Incidental Mutation 'R4689:Adgre4'
ID |
354803 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgre4
|
Ensembl Gene |
ENSMUSG00000032915 |
Gene Name |
adhesion G protein-coupled receptor E4 |
Synonyms |
EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e |
MMRRC Submission |
041940-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4689 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
56056984-56160662 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 56109096 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 368
(F368L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000025004
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025004]
|
AlphaFold |
Q91ZE5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000025004
AA Change: F368L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000025004 Gene: ENSMUSG00000032915 AA Change: F368L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
36 |
N/A |
INTRINSIC |
Blast:EGF_like
|
38 |
76 |
2e-10 |
BLAST |
Pfam:EGF_CA
|
77 |
117 |
3.6e-9 |
PFAM |
GPS
|
288 |
338 |
4.03e-12 |
SMART |
Pfam:7tm_2
|
343 |
588 |
5.7e-57 |
PFAM |
low complexity region
|
613 |
628 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
Validation Efficiency |
97% (72/74) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 67 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc10 |
C |
A |
17: 46,634,996 (GRCm39) |
V336L |
probably benign |
Het |
Acbd4 |
T |
C |
11: 102,996,194 (GRCm39) |
L165P |
possibly damaging |
Het |
Adam10 |
T |
C |
9: 70,673,236 (GRCm39) |
S456P |
possibly damaging |
Het |
Ahcyl1 |
G |
T |
3: 107,572,834 (GRCm39) |
Y528* |
probably null |
Het |
Aldh3b3 |
G |
A |
19: 4,014,516 (GRCm39) |
V84M |
probably damaging |
Het |
Cdca8 |
C |
T |
4: 124,824,896 (GRCm39) |
G78E |
probably damaging |
Het |
Cry2 |
T |
C |
2: 92,254,899 (GRCm39) |
D152G |
probably benign |
Het |
Cyp2c67 |
T |
C |
19: 39,627,032 (GRCm39) |
Y266C |
probably benign |
Het |
Dkk4 |
T |
C |
8: 23,115,336 (GRCm39) |
F62S |
probably benign |
Het |
Dnah12 |
G |
A |
14: 26,427,994 (GRCm39) |
V207I |
probably benign |
Het |
Dthd1 |
T |
C |
5: 63,000,255 (GRCm39) |
C526R |
probably damaging |
Het |
Dubr |
A |
T |
16: 50,552,866 (GRCm39) |
|
noncoding transcript |
Het |
F5 |
T |
C |
1: 163,979,542 (GRCm39) |
|
probably benign |
Het |
Flcn |
A |
C |
11: 59,691,870 (GRCm39) |
W260G |
possibly damaging |
Het |
Fmnl1 |
G |
A |
11: 103,084,562 (GRCm39) |
|
probably null |
Het |
Frem2 |
A |
T |
3: 53,455,056 (GRCm39) |
D2173E |
probably benign |
Het |
Fstl4 |
C |
T |
11: 52,959,477 (GRCm39) |
Q173* |
probably null |
Het |
Gfra3 |
G |
A |
18: 34,823,640 (GRCm39) |
P381S |
unknown |
Het |
Gm28308 |
C |
A |
6: 52,190,291 (GRCm39) |
|
probably benign |
Het |
Gm8730 |
T |
A |
8: 103,592,379 (GRCm39) |
|
noncoding transcript |
Het |
Gzmd |
T |
C |
14: 56,368,683 (GRCm39) |
|
probably null |
Het |
Hexb |
A |
G |
13: 97,317,600 (GRCm39) |
Y366H |
probably damaging |
Het |
Hydin |
A |
T |
8: 111,322,046 (GRCm39) |
H4566L |
probably benign |
Het |
Ifi213 |
G |
A |
1: 173,417,986 (GRCm39) |
T142I |
possibly damaging |
Het |
Kif13b |
T |
A |
14: 65,010,513 (GRCm39) |
C1271S |
probably damaging |
Het |
Krtap9-5 |
G |
T |
11: 99,840,286 (GRCm39) |
C329F |
unknown |
Het |
Larp1 |
G |
T |
11: 57,932,439 (GRCm39) |
G207W |
probably damaging |
Het |
Lfng |
A |
G |
5: 140,600,194 (GRCm39) |
D368G |
probably damaging |
Het |
Mbd5 |
G |
A |
2: 49,148,291 (GRCm39) |
V834I |
possibly damaging |
Het |
Mterf1b |
T |
A |
5: 4,247,263 (GRCm39) |
Y301* |
probably null |
Het |
Myh7b |
T |
C |
2: 155,472,434 (GRCm39) |
I1305T |
possibly damaging |
Het |
Myo16 |
T |
C |
8: 10,488,890 (GRCm39) |
V687A |
probably damaging |
Het |
Naip2 |
A |
T |
13: 100,285,320 (GRCm39) |
I1292N |
probably damaging |
Het |
Nmral1 |
A |
G |
16: 4,532,422 (GRCm39) |
F130L |
probably damaging |
Het |
Nos1 |
A |
G |
5: 118,017,450 (GRCm39) |
N271S |
probably benign |
Het |
Nrap |
A |
G |
19: 56,374,458 (GRCm39) |
S23P |
probably damaging |
Het |
Or12d16-ps1 |
A |
T |
17: 37,705,662 (GRCm39) |
N77I |
probably damaging |
Het |
Or2aj4 |
A |
T |
16: 19,385,263 (GRCm39) |
Y123* |
probably null |
Het |
Or4e2 |
T |
C |
14: 52,688,671 (GRCm39) |
I267T |
probably benign |
Het |
Or6c210 |
T |
C |
10: 129,496,185 (GRCm39) |
V170A |
probably benign |
Het |
Pkdcc |
C |
G |
17: 83,523,290 (GRCm39) |
C132W |
probably damaging |
Het |
Plekhg6 |
G |
A |
6: 125,350,144 (GRCm39) |
L265F |
probably benign |
Het |
Prkaa1 |
A |
G |
15: 5,208,177 (GRCm39) |
T473A |
probably benign |
Het |
Prpf3 |
G |
A |
3: 95,743,801 (GRCm39) |
Q451* |
probably null |
Het |
Psma5-ps |
T |
A |
10: 85,150,065 (GRCm39) |
|
noncoding transcript |
Het |
Ptprh |
T |
A |
7: 4,600,996 (GRCm39) |
D127V |
possibly damaging |
Het |
Rab36 |
T |
C |
10: 74,877,765 (GRCm39) |
|
probably null |
Het |
Rasa1 |
A |
T |
13: 85,386,282 (GRCm39) |
Y427* |
probably null |
Het |
Rgs11 |
T |
C |
17: 26,423,521 (GRCm39) |
|
probably null |
Het |
Serpinb13 |
C |
T |
1: 106,910,574 (GRCm39) |
S66L |
probably damaging |
Het |
Shank2 |
G |
A |
7: 143,974,342 (GRCm39) |
V1087I |
probably benign |
Het |
Slc39a10 |
A |
C |
1: 46,875,173 (GRCm39) |
M43R |
probably benign |
Het |
Slc40a1 |
T |
A |
1: 45,951,473 (GRCm39) |
Q228L |
probably benign |
Het |
Slc45a1 |
A |
T |
4: 150,722,996 (GRCm39) |
L296Q |
probably benign |
Het |
Stambpl1 |
A |
G |
19: 34,213,691 (GRCm39) |
T307A |
probably benign |
Het |
Stt3a |
T |
C |
9: 36,644,225 (GRCm39) |
T705A |
possibly damaging |
Het |
Tec |
G |
A |
5: 72,980,980 (GRCm39) |
|
probably benign |
Het |
Trp63 |
A |
T |
16: 25,684,012 (GRCm39) |
T300S |
possibly damaging |
Het |
Vmn1r235 |
A |
G |
17: 21,482,623 (GRCm39) |
H316R |
probably benign |
Het |
Vmn2r1 |
A |
G |
3: 64,012,074 (GRCm39) |
H645R |
possibly damaging |
Het |
Wdfy4 |
A |
G |
14: 32,831,505 (GRCm39) |
I907T |
possibly damaging |
Het |
Zcchc10 |
A |
G |
11: 53,218,151 (GRCm39) |
T33A |
probably benign |
Het |
Zfp318 |
T |
A |
17: 46,710,560 (GRCm39) |
V761D |
probably damaging |
Het |
Zfp358 |
T |
C |
8: 3,546,146 (GRCm39) |
|
probably null |
Het |
Zfp661 |
G |
A |
2: 127,419,468 (GRCm39) |
P224L |
probably damaging |
Het |
Zfp937 |
T |
C |
2: 150,078,706 (GRCm39) |
M33T |
probably damaging |
Het |
Zfp955a |
T |
C |
17: 33,461,040 (GRCm39) |
H364R |
probably damaging |
Het |
|
Other mutations in Adgre4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00089:Adgre4
|
APN |
17 |
56,098,915 (GRCm39) |
splice site |
probably benign |
|
IGL00228:Adgre4
|
APN |
17 |
56,109,135 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00572:Adgre4
|
APN |
17 |
56,127,648 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01404:Adgre4
|
APN |
17 |
56,104,639 (GRCm39) |
missense |
possibly damaging |
0.63 |
IGL01420:Adgre4
|
APN |
17 |
56,106,785 (GRCm39) |
splice site |
probably benign |
|
IGL01501:Adgre4
|
APN |
17 |
56,109,002 (GRCm39) |
splice site |
probably benign |
|
IGL01510:Adgre4
|
APN |
17 |
56,125,760 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01554:Adgre4
|
APN |
17 |
56,124,090 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01607:Adgre4
|
APN |
17 |
56,101,748 (GRCm39) |
splice site |
probably benign |
|
IGL01767:Adgre4
|
APN |
17 |
56,104,740 (GRCm39) |
missense |
probably benign |
0.19 |
IGL02253:Adgre4
|
APN |
17 |
56,067,573 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02358:Adgre4
|
APN |
17 |
56,150,209 (GRCm39) |
missense |
probably benign |
0.15 |
IGL02466:Adgre4
|
APN |
17 |
56,121,188 (GRCm39) |
missense |
probably benign |
0.42 |
IGL03057:Adgre4
|
APN |
17 |
56,106,602 (GRCm39) |
splice site |
probably benign |
|
R0070:Adgre4
|
UTSW |
17 |
56,109,154 (GRCm39) |
missense |
probably damaging |
0.98 |
R0070:Adgre4
|
UTSW |
17 |
56,109,154 (GRCm39) |
missense |
probably damaging |
0.98 |
R0111:Adgre4
|
UTSW |
17 |
56,124,073 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0311:Adgre4
|
UTSW |
17 |
56,109,010 (GRCm39) |
missense |
probably benign |
0.36 |
R0366:Adgre4
|
UTSW |
17 |
56,099,001 (GRCm39) |
nonsense |
probably null |
|
R0415:Adgre4
|
UTSW |
17 |
56,159,288 (GRCm39) |
missense |
probably benign |
0.03 |
R0465:Adgre4
|
UTSW |
17 |
56,092,137 (GRCm39) |
splice site |
probably benign |
|
R0619:Adgre4
|
UTSW |
17 |
56,127,679 (GRCm39) |
missense |
possibly damaging |
0.52 |
R0685:Adgre4
|
UTSW |
17 |
56,099,035 (GRCm39) |
missense |
probably benign |
0.05 |
R0724:Adgre4
|
UTSW |
17 |
56,159,281 (GRCm39) |
missense |
probably benign |
0.00 |
R0835:Adgre4
|
UTSW |
17 |
56,106,637 (GRCm39) |
missense |
probably damaging |
1.00 |
R1330:Adgre4
|
UTSW |
17 |
56,085,814 (GRCm39) |
missense |
probably benign |
0.36 |
R1452:Adgre4
|
UTSW |
17 |
56,091,996 (GRCm39) |
missense |
probably benign |
0.35 |
R1960:Adgre4
|
UTSW |
17 |
56,098,497 (GRCm39) |
missense |
probably benign |
|
R1961:Adgre4
|
UTSW |
17 |
56,098,497 (GRCm39) |
missense |
probably benign |
|
R2046:Adgre4
|
UTSW |
17 |
56,085,847 (GRCm39) |
missense |
possibly damaging |
0.82 |
R2421:Adgre4
|
UTSW |
17 |
56,085,872 (GRCm39) |
missense |
probably benign |
0.10 |
R2570:Adgre4
|
UTSW |
17 |
56,085,878 (GRCm39) |
missense |
possibly damaging |
0.54 |
R3162:Adgre4
|
UTSW |
17 |
56,109,218 (GRCm39) |
splice site |
probably benign |
|
R4222:Adgre4
|
UTSW |
17 |
56,092,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R4526:Adgre4
|
UTSW |
17 |
56,092,016 (GRCm39) |
nonsense |
probably null |
|
R4631:Adgre4
|
UTSW |
17 |
56,121,305 (GRCm39) |
missense |
probably null |
1.00 |
R4701:Adgre4
|
UTSW |
17 |
56,091,971 (GRCm39) |
missense |
probably damaging |
1.00 |
R4792:Adgre4
|
UTSW |
17 |
56,098,491 (GRCm39) |
missense |
probably benign |
0.00 |
R5205:Adgre4
|
UTSW |
17 |
56,101,727 (GRCm39) |
nonsense |
probably null |
|
R5210:Adgre4
|
UTSW |
17 |
56,092,029 (GRCm39) |
missense |
probably damaging |
0.97 |
R5358:Adgre4
|
UTSW |
17 |
56,125,758 (GRCm39) |
missense |
probably benign |
0.00 |
R5873:Adgre4
|
UTSW |
17 |
56,159,282 (GRCm39) |
missense |
probably benign |
0.13 |
R6025:Adgre4
|
UTSW |
17 |
56,099,013 (GRCm39) |
missense |
probably benign |
0.00 |
R6257:Adgre4
|
UTSW |
17 |
56,109,133 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6426:Adgre4
|
UTSW |
17 |
56,109,196 (GRCm39) |
missense |
probably benign |
0.18 |
R6440:Adgre4
|
UTSW |
17 |
56,101,744 (GRCm39) |
critical splice donor site |
probably null |
|
R6484:Adgre4
|
UTSW |
17 |
56,109,036 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6680:Adgre4
|
UTSW |
17 |
56,098,959 (GRCm39) |
missense |
probably benign |
0.09 |
R7086:Adgre4
|
UTSW |
17 |
56,127,649 (GRCm39) |
missense |
probably benign |
0.00 |
R7442:Adgre4
|
UTSW |
17 |
56,159,340 (GRCm39) |
missense |
probably benign |
0.04 |
R7467:Adgre4
|
UTSW |
17 |
56,098,952 (GRCm39) |
missense |
probably benign |
0.00 |
R7875:Adgre4
|
UTSW |
17 |
56,099,016 (GRCm39) |
missense |
probably benign |
0.00 |
R8007:Adgre4
|
UTSW |
17 |
56,121,233 (GRCm39) |
missense |
probably damaging |
0.99 |
R8096:Adgre4
|
UTSW |
17 |
56,127,700 (GRCm39) |
missense |
probably damaging |
1.00 |
R8172:Adgre4
|
UTSW |
17 |
56,104,769 (GRCm39) |
missense |
probably benign |
0.00 |
R8512:Adgre4
|
UTSW |
17 |
56,125,760 (GRCm39) |
critical splice donor site |
probably null |
|
R8972:Adgre4
|
UTSW |
17 |
56,109,189 (GRCm39) |
missense |
probably damaging |
1.00 |
R9018:Adgre4
|
UTSW |
17 |
56,098,993 (GRCm39) |
missense |
probably benign |
0.00 |
R9049:Adgre4
|
UTSW |
17 |
56,092,094 (GRCm39) |
missense |
probably benign |
0.05 |
S24628:Adgre4
|
UTSW |
17 |
56,159,288 (GRCm39) |
missense |
probably benign |
0.03 |
X0010:Adgre4
|
UTSW |
17 |
56,121,308 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Adgre4
|
UTSW |
17 |
56,121,152 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- ATCTGAGGGCCATCATGCTAC -3'
(R):5'- TCATACTTGCTAAGGACATGATAGG -3'
Sequencing Primer
(F):5'- GAGGGCCATCATGCTACATACTTC -3'
(R):5'- TGATGCCTGTGAGGAAGA -3'
|
Posted On |
2015-10-21 |