Incidental Mutation 'R4760:Ralgapa2'
| ID |
356775 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
041974-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.250)
|
| Stock # |
R4760 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 146188669 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1371
(L1371Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153734
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109986
AA Change: L1324Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: L1324Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131824
AA Change: L1286Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: L1286Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000146307
AA Change: L312Q
|
| SMART Domains |
Protein: ENSMUSP00000114547
Gene: ENSMUSG00000037110
AA Change: L312Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
285 |
290 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
690 |
830 |
4.9e-39 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000149499
AA Change: L956Q
|
| SMART Domains |
Protein: ENSMUSP00000122017
Gene: ENSMUSG00000037110
AA Change: L956Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
650 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
934 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1334 |
1511 |
2.4e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228797
AA Change: L1371Q
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.4%
|
| Validation Efficiency |
98% (90/92) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530053G22Rik |
A |
G |
6: 60,379,086 (GRCm39) |
|
noncoding transcript |
Het |
| Abcc2 |
A |
T |
19: 43,798,920 (GRCm39) |
Y512F |
probably benign |
Het |
| Adgrb1 |
T |
A |
15: 74,443,312 (GRCm39) |
I51N |
probably damaging |
Het |
| Adhfe1 |
A |
G |
1: 9,633,748 (GRCm39) |
Y332C |
probably damaging |
Het |
| Ambn |
C |
T |
5: 88,615,566 (GRCm39) |
L317F |
probably damaging |
Het |
| Amn1 |
T |
C |
6: 149,086,611 (GRCm39) |
Y17C |
probably benign |
Het |
| Apoa5 |
T |
C |
9: 46,181,593 (GRCm39) |
V223A |
probably damaging |
Het |
| Best3 |
A |
T |
10: 116,860,699 (GRCm39) |
H653L |
probably benign |
Het |
| Btnl2 |
C |
A |
17: 34,582,169 (GRCm39) |
S245Y |
probably damaging |
Het |
| Camk1d |
A |
G |
2: 5,366,867 (GRCm39) |
L116P |
probably damaging |
Het |
| Catsperg2 |
T |
A |
7: 29,405,060 (GRCm39) |
D698V |
probably damaging |
Het |
| Cd33 |
T |
C |
7: 43,178,919 (GRCm39) |
T307A |
probably benign |
Het |
| Cdk8 |
C |
T |
5: 146,229,476 (GRCm39) |
S230L |
probably benign |
Het |
| Cfap69 |
C |
T |
5: 5,696,939 (GRCm39) |
C119Y |
probably damaging |
Het |
| Chat |
T |
C |
14: 32,175,694 (GRCm39) |
N122S |
probably benign |
Het |
| Col20a1 |
A |
T |
2: 180,626,196 (GRCm39) |
|
probably benign |
Het |
| Cyp2j9 |
A |
T |
4: 96,457,028 (GRCm39) |
L481Q |
probably damaging |
Het |
| Dab1 |
A |
C |
4: 104,589,342 (GRCm39) |
S550R |
probably damaging |
Het |
| Dlgap2 |
A |
C |
8: 14,823,380 (GRCm39) |
Q533P |
probably damaging |
Het |
| Eif4g3 |
A |
T |
4: 137,811,629 (GRCm39) |
Q31L |
possibly damaging |
Het |
| Ets2 |
G |
A |
16: 95,520,087 (GRCm39) |
V438M |
probably damaging |
Het |
| Eva1c |
G |
A |
16: 90,701,138 (GRCm39) |
D258N |
probably benign |
Het |
| Fastkd2 |
A |
G |
1: 63,785,045 (GRCm39) |
H477R |
probably benign |
Het |
| Fga |
T |
G |
3: 82,938,821 (GRCm39) |
S399A |
probably benign |
Het |
| Fmo4 |
T |
A |
1: 162,637,396 (GRCm39) |
E32V |
probably damaging |
Het |
| Gm7204 |
T |
A |
16: 48,039,051 (GRCm39) |
|
noncoding transcript |
Het |
| Gpi-ps |
G |
A |
8: 5,690,473 (GRCm39) |
|
noncoding transcript |
Het |
| Hhipl1 |
A |
G |
12: 108,286,336 (GRCm39) |
I548V |
probably damaging |
Het |
| Hsfy2 |
T |
C |
1: 56,676,349 (GRCm39) |
T63A |
probably benign |
Het |
| Igf2r |
A |
G |
17: 12,922,352 (GRCm39) |
V1254A |
possibly damaging |
Het |
| Ighv8-4 |
A |
T |
12: 114,987,667 (GRCm39) |
D110E |
probably damaging |
Het |
| Igkv14-130 |
T |
C |
6: 67,768,446 (GRCm39) |
S101P |
probably benign |
Het |
| Igkv9-120 |
G |
T |
6: 68,027,351 (GRCm39) |
R88S |
possibly damaging |
Het |
| Ipo5 |
T |
C |
14: 121,179,054 (GRCm39) |
V779A |
probably benign |
Het |
| Itpr1 |
C |
T |
6: 108,326,593 (GRCm39) |
T105I |
probably benign |
Het |
| Kalrn |
T |
C |
16: 34,018,857 (GRCm39) |
M670V |
probably damaging |
Het |
| Kdm8 |
T |
A |
7: 125,054,431 (GRCm39) |
|
probably null |
Het |
| Kics2 |
T |
C |
10: 121,575,912 (GRCm39) |
V11A |
probably damaging |
Het |
| L3hypdh |
T |
C |
12: 72,124,016 (GRCm39) |
I281V |
probably benign |
Het |
| Lins1 |
T |
G |
7: 66,364,435 (GRCm39) |
|
probably benign |
Het |
| Map4k5 |
T |
A |
12: 69,871,372 (GRCm39) |
I517L |
possibly damaging |
Het |
| Marchf2 |
G |
T |
17: 33,928,890 (GRCm39) |
T2K |
probably damaging |
Het |
| Mlkl |
C |
G |
8: 112,046,348 (GRCm39) |
|
probably null |
Het |
| Mllt1 |
A |
G |
17: 57,209,630 (GRCm39) |
M160T |
probably benign |
Het |
| Mmp15 |
G |
A |
8: 96,094,824 (GRCm39) |
A233T |
possibly damaging |
Het |
| Moxd2 |
C |
A |
6: 40,868,537 (GRCm39) |
T23N |
probably benign |
Het |
| Nop53 |
C |
A |
7: 15,676,812 (GRCm39) |
K100N |
probably benign |
Het |
| Nrg1 |
C |
A |
8: 32,408,228 (GRCm39) |
E2* |
probably null |
Het |
| Or52u1 |
T |
A |
7: 104,237,696 (GRCm39) |
H228Q |
probably benign |
Het |
| Pank4 |
A |
G |
4: 155,059,091 (GRCm39) |
D408G |
possibly damaging |
Het |
| Pcdhb10 |
T |
C |
18: 37,544,995 (GRCm39) |
W24R |
probably benign |
Het |
| Pcm1 |
C |
T |
8: 41,740,775 (GRCm39) |
T968I |
probably damaging |
Het |
| Pkib |
G |
T |
10: 57,584,246 (GRCm39) |
M19I |
probably benign |
Het |
| Ppy |
A |
G |
11: 101,991,345 (GRCm39) |
|
probably null |
Het |
| Pramel21 |
G |
A |
4: 143,343,801 (GRCm39) |
R367K |
probably benign |
Het |
| Prdx3 |
A |
C |
19: 60,861,621 (GRCm39) |
C39W |
possibly damaging |
Het |
| Qrfpr |
T |
G |
3: 36,276,073 (GRCm39) |
N106H |
probably benign |
Het |
| Rai14 |
G |
A |
15: 10,575,776 (GRCm39) |
T394M |
possibly damaging |
Het |
| Rbm12 |
A |
G |
2: 155,939,048 (GRCm39) |
L408P |
probably damaging |
Het |
| Rdx |
T |
C |
9: 51,977,174 (GRCm39) |
I141T |
probably benign |
Het |
| Reep1 |
T |
A |
6: 71,684,985 (GRCm39) |
V11E |
possibly damaging |
Het |
| Relch |
T |
A |
1: 105,649,030 (GRCm39) |
M723K |
probably benign |
Het |
| Sall4 |
A |
G |
2: 168,592,347 (GRCm39) |
S936P |
probably damaging |
Het |
| Serac1 |
A |
G |
17: 6,102,065 (GRCm39) |
M403T |
possibly damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Slc35g2 |
T |
G |
9: 100,435,549 (GRCm39) |
I41L |
probably benign |
Het |
| Slc39a12 |
G |
A |
2: 14,405,134 (GRCm39) |
S242N |
probably benign |
Het |
| Slc9a2 |
T |
A |
1: 40,801,076 (GRCm39) |
D535E |
probably damaging |
Het |
| Spata31d1a |
G |
T |
13: 59,849,459 (GRCm39) |
P890T |
probably damaging |
Het |
| Sync |
A |
G |
4: 129,187,232 (GRCm39) |
Q88R |
probably benign |
Het |
| Tdrp |
A |
G |
8: 14,024,527 (GRCm39) |
|
probably benign |
Het |
| Tg |
G |
T |
15: 66,565,168 (GRCm39) |
C1170F |
probably damaging |
Het |
| Tnks |
A |
T |
8: 35,318,937 (GRCm39) |
D781E |
probably benign |
Het |
| Tnp2 |
T |
A |
16: 10,606,207 (GRCm39) |
T87S |
possibly damaging |
Het |
| Tpp2 |
T |
C |
1: 44,010,875 (GRCm39) |
V554A |
probably benign |
Het |
| Traf3ip2 |
T |
C |
10: 39,521,735 (GRCm39) |
I431T |
probably damaging |
Het |
| Trav9d-4 |
A |
T |
14: 53,221,258 (GRCm39) |
H84L |
probably damaging |
Het |
| Vmn2r42 |
T |
A |
7: 8,187,276 (GRCm39) |
Y782F |
probably damaging |
Het |
| Vwf |
T |
C |
6: 125,547,567 (GRCm39) |
S231P |
probably damaging |
Het |
| Wdr83os |
A |
G |
8: 85,808,496 (GRCm39) |
S83G |
probably damaging |
Het |
| Wdr91 |
T |
A |
6: 34,885,234 (GRCm39) |
Q109L |
probably damaging |
Het |
| Znrf4 |
A |
G |
17: 56,818,864 (GRCm39) |
C148R |
possibly damaging |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1905:Ralgapa2
|
UTSW |
2 |
146,229,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1956:Ralgapa2
|
UTSW |
2 |
146,302,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Ralgapa2
|
UTSW |
2 |
146,156,944 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4627:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7371:Ralgapa2
|
UTSW |
2 |
146,189,046 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCTTGGCAACCACTGATTC -3'
(R):5'- ACTGAGTATACACAGGGACAATTCTG -3'
Sequencing Primer
(F):5'- TGGCAACCACTGATTCTCTACAG -3'
(R):5'- CACAGGGACAATTCTGTTTATTTTC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation