Incidental Mutation 'R4715:Map4k4'
ID |
353913 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Map4k4
|
Ensembl Gene |
ENSMUSG00000026074 |
Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
Synonyms |
9430080K19Rik, Nik |
MMRRC Submission |
041982-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R4715 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
1 |
Chromosomal Location |
39940073-40065470 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 40058724 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Isoleucine
at position 1040
(V1040I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126961
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195860]
[ENSMUST00000195636]
[ENSMUST00000195259]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000163854
AA Change: V1040I
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000126961 Gene: ENSMUSG00000026074 AA Change: V1040I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000168431
AA Change: V990I
|
SMART Domains |
Protein: ENSMUSP00000129796 Gene: ENSMUSG00000026074 AA Change: V990I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191657
|
Predicted Effect |
unknown
Transcript: ENSMUST00000192509
AA Change: V986I
|
SMART Domains |
Protein: ENSMUSP00000141665 Gene: ENSMUSG00000026074 AA Change: V986I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192884
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000193682
AA Change: V973I
PolyPhen 2
Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000141862 Gene: ENSMUSG00000026074 AA Change: V973I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000195860
AA Change: V1040I
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000141400 Gene: ENSMUSG00000026074 AA Change: V1040I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000195636
AA Change: V1024I
|
SMART Domains |
Protein: ENSMUSP00000141613 Gene: ENSMUSG00000026074 AA Change: V1024I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000195259
AA Change: V960I
|
SMART Domains |
Protein: ENSMUSP00000142056 Gene: ENSMUSG00000026074 AA Change: V960I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
Meta Mutation Damage Score |
0.1046 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
Validation Efficiency |
92% (86/93) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 80 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc2 |
A |
C |
19: 43,805,321 (GRCm39) |
E725A |
possibly damaging |
Het |
Abcc5 |
G |
T |
16: 20,217,626 (GRCm39) |
L362I |
probably damaging |
Het |
Ammecr1l |
C |
T |
18: 31,907,706 (GRCm39) |
R179* |
probably null |
Het |
Arap2 |
G |
T |
5: 62,906,437 (GRCm39) |
T194K |
probably benign |
Het |
Atf2 |
C |
A |
2: 73,653,644 (GRCm39) |
V282F |
probably damaging |
Het |
Atosa |
T |
A |
9: 74,920,250 (GRCm39) |
W799R |
probably damaging |
Het |
Atp1a1 |
T |
C |
3: 101,499,122 (GRCm39) |
E159G |
possibly damaging |
Het |
B4galt2 |
T |
C |
4: 117,734,376 (GRCm39) |
S258G |
possibly damaging |
Het |
Bptf |
G |
T |
11: 106,938,007 (GRCm39) |
H2695N |
probably damaging |
Het |
Casq2 |
T |
C |
3: 102,017,560 (GRCm39) |
V80A |
probably benign |
Het |
Cdc42ep3 |
G |
A |
17: 79,642,887 (GRCm39) |
A11V |
probably benign |
Het |
Cdh4 |
A |
T |
2: 179,422,260 (GRCm39) |
H128L |
probably benign |
Het |
Cdk5rap1 |
C |
A |
2: 154,203,755 (GRCm39) |
*191L |
probably null |
Het |
Cfdp1 |
G |
A |
8: 112,557,523 (GRCm39) |
T206I |
probably benign |
Het |
Cgn |
C |
A |
3: 94,686,748 (GRCm39) |
G185W |
probably damaging |
Het |
Clpx |
A |
C |
9: 65,219,396 (GRCm39) |
R231S |
possibly damaging |
Het |
Copg1 |
T |
A |
6: 87,889,268 (GRCm39) |
L870* |
probably null |
Het |
Cyp4a10 |
A |
T |
4: 115,382,535 (GRCm39) |
D275V |
probably benign |
Het |
Dip2a |
T |
C |
10: 76,132,240 (GRCm39) |
T504A |
probably benign |
Het |
Dmxl2 |
A |
C |
9: 54,353,689 (GRCm39) |
|
probably null |
Het |
Dnaaf5 |
A |
T |
5: 139,163,755 (GRCm39) |
I671F |
probably damaging |
Het |
Dnah14 |
A |
G |
1: 181,584,788 (GRCm39) |
D3173G |
probably damaging |
Het |
Dock2 |
T |
C |
11: 34,244,118 (GRCm39) |
Y1074C |
probably damaging |
Het |
Dthd1 |
A |
C |
5: 63,045,530 (GRCm39) |
M765L |
probably benign |
Het |
E2f3 |
A |
C |
13: 30,095,258 (GRCm39) |
C220W |
probably damaging |
Het |
Elf3 |
C |
T |
1: 135,185,490 (GRCm39) |
S8N |
probably damaging |
Het |
F2rl1 |
A |
T |
13: 95,649,775 (GRCm39) |
V369E |
probably damaging |
Het |
Fpr-rs7 |
C |
T |
17: 20,333,690 (GRCm39) |
G267R |
probably benign |
Het |
Ggact |
A |
T |
14: 123,129,047 (GRCm39) |
L56Q |
possibly damaging |
Het |
Gm5546 |
T |
C |
3: 104,273,824 (GRCm39) |
|
noncoding transcript |
Het |
Gm8267 |
A |
G |
14: 44,955,292 (GRCm39) |
V243A |
probably benign |
Het |
Gtf2h1 |
A |
G |
7: 46,464,836 (GRCm39) |
T424A |
possibly damaging |
Het |
Gucy1b2 |
A |
G |
14: 62,660,466 (GRCm39) |
V140A |
possibly damaging |
Het |
Htatip2 |
T |
C |
7: 49,420,592 (GRCm39) |
L146P |
probably damaging |
Het |
Htr1b |
T |
C |
9: 81,513,563 (GRCm39) |
D348G |
possibly damaging |
Het |
Ifi205 |
T |
C |
1: 173,855,887 (GRCm39) |
I48V |
possibly damaging |
Het |
Igkv18-36 |
C |
T |
6: 69,969,575 (GRCm39) |
R72K |
probably damaging |
Het |
Kcnk7 |
T |
C |
19: 5,756,281 (GRCm39) |
L169P |
probably damaging |
Het |
Klf17 |
T |
C |
4: 117,617,733 (GRCm39) |
D208G |
probably benign |
Het |
Ltn1 |
A |
G |
16: 87,215,382 (GRCm39) |
F418L |
probably damaging |
Het |
Mark1 |
A |
G |
1: 184,644,329 (GRCm39) |
V445A |
probably benign |
Het |
Med11 |
T |
C |
11: 70,344,022 (GRCm39) |
I114T |
probably benign |
Het |
Moxd2 |
A |
G |
6: 40,864,181 (GRCm39) |
V83A |
probably damaging |
Het |
Mrpl33 |
A |
G |
5: 31,773,702 (GRCm39) |
|
probably benign |
Het |
Mrps27 |
A |
G |
13: 99,551,323 (GRCm39) |
|
probably null |
Het |
Nop58 |
T |
C |
1: 59,735,185 (GRCm39) |
V75A |
probably benign |
Het |
Or13p5 |
T |
C |
4: 118,591,852 (GRCm39) |
L42P |
probably damaging |
Het |
Or2n1d |
A |
C |
17: 38,646,731 (GRCm39) |
I228L |
possibly damaging |
Het |
Or2t46 |
A |
G |
11: 58,472,255 (GRCm39) |
D195G |
probably damaging |
Het |
Or4k42 |
A |
C |
2: 111,320,089 (GRCm39) |
M138R |
probably benign |
Het |
Or7g19 |
A |
G |
9: 18,856,742 (GRCm39) |
H266R |
probably benign |
Het |
Or7g26 |
C |
A |
9: 19,230,443 (GRCm39) |
F210L |
probably benign |
Het |
Pdzd2 |
G |
T |
15: 12,419,602 (GRCm39) |
N263K |
possibly damaging |
Het |
Podnl1 |
C |
A |
8: 84,852,690 (GRCm39) |
|
probably benign |
Het |
Prkd3 |
G |
T |
17: 79,259,366 (GRCm39) |
H864N |
possibly damaging |
Het |
Ptprd |
T |
C |
4: 76,025,570 (GRCm39) |
T543A |
probably benign |
Het |
Pum2 |
T |
A |
12: 8,797,272 (GRCm39) |
I788N |
probably damaging |
Het |
Ralgapa1 |
T |
A |
12: 55,740,243 (GRCm39) |
N1328I |
probably damaging |
Het |
Rhoc |
T |
C |
3: 104,701,355 (GRCm39) |
L193P |
probably damaging |
Het |
Rif1 |
T |
C |
2: 51,963,151 (GRCm39) |
|
probably benign |
Het |
Rspo2 |
A |
T |
15: 42,939,300 (GRCm39) |
C163* |
probably null |
Het |
Sco1 |
A |
G |
11: 66,947,425 (GRCm39) |
Y204C |
probably damaging |
Het |
Shc2 |
T |
C |
10: 79,458,213 (GRCm39) |
K490R |
probably benign |
Het |
Siglec1 |
T |
C |
2: 130,916,356 (GRCm39) |
D1198G |
probably damaging |
Het |
Slc25a18 |
T |
C |
6: 120,763,051 (GRCm39) |
V31A |
probably damaging |
Het |
Smpd5 |
A |
T |
15: 76,179,893 (GRCm39) |
I112L |
probably benign |
Het |
Synpr |
CT |
C |
14: 13,285,198 (GRCm38) |
|
probably null |
Het |
Tdrd9 |
T |
G |
12: 112,008,123 (GRCm39) |
S988A |
probably benign |
Het |
Tiam2 |
T |
A |
17: 3,504,443 (GRCm39) |
F982I |
probably damaging |
Het |
Tmc3 |
G |
A |
7: 83,271,604 (GRCm39) |
V919I |
probably benign |
Het |
Tmed2b |
A |
T |
9: 33,639,784 (GRCm39) |
|
noncoding transcript |
Het |
Tmem200c |
A |
T |
17: 69,147,465 (GRCm39) |
D16V |
probably damaging |
Het |
Tmem37 |
A |
T |
1: 119,995,935 (GRCm39) |
D47E |
probably damaging |
Het |
Top3a |
T |
A |
11: 60,633,823 (GRCm39) |
R733* |
probably null |
Het |
Treh |
T |
C |
9: 44,594,615 (GRCm39) |
V8A |
probably benign |
Het |
Trim17 |
A |
C |
11: 58,859,276 (GRCm39) |
|
probably benign |
Het |
Ubash3b |
T |
C |
9: 40,927,896 (GRCm39) |
K471E |
probably damaging |
Het |
Usp8 |
T |
A |
2: 126,571,142 (GRCm39) |
L144Q |
possibly damaging |
Het |
Wnk2 |
T |
A |
13: 49,300,708 (GRCm39) |
M1L |
unknown |
Het |
Yju2b |
A |
G |
8: 84,990,503 (GRCm39) |
I43T |
probably damaging |
Het |
|
Other mutations in Map4k4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00328:Map4k4
|
APN |
1 |
40,043,976 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL00417:Map4k4
|
APN |
1 |
40,053,692 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL00516:Map4k4
|
APN |
1 |
40,053,762 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01545:Map4k4
|
APN |
1 |
40,053,389 (GRCm39) |
splice site |
probably benign |
|
IGL02092:Map4k4
|
APN |
1 |
40,063,508 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02092:Map4k4
|
APN |
1 |
40,025,943 (GRCm39) |
missense |
probably benign |
0.12 |
IGL02570:Map4k4
|
APN |
1 |
40,019,739 (GRCm39) |
missense |
probably benign |
0.06 |
IGL02626:Map4k4
|
APN |
1 |
40,053,257 (GRCm39) |
splice site |
probably benign |
|
IGL02993:Map4k4
|
APN |
1 |
40,053,348 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03178:Map4k4
|
APN |
1 |
40,025,853 (GRCm39) |
missense |
possibly damaging |
0.63 |
tank
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02835:Map4k4
|
UTSW |
1 |
40,049,760 (GRCm39) |
missense |
probably damaging |
0.99 |
R0496:Map4k4
|
UTSW |
1 |
40,045,982 (GRCm39) |
missense |
probably damaging |
0.99 |
R0498:Map4k4
|
UTSW |
1 |
40,029,338 (GRCm39) |
missense |
probably benign |
0.22 |
R0588:Map4k4
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
R0674:Map4k4
|
UTSW |
1 |
40,042,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R1205:Map4k4
|
UTSW |
1 |
40,043,004 (GRCm39) |
missense |
probably damaging |
1.00 |
R1349:Map4k4
|
UTSW |
1 |
40,060,319 (GRCm39) |
missense |
probably damaging |
1.00 |
R1615:Map4k4
|
UTSW |
1 |
40,045,990 (GRCm39) |
splice site |
probably benign |
|
R1763:Map4k4
|
UTSW |
1 |
40,039,917 (GRCm39) |
splice site |
probably benign |
|
R1800:Map4k4
|
UTSW |
1 |
40,062,620 (GRCm39) |
missense |
probably damaging |
1.00 |
R1893:Map4k4
|
UTSW |
1 |
40,040,717 (GRCm39) |
missense |
probably benign |
0.08 |
R2411:Map4k4
|
UTSW |
1 |
40,046,656 (GRCm39) |
missense |
probably damaging |
0.96 |
R2851:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
R2852:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
R2987:Map4k4
|
UTSW |
1 |
40,025,925 (GRCm39) |
missense |
probably damaging |
1.00 |
R3087:Map4k4
|
UTSW |
1 |
40,060,242 (GRCm39) |
critical splice acceptor site |
probably null |
|
R3688:Map4k4
|
UTSW |
1 |
40,024,331 (GRCm39) |
splice site |
probably null |
|
R4075:Map4k4
|
UTSW |
1 |
40,062,622 (GRCm39) |
missense |
probably damaging |
0.96 |
R4304:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
R4564:Map4k4
|
UTSW |
1 |
40,028,135 (GRCm39) |
missense |
probably damaging |
1.00 |
R4569:Map4k4
|
UTSW |
1 |
40,039,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R4613:Map4k4
|
UTSW |
1 |
40,056,351 (GRCm39) |
missense |
probably benign |
0.05 |
R4788:Map4k4
|
UTSW |
1 |
40,043,076 (GRCm39) |
missense |
probably benign |
0.01 |
R4926:Map4k4
|
UTSW |
1 |
40,056,385 (GRCm39) |
missense |
probably damaging |
1.00 |
R4943:Map4k4
|
UTSW |
1 |
40,058,754 (GRCm39) |
missense |
probably damaging |
0.99 |
R5033:Map4k4
|
UTSW |
1 |
40,046,662 (GRCm39) |
missense |
probably damaging |
0.99 |
R5177:Map4k4
|
UTSW |
1 |
40,025,922 (GRCm39) |
missense |
probably damaging |
1.00 |
R5297:Map4k4
|
UTSW |
1 |
40,001,377 (GRCm39) |
missense |
probably damaging |
1.00 |
R5844:Map4k4
|
UTSW |
1 |
40,039,036 (GRCm39) |
splice site |
probably benign |
|
R5952:Map4k4
|
UTSW |
1 |
40,039,082 (GRCm39) |
unclassified |
probably benign |
|
R6111:Map4k4
|
UTSW |
1 |
40,050,822 (GRCm39) |
missense |
probably benign |
0.00 |
R6125:Map4k4
|
UTSW |
1 |
40,043,125 (GRCm39) |
missense |
possibly damaging |
0.77 |
R6838:Map4k4
|
UTSW |
1 |
40,015,882 (GRCm39) |
missense |
probably damaging |
1.00 |
R6927:Map4k4
|
UTSW |
1 |
40,050,842 (GRCm39) |
missense |
probably benign |
0.00 |
R7008:Map4k4
|
UTSW |
1 |
40,028,131 (GRCm39) |
missense |
probably benign |
0.44 |
R7164:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
R7195:Map4k4
|
UTSW |
1 |
40,058,829 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7352:Map4k4
|
UTSW |
1 |
40,001,387 (GRCm39) |
missense |
unknown |
|
R7589:Map4k4
|
UTSW |
1 |
40,060,251 (GRCm39) |
nonsense |
probably null |
|
R7816:Map4k4
|
UTSW |
1 |
40,053,368 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7869:Map4k4
|
UTSW |
1 |
40,013,204 (GRCm39) |
missense |
unknown |
|
R8013:Map4k4
|
UTSW |
1 |
40,001,372 (GRCm39) |
missense |
unknown |
|
R8145:Map4k4
|
UTSW |
1 |
40,039,694 (GRCm39) |
missense |
|
|
R8154:Map4k4
|
UTSW |
1 |
40,060,302 (GRCm39) |
nonsense |
probably null |
|
R8254:Map4k4
|
UTSW |
1 |
40,045,835 (GRCm39) |
missense |
probably damaging |
0.99 |
R8266:Map4k4
|
UTSW |
1 |
40,050,813 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8375:Map4k4
|
UTSW |
1 |
40,063,801 (GRCm39) |
missense |
possibly damaging |
0.73 |
R8487:Map4k4
|
UTSW |
1 |
40,028,136 (GRCm39) |
missense |
probably damaging |
1.00 |
R8699:Map4k4
|
UTSW |
1 |
40,015,910 (GRCm39) |
missense |
unknown |
|
R8726:Map4k4
|
UTSW |
1 |
40,043,142 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8907:Map4k4
|
UTSW |
1 |
40,058,770 (GRCm39) |
missense |
probably damaging |
0.97 |
R8956:Map4k4
|
UTSW |
1 |
40,039,840 (GRCm39) |
missense |
probably benign |
0.11 |
R8963:Map4k4
|
UTSW |
1 |
40,039,740 (GRCm39) |
missense |
probably damaging |
1.00 |
R9091:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
R9234:Map4k4
|
UTSW |
1 |
40,029,261 (GRCm39) |
missense |
unknown |
|
R9270:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
R9438:Map4k4
|
UTSW |
1 |
40,045,952 (GRCm39) |
missense |
probably damaging |
0.99 |
R9689:Map4k4
|
UTSW |
1 |
40,058,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9771:Map4k4
|
UTSW |
1 |
40,025,877 (GRCm39) |
missense |
unknown |
|
|
Predicted Primers |
PCR Primer
(F):5'- GTGTGTGCCTCTGTTTCTCA -3'
(R):5'- AGTTTCATACAGCCCAGTAACT -3'
Sequencing Primer
(F):5'- TTGATGCACACAGATAGCTTGGC -3'
(R):5'- CTTAAACCTGACTCTAATGGAACTC -3'
|
Posted On |
2015-10-21 |