Incidental Mutation 'R4762:Parp4'
| ID |
356984 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
042403-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
R4762 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 56848267 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 694
(H694Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160334
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161553
AA Change: H694Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: H694Q
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162231
|
| Meta Mutation Damage Score |
0.3218 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
100% (86/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
T |
C |
1: 158,797,126 (GRCm39) |
|
noncoding transcript |
Het |
| 2310030G06Rik |
T |
C |
9: 50,651,967 (GRCm39) |
E87G |
probably damaging |
Het |
| Aknad1 |
A |
T |
3: 108,682,547 (GRCm39) |
H541L |
possibly damaging |
Het |
| Asb15 |
A |
G |
6: 24,567,236 (GRCm39) |
E519G |
possibly damaging |
Het |
| Atad2 |
T |
C |
15: 57,971,758 (GRCm39) |
D373G |
probably benign |
Het |
| Bbs12 |
G |
A |
3: 37,374,529 (GRCm39) |
V326M |
probably damaging |
Het |
| Birc6 |
T |
C |
17: 74,936,484 (GRCm39) |
I2617T |
probably damaging |
Het |
| Brca2 |
A |
G |
5: 150,454,581 (GRCm39) |
T115A |
probably benign |
Het |
| Casz1 |
T |
C |
4: 149,023,438 (GRCm39) |
L495P |
probably damaging |
Het |
| Ccdc30 |
T |
A |
4: 119,190,785 (GRCm39) |
I481F |
probably damaging |
Het |
| Cept1 |
A |
T |
3: 106,446,677 (GRCm39) |
Y56* |
probably null |
Het |
| Cfap54 |
A |
C |
10: 92,897,315 (GRCm39) |
|
probably null |
Het |
| Cyp2j8 |
G |
T |
4: 96,358,886 (GRCm39) |
D344E |
probably damaging |
Het |
| Dido1 |
A |
T |
2: 180,331,368 (GRCm39) |
W27R |
probably damaging |
Het |
| Disp3 |
A |
G |
4: 148,356,575 (GRCm39) |
I95T |
probably damaging |
Het |
| Engase |
G |
T |
11: 118,377,920 (GRCm39) |
V237F |
possibly damaging |
Het |
| Ephb6 |
G |
A |
6: 41,595,094 (GRCm39) |
E703K |
probably damaging |
Het |
| Fnip1 |
T |
A |
11: 54,356,997 (GRCm39) |
F35L |
probably damaging |
Het |
| Fnip1 |
A |
T |
11: 54,390,352 (GRCm39) |
T440S |
probably benign |
Het |
| Fras1 |
T |
A |
5: 96,879,477 (GRCm39) |
H2431Q |
probably benign |
Het |
| Fzd4 |
A |
T |
7: 89,056,924 (GRCm39) |
T324S |
probably damaging |
Het |
| Gm10192 |
C |
G |
4: 97,071,345 (GRCm39) |
S20T |
probably null |
Het |
| Gpr84 |
A |
T |
15: 103,217,027 (GRCm39) |
V350E |
probably damaging |
Het |
| Gsto2 |
T |
C |
19: 47,863,312 (GRCm39) |
Y63H |
probably damaging |
Het |
| Gtpbp6 |
T |
C |
5: 110,252,186 (GRCm39) |
T449A |
probably damaging |
Het |
| Herc2 |
G |
A |
7: 55,820,388 (GRCm39) |
V2876I |
probably benign |
Het |
| Hnrnpa3 |
A |
G |
2: 75,492,351 (GRCm39) |
I152V |
possibly damaging |
Het |
| Hpse2 |
T |
C |
19: 42,777,510 (GRCm39) |
D552G |
possibly damaging |
Het |
| Itfg1 |
A |
G |
8: 86,459,070 (GRCm39) |
V460A |
possibly damaging |
Het |
| Jhy |
G |
A |
9: 40,822,494 (GRCm39) |
A548V |
probably benign |
Het |
| Klhl21 |
T |
A |
4: 152,094,268 (GRCm39) |
L290Q |
possibly damaging |
Het |
| Knl1 |
T |
C |
2: 118,902,417 (GRCm39) |
S1373P |
probably benign |
Het |
| Kpna2 |
A |
C |
11: 106,881,085 (GRCm39) |
M426R |
probably benign |
Het |
| Krt9 |
C |
T |
11: 100,081,675 (GRCm39) |
V285I |
probably damaging |
Het |
| Lpar1 |
T |
G |
4: 58,437,346 (GRCm39) |
H361P |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,349,237 (GRCm39) |
T2100A |
probably benign |
Het |
| Mfsd13b |
T |
C |
7: 120,590,549 (GRCm39) |
F97L |
probably damaging |
Het |
| Mmp15 |
A |
G |
8: 96,098,958 (GRCm39) |
K595R |
probably benign |
Het |
| Mrps25 |
C |
T |
6: 92,152,085 (GRCm39) |
G145D |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,574,916 (GRCm39) |
|
probably benign |
Het |
| Napa |
A |
T |
7: 15,849,196 (GRCm39) |
K245N |
probably benign |
Het |
| Or10p1 |
C |
A |
10: 129,444,043 (GRCm39) |
M102I |
probably damaging |
Het |
| Or14c39 |
A |
G |
7: 86,344,329 (GRCm39) |
T222A |
probably benign |
Het |
| Or2y1c |
A |
T |
11: 49,361,112 (GRCm39) |
I45F |
probably damaging |
Het |
| Or4g17 |
G |
A |
2: 111,210,082 (GRCm39) |
V246M |
probably damaging |
Het |
| Or4k39 |
T |
A |
2: 111,239,225 (GRCm39) |
|
noncoding transcript |
Het |
| Or5au1 |
T |
A |
14: 52,272,921 (GRCm39) |
I216F |
possibly damaging |
Het |
| Or8c20 |
A |
G |
9: 38,260,577 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or8k35 |
A |
G |
2: 86,424,381 (GRCm39) |
S264P |
possibly damaging |
Het |
| Papss2 |
A |
T |
19: 32,616,378 (GRCm39) |
T195S |
probably benign |
Het |
| Patj |
C |
T |
4: 98,293,807 (GRCm39) |
R20* |
probably null |
Het |
| Pcdhgb8 |
T |
A |
18: 37,895,419 (GRCm39) |
V163E |
probably damaging |
Het |
| Pkd2l1 |
T |
A |
19: 44,144,060 (GRCm39) |
T338S |
probably benign |
Het |
| Ppargc1b |
A |
T |
18: 61,444,328 (GRCm39) |
S278R |
possibly damaging |
Het |
| Ppl |
T |
C |
16: 4,906,846 (GRCm39) |
T1150A |
probably benign |
Het |
| Ralgds |
A |
G |
2: 28,442,164 (GRCm39) |
D858G |
probably damaging |
Het |
| Rassf2 |
G |
A |
2: 131,844,783 (GRCm39) |
|
probably benign |
Het |
| Ring1 |
T |
C |
17: 34,240,971 (GRCm39) |
|
probably benign |
Het |
| Rusc1 |
A |
C |
3: 88,998,949 (GRCm39) |
S278A |
probably benign |
Het |
| Samd9l |
T |
C |
6: 3,375,623 (GRCm39) |
N546S |
probably benign |
Het |
| Sct |
A |
C |
7: 140,858,954 (GRCm39) |
|
probably benign |
Het |
| Slc22a12 |
T |
G |
19: 6,588,474 (GRCm39) |
H348P |
probably benign |
Het |
| Slc25a15 |
A |
G |
8: 22,873,248 (GRCm39) |
S143P |
probably damaging |
Het |
| Slc26a11 |
C |
A |
11: 119,247,657 (GRCm39) |
|
probably benign |
Het |
| Slc6a20b |
A |
G |
9: 123,427,625 (GRCm39) |
M428T |
probably damaging |
Het |
| Smim17 |
G |
A |
7: 6,432,321 (GRCm39) |
V88M |
probably damaging |
Het |
| Smoc1 |
G |
T |
12: 81,214,425 (GRCm39) |
W269L |
probably damaging |
Het |
| Sox5 |
C |
T |
6: 143,807,109 (GRCm39) |
|
probably null |
Het |
| Sp100 |
A |
G |
1: 85,629,179 (GRCm39) |
*483W |
probably null |
Het |
| Sptbn5 |
T |
A |
2: 119,907,703 (GRCm39) |
|
noncoding transcript |
Het |
| Sun5 |
G |
A |
2: 153,707,283 (GRCm39) |
R132* |
probably null |
Het |
| Tedc2 |
A |
G |
17: 24,435,354 (GRCm39) |
V345A |
probably benign |
Het |
| Tlr6 |
T |
A |
5: 65,111,739 (GRCm39) |
R389S |
probably benign |
Het |
| Ttc17 |
G |
T |
2: 94,202,113 (GRCm39) |
H396Q |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,773,383 (GRCm39) |
S2340P |
probably damaging |
Het |
| Vmn1r219 |
C |
T |
13: 23,346,999 (GRCm39) |
Q63* |
probably null |
Het |
| Vmn1r224 |
A |
G |
17: 20,639,902 (GRCm39) |
T160A |
possibly damaging |
Het |
| Vmn2r11 |
T |
C |
5: 109,195,436 (GRCm39) |
N630S |
probably damaging |
Het |
| Zfp1005 |
T |
A |
2: 150,109,549 (GRCm39) |
C80S |
possibly damaging |
Het |
| Zfp747 |
A |
G |
7: 126,973,498 (GRCm39) |
V224A |
possibly damaging |
Het |
| Zfp804b |
T |
C |
5: 6,822,250 (GRCm39) |
N271S |
probably benign |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,886,300 (GRCm39) |
missense |
unknown |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,861,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,852,216 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTTGAGCATGGCACCTCAC -3'
(R):5'- TGACCTCCTGTACTCCTAAGG -3'
Sequencing Primer
(F):5'- CTGCCATCTCAGCAAGAGGATTG -3'
(R):5'- GAGCCTTGAACTTGCAGCAATTC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation