Incidental Mutation 'R3691:Cog3'
ID |
353155 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cog3
|
Ensembl Gene |
ENSMUSG00000034893 |
Gene Name |
component of oligomeric golgi complex 3 |
Synonyms |
|
MMRRC Submission |
040686-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R3691 (G1)
|
Quality Score |
40.1 |
Status
|
Validated
|
Chromosome |
14 |
Chromosomal Location |
75939790-75991998 bp(-) (GRCm39) |
Type of Mutation |
start codon destroyed |
DNA Base Change (assembly) |
T to C
at 75991878 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Valine
at position 1
(M1V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154131
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049168]
[ENSMUST00000227473]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably null
Transcript: ENSMUST00000049168
AA Change: M1V
|
SMART Domains |
Protein: ENSMUSP00000045016 Gene: ENSMUSG00000034893 AA Change: M1V
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
15 |
N/A |
INTRINSIC |
Pfam:Sec34
|
130 |
277 |
9.5e-57 |
PFAM |
Blast:HisKA
|
745 |
810 |
1e-5 |
BLAST |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000227473
AA Change: M1V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
Meta Mutation Damage Score |
0.8117 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.2%
- 20x: 95.0%
|
Validation Efficiency |
100% (34/34) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Afdn |
A |
G |
17: 14,108,671 (GRCm39) |
E1398G |
probably damaging |
Het |
Avl9 |
C |
T |
6: 56,713,812 (GRCm39) |
H357Y |
probably benign |
Het |
Best2 |
A |
G |
8: 85,737,883 (GRCm39) |
F171L |
probably benign |
Het |
Btbd19 |
A |
T |
4: 116,977,789 (GRCm39) |
|
probably benign |
Het |
Cap1 |
A |
G |
4: 122,758,419 (GRCm39) |
S254P |
probably damaging |
Het |
Cfap43 |
G |
A |
19: 47,885,512 (GRCm39) |
L368F |
probably benign |
Het |
Clasrp |
C |
A |
7: 19,319,165 (GRCm39) |
|
probably benign |
Het |
Drosha |
G |
A |
15: 12,834,724 (GRCm39) |
R276H |
unknown |
Het |
Efr3b |
T |
A |
12: 4,032,059 (GRCm39) |
D183V |
possibly damaging |
Het |
Epha1 |
T |
C |
6: 42,338,064 (GRCm39) |
T794A |
probably damaging |
Het |
Fbxo17 |
G |
A |
7: 28,436,887 (GRCm39) |
V281I |
probably damaging |
Het |
Flii |
T |
C |
11: 60,610,583 (GRCm39) |
Y571C |
probably benign |
Het |
Flywch1 |
G |
A |
17: 23,982,186 (GRCm39) |
P6L |
probably damaging |
Het |
Foxj3 |
T |
C |
4: 119,473,839 (GRCm39) |
|
probably benign |
Het |
Fras1 |
C |
T |
5: 96,929,371 (GRCm39) |
T3925I |
probably benign |
Het |
Gk5 |
T |
C |
9: 96,011,149 (GRCm39) |
|
probably null |
Het |
Gm12588 |
T |
G |
11: 121,796,751 (GRCm39) |
Q366P |
possibly damaging |
Het |
Gm3248 |
A |
G |
14: 5,943,068 (GRCm38) |
I161T |
probably damaging |
Het |
Gzmg |
T |
A |
14: 56,395,134 (GRCm39) |
|
probably benign |
Het |
Lrrc69 |
A |
T |
4: 14,795,980 (GRCm39) |
N22K |
possibly damaging |
Het |
Med13l |
A |
G |
5: 118,859,562 (GRCm39) |
R250G |
probably benign |
Het |
Mideas |
C |
T |
12: 84,203,245 (GRCm39) |
G886S |
probably benign |
Het |
Mxi1 |
T |
C |
19: 53,358,062 (GRCm39) |
L73P |
probably damaging |
Het |
Myo9b |
G |
A |
8: 71,786,981 (GRCm39) |
R721Q |
probably benign |
Het |
Napb |
T |
C |
2: 148,544,977 (GRCm39) |
|
probably null |
Het |
Nsun2 |
A |
G |
13: 69,760,456 (GRCm39) |
N45D |
probably damaging |
Het |
Or10ag2 |
T |
C |
2: 87,248,514 (GRCm39) |
F39L |
probably benign |
Het |
Oxct1 |
A |
G |
15: 4,076,999 (GRCm39) |
M111V |
probably benign |
Het |
Pcnx4 |
A |
G |
12: 72,620,493 (GRCm39) |
D771G |
probably damaging |
Het |
Serpina6 |
T |
C |
12: 103,620,668 (GRCm39) |
D27G |
probably benign |
Het |
Tecpr1 |
A |
G |
5: 144,146,797 (GRCm39) |
F523S |
probably benign |
Het |
Zan |
A |
G |
5: 137,418,281 (GRCm39) |
I2939T |
unknown |
Het |
Zfc3h1 |
A |
G |
10: 115,256,595 (GRCm39) |
T1522A |
probably benign |
Het |
|
Other mutations in Cog3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02019:Cog3
|
APN |
14 |
75,968,044 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL02637:Cog3
|
APN |
14 |
75,959,636 (GRCm39) |
splice site |
probably benign |
|
IGL02934:Cog3
|
APN |
14 |
75,979,129 (GRCm39) |
missense |
probably damaging |
0.99 |
R0105:Cog3
|
UTSW |
14 |
75,959,580 (GRCm39) |
missense |
probably damaging |
0.99 |
R0105:Cog3
|
UTSW |
14 |
75,959,580 (GRCm39) |
missense |
probably damaging |
0.99 |
R0403:Cog3
|
UTSW |
14 |
75,979,767 (GRCm39) |
splice site |
probably benign |
|
R0972:Cog3
|
UTSW |
14 |
75,954,610 (GRCm39) |
missense |
probably benign |
|
R1735:Cog3
|
UTSW |
14 |
75,966,761 (GRCm39) |
nonsense |
probably null |
|
R1813:Cog3
|
UTSW |
14 |
75,979,784 (GRCm39) |
missense |
probably benign |
0.03 |
R1896:Cog3
|
UTSW |
14 |
75,979,784 (GRCm39) |
missense |
probably benign |
0.03 |
R2517:Cog3
|
UTSW |
14 |
75,979,182 (GRCm39) |
missense |
probably benign |
0.01 |
R2567:Cog3
|
UTSW |
14 |
75,991,730 (GRCm39) |
missense |
probably benign |
|
R2962:Cog3
|
UTSW |
14 |
75,977,974 (GRCm39) |
critical splice donor site |
probably null |
|
R3103:Cog3
|
UTSW |
14 |
75,984,641 (GRCm39) |
critical splice acceptor site |
probably null |
|
R3689:Cog3
|
UTSW |
14 |
75,991,878 (GRCm39) |
start codon destroyed |
probably null |
|
R3927:Cog3
|
UTSW |
14 |
75,980,998 (GRCm39) |
splice site |
probably benign |
|
R4581:Cog3
|
UTSW |
14 |
75,970,391 (GRCm39) |
missense |
probably benign |
0.04 |
R4932:Cog3
|
UTSW |
14 |
75,970,394 (GRCm39) |
missense |
probably damaging |
0.98 |
R5560:Cog3
|
UTSW |
14 |
75,966,833 (GRCm39) |
missense |
probably damaging |
1.00 |
R5654:Cog3
|
UTSW |
14 |
75,962,239 (GRCm39) |
missense |
probably benign |
0.03 |
R6253:Cog3
|
UTSW |
14 |
75,957,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R6419:Cog3
|
UTSW |
14 |
75,962,178 (GRCm39) |
nonsense |
probably null |
|
R6791:Cog3
|
UTSW |
14 |
75,968,118 (GRCm39) |
missense |
probably damaging |
1.00 |
R6803:Cog3
|
UTSW |
14 |
75,941,479 (GRCm39) |
missense |
probably benign |
0.00 |
R7015:Cog3
|
UTSW |
14 |
75,950,716 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7998:Cog3
|
UTSW |
14 |
75,984,533 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7999:Cog3
|
UTSW |
14 |
75,984,533 (GRCm39) |
missense |
possibly damaging |
0.94 |
R8075:Cog3
|
UTSW |
14 |
75,968,142 (GRCm39) |
missense |
probably damaging |
1.00 |
R8294:Cog3
|
UTSW |
14 |
75,954,619 (GRCm39) |
missense |
probably damaging |
1.00 |
R8329:Cog3
|
UTSW |
14 |
75,978,003 (GRCm39) |
missense |
probably damaging |
0.99 |
R8434:Cog3
|
UTSW |
14 |
75,979,836 (GRCm39) |
missense |
probably damaging |
1.00 |
R9170:Cog3
|
UTSW |
14 |
75,966,802 (GRCm39) |
missense |
probably damaging |
1.00 |
X0017:Cog3
|
UTSW |
14 |
75,979,181 (GRCm39) |
missense |
probably benign |
0.01 |
X0021:Cog3
|
UTSW |
14 |
75,981,033 (GRCm39) |
missense |
possibly damaging |
0.87 |
X0066:Cog3
|
UTSW |
14 |
75,979,181 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- CCAGGATGCAGTTAACACAGACTAG -3'
(R):5'- AAAGCCACGTCTGTTTTGGC -3'
Sequencing Primer
(F):5'- TACTCTGACACGGGGACAC -3'
(R):5'- CACGTCTGTTTTGGCCTCGG -3'
|
Posted On |
2015-10-13 |