |
G |
9: 121,609,799 (GRCm39) |
E528G |
probably damaging |
Het |
| Lactb2 |
T |
C |
1: 13,717,624 (GRCm39) |
E133G |
probably damaging |
Het |
| Lratd2 |
A |
T |
15: 60,695,478 (GRCm39) |
D89E |
probably benign |
Het |
| Lrrtm2 |
T |
C |
18: 35,347,310 (GRCm39) |
|
probably null |
Het |
| Mab21l2 |
T |
A |
3: 86,454,811 (GRCm39) |
Y63F |
probably benign |
Het |
| Mbd1 |
T |
A |
18: 74,402,597 (GRCm39) |
I33N |
possibly damaging |
Het |
| Mertk |
G |
A |
2: 128,643,132 (GRCm39) |
V844M |
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,044,448 (GRCm39) |
T652A |
possibly damaging |
Het |
| Nlrp4a |
C |
A |
7: 26,148,943 (GRCm39) |
Y183* |
probably null |
Het |
| Noa1 |
T |
A |
5: 77,447,600 (GRCm39) |
T558S |
probably benign |
Het |
| Nol11 |
A |
T |
11: 107,071,826 (GRCm39) |
S256T |
possibly damaging |
Het |
| Nr1d1 |
G |
T |
11: 98,662,086 (GRCm39) |
R183S |
possibly damaging |
Het |
| Nrg2 |
G |
T |
18: 36,185,948 (GRCm39) |
Q264K |
possibly damaging |
Het |
| Nsd3 |
T |
A |
8: 26,188,894 (GRCm39) |
F1027I |
probably damaging |
Het |
| Ntrk3 |
T |
A |
7: 78,110,847 (GRCm39) |
I285F |
probably damaging |
Het |
| Obox8 |
T |
C |
7: 14,066,771 (GRCm39) |
N91S |
possibly damaging |
Het |
| Oga |
T |
C |
19: 45,760,384 (GRCm39) |
E258G |
probably benign |
Het |
| Orc5 |
C |
T |
5: 22,751,520 (GRCm39) |
S63N |
probably benign |
Het |
| Osbpl6 |
C |
T |
2: 76,398,552 (GRCm39) |
T412I |
probably benign |
Het |
| P2ry14 |
C |
T |
3: 59,022,563 (GRCm39) |
C308Y |
probably damaging |
Het |
| Pacsin1 |
T |
C |
17: 27,926,038 (GRCm39) |
F127L |
probably damaging |
Het |
| Pex11b |
T |
C |
3: 96,551,151 (GRCm39) |
L198P |
possibly damaging |
Het |
| Pla2g4e |
A |
T |
2: 120,001,669 (GRCm39) |
V660E |
probably damaging |
Het |
| Plxna4 |
C |
A |
6: 32,493,885 (GRCm39) |
V244F |
possibly damaging |
Het |
| Polr3b |
A |
G |
10: 84,550,233 (GRCm39) |
Y981C |
probably damaging |
Het |
| Popdc2 |
T |
A |
16: 38,194,649 (GRCm39) |
S357T |
probably damaging |
Het |
| Prr29 |
A |
G |
11: 106,267,159 (GRCm39) |
H58R |
probably damaging |
Het |
| Pyy |
T |
A |
11: 101,998,178 (GRCm39) |
M1L |
possibly damaging |
Het |
| Rasd2 |
T |
C |
8: 75,948,556 (GRCm39) |
S161P |
possibly damaging |
Het |
| Ryr3 |
C |
T |
2: 112,826,900 (GRCm39) |
|
probably benign |
Het |
| Sectm1a |
G |
A |
11: 120,960,552 (GRCm39) |
R88C |
possibly damaging |
Het |
| Serpinb13 |
C |
T |
1: 106,910,574 (GRCm39) |
S66L |
probably damaging |
Het |
| Siglecf |
A |
T |
7: 43,005,837 (GRCm39) |
I465F |
possibly damaging |
Het |
| Sorl1 |
A |
T |
9: 41,915,347 (GRCm39) |
M1294K |
probably damaging |
Het |
| Spam1 |
A |
T |
6: 24,796,661 (GRCm39) |
H204L |
probably benign |
Het |
| Sspo |
A |
T |
6: 48,450,468 (GRCm39) |
N2586Y |
possibly damaging |
Het |
| Tbc1d4 |
A |
G |
14: 101,700,263 (GRCm39) |
|
probably benign |
Het |
| Tceanc2 |
A |
T |
4: 107,022,757 (GRCm39) |
S77T |
probably damaging |
Het |
| Tedc2 |
A |
G |
17: 24,439,114 (GRCm39) |
|
probably benign |
Het |
| Tgm6 |
A |
G |
2: 129,979,314 (GRCm39) |
D148G |
probably benign |
Het |
| Tgm6 |
A |
T |
2: 129,983,128 (GRCm39) |
Q239L |
probably benign |
Het |
| Thsd7a |
T |
A |
6: 12,337,313 (GRCm39) |
T1235S |
possibly damaging |
Het |
| Thsd7a |
T |
A |
6: 12,504,012 (GRCm39) |
I381F |
possibly damaging |
Het |
| Tmc4 |
T |
C |
7: 3,674,270 (GRCm39) |
|
probably null |
Het |
| Tmem54 |
A |
T |
4: 129,004,704 (GRCm39) |
E186D |
possibly damaging |
Het |
| Tpk1 |
A |
T |
6: 43,588,269 (GRCm39) |
F32I |
probably benign |
Het |
| Trpc4ap |
A |
G |
2: 155,514,917 (GRCm39) |
I97T |
probably benign |
Het |
| Tut7 |
G |
A |
13: 59,948,413 (GRCm39) |
T636I |
possibly damaging |
Het |
| Txlnb |
A |
G |
10: 17,718,942 (GRCm39) |
E591G |
probably damaging |
Het |
| Tyk2 |
C |
T |
9: 21,025,503 (GRCm39) |
A741T |
probably damaging |
Het |
| Ubr4 |
G |
A |
4: 139,133,829 (GRCm39) |
E742K |
possibly damaging |
Het |
| Uckl1 |
A |
T |
2: 181,216,661 (GRCm39) |
S95T |
possibly damaging |
Het |
| Uevld |
T |
A |
7: 46,587,734 (GRCm39) |
D322V |
probably damaging |
Het |
| Ugt1a1 |
CAGAGAGAGAGAGA |
CAGAGAGAGAGA |
1: 88,139,706 (GRCm39) |
|
probably benign |
Het |
| Vmn1r238 |
G |
T |
18: 3,123,300 (GRCm39) |
T38K |
probably damaging |
Het |
| Vps8 |
T |
A |
16: 21,262,938 (GRCm39) |
|
probably null |
Het |
| Wdr83 |
T |
C |
8: 85,806,680 (GRCm39) |
|
probably benign |
Het |
| Zfp619 |
A |
G |
7: 39,183,559 (GRCm39) |
T51A |
probably benign |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAATGGAATGTACCTTGTAAGTGCC -3'
(R):5'- GCATAGCTGCTAACCAGTGTTG -3'
Sequencing Primer
(F):5'- GAATGTACCTTGTAAGTGCCATTACC -3'
(R):5'- GCTGCTAACCAGTGTTGCTTAAAGAC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation