Incidental Mutation 'R0402:Tm7sf3'
ID 35617
Institutional Source Beutler Lab
Gene Symbol Tm7sf3
Ensembl Gene ENSMUSG00000040234
Gene Name transmembrane 7 superfamily member 3
Synonyms 2010003B14Rik
MMRRC Submission 038607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R0402 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 146503774-146536103 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 146507685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Methionine at position 459 (R459M)
Ref Sequence ENSEMBL: ENSMUSP00000045650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037709] [ENSMUST00000127529]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000037709
AA Change: R459M

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000045650
Gene: ENSMUSG00000040234
AA Change: R459M

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:DUF4203 291 498 8.5e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000127529
SMART Domains Protein: ENSMUSP00000118517
Gene: ENSMUSG00000040234

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.0%
  • 10x: 94.5%
  • 20x: 88.7%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A T 10: 100,445,115 (GRCm39) K165N probably damaging Het
Adam6b T A 12: 113,453,615 (GRCm39) M144K probably damaging Het
Arhgap44 T C 11: 64,922,903 (GRCm39) probably benign Het
Arl5c T A 11: 97,885,939 (GRCm39) I21F probably damaging Het
Bglap2 C T 3: 88,285,552 (GRCm39) G40D probably damaging Het
Bptf T C 11: 106,964,940 (GRCm39) E1303G probably damaging Het
Calhm1 T C 19: 47,129,896 (GRCm39) T209A probably damaging Het
Ccr8 A G 9: 119,923,976 (GRCm39) probably null Het
Chkb C T 15: 89,313,610 (GRCm39) R65Q probably benign Het
Col4a1 T C 8: 11,249,838 (GRCm39) probably benign Het
Cryzl2 A G 1: 157,292,014 (GRCm39) T98A probably benign Het
D430041D05Rik T C 2: 103,998,509 (GRCm39) T1080A probably damaging Het
Dhx8 C A 11: 101,643,223 (GRCm39) T765N probably damaging Het
Dicer1 T C 12: 104,697,323 (GRCm39) D78G probably benign Het
Drd2 A G 9: 49,316,271 (GRCm39) I344V probably benign Het
Edil3 A T 13: 89,347,570 (GRCm39) probably benign Het
Fbxw19 C T 9: 109,313,493 (GRCm39) G235D probably benign Het
Fzd1 T C 5: 4,805,702 (GRCm39) K627E possibly damaging Het
Garin1b A G 6: 29,323,901 (GRCm39) T209A probably benign Het
Garin4 T C 1: 190,896,637 (GRCm39) D2G probably benign Het
Gm10638 A G 8: 87,472,828 (GRCm39) probably benign Het
H6pd G T 4: 150,080,773 (GRCm39) A24E probably damaging Het
Hectd2 G T 19: 36,578,929 (GRCm39) probably null Het
Hps5 A G 7: 46,440,333 (GRCm39) probably benign Het
Irx3 T C 8: 92,527,296 (GRCm39) N136S possibly damaging Het
Kcmf1 T C 6: 72,826,568 (GRCm39) M1V probably null Het
Klrb1 A T 6: 128,687,583 (GRCm39) F104I probably benign Het
Lrfn5 T C 12: 61,886,803 (GRCm39) M197T probably benign Het
Mpdz A C 4: 81,279,677 (GRCm39) M51R possibly damaging Het
Mtbp G T 15: 55,432,466 (GRCm39) E258* probably null Het
Mylk3 T A 8: 86,079,539 (GRCm39) H373L probably damaging Het
Myrfl A G 10: 116,664,882 (GRCm39) S383P probably damaging Het
Nt5c T C 11: 115,381,468 (GRCm39) *195W probably null Het
Ocstamp A G 2: 165,238,184 (GRCm39) V360A possibly damaging Het
Or10ak16 A T 4: 118,750,426 (GRCm39) I49F possibly damaging Het
Or10al6 T A 17: 38,083,284 (GRCm39) C247S probably damaging Het
Or4k35 A G 2: 111,100,208 (GRCm39) F168S probably damaging Het
Or4p19 A T 2: 88,242,378 (GRCm39) V208D probably damaging Het
Or5an9 A G 19: 12,186,953 (GRCm39) T8A probably damaging Het
Otop2 T C 11: 115,217,234 (GRCm39) probably benign Het
Pom121l2 A T 13: 22,172,649 (GRCm39) probably benign Het
Pon2 T A 6: 5,272,410 (GRCm39) K137* probably null Het
Ppip5k2 T A 1: 97,647,579 (GRCm39) Q1049L probably benign Het
Ralgapa2 C T 2: 146,276,729 (GRCm39) V504M probably damaging Het
Rph3a G A 5: 121,080,317 (GRCm39) H654Y probably damaging Het
Sh2d1b1 T C 1: 170,107,342 (GRCm39) probably benign Het
Slc15a2 G A 16: 36,595,960 (GRCm39) T154I probably benign Het
Slc45a3 T C 1: 131,905,265 (GRCm39) V96A possibly damaging Het
Slc7a4 A G 16: 17,393,497 (GRCm39) S101P probably damaging Het
Smco2 T C 6: 146,772,633 (GRCm39) probably benign Het
Spata2 A T 2: 167,325,580 (GRCm39) V413E probably benign Het
Specc1l A G 10: 75,082,260 (GRCm39) E552G probably damaging Het
Sstr5 C T 17: 25,711,008 (GRCm39) V74M probably benign Het
Timm50 G A 7: 28,006,280 (GRCm39) R274W probably damaging Het
Tll2 A G 19: 41,087,132 (GRCm39) V573A possibly damaging Het
Txk A G 5: 72,889,105 (GRCm39) probably null Het
Uroc1 A G 6: 90,324,284 (GRCm39) D436G probably damaging Het
Vmn1r13 T A 6: 57,187,083 (GRCm39) Y81N possibly damaging Het
Vmn2r19 A G 6: 123,313,141 (GRCm39) E737G probably damaging Het
Wfs1 A G 5: 37,134,324 (GRCm39) probably benign Het
Zfp1 G A 8: 112,396,875 (GRCm39) E285K probably damaging Het
Zfp1005 T A 2: 150,111,136 (GRCm39) C609S possibly damaging Het
Zfp661 G A 2: 127,419,640 (GRCm39) Q167* probably null Het
Zswim8 T C 14: 20,760,834 (GRCm39) F36S probably damaging Het
Zw10 A G 9: 48,980,023 (GRCm39) T385A probably benign Het
Other mutations in Tm7sf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00985:Tm7sf3 APN 6 146,507,692 (GRCm39) missense possibly damaging 0.51
IGL01930:Tm7sf3 APN 6 146,512,431 (GRCm39) missense possibly damaging 0.71
IGL02073:Tm7sf3 APN 6 146,525,208 (GRCm39) missense possibly damaging 0.96
IGL02720:Tm7sf3 APN 6 146,514,872 (GRCm39) splice site probably benign
IGL02815:Tm7sf3 APN 6 146,514,971 (GRCm39) splice site probably null
IGL03255:Tm7sf3 APN 6 146,507,618 (GRCm39) unclassified probably benign
R0245:Tm7sf3 UTSW 6 146,520,107 (GRCm39) missense possibly damaging 0.53
R0687:Tm7sf3 UTSW 6 146,523,388 (GRCm39) missense possibly damaging 0.96
R0763:Tm7sf3 UTSW 6 146,507,787 (GRCm39) missense possibly damaging 0.93
R1419:Tm7sf3 UTSW 6 146,505,475 (GRCm39) missense possibly damaging 0.71
R1511:Tm7sf3 UTSW 6 146,511,376 (GRCm39) missense probably benign 0.05
R4880:Tm7sf3 UTSW 6 146,511,358 (GRCm39) missense possibly damaging 0.93
R5930:Tm7sf3 UTSW 6 146,505,409 (GRCm39) missense possibly damaging 0.53
R6160:Tm7sf3 UTSW 6 146,507,787 (GRCm39) nonsense probably null
R6229:Tm7sf3 UTSW 6 146,514,887 (GRCm39) missense possibly damaging 0.71
R6755:Tm7sf3 UTSW 6 146,511,471 (GRCm39) splice site probably null
R6912:Tm7sf3 UTSW 6 146,527,601 (GRCm39) missense possibly damaging 0.91
R6920:Tm7sf3 UTSW 6 146,507,645 (GRCm39) missense possibly damaging 0.71
R8913:Tm7sf3 UTSW 6 146,527,621 (GRCm39) nonsense probably null
R9364:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9365:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9367:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9371:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9372:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9396:Tm7sf3 UTSW 6 146,523,472 (GRCm39) missense possibly damaging 0.53
R9447:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9449:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9450:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9451:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9454:Tm7sf3 UTSW 6 146,520,041 (GRCm39) missense probably benign 0.00
R9495:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9496:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9497:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9514:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9516:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9551:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9552:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9553:Tm7sf3 UTSW 6 146,525,179 (GRCm39) missense possibly damaging 0.85
R9576:Tm7sf3 UTSW 6 146,511,335 (GRCm39) missense probably damaging 1.00
R9652:Tm7sf3 UTSW 6 146,527,698 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTCACCGGATAGATGCCAAACAGG -3'
(R):5'- GCTGCTCTCATTCCAAGGGTGATAC -3'

Sequencing Primer
(F):5'- GGATGAGTACCCAGTACCTTAGAC -3'
(R):5'- ATTCCAAGGGTGATACCTGTC -3'
Posted On 2013-05-09