Incidental Mutation 'R4714:Grm7'
ID 353435
Institutional Source Beutler Lab
Gene Symbol Grm7
Ensembl Gene ENSMUSG00000056755
Gene Name glutamate receptor, metabotropic 7
Synonyms 6330570A01Rik, Gpr1g, mGlu7a receptor, mGluR7, E130018M02Rik
MMRRC Submission 041956-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4714 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 110622542-111544191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 111057383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 328 (D328N)
Ref Sequence ENSEMBL: ENSMUSP00000133957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071076] [ENSMUST00000172951] [ENSMUST00000174018]
AlphaFold Q68ED2
Predicted Effect possibly damaging
Transcript: ENSMUST00000071076
AA Change: D328N

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000064404
Gene: ENSMUSG00000056755
AA Change: D328N

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 3e-108 PFAM
Pfam:Peripla_BP_6 144 371 3e-11 PFAM
Pfam:NCD3G 519 569 1.2e-13 PFAM
Pfam:7tm_3 602 847 5.1e-59 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000172951
AA Change: D328N

PolyPhen 2 Score 0.516 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000133957
Gene: ENSMUSG00000056755
AA Change: D328N

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 1.7e-103 PFAM
Pfam:Peripla_BP_6 144 487 1e-12 PFAM
Pfam:NCD3G 519 569 1.2e-17 PFAM
Pfam:7tm_3 600 848 1.4e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174018
SMART Domains Protein: ENSMUSP00000134635
Gene: ENSMUSG00000056755

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 176 4.9e-20 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
PHENOTYPE: Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
4930486L24Rik A G 13: 60,992,132 (GRCm39) V298A probably damaging Het
Abca12 A G 1: 71,360,609 (GRCm39) V534A probably benign Het
Abcb4 A G 5: 8,980,906 (GRCm39) probably null Het
Adam30 A T 3: 98,070,170 (GRCm39) S668C probably damaging Het
Ap1g1 T A 8: 110,556,252 (GRCm39) V196D probably damaging Het
Atp11b G A 3: 35,888,543 (GRCm39) V738I probably benign Het
Cast C T 13: 74,946,834 (GRCm39) V27I probably damaging Het
Cfap54 A G 10: 92,651,780 (GRCm39) I3090T probably benign Het
Cgn C A 3: 94,686,748 (GRCm39) G185W probably damaging Het
Champ1 T C 8: 13,928,063 (GRCm39) Y74H probably damaging Het
Cpm T C 10: 117,511,890 (GRCm39) I278T probably damaging Het
Dcaf15 T C 8: 84,828,845 (GRCm39) T141A probably benign Het
Dcun1d1 C T 3: 35,949,819 (GRCm39) V244M probably damaging Het
Defb8 A G 8: 19,497,575 (GRCm39) L12P probably damaging Het
Dlg1 A T 16: 31,609,079 (GRCm39) I225F probably damaging Het
Dync2h1 G T 9: 7,118,932 (GRCm39) H2178N possibly damaging Het
Enam A G 5: 88,651,395 (GRCm39) E893G probably damaging Het
Flt4 T A 11: 49,518,034 (GRCm39) L358Q probably damaging Het
Frmpd1 A G 4: 45,284,785 (GRCm39) Q1202R probably benign Het
Ghr T A 15: 3,349,879 (GRCm39) D433V possibly damaging Het
Haus4 T C 14: 54,779,577 (GRCm39) D349G probably benign Het
Helz T C 11: 107,517,542 (GRCm39) probably null Het
Hif3a A G 7: 16,790,196 (GRCm39) L69P probably damaging Het
Ifit1 A G 19: 34,625,563 (GRCm39) E233G probably damaging Het
Kcnc2 T C 10: 112,291,733 (GRCm39) F307S possibly damaging Het
Lrp1b A T 2: 41,000,771 (GRCm39) V2151E possibly damaging Het
Lrp5 T C 19: 3,709,454 (GRCm39) N92S probably damaging Het
Metrnl C T 11: 121,606,839 (GRCm39) A216V probably damaging Het
Msh2 A G 17: 88,026,217 (GRCm39) T732A probably damaging Het
Necab2 T C 8: 120,194,334 (GRCm39) L270P probably damaging Het
Noc3l T C 19: 38,804,157 (GRCm39) K74E probably benign Het
Oas2 A T 5: 120,871,537 (GRCm39) L702Q probably damaging Het
Or1j1 A T 2: 36,703,047 (GRCm39) I19N probably benign Het
Or2n1d A C 17: 38,646,731 (GRCm39) I228L possibly damaging Het
Or4k1 A G 14: 50,377,436 (GRCm39) I220T possibly damaging Het
Or4k6 C A 14: 50,475,824 (GRCm39) V173L possibly damaging Het
Or6c216 A T 10: 129,678,814 (GRCm39) N32K probably damaging Het
Pax6 A G 2: 105,525,745 (GRCm39) H376R possibly damaging Het
Pnkd C T 1: 74,390,941 (GRCm39) R376C probably damaging Het
Pnpla8 T C 12: 44,342,696 (GRCm39) F484S probably damaging Het
Psme4 T A 11: 30,782,573 (GRCm39) H909Q probably benign Het
Rasip1 CGG CGGG 7: 45,281,820 (GRCm39) probably null Het
Rbm47 A T 5: 66,182,395 (GRCm39) Y413N probably damaging Het
Rnf123 A G 9: 107,929,638 (GRCm39) probably null Het
Ruvbl1 T A 6: 88,461,412 (GRCm39) M259K possibly damaging Het
Sohlh2 A G 3: 55,097,950 (GRCm39) H134R probably benign Het
Sorbs2 A G 8: 46,248,330 (GRCm39) D447G possibly damaging Het
Tank C T 2: 61,480,573 (GRCm39) P370S probably benign Het
Tenm4 A G 7: 96,544,131 (GRCm39) E2049G probably damaging Het
Tnik A G 3: 28,648,226 (GRCm39) H426R possibly damaging Het
Trpm6 C A 19: 18,831,564 (GRCm39) S1476R possibly damaging Het
Trpm7 G A 2: 126,682,703 (GRCm39) Q389* probably null Het
Ttc28 G A 5: 111,433,095 (GRCm39) R2043Q possibly damaging Het
Tymp A G 15: 89,260,510 (GRCm39) S103P probably damaging Het
Usp40 C T 1: 87,894,901 (GRCm39) probably null Het
Vmn1r202 T A 13: 22,685,977 (GRCm39) N147Y probably damaging Het
Vmn2r89 T C 14: 51,689,688 (GRCm39) S64P probably damaging Het
Vps13a A T 19: 16,727,220 (GRCm39) D229E probably benign Het
Vps52 A G 17: 34,180,153 (GRCm39) I354V probably benign Het
Zbtb8os T C 4: 129,235,557 (GRCm39) F90L probably damaging Het
Zfp36l1 T C 12: 80,157,270 (GRCm39) D37G possibly damaging Het
Zfp467 A G 6: 48,404,751 (GRCm39) S109P unknown Het
Zzef1 T A 11: 72,728,038 (GRCm39) C535S probably damaging Het
Other mutations in Grm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Grm7 APN 6 111,223,145 (GRCm39) missense probably benign 0.14
IGL02058:Grm7 APN 6 111,335,278 (GRCm39) missense probably damaging 1.00
IGL02650:Grm7 APN 6 111,335,919 (GRCm39) missense probably damaging 1.00
IGL02892:Grm7 APN 6 111,230,981 (GRCm39) missense probably damaging 0.99
IGL03074:Grm7 APN 6 111,472,604 (GRCm39) splice site probably null
IGL03185:Grm7 APN 6 110,623,183 (GRCm39) missense possibly damaging 0.84
Appropriated UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
Consumed UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
Devoured UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
Ravaged UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
shaky UTSW 6 111,472,752 (GRCm39) nonsense probably null
PIT4651001:Grm7 UTSW 6 110,623,050 (GRCm39) missense probably benign
R0539:Grm7 UTSW 6 111,336,055 (GRCm39) splice site probably benign
R0622:Grm7 UTSW 6 111,335,457 (GRCm39) missense probably damaging 1.00
R1356:Grm7 UTSW 6 111,335,985 (GRCm39) missense probably damaging 1.00
R1762:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1783:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1785:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1816:Grm7 UTSW 6 111,472,752 (GRCm39) nonsense probably null
R1823:Grm7 UTSW 6 111,184,730 (GRCm39) missense probably benign 0.17
R1864:Grm7 UTSW 6 111,057,384 (GRCm39) missense probably benign 0.03
R1894:Grm7 UTSW 6 111,335,568 (GRCm39) missense probably benign
R1987:Grm7 UTSW 6 110,891,472 (GRCm39) missense probably damaging 1.00
R1993:Grm7 UTSW 6 111,184,769 (GRCm39) missense probably benign 0.13
R2138:Grm7 UTSW 6 110,623,098 (GRCm39) missense probably damaging 1.00
R2214:Grm7 UTSW 6 111,335,958 (GRCm39) missense probably damaging 1.00
R2289:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2296:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2339:Grm7 UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
R2847:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2849:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2879:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2884:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2921:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R2923:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R3014:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3015:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3703:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3713:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3963:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4009:Grm7 UTSW 6 111,472,683 (GRCm39) missense probably damaging 1.00
R4091:Grm7 UTSW 6 110,891,301 (GRCm39) missense probably damaging 1.00
R4131:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4132:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4161:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 0.99
R4329:Grm7 UTSW 6 110,891,325 (GRCm39) missense probably damaging 1.00
R4357:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4359:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 111,223,335 (GRCm39) missense probably benign 0.05
R4379:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4380:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4514:Grm7 UTSW 6 111,335,265 (GRCm39) missense possibly damaging 0.81
R4518:Grm7 UTSW 6 110,891,507 (GRCm39) splice site probably null
R4647:Grm7 UTSW 6 110,891,344 (GRCm39) nonsense probably null
R4775:Grm7 UTSW 6 110,891,332 (GRCm39) missense probably damaging 1.00
R4957:Grm7 UTSW 6 111,335,824 (GRCm39) missense probably damaging 1.00
R5056:Grm7 UTSW 6 111,057,404 (GRCm39) missense probably damaging 0.99
R5062:Grm7 UTSW 6 110,623,097 (GRCm39) missense probably damaging 1.00
R5256:Grm7 UTSW 6 111,335,182 (GRCm39) missense probably benign 0.01
R5431:Grm7 UTSW 6 111,335,387 (GRCm39) missense probably benign
R6026:Grm7 UTSW 6 111,478,500 (GRCm39) nonsense probably null
R6174:Grm7 UTSW 6 111,223,258 (GRCm39) missense probably benign
R6305:Grm7 UTSW 6 111,335,626 (GRCm39) missense probably damaging 1.00
R6318:Grm7 UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
R6440:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 1.00
R6519:Grm7 UTSW 6 111,184,713 (GRCm39) missense probably benign 0.00
R6531:Grm7 UTSW 6 111,335,386 (GRCm39) missense probably benign 0.29
R6888:Grm7 UTSW 6 111,335,314 (GRCm39) missense possibly damaging 0.79
R6949:Grm7 UTSW 6 111,472,690 (GRCm39) missense probably damaging 1.00
R6949:Grm7 UTSW 6 110,623,265 (GRCm39) missense probably benign 0.03
R6989:Grm7 UTSW 6 111,184,766 (GRCm39) missense probably damaging 1.00
R7076:Grm7 UTSW 6 111,335,113 (GRCm39) missense probably benign 0.04
R7203:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7208:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7217:Grm7 UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
R7257:Grm7 UTSW 6 110,623,079 (GRCm39) missense probably damaging 1.00
R7297:Grm7 UTSW 6 110,622,974 (GRCm39) missense probably benign 0.16
R7470:Grm7 UTSW 6 111,478,476 (GRCm39) missense
R7567:Grm7 UTSW 6 111,335,722 (GRCm39) missense probably damaging 0.96
R7806:Grm7 UTSW 6 111,223,314 (GRCm39) nonsense probably null
R8018:Grm7 UTSW 6 111,184,737 (GRCm39) missense probably benign 0.01
R8076:Grm7 UTSW 6 111,543,000 (GRCm39) missense probably damaging 1.00
R8409:Grm7 UTSW 6 110,891,297 (GRCm39) missense probably benign 0.02
R8420:Grm7 UTSW 6 111,057,315 (GRCm39) missense probably benign
R8523:Grm7 UTSW 6 111,223,280 (GRCm39) missense possibly damaging 0.76
R8816:Grm7 UTSW 6 111,230,966 (GRCm39) missense possibly damaging 0.46
R8958:Grm7 UTSW 6 111,472,783 (GRCm39) missense probably damaging 0.96
R9135:Grm7 UTSW 6 111,472,729 (GRCm39) missense probably benign 0.39
R9207:Grm7 UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
R9210:Grm7 UTSW 6 110,622,869 (GRCm39) missense probably benign 0.01
R9438:Grm7 UTSW 6 111,231,077 (GRCm39) missense possibly damaging 0.94
R9448:Grm7 UTSW 6 111,335,193 (GRCm39) missense probably benign 0.01
Z1176:Grm7 UTSW 6 111,335,451 (GRCm39) missense probably damaging 1.00
Z1176:Grm7 UTSW 6 111,335,110 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGCTTGCACATCTCTTTACATATGC -3'
(R):5'- AGGTGTGCAGCTTCATTTGC -3'

Sequencing Primer
(F):5'- GCACATCTCTTTACATATGCAAGATC -3'
(R):5'- ATCGCCCTACTCTGGAAAAC -3'
Posted On 2015-10-21