Incidental Mutation 'R4735:Flnc'
| ID |
356452 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Flnc
|
| Ensembl Gene |
ENSMUSG00000068699 |
| Gene Name |
filamin C, gamma |
| Synonyms |
1110055E19Rik, Fln2, actin binding protein 280 |
| MMRRC Submission |
041962-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4735 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
29433255-29461882 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 29455812 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Serine
at position 2048
(G2048S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099139
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065090]
[ENSMUST00000101617]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000065090
AA Change: G2081S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000064163
Gene: ENSMUSG00000068699
AA Change: G2081S
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
39 |
141 |
1.17e-25 |
SMART |
|
CH
|
162 |
258 |
2.09e-22 |
SMART |
|
IG_FLMN
|
275 |
372 |
3.84e-38 |
SMART |
|
IG_FLMN
|
375 |
472 |
3.73e-36 |
SMART |
|
IG_FLMN
|
474 |
569 |
4.41e-38 |
SMART |
|
IG_FLMN
|
571 |
662 |
3.61e-34 |
SMART |
|
IG_FLMN
|
667 |
762 |
2.48e-41 |
SMART |
|
IG_FLMN
|
764 |
865 |
6.7e-29 |
SMART |
|
IG_FLMN
|
867 |
964 |
3.42e-35 |
SMART |
|
IG_FLMN
|
966 |
1060 |
2.92e-29 |
SMART |
|
IG_FLMN
|
1062 |
1153 |
3.69e-40 |
SMART |
|
IG_FLMN
|
1155 |
1248 |
6.53e-41 |
SMART |
|
IG_FLMN
|
1250 |
1348 |
7.23e-34 |
SMART |
|
IG_FLMN
|
1350 |
1441 |
2.04e-42 |
SMART |
|
IG_FLMN
|
1443 |
1537 |
1.75e-41 |
SMART |
|
IG_FLMN
|
1539 |
1634 |
1.31e-40 |
SMART |
|
IG_FLMN
|
1636 |
1738 |
1.05e-30 |
SMART |
|
IG_FLMN
|
1777 |
1858 |
2.93e-11 |
SMART |
|
IG_FLMN
|
1859 |
1950 |
2.55e-43 |
SMART |
|
IG_FLMN
|
1951 |
2037 |
2.43e-17 |
SMART |
|
IG_FLMN
|
2041 |
2132 |
1.52e-41 |
SMART |
|
PDB:2E9I|A
|
2133 |
2162 |
3e-7 |
PDB |
|
IG_FLMN
|
2217 |
2310 |
2.93e-11 |
SMART |
|
IG_FLMN
|
2314 |
2405 |
1.67e-38 |
SMART |
|
IG_FLMN
|
2408 |
2500 |
2.56e-25 |
SMART |
|
IG_FLMN
|
2505 |
2596 |
9.54e-34 |
SMART |
|
low complexity region
|
2618 |
2628 |
N/A |
INTRINSIC |
|
IG_FLMN
|
2635 |
2737 |
2.11e-26 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000101617
AA Change: G2048S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099139
Gene: ENSMUSG00000068699
AA Change: G2048S
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
39 |
141 |
1.17e-25 |
SMART |
|
CH
|
162 |
258 |
2.09e-22 |
SMART |
|
IG_FLMN
|
275 |
372 |
3.84e-38 |
SMART |
|
IG_FLMN
|
375 |
472 |
3.73e-36 |
SMART |
|
IG_FLMN
|
474 |
569 |
4.41e-38 |
SMART |
|
IG_FLMN
|
571 |
662 |
3.61e-34 |
SMART |
|
IG_FLMN
|
667 |
762 |
2.48e-41 |
SMART |
|
IG_FLMN
|
764 |
865 |
6.7e-29 |
SMART |
|
IG_FLMN
|
867 |
964 |
3.42e-35 |
SMART |
|
IG_FLMN
|
966 |
1060 |
2.92e-29 |
SMART |
|
IG_FLMN
|
1062 |
1153 |
3.69e-40 |
SMART |
|
IG_FLMN
|
1155 |
1248 |
6.53e-41 |
SMART |
|
IG_FLMN
|
1250 |
1348 |
7.23e-34 |
SMART |
|
IG_FLMN
|
1350 |
1441 |
2.04e-42 |
SMART |
|
IG_FLMN
|
1443 |
1537 |
1.75e-41 |
SMART |
|
IG_FLMN
|
1539 |
1634 |
1.31e-40 |
SMART |
|
IG_FLMN
|
1636 |
1738 |
6.11e-32 |
SMART |
|
IG_FLMN
|
1744 |
1825 |
2.93e-11 |
SMART |
|
IG_FLMN
|
1826 |
1917 |
2.55e-43 |
SMART |
|
IG_FLMN
|
1918 |
2004 |
2.43e-17 |
SMART |
|
IG_FLMN
|
2008 |
2099 |
1.52e-41 |
SMART |
|
PDB:2E9I|A
|
2100 |
2129 |
3e-7 |
PDB |
|
IG_FLMN
|
2184 |
2277 |
2.93e-11 |
SMART |
|
IG_FLMN
|
2281 |
2372 |
1.67e-38 |
SMART |
|
IG_FLMN
|
2375 |
2467 |
2.56e-25 |
SMART |
|
IG_FLMN
|
2472 |
2563 |
9.54e-34 |
SMART |
|
low complexity region
|
2585 |
2595 |
N/A |
INTRINSIC |
|
IG_FLMN
|
2602 |
2704 |
2.11e-26 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 133 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
A |
12: 71,262,897 (GRCm39) |
I1410N |
possibly damaging |
Het |
| 9230106D20Rik |
T |
C |
10: 19,536,001 (GRCm39) |
|
noncoding transcript |
Het |
| Acsf3 |
T |
A |
8: 123,508,218 (GRCm39) |
I238N |
probably damaging |
Het |
| Ahctf1 |
T |
C |
1: 179,580,964 (GRCm39) |
N1746S |
probably benign |
Het |
| Akap3 |
T |
C |
6: 126,842,601 (GRCm39) |
S407P |
probably damaging |
Het |
| Ankfy1 |
T |
A |
11: 72,621,437 (GRCm39) |
M241K |
probably benign |
Het |
| Ano7 |
C |
A |
1: 93,328,216 (GRCm39) |
T622K |
probably benign |
Het |
| App |
T |
C |
16: 84,900,202 (GRCm39) |
T83A |
probably damaging |
Het |
| Arhgef28 |
T |
A |
13: 98,036,237 (GRCm39) |
E1674V |
probably damaging |
Het |
| Asb2 |
C |
A |
12: 103,291,317 (GRCm39) |
V489L |
probably benign |
Het |
| Atrn |
T |
C |
2: 130,862,910 (GRCm39) |
V1330A |
probably benign |
Het |
| Bltp1 |
T |
A |
3: 37,059,116 (GRCm39) |
N3267K |
possibly damaging |
Het |
| Brca1 |
A |
G |
11: 101,383,001 (GRCm39) |
|
probably null |
Het |
| Bspry |
G |
A |
4: 62,404,762 (GRCm39) |
R186Q |
probably damaging |
Het |
| Ccdc168 |
A |
G |
1: 44,100,861 (GRCm39) |
I79T |
probably benign |
Het |
| Cdkn2d |
C |
G |
9: 21,202,185 (GRCm39) |
V21L |
probably benign |
Het |
| Celsr1 |
T |
A |
15: 85,790,230 (GRCm39) |
|
probably null |
Het |
| Ckap4 |
A |
G |
10: 84,369,384 (GRCm39) |
V116A |
possibly damaging |
Het |
| Crb3 |
A |
G |
17: 57,372,207 (GRCm39) |
T85A |
probably damaging |
Het |
| Cyld |
T |
C |
8: 89,456,278 (GRCm39) |
S443P |
probably damaging |
Het |
| Cyp27a1 |
T |
G |
1: 74,776,366 (GRCm39) |
V434G |
possibly damaging |
Het |
| Cyp2b13 |
A |
G |
7: 25,787,720 (GRCm39) |
T339A |
probably benign |
Het |
| Dars1 |
A |
T |
1: 128,303,971 (GRCm39) |
L252* |
probably null |
Het |
| Dcaf10 |
G |
A |
4: 45,372,769 (GRCm39) |
R394Q |
possibly damaging |
Het |
| Ddx55 |
T |
C |
5: 124,704,539 (GRCm39) |
F382S |
probably damaging |
Het |
| Dmtf1l |
T |
A |
X: 125,722,217 (GRCm39) |
K296M |
probably damaging |
Het |
| Dnah7b |
G |
A |
1: 46,106,115 (GRCm39) |
R33Q |
unknown |
Het |
| Dnm2 |
G |
T |
9: 21,385,883 (GRCm39) |
S302I |
probably damaging |
Het |
| Dock4 |
T |
A |
12: 40,681,525 (GRCm39) |
F75I |
probably benign |
Het |
| Dpp10 |
T |
C |
1: 123,326,356 (GRCm39) |
N365S |
probably benign |
Het |
| Dpy19l3 |
G |
T |
7: 35,422,146 (GRCm39) |
Q236K |
probably benign |
Het |
| Dsp |
T |
C |
13: 38,380,016 (GRCm39) |
S1655P |
probably damaging |
Het |
| Ebpl |
A |
T |
14: 61,579,567 (GRCm39) |
I117N |
probably damaging |
Het |
| Edc4 |
T |
A |
8: 106,613,818 (GRCm39) |
V386E |
probably damaging |
Het |
| Eif2s2 |
T |
A |
2: 154,720,467 (GRCm39) |
|
probably null |
Het |
| Elob |
A |
T |
17: 24,046,562 (GRCm39) |
|
probably null |
Het |
| Enox2 |
T |
C |
X: 48,158,554 (GRCm39) |
I71V |
probably damaging |
Het |
| Fez1 |
A |
T |
9: 36,772,141 (GRCm39) |
K149* |
probably null |
Het |
| Fhip2a |
A |
G |
19: 57,359,661 (GRCm39) |
E67G |
probably damaging |
Het |
| Fign |
A |
G |
2: 63,810,782 (GRCm39) |
Y163H |
probably damaging |
Het |
| Fras1 |
A |
G |
5: 96,736,022 (GRCm39) |
D539G |
probably benign |
Het |
| Frmd4b |
T |
C |
6: 97,436,220 (GRCm39) |
|
probably benign |
Het |
| Gan |
C |
T |
8: 117,920,970 (GRCm39) |
T402M |
probably damaging |
Het |
| Ganc |
T |
A |
2: 120,267,104 (GRCm39) |
|
silent |
Het |
| Ggt6 |
C |
A |
11: 72,327,425 (GRCm39) |
R103S |
probably benign |
Het |
| Gli2 |
T |
C |
1: 118,768,052 (GRCm39) |
D725G |
probably damaging |
Het |
| Gm15446 |
T |
A |
5: 110,090,818 (GRCm39) |
C357S |
probably damaging |
Het |
| Gm44501 |
A |
G |
17: 40,889,810 (GRCm39) |
N108S |
probably benign |
Het |
| Gm6309 |
A |
T |
5: 146,105,054 (GRCm39) |
D286E |
probably damaging |
Het |
| Gm6358 |
G |
A |
16: 88,937,848 (GRCm39) |
G29E |
unknown |
Het |
| Grik5 |
A |
G |
7: 24,757,713 (GRCm39) |
I422T |
probably damaging |
Het |
| Grin2c |
A |
G |
11: 115,140,422 (GRCm39) |
I1232T |
possibly damaging |
Het |
| Gsg1 |
C |
T |
6: 135,214,405 (GRCm39) |
R365H |
possibly damaging |
Het |
| H2-M2 |
A |
G |
17: 37,794,135 (GRCm39) |
S30P |
possibly damaging |
Het |
| Hcfc2 |
A |
G |
10: 82,547,914 (GRCm39) |
D302G |
probably damaging |
Het |
| Hk2 |
T |
C |
6: 82,721,955 (GRCm39) |
D128G |
probably benign |
Het |
| Hmcn2 |
C |
A |
2: 31,273,787 (GRCm39) |
Q1380K |
probably benign |
Het |
| Hsp90b1 |
G |
T |
10: 86,529,819 (GRCm39) |
P617T |
probably damaging |
Het |
| Htr1d |
A |
G |
4: 136,170,197 (GRCm39) |
E142G |
probably benign |
Het |
| Hydin |
G |
A |
8: 111,282,264 (GRCm39) |
|
probably null |
Het |
| Il1r1 |
T |
A |
1: 40,332,455 (GRCm39) |
N81K |
probably benign |
Het |
| Inpp5b |
T |
C |
4: 124,677,760 (GRCm39) |
S407P |
probably damaging |
Het |
| Itpkb |
T |
C |
1: 180,245,780 (GRCm39) |
Y766H |
probably damaging |
Het |
| Lyrm2 |
T |
A |
4: 32,801,150 (GRCm39) |
I65N |
probably damaging |
Het |
| Mink1 |
T |
A |
11: 70,500,086 (GRCm39) |
|
probably null |
Het |
| Mkrn3 |
C |
T |
7: 62,069,452 (GRCm39) |
R113H |
probably damaging |
Het |
| Msx3 |
G |
A |
7: 139,627,798 (GRCm39) |
A157V |
probably damaging |
Het |
| Nrxn2 |
T |
G |
19: 6,548,484 (GRCm39) |
V59G |
possibly damaging |
Het |
| Nt5c3b |
T |
C |
11: 100,331,732 (GRCm39) |
T12A |
probably benign |
Het |
| Nwd2 |
G |
A |
5: 63,965,594 (GRCm39) |
R1726Q |
probably benign |
Het |
| Nynrin |
A |
G |
14: 56,107,625 (GRCm39) |
T911A |
probably benign |
Het |
| Or11i1 |
T |
A |
3: 106,728,996 (GRCm39) |
Y293F |
probably damaging |
Het |
| Or4p18 |
T |
C |
2: 88,233,267 (GRCm39) |
T4A |
probably benign |
Het |
| Or51aa5 |
A |
G |
7: 103,167,030 (GRCm39) |
I187T |
possibly damaging |
Het |
| Or51af1 |
C |
T |
7: 103,141,267 (GRCm39) |
V273M |
possibly damaging |
Het |
| Or52n20 |
C |
T |
7: 104,320,200 (GRCm39) |
T97I |
probably benign |
Het |
| Or5p66 |
A |
G |
7: 107,885,520 (GRCm39) |
M271T |
probably benign |
Het |
| Or6c212 |
A |
G |
10: 129,558,792 (GRCm39) |
I207T |
probably benign |
Het |
| Patl1 |
G |
T |
19: 11,899,869 (GRCm39) |
M220I |
probably benign |
Het |
| Pcnx2 |
A |
T |
8: 126,554,780 (GRCm39) |
|
probably null |
Het |
| Pigr |
A |
T |
1: 130,774,291 (GRCm39) |
T424S |
probably damaging |
Het |
| Pik3c2b |
T |
A |
1: 132,994,787 (GRCm39) |
D250E |
probably benign |
Het |
| Ppa2 |
G |
A |
3: 133,076,186 (GRCm39) |
E272K |
probably benign |
Het |
| Pramel7 |
G |
A |
2: 87,321,187 (GRCm39) |
Q283* |
probably null |
Het |
| Prelid3b |
A |
G |
2: 174,307,683 (GRCm39) |
I81T |
probably benign |
Het |
| Prpf38a |
T |
C |
4: 108,436,242 (GRCm39) |
I24V |
possibly damaging |
Het |
| Ptger2 |
A |
G |
14: 45,239,295 (GRCm39) |
D311G |
possibly damaging |
Het |
| Rab4b |
A |
T |
7: 26,872,191 (GRCm39) |
|
probably benign |
Het |
| Rad17 |
A |
C |
13: 100,755,637 (GRCm39) |
D581E |
probably damaging |
Het |
| Samd11 |
T |
C |
4: 156,333,230 (GRCm39) |
T333A |
probably benign |
Het |
| Scaf4 |
C |
T |
16: 90,049,320 (GRCm39) |
D256N |
unknown |
Het |
| Serinc2 |
A |
G |
4: 130,157,438 (GRCm39) |
F82L |
probably benign |
Het |
| Serpina3g |
T |
A |
12: 104,205,372 (GRCm39) |
V37E |
probably damaging |
Het |
| Serpinb9c |
T |
A |
13: 33,334,254 (GRCm39) |
M263L |
probably benign |
Het |
| Shbg |
A |
G |
11: 69,508,326 (GRCm39) |
I67T |
possibly damaging |
Het |
| Slc25a48 |
G |
A |
13: 56,596,887 (GRCm39) |
|
probably null |
Het |
| Slc25a54 |
T |
C |
3: 109,005,923 (GRCm39) |
W144R |
probably damaging |
Het |
| Slc34a1 |
A |
T |
13: 55,561,397 (GRCm39) |
T621S |
probably benign |
Het |
| Slc6a18 |
A |
T |
13: 73,814,554 (GRCm39) |
C419S |
probably benign |
Het |
| Smc5 |
A |
T |
19: 23,220,069 (GRCm39) |
D389E |
probably benign |
Het |
| Smco3 |
T |
A |
6: 136,808,636 (GRCm39) |
E79D |
probably damaging |
Het |
| Sox5 |
A |
G |
6: 143,906,561 (GRCm39) |
F298S |
probably damaging |
Het |
| Sphkap |
A |
G |
1: 83,256,838 (GRCm39) |
S304P |
probably benign |
Het |
| Tcea2 |
C |
T |
2: 181,328,514 (GRCm39) |
T211I |
probably damaging |
Het |
| Tcf4 |
G |
T |
18: 69,697,226 (GRCm39) |
S34I |
possibly damaging |
Het |
| Tlr4 |
C |
T |
4: 66,759,435 (GRCm39) |
R743C |
probably damaging |
Het |
| Tmem183a |
T |
C |
1: 134,288,620 (GRCm39) |
E67G |
probably damaging |
Het |
| Tpr |
C |
T |
1: 150,317,947 (GRCm39) |
R2152C |
possibly damaging |
Het |
| Trbv15 |
T |
C |
6: 41,118,358 (GRCm39) |
I38T |
probably benign |
Het |
| Treh |
G |
A |
9: 44,592,849 (GRCm39) |
A125T |
probably damaging |
Het |
| Trio |
A |
T |
15: 27,752,875 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,782,293 (GRCm39) |
V981A |
probably damaging |
Het |
| Uap1l1 |
A |
G |
2: 25,252,732 (GRCm39) |
L436P |
probably damaging |
Het |
| Uba7 |
A |
T |
9: 107,854,115 (GRCm39) |
I182F |
possibly damaging |
Het |
| Unc13c |
A |
T |
9: 73,600,620 (GRCm39) |
S1375T |
probably benign |
Het |
| Usp48 |
C |
CT |
4: 137,360,680 (GRCm39) |
|
probably null |
Het |
| Utp20 |
A |
C |
10: 88,652,780 (GRCm39) |
V378G |
possibly damaging |
Het |
| Vmn1r69 |
A |
T |
7: 10,314,926 (GRCm39) |
|
probably benign |
Het |
| Vmn1r86 |
A |
T |
7: 12,836,221 (GRCm39) |
H218Q |
probably damaging |
Het |
| Vmn2r121 |
T |
A |
X: 123,038,335 (GRCm39) |
I562L |
probably benign |
Het |
| Vmn2r45 |
A |
T |
7: 8,486,472 (GRCm39) |
I272N |
probably damaging |
Het |
| Wdr90 |
A |
G |
17: 26,078,424 (GRCm39) |
V320A |
probably benign |
Het |
| Wfikkn1 |
A |
G |
17: 26,097,367 (GRCm39) |
V319A |
possibly damaging |
Het |
| Whamm |
A |
G |
7: 81,221,122 (GRCm39) |
D18G |
probably benign |
Het |
| Wrn |
T |
A |
8: 33,775,250 (GRCm39) |
I605F |
probably damaging |
Het |
| Zdhhc18 |
A |
G |
4: 133,341,178 (GRCm39) |
F232L |
probably damaging |
Het |
| Zfp41 |
T |
C |
15: 75,490,609 (GRCm39) |
I187T |
probably benign |
Het |
| Zfp418 |
A |
G |
7: 7,185,561 (GRCm39) |
Y508C |
probably damaging |
Het |
| Zfp560 |
T |
G |
9: 20,260,347 (GRCm39) |
I172L |
probably benign |
Het |
| Zfp943 |
A |
T |
17: 22,211,391 (GRCm39) |
D159V |
probably benign |
Het |
| Zfp955a |
T |
C |
17: 33,460,696 (GRCm39) |
I479V |
probably benign |
Het |
| Zfpm1 |
T |
A |
8: 123,062,219 (GRCm39) |
V426D |
probably benign |
Het |
| Zic1 |
C |
T |
9: 91,246,558 (GRCm39) |
M171I |
possibly damaging |
Het |
|
| Other mutations in Flnc |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00952:Flnc
|
APN |
6 |
29,459,546 (GRCm39) |
nonsense |
probably null |
|
|
IGL01099:Flnc
|
APN |
6 |
29,433,617 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01656:Flnc
|
APN |
6 |
29,443,507 (GRCm39) |
splice site |
probably benign |
|
|
IGL01659:Flnc
|
APN |
6 |
29,448,670 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01780:Flnc
|
APN |
6 |
29,438,492 (GRCm39) |
nonsense |
probably null |
|
|
IGL01935:Flnc
|
APN |
6 |
29,454,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02039:Flnc
|
APN |
6 |
29,450,718 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02119:Flnc
|
APN |
6 |
29,447,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02122:Flnc
|
APN |
6 |
29,444,335 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02236:Flnc
|
APN |
6 |
29,454,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Flnc
|
APN |
6 |
29,438,492 (GRCm39) |
nonsense |
probably null |
|
|
IGL02357:Flnc
|
APN |
6 |
29,438,492 (GRCm39) |
nonsense |
probably null |
|
|
IGL02428:Flnc
|
APN |
6 |
29,451,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02496:Flnc
|
APN |
6 |
29,440,684 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02516:Flnc
|
APN |
6 |
29,450,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02696:Flnc
|
APN |
6 |
29,446,697 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03165:Flnc
|
APN |
6 |
29,449,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03190:Flnc
|
APN |
6 |
29,445,636 (GRCm39) |
splice site |
probably benign |
|
|
I1329:Flnc
|
UTSW |
6 |
29,451,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0111:Flnc
|
UTSW |
6 |
29,454,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0665:Flnc
|
UTSW |
6 |
29,455,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0748:Flnc
|
UTSW |
6 |
29,446,343 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0960:Flnc
|
UTSW |
6 |
29,441,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1328:Flnc
|
UTSW |
6 |
29,438,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Flnc
|
UTSW |
6 |
29,438,693 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1544:Flnc
|
UTSW |
6 |
29,444,079 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1565:Flnc
|
UTSW |
6 |
29,455,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Flnc
|
UTSW |
6 |
29,433,806 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1691:Flnc
|
UTSW |
6 |
29,441,213 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1818:Flnc
|
UTSW |
6 |
29,457,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Flnc
|
UTSW |
6 |
29,455,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1851:Flnc
|
UTSW |
6 |
29,443,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1898:Flnc
|
UTSW |
6 |
29,438,665 (GRCm39) |
nonsense |
probably null |
|
|
R1905:Flnc
|
UTSW |
6 |
29,459,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Flnc
|
UTSW |
6 |
29,444,415 (GRCm39) |
splice site |
probably benign |
|
|
R2016:Flnc
|
UTSW |
6 |
29,443,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2017:Flnc
|
UTSW |
6 |
29,443,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2020:Flnc
|
UTSW |
6 |
29,444,362 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2104:Flnc
|
UTSW |
6 |
29,450,734 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2132:Flnc
|
UTSW |
6 |
29,443,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2141:Flnc
|
UTSW |
6 |
29,448,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2197:Flnc
|
UTSW |
6 |
29,459,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Flnc
|
UTSW |
6 |
29,459,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2203:Flnc
|
UTSW |
6 |
29,459,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2204:Flnc
|
UTSW |
6 |
29,459,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Flnc
|
UTSW |
6 |
29,459,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Flnc
|
UTSW |
6 |
29,455,844 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2248:Flnc
|
UTSW |
6 |
29,451,400 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2258:Flnc
|
UTSW |
6 |
29,438,665 (GRCm39) |
nonsense |
probably null |
|
|
R2259:Flnc
|
UTSW |
6 |
29,438,665 (GRCm39) |
nonsense |
probably null |
|
|
R2280:Flnc
|
UTSW |
6 |
29,438,665 (GRCm39) |
nonsense |
probably null |
|
|
R2281:Flnc
|
UTSW |
6 |
29,438,665 (GRCm39) |
nonsense |
probably null |
|
|
R2873:Flnc
|
UTSW |
6 |
29,447,542 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2900:Flnc
|
UTSW |
6 |
29,448,584 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3788:Flnc
|
UTSW |
6 |
29,454,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3799:Flnc
|
UTSW |
6 |
29,443,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Flnc
|
UTSW |
6 |
29,447,403 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3851:Flnc
|
UTSW |
6 |
29,453,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3910:Flnc
|
UTSW |
6 |
29,459,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Flnc
|
UTSW |
6 |
29,442,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3983:Flnc
|
UTSW |
6 |
29,442,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4023:Flnc
|
UTSW |
6 |
29,451,634 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4676:Flnc
|
UTSW |
6 |
29,445,153 (GRCm39) |
splice site |
probably null |
|
|
R4694:Flnc
|
UTSW |
6 |
29,443,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4695:Flnc
|
UTSW |
6 |
29,440,428 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4773:Flnc
|
UTSW |
6 |
29,445,038 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4828:Flnc
|
UTSW |
6 |
29,455,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4856:Flnc
|
UTSW |
6 |
29,447,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Flnc
|
UTSW |
6 |
29,460,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4899:Flnc
|
UTSW |
6 |
29,446,842 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4906:Flnc
|
UTSW |
6 |
29,447,524 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5089:Flnc
|
UTSW |
6 |
29,447,812 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5173:Flnc
|
UTSW |
6 |
29,455,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Flnc
|
UTSW |
6 |
29,448,893 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5290:Flnc
|
UTSW |
6 |
29,457,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5338:Flnc
|
UTSW |
6 |
29,444,063 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5352:Flnc
|
UTSW |
6 |
29,449,317 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5397:Flnc
|
UTSW |
6 |
29,441,160 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5431:Flnc
|
UTSW |
6 |
29,456,383 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5481:Flnc
|
UTSW |
6 |
29,441,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5511:Flnc
|
UTSW |
6 |
29,458,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5539:Flnc
|
UTSW |
6 |
29,446,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5549:Flnc
|
UTSW |
6 |
29,453,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Flnc
|
UTSW |
6 |
29,444,044 (GRCm39) |
nonsense |
probably null |
|
|
R5584:Flnc
|
UTSW |
6 |
29,446,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5689:Flnc
|
UTSW |
6 |
29,441,591 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5753:Flnc
|
UTSW |
6 |
29,433,488 (GRCm39) |
missense |
probably benign |
|
|
R5786:Flnc
|
UTSW |
6 |
29,459,536 (GRCm39) |
nonsense |
probably null |
|
|
R5822:Flnc
|
UTSW |
6 |
29,459,429 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5823:Flnc
|
UTSW |
6 |
29,461,201 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5933:Flnc
|
UTSW |
6 |
29,441,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6043:Flnc
|
UTSW |
6 |
29,446,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6320:Flnc
|
UTSW |
6 |
29,459,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Flnc
|
UTSW |
6 |
29,454,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6399:Flnc
|
UTSW |
6 |
29,458,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6423:Flnc
|
UTSW |
6 |
29,445,155 (GRCm39) |
splice site |
probably null |
|
|
R6540:Flnc
|
UTSW |
6 |
29,446,376 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6547:Flnc
|
UTSW |
6 |
29,448,607 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6717:Flnc
|
UTSW |
6 |
29,450,901 (GRCm39) |
small deletion |
probably benign |
|
|
R6875:Flnc
|
UTSW |
6 |
29,445,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Flnc
|
UTSW |
6 |
29,450,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7255:Flnc
|
UTSW |
6 |
29,445,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7303:Flnc
|
UTSW |
6 |
29,460,849 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7413:Flnc
|
UTSW |
6 |
29,452,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Flnc
|
UTSW |
6 |
29,455,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7559:Flnc
|
UTSW |
6 |
29,459,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7632:Flnc
|
UTSW |
6 |
29,446,984 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Flnc
|
UTSW |
6 |
29,444,049 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7679:Flnc
|
UTSW |
6 |
29,456,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7697:Flnc
|
UTSW |
6 |
29,456,516 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7788:Flnc
|
UTSW |
6 |
29,456,443 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7852:Flnc
|
UTSW |
6 |
29,440,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7870:Flnc
|
UTSW |
6 |
29,454,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7873:Flnc
|
UTSW |
6 |
29,456,990 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7921:Flnc
|
UTSW |
6 |
29,447,769 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7950:Flnc
|
UTSW |
6 |
29,456,381 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7953:Flnc
|
UTSW |
6 |
29,447,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7970:Flnc
|
UTSW |
6 |
29,447,525 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8071:Flnc
|
UTSW |
6 |
29,457,445 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8143:Flnc
|
UTSW |
6 |
29,441,484 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8166:Flnc
|
UTSW |
6 |
29,433,731 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8167:Flnc
|
UTSW |
6 |
29,455,921 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8306:Flnc
|
UTSW |
6 |
29,449,369 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8428:Flnc
|
UTSW |
6 |
29,450,849 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8466:Flnc
|
UTSW |
6 |
29,438,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8671:Flnc
|
UTSW |
6 |
29,443,501 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8885:Flnc
|
UTSW |
6 |
29,455,410 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8922:Flnc
|
UTSW |
6 |
29,456,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8923:Flnc
|
UTSW |
6 |
29,452,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8985:Flnc
|
UTSW |
6 |
29,440,499 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9075:Flnc
|
UTSW |
6 |
29,447,646 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9098:Flnc
|
UTSW |
6 |
29,455,518 (GRCm39) |
nonsense |
probably null |
|
|
R9162:Flnc
|
UTSW |
6 |
29,455,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9199:Flnc
|
UTSW |
6 |
29,441,490 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9204:Flnc
|
UTSW |
6 |
29,452,353 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9273:Flnc
|
UTSW |
6 |
29,447,815 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9411:Flnc
|
UTSW |
6 |
29,441,484 (GRCm39) |
missense |
probably benign |
|
|
R9412:Flnc
|
UTSW |
6 |
29,441,484 (GRCm39) |
missense |
probably benign |
|
|
R9413:Flnc
|
UTSW |
6 |
29,441,484 (GRCm39) |
missense |
probably benign |
|
|
R9451:Flnc
|
UTSW |
6 |
29,445,462 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9524:Flnc
|
UTSW |
6 |
29,461,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Flnc
|
UTSW |
6 |
29,454,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9582:Flnc
|
UTSW |
6 |
29,460,736 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9595:Flnc
|
UTSW |
6 |
29,433,720 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9664:Flnc
|
UTSW |
6 |
29,457,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Flnc
|
UTSW |
6 |
29,455,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9686:Flnc
|
UTSW |
6 |
29,456,434 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
Z1088:Flnc
|
UTSW |
6 |
29,457,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Flnc
|
UTSW |
6 |
29,457,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Flnc
|
UTSW |
6 |
29,447,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCACTCCAGATTCTTGTCC -3'
(R):5'- AGGAGAAGATCATGTTCACAGGTC -3'
Sequencing Primer
(F):5'- CTGTGGCCTCCCTCTGG -3'
(R):5'- CTTACCAGGTACGTGCTT -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation