Incidental Mutation 'R4745:Bag2'
ID 356618
Institutional Source Beutler Lab
Gene Symbol Bag2
Ensembl Gene ENSMUSG00000042215
Gene Name BCL2-associated athanogene 2
Synonyms 2610042A13Rik
MMRRC Submission 042028-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R4745 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 33784565-33796831 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 33787417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000042009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044691] [ENSMUST00000187602]
AlphaFold Q91YN9
PDB Structure Chaperone Complex [X-RAY DIFFRACTION]
Structure of the BNB domain of the Hsp70 cochaperone Bag2 [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000044691
SMART Domains Protein: ENSMUSP00000042009
Gene: ENSMUSG00000042215

DomainStartEndE-ValueType
coiled coil region 20 60 N/A INTRINSIC
BAG 109 189 4.18e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155484
Predicted Effect probably benign
Transcript: ENSMUST00000187602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195310
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 97% (89/92)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,526,427 (GRCm39) Y619C probably damaging Het
Adck1 A G 12: 88,368,949 (GRCm39) probably null Het
Agap3 A C 5: 24,656,123 (GRCm39) probably null Het
Ankib1 A T 5: 3,782,566 (GRCm39) H354Q probably damaging Het
Ankrd29 T G 18: 12,387,679 (GRCm39) N301T probably benign Het
Arhgef4 A G 1: 34,846,356 (GRCm39) T379A probably damaging Het
Arid1a A G 4: 133,480,417 (GRCm39) V169A probably benign Het
Bmt2 A C 6: 13,628,686 (GRCm39) Y332* probably null Het
Bpifb1 A T 2: 154,053,501 (GRCm39) K248* probably null Het
Caap1 C A 4: 94,444,751 (GRCm39) probably null Het
Calcr T A 6: 3,692,576 (GRCm39) Y389F probably damaging Het
Capn1 C T 19: 6,043,946 (GRCm39) V562I probably benign Het
Ccr1 T A 9: 123,763,985 (GRCm39) T182S probably benign Het
Ceacam15 T C 7: 16,407,259 (GRCm39) D86G probably benign Het
Cldnd1 C T 16: 58,550,006 (GRCm39) T63I probably benign Het
Col12a1 A T 9: 79,559,368 (GRCm39) probably null Het
Cystm1 A G 18: 36,526,348 (GRCm39) probably benign Het
Ddx55 T A 5: 124,705,028 (GRCm39) Y428* probably null Het
Ensa G A 3: 95,538,745 (GRCm39) G118D probably benign Het
Folh1 A T 7: 86,372,482 (GRCm39) probably null Het
Foxj2 C A 6: 122,814,948 (GRCm39) P328Q probably damaging Het
Fscn3 A G 6: 28,435,627 (GRCm39) I417V probably damaging Het
Galnt7 T C 8: 57,995,761 (GRCm39) probably benign Het
Gm11563 T A 11: 99,549,246 (GRCm39) *169C probably null Het
Hfm1 A T 5: 107,049,709 (GRCm39) D417E possibly damaging Het
Ighv15-2 A G 12: 114,528,230 (GRCm39) S107P probably damaging Het
Itsn2 A G 12: 4,711,944 (GRCm39) D904G probably damaging Het
Kif1b A T 4: 149,322,339 (GRCm39) L860* probably null Het
Krt79 T C 15: 101,839,119 (GRCm39) E450G probably damaging Het
Lama1 T C 17: 68,045,775 (GRCm39) S227P probably damaging Het
Lamp5 C A 2: 135,902,786 (GRCm39) H168Q probably benign Het
Lilra5 A T 7: 4,245,076 (GRCm39) Q240L possibly damaging Het
Lrp1 A T 10: 127,385,813 (GRCm39) C3521S probably benign Het
Mroh1 T A 15: 76,292,730 (GRCm39) probably null Het
Nlrp4g A T 9: 124,349,515 (GRCm38) noncoding transcript Het
Nr2f6 A T 8: 71,831,179 (GRCm39) I70N probably benign Het
Nr4a2 T A 2: 57,000,163 (GRCm39) D311V probably damaging Het
Odad2 G A 18: 7,286,763 (GRCm39) T156M probably benign Het
Or10w1 T A 19: 13,632,750 (GRCm39) M319K probably benign Het
Or10x4 T C 1: 174,219,442 (GRCm39) L269P probably damaging Het
Or52n20 T A 7: 104,320,711 (GRCm39) F267L probably damaging Het
Pcdhb6 C A 18: 37,468,426 (GRCm39) A449D possibly damaging Het
Pcgf6 A G 19: 47,036,545 (GRCm39) probably null Het
Prc1 C A 7: 79,962,911 (GRCm39) H131Q probably benign Het
Ptprq C A 10: 107,360,114 (GRCm39) R2187L probably damaging Het
Rasl2-9 C A 7: 5,128,702 (GRCm39) R76L possibly damaging Het
Rdh16f1 A T 10: 127,626,685 (GRCm39) Y246F probably benign Het
Rit1 T C 3: 88,624,982 (GRCm39) probably benign Het
Sash1 A G 10: 8,605,672 (GRCm39) V906A probably benign Het
Scnn1b T C 7: 121,501,509 (GRCm39) V108A probably benign Het
Sema4f A T 6: 82,895,265 (GRCm39) I356N probably damaging Het
Shc4 A T 2: 125,491,197 (GRCm39) L447Q probably damaging Het
Slc24a1 T C 9: 64,856,758 (GRCm39) M50V unknown Het
Slc28a3 T A 13: 58,722,077 (GRCm39) D269V possibly damaging Het
Slc35e1 A G 8: 73,246,166 (GRCm39) S89P possibly damaging Het
Smpd5 T A 15: 76,179,008 (GRCm39) H125Q probably benign Het
Snapc2 A G 8: 4,304,578 (GRCm39) T31A probably damaging Het
Sox5 G C 6: 143,779,214 (GRCm39) H606D possibly damaging Het
Spag6 A G 2: 18,742,107 (GRCm39) T367A possibly damaging Het
Spag8 T C 4: 43,651,636 (GRCm39) T413A probably damaging Het
Sptlc3 G A 2: 139,389,087 (GRCm39) G156R probably damaging Het
Stx19 A G 16: 62,642,783 (GRCm39) T200A probably benign Het
Tas2r116 A G 6: 132,832,668 (GRCm39) T90A probably benign Het
Tasor2 G A 13: 3,640,069 (GRCm39) T356I probably benign Het
Tbl3 A G 17: 24,924,304 (GRCm39) probably benign Het
Tekt5 G T 16: 10,213,058 (GRCm39) P76T probably damaging Het
Tjp2 C T 19: 24,074,030 (GRCm39) E1086K possibly damaging Het
Topbp1 T C 9: 103,200,770 (GRCm39) L601P probably damaging Het
Trav16 T A 14: 53,980,934 (GRCm39) M41K possibly damaging Het
Trav6-5 C A 14: 53,728,960 (GRCm39) N72K probably benign Het
Trpm3 C G 19: 22,692,659 (GRCm39) T250S possibly damaging Het
Vps35 A T 8: 85,987,891 (GRCm39) D753E probably benign Het
Vstm2a A T 11: 16,213,061 (GRCm39) N149Y probably damaging Het
Vwa2 G T 19: 56,895,318 (GRCm39) M497I probably benign Het
Zfat C A 15: 68,052,223 (GRCm39) V517L probably benign Het
Zfp169 C A 13: 48,643,708 (GRCm39) R473L possibly damaging Het
Zfp672 T C 11: 58,220,324 (GRCm39) probably benign Het
Zranb1 T C 7: 132,574,443 (GRCm39) V420A probably damaging Het
Other mutations in Bag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01635:Bag2 APN 1 33,786,013 (GRCm39) missense possibly damaging 0.86
R0568:Bag2 UTSW 1 33,786,059 (GRCm39) missense probably benign 0.01
R2144:Bag2 UTSW 1 33,785,912 (GRCm39) missense possibly damaging 0.87
R3712:Bag2 UTSW 1 33,785,997 (GRCm39) missense probably benign 0.11
R4663:Bag2 UTSW 1 33,786,074 (GRCm39) missense probably damaging 1.00
R4828:Bag2 UTSW 1 33,785,968 (GRCm39) missense probably damaging 0.99
R4859:Bag2 UTSW 1 33,786,022 (GRCm39) missense probably damaging 1.00
R4911:Bag2 UTSW 1 33,787,357 (GRCm39) missense probably benign
R5643:Bag2 UTSW 1 33,786,034 (GRCm39) missense probably damaging 0.99
R5644:Bag2 UTSW 1 33,786,034 (GRCm39) missense probably damaging 0.99
R6899:Bag2 UTSW 1 33,785,912 (GRCm39) missense possibly damaging 0.87
R8518:Bag2 UTSW 1 33,787,358 (GRCm39) missense probably benign
R9025:Bag2 UTSW 1 33,785,905 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TTACTGCTGAACGGGGTCAG -3'
(R):5'- CACCCAGGGAAGAAACTGTTTG -3'

Sequencing Primer
(F):5'- AGGCAAGCCCTGACTCACG -3'
(R):5'- AGACAAGGTTTCTCTGTGTAGCCC -3'
Posted On 2015-11-11