Incidental Mutation 'R0211:Cntnap5b'
ID 35497
Institutional Source Beutler Lab
Gene Symbol Cntnap5b
Ensembl Gene ENSMUSG00000067028
Gene Name contactin associated protein-like 5B
Synonyms C230078M14Rik, Caspr5-2
MMRRC Submission 038462-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R0211 (G1)
Quality Score 153
Status Not validated
Chromosome 1
Chromosomal Location 99700490-100413667 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 100406099 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 1136 (D1136E)
Ref Sequence ENSEMBL: ENSMUSP00000083944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086738] [ENSMUST00000188735]
AlphaFold Q0V8T8
Predicted Effect possibly damaging
Transcript: ENSMUST00000086738
AA Change: D1136E

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000083944
Gene: ENSMUSG00000067028
AA Change: D1136E

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
FA58C 39 174 2.76e-16 SMART
LamG 201 338 2.84e-27 SMART
LamG 387 521 9.22e-27 SMART
EGF 549 583 1.14e0 SMART
Blast:FBG 586 758 3e-66 BLAST
LamG 798 925 2.12e-26 SMART
EGF 946 982 1.51e0 SMART
LamG 1023 1159 2.14e-13 SMART
transmembrane domain 1227 1249 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188735
AA Change: D765E

PolyPhen 2 Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000139877
Gene: ENSMUSG00000067028
AA Change: D765E

DomainStartEndE-ValueType
LamG 73 207 5.9e-29 SMART
EGF 235 269 5.6e-3 SMART
Blast:FBG 272 402 2e-42 BLAST
LamG 415 554 2.5e-11 SMART
EGF 575 611 7.1e-3 SMART
LamG 652 788 1.4e-15 SMART
transmembrane domain 856 878 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.0%
  • 10x: 94.6%
  • 20x: 89.0%
Validation Efficiency 100% (1/1)
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,262,870 (GRCm39) L1401P possibly damaging Het
4930503B20Rik C T 3: 146,356,251 (GRCm39) R219H probably benign Het
Abcc9 T A 6: 142,634,710 (GRCm39) I185F probably benign Het
Adgrf1 T C 17: 43,607,581 (GRCm39) L100P probably damaging Het
Akt1 T C 12: 112,621,576 (GRCm39) T407A probably damaging Het
Alk C T 17: 72,910,511 (GRCm39) R65H probably damaging Het
Aplp2 T C 9: 31,069,086 (GRCm39) E525G probably damaging Het
Arhgef12 G A 9: 42,883,300 (GRCm39) R1411C probably damaging Het
Arnt T A 3: 95,383,460 (GRCm39) M242K probably damaging Het
Atad5 T G 11: 79,986,473 (GRCm39) V520G probably benign Het
Avpr1a T A 10: 122,285,374 (GRCm39) M222K possibly damaging Het
Cbr2 T A 11: 120,621,614 (GRCm39) I88L probably benign Het
Cc2d2a T A 5: 43,845,608 (GRCm39) probably null Het
Ccdc51 T C 9: 108,918,441 (GRCm39) M10T probably benign Het
Coil T A 11: 88,872,979 (GRCm39) S447T probably damaging Het
Cryba1 T A 11: 77,609,693 (GRCm39) Y179F probably damaging Het
Dcaf4 T A 12: 83,582,735 (GRCm39) F277I probably damaging Het
Ddost G A 4: 138,036,913 (GRCm39) V159M probably damaging Het
Dnaaf4 A T 9: 72,868,649 (GRCm39) R127S possibly damaging Het
Dnajb6 T C 5: 29,990,077 (GRCm39) probably benign Het
Dnase2a A G 8: 85,635,417 (GRCm39) probably benign Het
Dscam T C 16: 96,517,279 (GRCm39) I877V possibly damaging Het
Efcc1 A T 6: 87,726,136 (GRCm39) T312S probably benign Het
Elp1 T A 4: 56,795,545 (GRCm39) I143F probably damaging Het
Ermard A T 17: 15,242,205 (GRCm39) Q127L probably damaging Het
F2 T C 2: 91,460,503 (GRCm39) E329G probably damaging Het
Foxc2 T A 8: 121,843,355 (GRCm39) M1K probably null Het
Fuz T A 7: 44,548,446 (GRCm39) probably null Het
Ggnbp2 G A 11: 84,731,139 (GRCm39) T325M probably damaging Het
Gm6408 T A 5: 146,419,870 (GRCm39) F115I probably benign Het
Gp6 C T 7: 4,376,208 (GRCm39) probably null Het
Grin2a A G 16: 9,397,037 (GRCm39) S1017P possibly damaging Het
H2-T5 T C 17: 36,478,899 (GRCm39) T117A probably damaging Het
Hmmr A T 11: 40,605,635 (GRCm39) M318K probably damaging Het
Ifi205 T C 1: 173,855,994 (GRCm39) E12G probably benign Het
Ift74 C T 4: 94,567,492 (GRCm39) T395I probably benign Het
Irf8 A T 8: 121,466,714 (GRCm39) D53V probably damaging Het
Itgad A G 7: 127,803,813 (GRCm39) Y69C probably damaging Het
Itpr2 C A 6: 146,096,111 (GRCm39) R2084L probably benign Het
Krt4 C A 15: 101,831,217 (GRCm39) S228I possibly damaging Het
Lpin3 A T 2: 160,740,601 (GRCm39) D382V probably damaging Het
Ltbp3 T C 19: 5,802,171 (GRCm39) probably null Het
Map4k3 C T 17: 80,952,270 (GRCm39) A179T probably damaging Het
Nck1 A T 9: 100,379,820 (GRCm39) W144R probably damaging Het
Ndufb9 A T 15: 58,811,131 (GRCm39) Q139L possibly damaging Het
Ngfr T G 11: 95,462,738 (GRCm39) E300A probably damaging Het
Nin T G 12: 70,061,649 (GRCm39) T2072P probably damaging Het
Nop2 T G 6: 125,118,307 (GRCm39) L529R probably damaging Het
Nrm T A 17: 36,175,503 (GRCm39) L203Q probably damaging Het
Nynrin T C 14: 56,109,255 (GRCm39) F1454S probably benign Het
Or10ak7 T A 4: 118,791,467 (GRCm39) M191L probably benign Het
Or5b101 T C 19: 13,005,646 (GRCm39) T16A possibly damaging Het
Or8j3c A C 2: 86,253,451 (GRCm39) S190A probably damaging Het
Os9 A G 10: 126,956,905 (GRCm39) V27A probably damaging Het
Osbpl9 T G 4: 108,930,321 (GRCm39) T332P probably damaging Het
Pcdhb10 A T 18: 37,547,059 (GRCm39) M712L probably benign Het
Pcx C T 19: 4,670,227 (GRCm39) A935V probably damaging Het
Pdzd7 A G 19: 45,022,106 (GRCm39) V514A possibly damaging Het
Plin4 C T 17: 56,409,242 (GRCm39) G1326D probably damaging Het
Plxnb1 T A 9: 108,932,731 (GRCm39) Y568* probably null Het
Pmfbp1 T A 8: 110,268,372 (GRCm39) V973D probably benign Het
Ppp2r1b T C 9: 50,772,925 (GRCm39) V70A probably benign Het
Prkar2b C A 12: 32,022,183 (GRCm39) V201L probably benign Het
Rgr T G 14: 36,768,925 (GRCm39) T37P probably damaging Het
Ripk3 A T 14: 56,025,375 (GRCm39) L63Q probably damaging Het
Rpusd2 A G 2: 118,868,893 (GRCm39) S439G probably benign Het
Serac1 T A 17: 6,100,335 (GRCm39) R438S possibly damaging Het
Slc19a1 T A 10: 76,874,300 (GRCm39) S24T possibly damaging Het
Slc6a21 A C 7: 44,937,667 (GRCm39) T653P possibly damaging Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spdef C T 17: 27,933,894 (GRCm39) R309H probably damaging Het
Srp68 A T 11: 116,156,377 (GRCm39) Y84N probably damaging Het
Syne2 A T 12: 76,144,731 (GRCm39) Q6299L probably damaging Het
Tmem63b T A 17: 45,972,839 (GRCm39) M652L probably benign Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Tnk1 A G 11: 69,746,007 (GRCm39) V306A probably damaging Het
Tnnc2 T A 2: 164,619,404 (GRCm39) I147F probably damaging Het
Tnni3k C T 3: 154,760,981 (GRCm39) probably benign Het
Togaram2 T A 17: 72,036,243 (GRCm39) V911D probably damaging Het
Tyw3 T C 3: 154,293,132 (GRCm39) N181S probably damaging Het
Unc79 T A 12: 103,039,051 (GRCm39) S682T probably benign Het
Vps13d A G 4: 144,841,348 (GRCm39) L2634S probably benign Het
Wasl G T 6: 24,633,892 (GRCm39) A124E probably damaging Het
Zfp287 T C 11: 62,605,743 (GRCm39) H388R probably damaging Het
Zfp335 T C 2: 164,749,612 (GRCm39) T262A probably damaging Het
Zfp457 C G 13: 67,441,211 (GRCm39) G359R probably benign Het
Zfp536 T A 7: 37,267,874 (GRCm39) E514V probably damaging Het
Zfp872 T A 9: 22,111,469 (GRCm39) I316N probably damaging Het
Other mutations in Cntnap5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00417:Cntnap5b APN 1 99,978,479 (GRCm39) missense probably damaging 1.00
IGL00477:Cntnap5b APN 1 100,141,468 (GRCm39) missense probably damaging 0.97
IGL00505:Cntnap5b APN 1 100,306,886 (GRCm39) missense possibly damaging 0.81
IGL00596:Cntnap5b APN 1 100,306,886 (GRCm39) missense possibly damaging 0.81
IGL00846:Cntnap5b APN 1 100,091,948 (GRCm39) missense probably damaging 1.00
IGL00895:Cntnap5b APN 1 100,311,310 (GRCm39) missense probably damaging 0.98
IGL00948:Cntnap5b APN 1 100,069,082 (GRCm39) missense probably benign 0.00
IGL01073:Cntnap5b APN 1 100,003,755 (GRCm39) missense probably benign 0.08
IGL01523:Cntnap5b APN 1 100,359,504 (GRCm39) missense probably benign 0.02
IGL01779:Cntnap5b APN 1 99,895,064 (GRCm39) missense probably damaging 1.00
IGL02253:Cntnap5b APN 1 100,091,936 (GRCm39) missense possibly damaging 0.75
IGL02628:Cntnap5b APN 1 99,999,794 (GRCm39) missense probably damaging 0.97
R0166:Cntnap5b UTSW 1 100,202,086 (GRCm39) missense probably benign 0.41
R0281:Cntnap5b UTSW 1 99,999,878 (GRCm39) missense probably benign 0.22
R0363:Cntnap5b UTSW 1 100,202,193 (GRCm39) missense probably benign 0.01
R0514:Cntnap5b UTSW 1 99,700,511 (GRCm39) missense probably benign
R0645:Cntnap5b UTSW 1 99,999,767 (GRCm39) splice site probably benign
R0848:Cntnap5b UTSW 1 100,182,888 (GRCm39) missense probably benign 0.22
R1006:Cntnap5b UTSW 1 100,311,342 (GRCm39) missense probably benign 0.00
R1349:Cntnap5b UTSW 1 100,091,813 (GRCm39) missense probably benign 0.09
R1372:Cntnap5b UTSW 1 100,091,813 (GRCm39) missense probably benign 0.09
R1474:Cntnap5b UTSW 1 99,999,814 (GRCm39) missense probably benign 0.25
R1681:Cntnap5b UTSW 1 100,003,832 (GRCm39) missense probably damaging 0.98
R1727:Cntnap5b UTSW 1 100,141,469 (GRCm39) missense possibly damaging 0.91
R1760:Cntnap5b UTSW 1 99,700,535 (GRCm39) missense probably benign 0.05
R1777:Cntnap5b UTSW 1 100,297,803 (GRCm39) missense probably benign 0.10
R1939:Cntnap5b UTSW 1 99,895,073 (GRCm39) missense probably benign
R1988:Cntnap5b UTSW 1 99,999,865 (GRCm39) missense possibly damaging 0.92
R2069:Cntnap5b UTSW 1 100,286,450 (GRCm39) missense probably benign 0.04
R2113:Cntnap5b UTSW 1 100,202,140 (GRCm39) missense probably benign
R2148:Cntnap5b UTSW 1 100,311,199 (GRCm39) missense probably benign 0.01
R2158:Cntnap5b UTSW 1 100,318,297 (GRCm39) missense probably damaging 1.00
R2223:Cntnap5b UTSW 1 100,141,412 (GRCm39) missense probably damaging 1.00
R2350:Cntnap5b UTSW 1 100,306,851 (GRCm39) missense probably damaging 1.00
R3840:Cntnap5b UTSW 1 100,311,202 (GRCm39) missense possibly damaging 0.50
R4329:Cntnap5b UTSW 1 99,999,888 (GRCm39) missense probably damaging 0.99
R4609:Cntnap5b UTSW 1 99,700,572 (GRCm39) critical splice donor site probably null
R4799:Cntnap5b UTSW 1 100,286,450 (GRCm39) missense probably benign 0.04
R5129:Cntnap5b UTSW 1 100,306,815 (GRCm39) missense probably damaging 1.00
R5323:Cntnap5b UTSW 1 100,311,275 (GRCm39) nonsense probably null
R5434:Cntnap5b UTSW 1 99,999,926 (GRCm39) missense probably benign 0.02
R5579:Cntnap5b UTSW 1 100,311,124 (GRCm39) missense probably benign 0.27
R5579:Cntnap5b UTSW 1 100,311,120 (GRCm39) nonsense probably null
R5630:Cntnap5b UTSW 1 99,999,794 (GRCm39) missense probably damaging 0.99
R5644:Cntnap5b UTSW 1 100,311,326 (GRCm39) missense probably benign 0.00
R5761:Cntnap5b UTSW 1 100,374,619 (GRCm39) missense probably damaging 1.00
R6042:Cntnap5b UTSW 1 100,318,317 (GRCm39) missense probably benign
R6147:Cntnap5b UTSW 1 99,978,506 (GRCm39) missense probably damaging 1.00
R6190:Cntnap5b UTSW 1 100,306,800 (GRCm39) missense possibly damaging 0.80
R6248:Cntnap5b UTSW 1 99,999,827 (GRCm39) missense probably benign 0.30
R6286:Cntnap5b UTSW 1 100,182,798 (GRCm39) missense possibly damaging 0.82
R6306:Cntnap5b UTSW 1 100,091,871 (GRCm39) missense probably damaging 1.00
R6336:Cntnap5b UTSW 1 100,286,394 (GRCm39) missense probably benign 0.00
R6360:Cntnap5b UTSW 1 100,359,461 (GRCm39) nonsense probably null
R6722:Cntnap5b UTSW 1 100,406,211 (GRCm39) missense probably damaging 0.98
R6750:Cntnap5b UTSW 1 100,202,224 (GRCm39) missense probably damaging 1.00
R6806:Cntnap5b UTSW 1 99,868,374 (GRCm39) missense probably damaging 1.00
R6933:Cntnap5b UTSW 1 100,311,175 (GRCm39) missense probably benign 0.01
R6957:Cntnap5b UTSW 1 100,202,197 (GRCm39) missense probably benign 0.08
R6958:Cntnap5b UTSW 1 100,202,197 (GRCm39) missense probably benign 0.08
R6959:Cntnap5b UTSW 1 100,202,197 (GRCm39) missense probably benign 0.08
R6961:Cntnap5b UTSW 1 100,202,197 (GRCm39) missense probably benign 0.08
R6962:Cntnap5b UTSW 1 100,202,197 (GRCm39) missense probably benign 0.08
R7088:Cntnap5b UTSW 1 100,087,802 (GRCm39) missense probably damaging 0.99
R7146:Cntnap5b UTSW 1 99,978,519 (GRCm39) splice site probably null
R7165:Cntnap5b UTSW 1 100,003,887 (GRCm39) missense possibly damaging 0.94
R7190:Cntnap5b UTSW 1 100,359,574 (GRCm39) splice site probably null
R7376:Cntnap5b UTSW 1 99,894,994 (GRCm39) missense possibly damaging 0.92
R7385:Cntnap5b UTSW 1 100,306,815 (GRCm39) missense probably damaging 1.00
R8053:Cntnap5b UTSW 1 100,318,402 (GRCm39) missense probably damaging 0.98
R8080:Cntnap5b UTSW 1 99,999,928 (GRCm39) missense probably benign 0.16
R8082:Cntnap5b UTSW 1 100,306,941 (GRCm39) missense probably benign 0.00
R8271:Cntnap5b UTSW 1 99,999,832 (GRCm39) missense probably benign 0.00
R8303:Cntnap5b UTSW 1 100,069,022 (GRCm39) missense probably damaging 1.00
R8428:Cntnap5b UTSW 1 100,311,310 (GRCm39) missense probably damaging 0.98
R9131:Cntnap5b UTSW 1 99,978,368 (GRCm39) missense probably benign 0.22
R9144:Cntnap5b UTSW 1 99,978,512 (GRCm39) missense probably damaging 1.00
R9522:Cntnap5b UTSW 1 100,412,347 (GRCm39) missense probably benign 0.00
R9611:Cntnap5b UTSW 1 99,894,935 (GRCm39) missense probably damaging 1.00
RF007:Cntnap5b UTSW 1 100,091,795 (GRCm39) missense probably damaging 1.00
X0020:Cntnap5b UTSW 1 100,359,573 (GRCm39) critical splice donor site probably null
Z1176:Cntnap5b UTSW 1 100,374,565 (GRCm39) missense probably benign 0.01
Z1176:Cntnap5b UTSW 1 100,091,953 (GRCm39) missense possibly damaging 0.86
Z1176:Cntnap5b UTSW 1 99,894,995 (GRCm39) missense probably damaging 0.99
Z1177:Cntnap5b UTSW 1 99,978,431 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CTACACAGCTTCCCGGAGATAATGAAC -3'
(R):5'- AGTAGTCACTCCAGTCACATCAGAGTC -3'

Sequencing Primer
(F):5'- CTTCAAAGGAGTGATAGTCATAGCCC -3'
(R):5'- AGTCTATCATGGAGTCACAGC -3'
Posted On 2013-05-09