Incidental Mutation 'R4694:Or5w13'
ID 355535
Institutional Source Beutler Lab
Gene Symbol Or5w13
Ensembl Gene ENSMUSG00000075151
Gene Name olfactory receptor family 5 subfamily W member 13
Synonyms Olfr1136, MOR177-3, GA_x6K02T2Q125-49193051-49192119
MMRRC Submission 041945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R4694 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87523225-87524291 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87524104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 41 (T41S)
Ref Sequence ENSEMBL: ENSMUSP00000076681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077471] [ENSMUST00000099852]
AlphaFold Q0VBI4
Predicted Effect probably benign
Transcript: ENSMUST00000077471
AA Change: T41S

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000076681
Gene: ENSMUSG00000075151
AA Change: T41S

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6e-48 PFAM
Pfam:7tm_1 40 289 2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099852
AA Change: T41S

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000097438
Gene: ENSMUSG00000068815
AA Change: T41S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-41 PFAM
Pfam:7tm_1 41 290 4.3e-14 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A T 17: 84,979,586 (GRCm39) F258Y probably damaging Het
Adamtsl4 C T 3: 95,587,055 (GRCm39) R765H probably damaging Het
Bicd1 T A 6: 149,311,051 (GRCm39) L42Q probably damaging Het
Cacna1e C T 1: 154,313,012 (GRCm39) probably null Het
Capn1 T A 19: 6,044,761 (GRCm39) K504* probably null Het
Cdh15 G A 8: 123,588,763 (GRCm39) R279Q probably damaging Het
Cep350 T C 1: 155,804,332 (GRCm39) K917R probably damaging Het
Cp A T 3: 20,029,049 (GRCm39) T509S probably benign Het
Cyp2d10 T C 15: 82,288,684 (GRCm39) D266G probably damaging Het
Dhodh C G 8: 110,333,048 (GRCm39) R7P probably damaging Het
Dmxl2 A G 9: 54,354,189 (GRCm39) L419P probably benign Het
Epb41l4b A T 4: 57,019,875 (GRCm39) M84K probably benign Het
Fbln7 A G 2: 128,722,345 (GRCm39) probably null Het
Fbxw11 C T 11: 32,592,820 (GRCm39) probably benign Het
Flnc C A 6: 29,443,447 (GRCm39) P543T probably damaging Het
Grid1 T C 14: 34,748,737 (GRCm39) S186P probably damaging Het
Hcfc2 C T 10: 82,559,534 (GRCm39) T382M probably damaging Het
Hdac9 G T 12: 34,487,246 (GRCm39) L73I probably damaging Het
Hnrnpa2b1 A T 6: 51,441,163 (GRCm39) D302E probably damaging Het
Ifi204 C T 1: 173,576,825 (GRCm39) C592Y probably damaging Het
Jph1 T A 1: 17,067,729 (GRCm39) I653F probably damaging Het
Kcnj3 A G 2: 55,484,918 (GRCm39) K339E probably benign Het
Kcp G A 6: 29,493,196 (GRCm39) T838I probably benign Het
Krtap26-1 A T 16: 88,444,108 (GRCm39) V171E possibly damaging Het
Lck G T 4: 129,442,765 (GRCm39) N452K possibly damaging Het
Madd A G 2: 90,990,673 (GRCm39) L1134S probably damaging Het
Mafk T C 5: 139,786,248 (GRCm39) S149P probably damaging Het
Man1c1 T C 4: 134,430,500 (GRCm39) D94G probably benign Het
Me2 T A 18: 73,934,930 (GRCm39) M38L probably benign Het
Muc2 A C 7: 141,306,082 (GRCm39) D257A probably damaging Het
Myh11 T C 16: 14,018,566 (GRCm39) K1927E probably damaging Het
Naaladl1 C T 19: 6,158,920 (GRCm39) P324S probably damaging Het
Ndufa10 T C 1: 92,379,824 (GRCm39) E303G probably benign Het
Nedd1 C T 10: 92,555,444 (GRCm39) V14I probably benign Het
Nwd1 T G 8: 73,393,958 (GRCm39) V407G probably damaging Het
Or2h15 A C 17: 38,441,748 (GRCm39) C112G probably damaging Het
Or4b1d T A 2: 89,968,593 (GRCm39) K297* probably null Het
Or4k15c T C 14: 50,321,476 (GRCm39) I221V probably benign Het
Or7g29 A G 9: 19,286,694 (GRCm39) L161P probably damaging Het
Pgrmc2 T C 3: 41,024,840 (GRCm39) D144G probably damaging Het
Ppp3cb T C 14: 20,551,583 (GRCm39) N516S probably benign Het
Pramel27 T C 4: 143,579,530 (GRCm39) S372P probably damaging Het
Prelp A G 1: 133,842,485 (GRCm39) M220T probably damaging Het
Prss36 A G 7: 127,534,787 (GRCm39) W465R probably damaging Het
Pth2r C A 1: 65,375,920 (GRCm39) F59L probably benign Het
Rab20 C T 8: 11,504,485 (GRCm39) G72R probably damaging Het
Rab4a G T 8: 124,555,769 (GRCm39) G49W probably damaging Het
Rad9a G A 19: 4,250,560 (GRCm39) R85C probably damaging Het
Rhox2c A C X: 36,635,351 (GRCm39) Q4H probably benign Het
Rock1 A T 18: 10,136,152 (GRCm39) Y178* probably null Het
Scaf8 C A 17: 3,247,679 (GRCm39) L1001I probably damaging Het
Sema3b G A 9: 107,482,201 (GRCm39) P26S probably benign Het
Slc23a1 A G 18: 35,752,633 (GRCm39) L548P probably damaging Het
Sncaip A C 18: 53,039,629 (GRCm39) T548P probably benign Het
Stpg2 C T 3: 139,023,177 (GRCm39) P398S possibly damaging Het
Stpg3 A C 2: 25,103,309 (GRCm39) V260G probably damaging Het
Tbc1d9 T A 8: 83,960,875 (GRCm39) F242I probably damaging Het
Tnks1bp1 G A 2: 84,902,066 (GRCm39) R992Q probably damaging Het
Tom1l1 T G 11: 90,537,675 (GRCm39) H394P possibly damaging Het
Topors T G 4: 40,261,442 (GRCm39) N614T possibly damaging Het
Trank1 A T 9: 111,221,129 (GRCm39) Q2622L probably benign Het
Trub2 A G 2: 29,668,858 (GRCm39) S186P probably damaging Het
Unc13c T A 9: 73,479,636 (GRCm39) H1756L probably benign Het
Vmn1r9 A T 6: 57,048,314 (GRCm39) I130F probably benign Het
Wdr72 A T 9: 74,086,837 (GRCm39) I602F probably damaging Het
Zfand3 T A 17: 30,354,362 (GRCm39) F60I possibly damaging Het
Zfp946 G A 17: 22,674,692 (GRCm39) G482E probably benign Het
Other mutations in Or5w13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01809:Or5w13 APN 2 87,524,089 (GRCm39) missense possibly damaging 0.73
IGL02190:Or5w13 APN 2 87,523,407 (GRCm39) missense probably benign 0.21
IGL02902:Or5w13 APN 2 87,523,344 (GRCm39) missense probably damaging 1.00
PIT4508001:Or5w13 UTSW 2 87,524,059 (GRCm39) missense probably damaging 1.00
R0153:Or5w13 UTSW 2 87,523,948 (GRCm39) missense probably benign 0.05
R0665:Or5w13 UTSW 2 87,524,152 (GRCm39) missense probably benign 0.00
R1462:Or5w13 UTSW 2 87,523,720 (GRCm39) missense probably damaging 1.00
R1462:Or5w13 UTSW 2 87,523,720 (GRCm39) missense probably damaging 1.00
R1518:Or5w13 UTSW 2 87,523,872 (GRCm39) missense probably damaging 1.00
R1812:Or5w13 UTSW 2 87,523,447 (GRCm39) missense probably benign 0.01
R1993:Or5w13 UTSW 2 87,523,777 (GRCm39) missense probably benign 0.07
R2098:Or5w13 UTSW 2 87,524,073 (GRCm39) missense probably benign 0.25
R3106:Or5w13 UTSW 2 87,523,849 (GRCm39) missense probably damaging 0.98
R4622:Or5w13 UTSW 2 87,523,987 (GRCm39) nonsense probably null
R5079:Or5w13 UTSW 2 87,523,552 (GRCm39) missense probably damaging 0.99
R5474:Or5w13 UTSW 2 87,523,401 (GRCm39) missense probably damaging 1.00
R6432:Or5w13 UTSW 2 87,523,872 (GRCm39) missense probably damaging 1.00
R6667:Or5w13 UTSW 2 87,523,914 (GRCm39) missense probably benign 0.00
R7519:Or5w13 UTSW 2 87,523,753 (GRCm39) missense probably benign 0.01
R7652:Or5w13 UTSW 2 87,523,704 (GRCm39) missense probably damaging 1.00
R7657:Or5w13 UTSW 2 87,523,336 (GRCm39) missense probably damaging 0.99
R8230:Or5w13 UTSW 2 87,523,705 (GRCm39) missense probably damaging 1.00
R8439:Or5w13 UTSW 2 87,524,088 (GRCm39) missense probably damaging 1.00
R8799:Or5w13 UTSW 2 87,524,057 (GRCm39) missense possibly damaging 0.73
R9448:Or5w13 UTSW 2 87,523,824 (GRCm39) missense probably damaging 0.98
R9657:Or5w13 UTSW 2 87,524,121 (GRCm39) missense probably damaging 1.00
Z1176:Or5w13 UTSW 2 87,523,495 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTATCTATCAAAGGCCATCACCGC -3'
(R):5'- TCAAACCCTAAGAGACCTTTGTC -3'

Sequencing Primer
(F):5'- TCACCGCCAGCAGCATG -3'
(R):5'- CTCATCTGTGCCTGAGTT -3'
Posted On 2015-10-21