Incidental Mutation 'R4762:Cyp2j8'
ID 356940
Institutional Source Beutler Lab
Gene Symbol Cyp2j8
Ensembl Gene ENSMUSG00000082932
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms OTTMUSG00000007938, Cyp2j8-ps
MMRRC Submission 042403-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R4762 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 96332833-96395623 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 96358886 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 344 (D344E)
Ref Sequence ENSEMBL: ENSMUSP00000134591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124729]
AlphaFold G3UZ38
Predicted Effect probably damaging
Transcript: ENSMUST00000124729
AA Change: D344E

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000134591
Gene: ENSMUSG00000082932
AA Change: D344E

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:p450 44 500 1.2e-134 PFAM
Meta Mutation Damage Score 0.4071 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency 100% (86/86)
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012P17Rik T C 1: 158,797,126 (GRCm39) noncoding transcript Het
2310030G06Rik T C 9: 50,651,967 (GRCm39) E87G probably damaging Het
Aknad1 A T 3: 108,682,547 (GRCm39) H541L possibly damaging Het
Asb15 A G 6: 24,567,236 (GRCm39) E519G possibly damaging Het
Atad2 T C 15: 57,971,758 (GRCm39) D373G probably benign Het
Bbs12 G A 3: 37,374,529 (GRCm39) V326M probably damaging Het
Birc6 T C 17: 74,936,484 (GRCm39) I2617T probably damaging Het
Brca2 A G 5: 150,454,581 (GRCm39) T115A probably benign Het
Casz1 T C 4: 149,023,438 (GRCm39) L495P probably damaging Het
Ccdc30 T A 4: 119,190,785 (GRCm39) I481F probably damaging Het
Cept1 A T 3: 106,446,677 (GRCm39) Y56* probably null Het
Cfap54 A C 10: 92,897,315 (GRCm39) probably null Het
Dido1 A T 2: 180,331,368 (GRCm39) W27R probably damaging Het
Disp3 A G 4: 148,356,575 (GRCm39) I95T probably damaging Het
Engase G T 11: 118,377,920 (GRCm39) V237F possibly damaging Het
Ephb6 G A 6: 41,595,094 (GRCm39) E703K probably damaging Het
Fnip1 T A 11: 54,356,997 (GRCm39) F35L probably damaging Het
Fnip1 A T 11: 54,390,352 (GRCm39) T440S probably benign Het
Fras1 T A 5: 96,879,477 (GRCm39) H2431Q probably benign Het
Fzd4 A T 7: 89,056,924 (GRCm39) T324S probably damaging Het
Gm10192 C G 4: 97,071,345 (GRCm39) S20T probably null Het
Gpr84 A T 15: 103,217,027 (GRCm39) V350E probably damaging Het
Gsto2 T C 19: 47,863,312 (GRCm39) Y63H probably damaging Het
Gtpbp6 T C 5: 110,252,186 (GRCm39) T449A probably damaging Het
Herc2 G A 7: 55,820,388 (GRCm39) V2876I probably benign Het
Hnrnpa3 A G 2: 75,492,351 (GRCm39) I152V possibly damaging Het
Hpse2 T C 19: 42,777,510 (GRCm39) D552G possibly damaging Het
Itfg1 A G 8: 86,459,070 (GRCm39) V460A possibly damaging Het
Jhy G A 9: 40,822,494 (GRCm39) A548V probably benign Het
Klhl21 T A 4: 152,094,268 (GRCm39) L290Q possibly damaging Het
Knl1 T C 2: 118,902,417 (GRCm39) S1373P probably benign Het
Kpna2 A C 11: 106,881,085 (GRCm39) M426R probably benign Het
Krt9 C T 11: 100,081,675 (GRCm39) V285I probably damaging Het
Lpar1 T G 4: 58,437,346 (GRCm39) H361P possibly damaging Het
Macf1 T C 4: 123,349,237 (GRCm39) T2100A probably benign Het
Mfsd13b T C 7: 120,590,549 (GRCm39) F97L probably damaging Het
Mmp15 A G 8: 96,098,958 (GRCm39) K595R probably benign Het
Mrps25 C T 6: 92,152,085 (GRCm39) G145D probably damaging Het
Muc4 T A 16: 32,574,916 (GRCm39) probably benign Het
Napa A T 7: 15,849,196 (GRCm39) K245N probably benign Het
Or10p1 C A 10: 129,444,043 (GRCm39) M102I probably damaging Het
Or14c39 A G 7: 86,344,329 (GRCm39) T222A probably benign Het
Or2y1c A T 11: 49,361,112 (GRCm39) I45F probably damaging Het
Or4g17 G A 2: 111,210,082 (GRCm39) V246M probably damaging Het
Or4k39 T A 2: 111,239,225 (GRCm39) noncoding transcript Het
Or5au1 T A 14: 52,272,921 (GRCm39) I216F possibly damaging Het
Or8c20 A G 9: 38,260,577 (GRCm39) Y60C probably damaging Het
Or8k35 A G 2: 86,424,381 (GRCm39) S264P possibly damaging Het
Papss2 A T 19: 32,616,378 (GRCm39) T195S probably benign Het
Parp4 T A 14: 56,848,267 (GRCm39) H694Q probably damaging Het
Patj C T 4: 98,293,807 (GRCm39) R20* probably null Het
Pcdhgb8 T A 18: 37,895,419 (GRCm39) V163E probably damaging Het
Pkd2l1 T A 19: 44,144,060 (GRCm39) T338S probably benign Het
Ppargc1b A T 18: 61,444,328 (GRCm39) S278R possibly damaging Het
Ppl T C 16: 4,906,846 (GRCm39) T1150A probably benign Het
Ralgds A G 2: 28,442,164 (GRCm39) D858G probably damaging Het
Rassf2 G A 2: 131,844,783 (GRCm39) probably benign Het
Ring1 T C 17: 34,240,971 (GRCm39) probably benign Het
Rusc1 A C 3: 88,998,949 (GRCm39) S278A probably benign Het
Samd9l T C 6: 3,375,623 (GRCm39) N546S probably benign Het
Sct A C 7: 140,858,954 (GRCm39) probably benign Het
Slc22a12 T G 19: 6,588,474 (GRCm39) H348P probably benign Het
Slc25a15 A G 8: 22,873,248 (GRCm39) S143P probably damaging Het
Slc26a11 C A 11: 119,247,657 (GRCm39) probably benign Het
Slc6a20b A G 9: 123,427,625 (GRCm39) M428T probably damaging Het
Smim17 G A 7: 6,432,321 (GRCm39) V88M probably damaging Het
Smoc1 G T 12: 81,214,425 (GRCm39) W269L probably damaging Het
Sox5 C T 6: 143,807,109 (GRCm39) probably null Het
Sp100 A G 1: 85,629,179 (GRCm39) *483W probably null Het
Sptbn5 T A 2: 119,907,703 (GRCm39) noncoding transcript Het
Sun5 G A 2: 153,707,283 (GRCm39) R132* probably null Het
Tedc2 A G 17: 24,435,354 (GRCm39) V345A probably benign Het
Tlr6 T A 5: 65,111,739 (GRCm39) R389S probably benign Het
Ttc17 G T 2: 94,202,113 (GRCm39) H396Q probably damaging Het
Ttn A G 2: 76,773,383 (GRCm39) S2340P probably damaging Het
Vmn1r219 C T 13: 23,346,999 (GRCm39) Q63* probably null Het
Vmn1r224 A G 17: 20,639,902 (GRCm39) T160A possibly damaging Het
Vmn2r11 T C 5: 109,195,436 (GRCm39) N630S probably damaging Het
Zfp1005 T A 2: 150,109,549 (GRCm39) C80S possibly damaging Het
Zfp747 A G 7: 126,973,498 (GRCm39) V224A possibly damaging Het
Zfp804b T C 5: 6,822,250 (GRCm39) N271S probably benign Het
Other mutations in Cyp2j8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Cyp2j8 APN 4 96,392,079 (GRCm39) missense probably benign 0.06
IGL00418:Cyp2j8 APN 4 96,332,853 (GRCm39) missense possibly damaging 0.85
IGL01577:Cyp2j8 APN 4 96,367,308 (GRCm39) missense probably damaging 0.96
IGL01629:Cyp2j8 APN 4 96,387,840 (GRCm39) missense probably damaging 1.00
IGL01928:Cyp2j8 APN 4 96,358,713 (GRCm39) splice site probably benign
IGL01978:Cyp2j8 APN 4 96,392,246 (GRCm39) splice site probably null
IGL02053:Cyp2j8 APN 4 96,358,891 (GRCm39) missense probably damaging 1.00
IGL02500:Cyp2j8 APN 4 96,358,887 (GRCm39) missense probably damaging 1.00
IGL02947:Cyp2j8 APN 4 96,358,815 (GRCm39) missense probably damaging 1.00
cyprus UTSW 4 96,387,840 (GRCm39) missense probably damaging 1.00
R0558:Cyp2j8 UTSW 4 96,332,871 (GRCm39) missense probably benign 0.01
R0718:Cyp2j8 UTSW 4 96,389,433 (GRCm39) missense probably benign
R1553:Cyp2j8 UTSW 4 96,363,794 (GRCm39) missense probably benign
R1557:Cyp2j8 UTSW 4 96,358,713 (GRCm39) splice site probably benign
R1632:Cyp2j8 UTSW 4 96,335,561 (GRCm39) missense probably benign 0.02
R1708:Cyp2j8 UTSW 4 96,387,832 (GRCm39) missense probably damaging 1.00
R2119:Cyp2j8 UTSW 4 96,395,438 (GRCm39) missense probably benign
R2220:Cyp2j8 UTSW 4 96,332,862 (GRCm39) missense probably benign 0.03
R3123:Cyp2j8 UTSW 4 96,389,450 (GRCm39) splice site probably benign
R3735:Cyp2j8 UTSW 4 96,332,836 (GRCm39) missense probably damaging 1.00
R3736:Cyp2j8 UTSW 4 96,332,836 (GRCm39) missense probably damaging 1.00
R4326:Cyp2j8 UTSW 4 96,395,566 (GRCm39) missense probably benign 0.10
R4327:Cyp2j8 UTSW 4 96,395,566 (GRCm39) missense probably benign 0.10
R4901:Cyp2j8 UTSW 4 96,367,323 (GRCm39) missense probably benign 0.16
R4960:Cyp2j8 UTSW 4 96,395,614 (GRCm39) missense probably benign
R5260:Cyp2j8 UTSW 4 96,389,301 (GRCm39) missense possibly damaging 0.65
R5562:Cyp2j8 UTSW 4 96,358,890 (GRCm39) missense probably damaging 1.00
R5596:Cyp2j8 UTSW 4 96,395,578 (GRCm39) missense probably benign 0.00
R5741:Cyp2j8 UTSW 4 96,332,880 (GRCm39) missense probably benign 0.00
R5825:Cyp2j8 UTSW 4 96,395,451 (GRCm39) missense probably benign 0.01
R5903:Cyp2j8 UTSW 4 96,395,514 (GRCm39) missense possibly damaging 0.46
R6122:Cyp2j8 UTSW 4 96,332,877 (GRCm39) missense probably benign
R6232:Cyp2j8 UTSW 4 96,395,427 (GRCm39) missense possibly damaging 0.94
R6748:Cyp2j8 UTSW 4 96,363,782 (GRCm39) missense probably benign 0.01
R6931:Cyp2j8 UTSW 4 96,333,018 (GRCm39) splice site probably null
R7000:Cyp2j8 UTSW 4 96,335,588 (GRCm39) missense probably benign 0.06
R7183:Cyp2j8 UTSW 4 96,367,418 (GRCm39) missense probably damaging 0.97
R7186:Cyp2j8 UTSW 4 96,363,787 (GRCm39) missense probably benign 0.00
R7348:Cyp2j8 UTSW 4 96,332,877 (GRCm39) missense probably benign 0.00
R7575:Cyp2j8 UTSW 4 96,358,785 (GRCm39) missense possibly damaging 0.63
R7648:Cyp2j8 UTSW 4 96,387,840 (GRCm39) missense probably damaging 1.00
R7975:Cyp2j8 UTSW 4 96,358,776 (GRCm39) missense possibly damaging 0.65
R7993:Cyp2j8 UTSW 4 96,335,456 (GRCm39) critical splice donor site probably null
R8878:Cyp2j8 UTSW 4 96,358,807 (GRCm39) missense possibly damaging 0.56
Predicted Primers PCR Primer
(F):5'- TGCATGGTTACCTTAGGCAG -3'
(R):5'- TGTTAGGATACAGAATAGCTTGACC -3'

Sequencing Primer
(F):5'- CTTAGGCAGGTGGAATCCG -3'
(R):5'- ACAGAATAGCTTGACCATATAGAGTC -3'
Posted On 2015-11-11