Incidental Mutation 'R4704:Cux1'
| ID |
356285 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| MMRRC Submission |
041952-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.847)
|
| Stock # |
R4704 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 136278055 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 645
(V645A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135054
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005188]
[ENSMUST00000175918]
[ENSMUST00000175998]
[ENSMUST00000176216]
[ENSMUST00000176745]
[ENSMUST00000177297]
[ENSMUST00000196245]
[ENSMUST00000196447]
[ENSMUST00000196397]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005188
|
| SMART Domains |
Protein: ENSMUSP00000005188
Gene: ENSMUSG00000005057
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
16 |
N/A |
INTRINSIC |
|
Pfam:Phe_ZIP
|
17 |
73 |
9.3e-22 |
PFAM |
|
Blast:PH
|
95 |
168 |
2e-21 |
BLAST |
|
low complexity region
|
169 |
180 |
N/A |
INTRINSIC |
|
PH
|
187 |
301 |
4.97e-9 |
SMART |
|
low complexity region
|
340 |
350 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
404 |
N/A |
INTRINSIC |
|
SH2
|
407 |
492 |
1.38e-21 |
SMART |
|
low complexity region
|
509 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
548 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
AA Change: V439A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
AA Change: V439A
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176216
AA Change: V645A
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
AA Change: V645A
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
AA Change: V643A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
AA Change: V643A
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177297
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196245
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196447
|
| SMART Domains |
Protein: ENSMUSP00000142728
Gene: ENSMUSG00000005057
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Phe_ZIP
|
16 |
74 |
9.1e-28 |
PFAM |
|
Blast:PH
|
95 |
168 |
9e-22 |
BLAST |
|
low complexity region
|
169 |
180 |
N/A |
INTRINSIC |
|
PH
|
187 |
301 |
2.2e-11 |
SMART |
|
low complexity region
|
340 |
350 |
N/A |
INTRINSIC |
|
low complexity region
|
406 |
417 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196397
|
| SMART Domains |
Protein: ENSMUSP00000142398
Gene: ENSMUSG00000005057
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Phe_ZIP
|
16 |
74 |
1.5e-30 |
PFAM |
|
Blast:PH
|
95 |
168 |
2e-21 |
BLAST |
|
low complexity region
|
169 |
180 |
N/A |
INTRINSIC |
|
PH
|
187 |
301 |
4.97e-9 |
SMART |
|
low complexity region
|
340 |
350 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
404 |
N/A |
INTRINSIC |
|
SH2
|
407 |
492 |
1.38e-21 |
SMART |
|
low complexity region
|
509 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
548 |
576 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (89/92) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310057M21Rik |
A |
T |
7: 130,959,259 (GRCm39) |
M147K |
probably damaging |
Het |
| Abca13 |
A |
G |
11: 9,226,990 (GRCm39) |
D582G |
possibly damaging |
Het |
| Abca2 |
T |
C |
2: 25,333,424 (GRCm39) |
L1683P |
probably damaging |
Het |
| Adam39 |
A |
G |
8: 41,278,833 (GRCm39) |
H408R |
probably benign |
Het |
| Adcy4 |
A |
G |
14: 56,012,482 (GRCm39) |
S554P |
possibly damaging |
Het |
| Ahnak |
T |
C |
19: 8,990,545 (GRCm39) |
I3943T |
probably damaging |
Het |
| Ahnak |
T |
G |
19: 8,989,622 (GRCm39) |
|
probably benign |
Het |
| Alkal2 |
T |
A |
12: 30,937,195 (GRCm39) |
S109R |
probably damaging |
Het |
| Apobec4 |
A |
G |
1: 152,632,001 (GRCm39) |
T10A |
probably benign |
Het |
| Arhgef40 |
A |
G |
14: 52,239,767 (GRCm39) |
N1327S |
probably damaging |
Het |
| Arpc3 |
A |
G |
5: 122,538,471 (GRCm39) |
M1V |
probably null |
Het |
| Ascc1 |
A |
G |
10: 59,885,624 (GRCm39) |
Y225C |
probably damaging |
Het |
| Ascc3 |
A |
G |
10: 50,535,110 (GRCm39) |
I668V |
probably benign |
Het |
| Bdnf |
T |
A |
2: 109,554,037 (GRCm39) |
M137K |
possibly damaging |
Het |
| Cacna1b |
T |
C |
2: 24,544,475 (GRCm39) |
D1231G |
probably damaging |
Het |
| Cds2 |
T |
A |
2: 132,142,522 (GRCm39) |
Y239* |
probably null |
Het |
| Cpped1 |
G |
A |
16: 11,703,493 (GRCm39) |
|
probably benign |
Het |
| Ctu2 |
G |
A |
8: 123,206,042 (GRCm39) |
R261Q |
probably damaging |
Het |
| Cyp4f13 |
A |
G |
17: 33,144,709 (GRCm39) |
C401R |
probably damaging |
Het |
| Dpt |
T |
G |
1: 164,646,518 (GRCm39) |
Y162* |
probably null |
Het |
| Ednra |
A |
G |
8: 78,394,592 (GRCm39) |
|
probably benign |
Het |
| Eepd1 |
A |
G |
9: 25,394,122 (GRCm39) |
T129A |
probably benign |
Het |
| Eif2s1 |
A |
G |
12: 78,923,944 (GRCm39) |
T134A |
probably benign |
Het |
| Eloa |
A |
G |
4: 135,738,525 (GRCm39) |
V145A |
probably benign |
Het |
| Enam |
T |
A |
5: 88,651,650 (GRCm39) |
L1053* |
probably null |
Het |
| Eng |
T |
C |
2: 32,568,924 (GRCm39) |
S484P |
probably benign |
Het |
| Eogt |
A |
T |
6: 97,090,813 (GRCm39) |
V442E |
probably damaging |
Het |
| Fam185a |
C |
T |
5: 21,685,471 (GRCm39) |
|
probably benign |
Het |
| Gm4922 |
C |
T |
10: 18,660,567 (GRCm39) |
V52I |
probably benign |
Het |
| Gnao1 |
A |
G |
8: 94,538,004 (GRCm39) |
E14G |
probably benign |
Het |
| Gpr75 |
C |
A |
11: 30,841,110 (GRCm39) |
A5D |
probably benign |
Het |
| Hbq1b |
T |
A |
11: 32,237,448 (GRCm39) |
|
probably benign |
Het |
| Hdac7 |
G |
A |
15: 97,694,097 (GRCm39) |
T724M |
probably damaging |
Het |
| Ifi204 |
C |
A |
1: 173,587,927 (GRCm39) |
|
probably benign |
Het |
| Ift88 |
A |
G |
14: 57,718,307 (GRCm39) |
|
probably benign |
Het |
| Irak4 |
A |
G |
15: 94,464,781 (GRCm39) |
|
probably null |
Het |
| Kalrn |
T |
C |
16: 34,024,327 (GRCm39) |
D610G |
probably damaging |
Het |
| Kifc2 |
T |
C |
15: 76,547,177 (GRCm39) |
|
probably null |
Het |
| Kmt2c |
G |
A |
5: 25,519,025 (GRCm39) |
Q2362* |
probably null |
Het |
| Kntc1 |
G |
A |
5: 123,949,496 (GRCm39) |
E1956K |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,686,280 (GRCm39) |
V2781A |
probably benign |
Het |
| Lipt2 |
A |
G |
7: 99,809,534 (GRCm39) |
E207G |
probably damaging |
Het |
| Mag |
A |
T |
7: 30,608,598 (GRCm39) |
L172Q |
probably damaging |
Het |
| Map1b |
A |
T |
13: 99,566,983 (GRCm39) |
C1913S |
unknown |
Het |
| Mical3 |
A |
G |
6: 120,935,649 (GRCm39) |
S1626P |
probably benign |
Het |
| Mslnl |
G |
T |
17: 25,957,952 (GRCm39) |
W65L |
possibly damaging |
Het |
| Muc20 |
G |
T |
16: 32,599,448 (GRCm39) |
A3332S |
possibly damaging |
Het |
| Nadk |
C |
A |
4: 155,669,684 (GRCm39) |
P157T |
probably benign |
Het |
| Nkx2-3 |
G |
A |
19: 43,601,123 (GRCm39) |
E62K |
probably damaging |
Het |
| Or6c2 |
T |
C |
10: 129,362,171 (GRCm39) |
L25P |
possibly damaging |
Het |
| Pclo |
A |
G |
5: 14,726,494 (GRCm39) |
|
probably benign |
Het |
| Pcna-ps2 |
T |
A |
19: 9,260,786 (GRCm39) |
V15E |
possibly damaging |
Het |
| Plekhg3 |
G |
T |
12: 76,625,012 (GRCm39) |
G1285W |
probably damaging |
Het |
| Pramel29 |
A |
T |
4: 143,935,162 (GRCm39) |
I193N |
probably damaging |
Het |
| Procr |
A |
G |
2: 155,596,258 (GRCm39) |
S142G |
probably damaging |
Het |
| Ptpn3 |
A |
T |
4: 57,270,119 (GRCm39) |
N14K |
possibly damaging |
Het |
| Rin1 |
C |
A |
19: 5,105,018 (GRCm39) |
L693I |
probably damaging |
Het |
| Ripk4 |
C |
A |
16: 97,547,204 (GRCm39) |
E290* |
probably null |
Het |
| Rnf213 |
A |
G |
11: 119,331,175 (GRCm39) |
Y2128C |
probably damaging |
Het |
| Saal1 |
T |
C |
7: 46,349,164 (GRCm39) |
|
probably benign |
Het |
| Selplg |
T |
C |
5: 113,957,094 (GRCm39) |
D404G |
probably benign |
Het |
| Serpinf1 |
C |
A |
11: 75,301,867 (GRCm39) |
A263S |
probably damaging |
Het |
| Sgo2b |
A |
T |
8: 64,380,824 (GRCm39) |
D669E |
probably damaging |
Het |
| Slc30a9 |
T |
C |
5: 67,499,616 (GRCm39) |
|
probably benign |
Het |
| Sri |
A |
T |
5: 8,112,430 (GRCm39) |
|
probably null |
Het |
| Sspo |
G |
A |
6: 48,475,638 (GRCm39) |
C4918Y |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,251,026 (GRCm39) |
Y361H |
probably damaging |
Het |
| Tbc1d12 |
T |
A |
19: 38,889,781 (GRCm39) |
W404R |
probably damaging |
Het |
| Tcf20 |
T |
C |
15: 82,735,928 (GRCm39) |
E1841G |
possibly damaging |
Het |
| Tep1 |
T |
C |
14: 51,074,530 (GRCm39) |
T1832A |
probably benign |
Het |
| Tmem132e |
G |
A |
11: 82,334,357 (GRCm39) |
A623T |
probably damaging |
Het |
| Tmem201 |
A |
T |
4: 149,811,774 (GRCm39) |
F357Y |
possibly damaging |
Het |
| Trappc13 |
T |
G |
13: 104,303,329 (GRCm39) |
|
probably benign |
Het |
| Trav6-5 |
C |
T |
14: 53,728,883 (GRCm39) |
Q47* |
probably null |
Het |
| Ubxn1 |
T |
A |
19: 8,849,399 (GRCm39) |
D47E |
probably benign |
Het |
| Vmn2r45 |
G |
T |
7: 8,486,535 (GRCm39) |
S251* |
probably null |
Het |
| Wnk1 |
A |
G |
6: 119,942,705 (GRCm39) |
L774S |
possibly damaging |
Het |
| Zfp189 |
T |
C |
4: 49,530,081 (GRCm39) |
S395P |
probably damaging |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACAGCTGAGACAGTGCAG -3'
(R):5'- CATCTGGGAAGTAGGTTGGCTC -3'
Sequencing Primer
(F):5'- ATGGGTGACTACAGGGCTG -3'
(R):5'- AAGTAGGTTGGCTCAGGAGTATCTC -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation