Incidental Mutation 'R0276:Triobp'
| ID |
35415 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
038498-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0276 (G1)
|
| Quality Score |
223 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 78857876 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 1159
(I1159K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109689]
[ENSMUST00000109690]
[ENSMUST00000140228]
[ENSMUST00000229270]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109689
AA Change: I1159K
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
AA Change: I1159K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109690
AA Change: I1159K
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
AA Change: I1159K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140228
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229270
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.8%
- 10x: 96.2%
- 20x: 93.8%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts13 |
A |
G |
2: 26,865,772 (GRCm39) |
N109S |
possibly damaging |
Het |
| Adcy10 |
T |
A |
1: 165,400,160 (GRCm39) |
M1523K |
possibly damaging |
Het |
| Agtpbp1 |
C |
T |
13: 59,609,845 (GRCm39) |
S1095N |
possibly damaging |
Het |
| Ang2 |
C |
T |
14: 51,432,975 (GRCm39) |
V136I |
probably damaging |
Het |
| Arhgap10 |
A |
T |
8: 78,140,210 (GRCm39) |
M250K |
probably benign |
Het |
| Arhgap33 |
A |
T |
7: 30,222,669 (GRCm39) |
W1088R |
probably benign |
Het |
| Arhgef15 |
T |
C |
11: 68,844,298 (GRCm39) |
|
probably benign |
Het |
| Aspm |
T |
C |
1: 139,406,209 (GRCm39) |
S1699P |
possibly damaging |
Het |
| Atp12a |
C |
A |
14: 56,625,151 (GRCm39) |
D1014E |
probably damaging |
Het |
| Atp1a4 |
T |
A |
1: 172,085,468 (GRCm39) |
K45M |
probably damaging |
Het |
| Atp8a1 |
A |
T |
5: 67,944,016 (GRCm39) |
|
probably benign |
Het |
| Baiap3 |
A |
C |
17: 25,462,661 (GRCm39) |
F1099C |
probably damaging |
Het |
| Bcas3 |
T |
A |
11: 85,361,663 (GRCm39) |
|
probably null |
Het |
| Bms1 |
G |
A |
6: 118,385,095 (GRCm39) |
T371M |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Capn3 |
T |
C |
2: 120,318,546 (GRCm39) |
|
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,923,534 (GRCm39) |
D1105G |
probably damaging |
Het |
| Ccdc33 |
G |
T |
9: 57,965,675 (GRCm39) |
P364Q |
probably damaging |
Het |
| Clstn3 |
A |
G |
6: 124,408,699 (GRCm39) |
|
probably benign |
Het |
| Cntrl |
A |
T |
2: 35,041,744 (GRCm39) |
Y619F |
possibly damaging |
Het |
| Col12a1 |
A |
T |
9: 79,538,023 (GRCm39) |
Y2514* |
probably null |
Het |
| Cpt1b |
T |
C |
15: 89,304,162 (GRCm39) |
H503R |
probably benign |
Het |
| Crb1 |
T |
A |
1: 139,251,073 (GRCm39) |
T293S |
possibly damaging |
Het |
| D130043K22Rik |
C |
T |
13: 25,042,028 (GRCm39) |
T319I |
possibly damaging |
Het |
| Dnaaf10 |
T |
C |
11: 17,179,821 (GRCm39) |
I274T |
probably benign |
Het |
| Dzip1l |
G |
A |
9: 99,543,051 (GRCm39) |
R502Q |
probably benign |
Het |
| Efcab5 |
A |
G |
11: 77,020,702 (GRCm39) |
M673T |
probably damaging |
Het |
| Efcab5 |
G |
A |
11: 77,031,749 (GRCm39) |
R42W |
probably damaging |
Het |
| F2rl3 |
A |
G |
8: 73,489,426 (GRCm39) |
T218A |
probably benign |
Het |
| Fam135a |
C |
T |
1: 24,107,045 (GRCm39) |
R31H |
probably damaging |
Het |
| Fcer2a |
A |
T |
8: 3,739,811 (GRCm39) |
N53K |
possibly damaging |
Het |
| Golgb1 |
A |
C |
16: 36,734,238 (GRCm39) |
K1162Q |
probably damaging |
Het |
| Gpr137b |
A |
T |
13: 13,542,160 (GRCm39) |
|
probably benign |
Het |
| Haspin |
A |
T |
11: 73,027,313 (GRCm39) |
L592Q |
probably damaging |
Het |
| Helq |
A |
G |
5: 100,938,013 (GRCm39) |
F478L |
probably damaging |
Het |
| Iho1 |
A |
T |
9: 108,305,639 (GRCm39) |
M11K |
possibly damaging |
Het |
| Il17rb |
T |
A |
14: 29,726,337 (GRCm39) |
T84S |
probably damaging |
Het |
| Itga4 |
T |
C |
2: 79,151,837 (GRCm39) |
L880P |
probably damaging |
Het |
| Itih5 |
A |
G |
2: 10,190,375 (GRCm39) |
I61V |
possibly damaging |
Het |
| Ivl |
G |
A |
3: 92,478,821 (GRCm39) |
L415F |
unknown |
Het |
| Kif2a |
A |
G |
13: 107,113,158 (GRCm39) |
|
probably benign |
Het |
| Kmt2d |
T |
C |
15: 98,748,192 (GRCm39) |
|
probably benign |
Het |
| Lars2 |
A |
G |
9: 123,267,186 (GRCm39) |
|
probably benign |
Het |
| Lilrb4a |
T |
C |
10: 51,367,677 (GRCm39) |
V73A |
probably benign |
Het |
| Lratd2 |
G |
T |
15: 60,695,523 (GRCm39) |
Y74* |
probably null |
Het |
| Lrrc8a |
A |
G |
2: 30,146,800 (GRCm39) |
D538G |
possibly damaging |
Het |
| Lrrk1 |
G |
A |
7: 65,946,011 (GRCm39) |
|
probably benign |
Het |
| Mc2r |
A |
T |
18: 68,541,203 (GRCm39) |
I30K |
possibly damaging |
Het |
| Mybbp1a |
C |
A |
11: 72,340,933 (GRCm39) |
|
probably null |
Het |
| Napg |
C |
T |
18: 63,120,034 (GRCm39) |
R149C |
probably damaging |
Het |
| Ncam2 |
A |
G |
16: 81,314,517 (GRCm39) |
|
probably benign |
Het |
| Nlk |
T |
C |
11: 78,462,301 (GRCm39) |
I509V |
probably benign |
Het |
| Nlrp2 |
A |
T |
7: 5,331,108 (GRCm39) |
N429K |
probably benign |
Het |
| Nlrp9b |
A |
G |
7: 19,762,423 (GRCm39) |
T247A |
probably benign |
Het |
| Noxo1 |
A |
T |
17: 24,919,136 (GRCm39) |
|
probably null |
Het |
| Or1n1b |
A |
T |
2: 36,780,035 (GRCm39) |
M275K |
probably benign |
Het |
| Or2ag2b |
A |
T |
7: 106,417,904 (GRCm39) |
I205L |
probably benign |
Het |
| Or3a10 |
A |
G |
11: 73,935,944 (GRCm39) |
I52T |
probably damaging |
Het |
| Or4c107 |
T |
A |
2: 88,789,099 (GRCm39) |
C96* |
probably null |
Het |
| Or4m1 |
C |
A |
14: 50,557,636 (GRCm39) |
A219S |
probably benign |
Het |
| Oxr1 |
T |
C |
15: 41,683,458 (GRCm39) |
S294P |
probably damaging |
Het |
| Pfpl |
A |
G |
19: 12,406,601 (GRCm39) |
Y284C |
probably damaging |
Het |
| Pi16 |
A |
T |
17: 29,545,917 (GRCm39) |
T232S |
probably benign |
Het |
| Plcxd2 |
A |
T |
16: 45,830,070 (GRCm39) |
N50K |
probably benign |
Het |
| Plekhn1 |
T |
A |
4: 156,312,703 (GRCm39) |
N52Y |
probably damaging |
Het |
| Prl2c5 |
T |
C |
13: 13,357,634 (GRCm39) |
|
probably benign |
Het |
| Prrc2b |
G |
A |
2: 32,109,666 (GRCm39) |
V1080I |
probably damaging |
Het |
| Psg28 |
A |
T |
7: 18,164,321 (GRCm39) |
N130K |
probably benign |
Het |
| Psme4 |
C |
A |
11: 30,761,980 (GRCm39) |
T440K |
probably damaging |
Het |
| Ptcd2 |
T |
C |
13: 99,458,104 (GRCm39) |
K296E |
probably benign |
Het |
| Ptprq |
T |
C |
10: 107,378,596 (GRCm39) |
|
probably null |
Het |
| Rab5b |
A |
C |
10: 128,522,615 (GRCm39) |
|
probably null |
Het |
| Rft1 |
T |
A |
14: 30,412,540 (GRCm39) |
S534T |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Rsu1 |
A |
T |
2: 13,174,946 (GRCm39) |
|
probably benign |
Het |
| Senp6 |
A |
G |
9: 80,044,029 (GRCm39) |
M887V |
probably benign |
Het |
| Sgcz |
T |
A |
8: 38,420,073 (GRCm39) |
M60L |
probably benign |
Het |
| Siglec1 |
G |
A |
2: 130,925,861 (GRCm39) |
Q282* |
probably null |
Het |
| Sipa1l2 |
T |
C |
8: 126,148,679 (GRCm39) |
T1655A |
probably damaging |
Het |
| Slc28a2b |
T |
A |
2: 122,352,409 (GRCm39) |
S389T |
probably damaging |
Het |
| Slc43a3 |
G |
A |
2: 84,768,007 (GRCm39) |
|
probably benign |
Het |
| Snx29 |
T |
C |
16: 11,556,237 (GRCm39) |
V756A |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,045,460 (GRCm39) |
H1539Q |
probably damaging |
Het |
| Stk3 |
A |
C |
15: 35,099,615 (GRCm39) |
S104A |
probably damaging |
Het |
| Stk38 |
C |
A |
17: 29,211,390 (GRCm39) |
|
probably null |
Het |
| Stx6 |
T |
C |
1: 155,049,909 (GRCm39) |
|
probably benign |
Het |
| Thbs4 |
G |
A |
13: 92,912,040 (GRCm39) |
T230I |
probably benign |
Het |
| Thrsp |
A |
G |
7: 97,066,709 (GRCm39) |
M1T |
probably null |
Het |
| Tmem63b |
A |
T |
17: 45,986,299 (GRCm39) |
|
probably benign |
Het |
| Top2a |
A |
G |
11: 98,900,733 (GRCm39) |
|
probably benign |
Het |
| Tpd52l2 |
T |
C |
2: 181,143,852 (GRCm39) |
|
probably null |
Het |
| Trak1 |
A |
G |
9: 121,283,404 (GRCm39) |
E390G |
probably damaging |
Het |
| Trappc3 |
T |
A |
4: 126,167,745 (GRCm39) |
D101E |
possibly damaging |
Het |
| Trhr |
A |
G |
15: 44,060,482 (GRCm39) |
M1V |
probably null |
Het |
| Unc45a |
A |
G |
7: 79,976,045 (GRCm39) |
|
probably benign |
Het |
| Usb1 |
A |
G |
8: 96,060,085 (GRCm39) |
D12G |
probably damaging |
Het |
| Ushbp1 |
C |
T |
8: 71,847,293 (GRCm39) |
C113Y |
possibly damaging |
Het |
| Vim |
A |
G |
2: 13,579,670 (GRCm39) |
K143R |
probably benign |
Het |
| Vmn2r75 |
T |
C |
7: 85,797,515 (GRCm39) |
K766R |
probably benign |
Het |
| Xpo5 |
T |
G |
17: 46,552,433 (GRCm39) |
C1089G |
probably damaging |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1510:Triobp
|
UTSW |
15 |
78,887,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2051:Triobp
|
UTSW |
15 |
78,888,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2351:Triobp
|
UTSW |
15 |
78,888,780 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Triobp
|
UTSW |
15 |
78,878,591 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9514:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCAGGACCTCAAAGTCCTAACAGAC -3'
(R):5'- GCTCTCTAGGTGATCTATCTGCTCCAG -3'
Sequencing Primer
(F):5'- CAGACACCCAGAGAAGAGCTG -3'
(R):5'- TCAGCACTACGCTGATGTG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation