Incidental Mutation 'R0402:Or10ak16'
ID 35604
Institutional Source Beutler Lab
Gene Symbol Or10ak16
Ensembl Gene ENSMUSG00000073768
Gene Name olfactory receptor family 10 subfamily AK member 16
Synonyms Olfr1330, MOR259-8, GA_x6K02T2QD9B-18644371-18643424
MMRRC Submission 038607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R0402 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 118750282-118751229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 118750426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 49 (I49F)
Ref Sequence ENSEMBL: ENSMUSP00000101968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094830] [ENSMUST00000105035] [ENSMUST00000106361]
AlphaFold Q8VEY6
Predicted Effect possibly damaging
Transcript: ENSMUST00000094830
AA Change: I49F

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000092425
Gene: ENSMUSG00000073768
AA Change: I49F

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.4e-6 PFAM
Pfam:7tm_1 44 293 1.6e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105035
AA Change: I49F

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000100652
Gene: ENSMUSG00000073768
AA Change: I49F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 307 6.4e-8 PFAM
Pfam:7tm_1 44 293 2.9e-31 PFAM
Pfam:7tm_4 142 286 6.7e-46 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000106361
AA Change: I49F

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: I49F

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216386
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.0%
  • 10x: 94.5%
  • 20x: 88.7%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A T 10: 100,445,115 (GRCm39) K165N probably damaging Het
Adam6b T A 12: 113,453,615 (GRCm39) M144K probably damaging Het
Arhgap44 T C 11: 64,922,903 (GRCm39) probably benign Het
Arl5c T A 11: 97,885,939 (GRCm39) I21F probably damaging Het
Bglap2 C T 3: 88,285,552 (GRCm39) G40D probably damaging Het
Bptf T C 11: 106,964,940 (GRCm39) E1303G probably damaging Het
Calhm1 T C 19: 47,129,896 (GRCm39) T209A probably damaging Het
Ccr8 A G 9: 119,923,976 (GRCm39) probably null Het
Chkb C T 15: 89,313,610 (GRCm39) R65Q probably benign Het
Col4a1 T C 8: 11,249,838 (GRCm39) probably benign Het
Cryzl2 A G 1: 157,292,014 (GRCm39) T98A probably benign Het
D430041D05Rik T C 2: 103,998,509 (GRCm39) T1080A probably damaging Het
Dhx8 C A 11: 101,643,223 (GRCm39) T765N probably damaging Het
Dicer1 T C 12: 104,697,323 (GRCm39) D78G probably benign Het
Drd2 A G 9: 49,316,271 (GRCm39) I344V probably benign Het
Edil3 A T 13: 89,347,570 (GRCm39) probably benign Het
Fbxw19 C T 9: 109,313,493 (GRCm39) G235D probably benign Het
Fzd1 T C 5: 4,805,702 (GRCm39) K627E possibly damaging Het
Garin1b A G 6: 29,323,901 (GRCm39) T209A probably benign Het
Garin4 T C 1: 190,896,637 (GRCm39) D2G probably benign Het
Gm10638 A G 8: 87,472,828 (GRCm39) probably benign Het
H6pd G T 4: 150,080,773 (GRCm39) A24E probably damaging Het
Hectd2 G T 19: 36,578,929 (GRCm39) probably null Het
Hps5 A G 7: 46,440,333 (GRCm39) probably benign Het
Irx3 T C 8: 92,527,296 (GRCm39) N136S possibly damaging Het
Kcmf1 T C 6: 72,826,568 (GRCm39) M1V probably null Het
Klrb1 A T 6: 128,687,583 (GRCm39) F104I probably benign Het
Lrfn5 T C 12: 61,886,803 (GRCm39) M197T probably benign Het
Mpdz A C 4: 81,279,677 (GRCm39) M51R possibly damaging Het
Mtbp G T 15: 55,432,466 (GRCm39) E258* probably null Het
Mylk3 T A 8: 86,079,539 (GRCm39) H373L probably damaging Het
Myrfl A G 10: 116,664,882 (GRCm39) S383P probably damaging Het
Nt5c T C 11: 115,381,468 (GRCm39) *195W probably null Het
Ocstamp A G 2: 165,238,184 (GRCm39) V360A possibly damaging Het
Or10al6 T A 17: 38,083,284 (GRCm39) C247S probably damaging Het
Or4k35 A G 2: 111,100,208 (GRCm39) F168S probably damaging Het
Or4p19 A T 2: 88,242,378 (GRCm39) V208D probably damaging Het
Or5an9 A G 19: 12,186,953 (GRCm39) T8A probably damaging Het
Otop2 T C 11: 115,217,234 (GRCm39) probably benign Het
Pom121l2 A T 13: 22,172,649 (GRCm39) probably benign Het
Pon2 T A 6: 5,272,410 (GRCm39) K137* probably null Het
Ppip5k2 T A 1: 97,647,579 (GRCm39) Q1049L probably benign Het
Ralgapa2 C T 2: 146,276,729 (GRCm39) V504M probably damaging Het
Rph3a G A 5: 121,080,317 (GRCm39) H654Y probably damaging Het
Sh2d1b1 T C 1: 170,107,342 (GRCm39) probably benign Het
Slc15a2 G A 16: 36,595,960 (GRCm39) T154I probably benign Het
Slc45a3 T C 1: 131,905,265 (GRCm39) V96A possibly damaging Het
Slc7a4 A G 16: 17,393,497 (GRCm39) S101P probably damaging Het
Smco2 T C 6: 146,772,633 (GRCm39) probably benign Het
Spata2 A T 2: 167,325,580 (GRCm39) V413E probably benign Het
Specc1l A G 10: 75,082,260 (GRCm39) E552G probably damaging Het
Sstr5 C T 17: 25,711,008 (GRCm39) V74M probably benign Het
Timm50 G A 7: 28,006,280 (GRCm39) R274W probably damaging Het
Tll2 A G 19: 41,087,132 (GRCm39) V573A possibly damaging Het
Tm7sf3 C A 6: 146,507,685 (GRCm39) R459M possibly damaging Het
Txk A G 5: 72,889,105 (GRCm39) probably null Het
Uroc1 A G 6: 90,324,284 (GRCm39) D436G probably damaging Het
Vmn1r13 T A 6: 57,187,083 (GRCm39) Y81N possibly damaging Het
Vmn2r19 A G 6: 123,313,141 (GRCm39) E737G probably damaging Het
Wfs1 A G 5: 37,134,324 (GRCm39) probably benign Het
Zfp1 G A 8: 112,396,875 (GRCm39) E285K probably damaging Het
Zfp1005 T A 2: 150,111,136 (GRCm39) C609S possibly damaging Het
Zfp661 G A 2: 127,419,640 (GRCm39) Q167* probably null Het
Zswim8 T C 14: 20,760,834 (GRCm39) F36S probably damaging Het
Zw10 A G 9: 48,980,023 (GRCm39) T385A probably benign Het
Other mutations in Or10ak16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01385:Or10ak16 APN 4 118,750,748 (GRCm39) missense probably benign 0.00
IGL01642:Or10ak16 APN 4 118,750,658 (GRCm39) missense probably damaging 1.00
R0418:Or10ak16 UTSW 4 118,750,448 (GRCm39) missense possibly damaging 0.51
R0646:Or10ak16 UTSW 4 118,750,687 (GRCm39) missense probably damaging 0.96
R1075:Or10ak16 UTSW 4 118,750,402 (GRCm39) missense probably damaging 1.00
R1743:Or10ak16 UTSW 4 118,750,723 (GRCm39) missense probably benign
R1950:Or10ak16 UTSW 4 118,750,537 (GRCm39) missense probably benign 0.22
R2265:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2268:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2269:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R4648:Or10ak16 UTSW 4 118,751,147 (GRCm39) missense possibly damaging 0.84
R5635:Or10ak16 UTSW 4 118,750,832 (GRCm39) missense probably benign 0.31
R6881:Or10ak16 UTSW 4 118,750,304 (GRCm39) missense probably damaging 1.00
R7351:Or10ak16 UTSW 4 118,751,033 (GRCm39) missense probably benign 0.05
R7412:Or10ak16 UTSW 4 118,750,327 (GRCm39) missense possibly damaging 0.83
R8402:Or10ak16 UTSW 4 118,750,716 (GRCm39) missense probably benign 0.01
R9355:Or10ak16 UTSW 4 118,750,784 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAGCATCAGTACCTCACTTTTGGAC -3'
(R):5'- TGCACTCAGTTATACCCAGGGCAC -3'

Sequencing Primer
(F):5'- GCCTCTATTGTTACCATGTGTCAAG -3'
(R):5'- GTTATACCCAGGGCACTGAAAAC -3'
Posted On 2013-05-09