Incidental Mutation 'R4749:Gcn1'
| ID |
357381 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gcn1
|
| Ensembl Gene |
ENSMUSG00000041638 |
| Gene Name |
GCN1 activator of EIF2AK4 |
| Synonyms |
Gcn1l1, G431004K08Rik, GCN1L |
| MMRRC Submission |
041969-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R4749 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
115703313-115760713 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 115752461 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 2155
(D2155E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000069432
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064454]
|
| AlphaFold |
E9PVA8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064454
AA Change: D2155E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000069432
Gene: ENSMUSG00000041638
AA Change: D2155E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
64 |
84 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
117 |
N/A |
INTRINSIC |
|
low complexity region
|
142 |
154 |
N/A |
INTRINSIC |
|
Pfam:DUF3554
|
357 |
705 |
2e-61 |
PFAM |
|
coiled coil region
|
806 |
866 |
N/A |
INTRINSIC |
|
Blast:ARM
|
1028 |
1068 |
6e-11 |
BLAST |
|
coiled coil region
|
1180 |
1203 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1501 |
1510 |
N/A |
INTRINSIC |
|
ARM
|
1527 |
1567 |
3.69e1 |
SMART |
|
Blast:ARM
|
1602 |
1644 |
1e-5 |
BLAST |
|
Blast:EZ_HEAT
|
1671 |
1704 |
1e-7 |
BLAST |
|
low complexity region
|
1926 |
1934 |
N/A |
INTRINSIC |
|
low complexity region
|
1956 |
1972 |
N/A |
INTRINSIC |
|
ARM
|
2034 |
2070 |
9.27e1 |
SMART |
|
low complexity region
|
2326 |
2334 |
N/A |
INTRINSIC |
|
ARM
|
2416 |
2455 |
2.16e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000094427
|
| SMART Domains |
Protein: ENSMUSP00000091994
Gene: ENSMUSG00000041638
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HEAT
|
42 |
72 |
5.8e-5 |
PFAM |
|
low complexity region
|
310 |
318 |
N/A |
INTRINSIC |
|
Pfam:HEAT_EZ
|
326 |
374 |
2.2e-5 |
PFAM |
|
Blast:EZ_HEAT
|
403 |
439 |
1e-15 |
BLAST |
|
Pfam:HEAT_EZ
|
703 |
757 |
1.3e-5 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122964
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137523
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139933
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim1 |
A |
T |
19: 57,204,153 (GRCm39) |
D79E |
probably benign |
Het |
| Adgra2 |
A |
G |
8: 27,604,225 (GRCm39) |
K472E |
probably damaging |
Het |
| Akap9 |
A |
G |
5: 4,018,737 (GRCm39) |
D1106G |
probably benign |
Het |
| Arhgap35 |
T |
C |
7: 16,232,551 (GRCm39) |
E1367G |
possibly damaging |
Het |
| Arsi |
A |
T |
18: 61,050,533 (GRCm39) |
Y472F |
probably benign |
Het |
| Asxl3 |
A |
G |
18: 22,649,826 (GRCm39) |
D605G |
probably damaging |
Het |
| Atp6v1e2 |
C |
T |
17: 87,252,135 (GRCm39) |
D88N |
probably benign |
Het |
| BC061237 |
T |
A |
14: 44,743,469 (GRCm39) |
V169E |
probably damaging |
Het |
| C1galt1 |
A |
G |
6: 7,866,379 (GRCm39) |
E75G |
probably benign |
Het |
| C9 |
G |
A |
15: 6,519,311 (GRCm39) |
V383I |
probably benign |
Het |
| Ccdc88a |
A |
G |
11: 29,432,720 (GRCm39) |
K222R |
probably benign |
Het |
| Ccna2 |
T |
C |
3: 36,620,391 (GRCm39) |
S421G |
probably benign |
Het |
| Cflar |
T |
G |
1: 58,779,431 (GRCm39) |
V229G |
possibly damaging |
Het |
| Clcn1 |
A |
G |
6: 42,267,131 (GRCm39) |
|
probably null |
Het |
| Col14a1 |
T |
A |
15: 55,315,732 (GRCm39) |
F1342L |
unknown |
Het |
| Colq |
C |
T |
14: 31,251,472 (GRCm39) |
R313H |
possibly damaging |
Het |
| Coro6 |
A |
G |
11: 77,359,974 (GRCm39) |
E345G |
probably damaging |
Het |
| Cracd |
T |
C |
5: 77,006,681 (GRCm39) |
V1014A |
unknown |
Het |
| Cyb561 |
A |
G |
11: 105,826,708 (GRCm39) |
F182L |
probably benign |
Het |
| Dap3 |
A |
G |
3: 88,833,617 (GRCm39) |
S317P |
probably benign |
Het |
| Dnah9 |
G |
A |
11: 65,724,941 (GRCm39) |
A4404V |
probably damaging |
Het |
| Dsg4 |
A |
G |
18: 20,579,888 (GRCm39) |
E31G |
possibly damaging |
Het |
| Dsn1 |
G |
A |
2: 156,843,660 (GRCm39) |
L147F |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,043,990 (GRCm39) |
V277A |
probably damaging |
Het |
| Eprs1 |
T |
A |
1: 185,128,327 (GRCm39) |
I569K |
probably damaging |
Het |
| Erg |
T |
C |
16: 95,162,029 (GRCm39) |
N342S |
probably damaging |
Het |
| Fam114a1 |
G |
A |
5: 65,166,409 (GRCm39) |
D247N |
probably damaging |
Het |
| Fat2 |
A |
G |
11: 55,202,294 (GRCm39) |
V260A |
probably benign |
Het |
| Foxn4 |
T |
C |
5: 114,393,628 (GRCm39) |
D497G |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,819,629 (GRCm39) |
I5121V |
probably benign |
Het |
| Glra1 |
C |
A |
11: 55,427,210 (GRCm39) |
D42Y |
probably damaging |
Het |
| Gpr171 |
A |
G |
3: 59,004,887 (GRCm39) |
V296A |
probably benign |
Het |
| Grid1 |
T |
A |
14: 35,302,644 (GRCm39) |
S970T |
possibly damaging |
Het |
| Hcn3 |
A |
T |
3: 89,057,370 (GRCm39) |
|
probably null |
Het |
| Helb |
T |
C |
10: 119,920,754 (GRCm39) |
D1063G |
probably benign |
Het |
| Hsd3b3 |
G |
A |
3: 98,649,931 (GRCm39) |
P131S |
probably damaging |
Het |
| Hsp90b1 |
A |
G |
10: 86,537,672 (GRCm39) |
V211A |
probably damaging |
Het |
| Htr2c |
A |
G |
X: 145,976,793 (GRCm39) |
T163A |
probably benign |
Het |
| Ifi208 |
T |
A |
1: 173,523,180 (GRCm39) |
D483E |
possibly damaging |
Het |
| Kbtbd6 |
T |
A |
14: 79,690,727 (GRCm39) |
V474E |
possibly damaging |
Het |
| Kif21b |
T |
A |
1: 136,072,487 (GRCm39) |
Y64* |
probably null |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Map3k10 |
T |
C |
7: 27,357,786 (GRCm39) |
D664G |
possibly damaging |
Het |
| Map3k5 |
C |
A |
10: 20,007,798 (GRCm39) |
S1201Y |
probably benign |
Het |
| Mcm2 |
T |
C |
6: 88,868,973 (GRCm39) |
E293G |
possibly damaging |
Het |
| Med21 |
T |
A |
6: 146,551,599 (GRCm39) |
|
probably null |
Het |
| Mettl18 |
T |
C |
1: 163,824,354 (GRCm39) |
V225A |
probably benign |
Het |
| Mmp10 |
A |
T |
9: 7,508,169 (GRCm39) |
I432F |
probably damaging |
Het |
| Muc5b |
T |
G |
7: 141,415,185 (GRCm39) |
Y2710* |
probably null |
Het |
| Neurl4 |
A |
T |
11: 69,801,894 (GRCm39) |
I1282F |
probably benign |
Het |
| Nipbl |
A |
T |
15: 8,395,313 (GRCm39) |
H191Q |
possibly damaging |
Het |
| Nktr |
A |
G |
9: 121,570,759 (GRCm39) |
D167G |
probably damaging |
Het |
| Nrap |
A |
G |
19: 56,368,669 (GRCm39) |
I249T |
probably damaging |
Het |
| Nsfl1c |
A |
G |
2: 151,351,526 (GRCm39) |
T297A |
probably benign |
Het |
| Oit3 |
A |
T |
10: 59,259,904 (GRCm39) |
C500S |
probably damaging |
Het |
| Or1e1 |
G |
A |
11: 73,245,322 (GRCm39) |
V248M |
probably damaging |
Het |
| Or4a39 |
C |
T |
2: 89,236,599 (GRCm39) |
V275I |
probably benign |
Het |
| Or4k6 |
A |
G |
14: 50,476,190 (GRCm39) |
S51P |
probably damaging |
Het |
| Or5b24 |
C |
T |
19: 12,912,581 (GRCm39) |
H160Y |
probably benign |
Het |
| Or5d36 |
T |
A |
2: 87,900,956 (GRCm39) |
I257L |
probably benign |
Het |
| Pcnx2 |
T |
C |
8: 126,614,327 (GRCm39) |
S375G |
probably damaging |
Het |
| Pgap6 |
T |
C |
17: 26,335,757 (GRCm39) |
F48S |
probably damaging |
Het |
| Phf2 |
A |
T |
13: 48,975,185 (GRCm39) |
|
probably null |
Het |
| Piezo1 |
A |
T |
8: 123,213,678 (GRCm39) |
M1739K |
possibly damaging |
Het |
| Piezo1 |
G |
T |
8: 123,224,945 (GRCm39) |
Q654K |
probably damaging |
Het |
| Pml |
C |
T |
9: 58,141,935 (GRCm39) |
R299H |
probably damaging |
Het |
| Ppp3cb |
A |
T |
14: 20,574,130 (GRCm39) |
M236K |
probably damaging |
Het |
| Prkch |
T |
A |
12: 73,739,734 (GRCm39) |
C203S |
probably damaging |
Het |
| Prob1 |
C |
T |
18: 35,785,869 (GRCm39) |
R795H |
possibly damaging |
Het |
| Prr22 |
G |
C |
17: 57,078,274 (GRCm39) |
E142D |
possibly damaging |
Het |
| Prss56 |
C |
A |
1: 87,113,305 (GRCm39) |
A211E |
possibly damaging |
Het |
| Qser1 |
A |
C |
2: 104,617,649 (GRCm39) |
S1054R |
probably benign |
Het |
| Rhbdl2 |
T |
C |
4: 123,720,694 (GRCm39) |
|
probably null |
Het |
| Rhot2 |
C |
A |
17: 26,063,248 (GRCm39) |
G19V |
probably damaging |
Het |
| Rp1l1 |
C |
T |
14: 64,267,249 (GRCm39) |
T945M |
probably damaging |
Het |
| Ryr3 |
T |
C |
2: 112,794,750 (GRCm39) |
T121A |
possibly damaging |
Het |
| Sdad1 |
C |
T |
5: 92,452,836 (GRCm39) |
R134Q |
possibly damaging |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Sharpin |
T |
A |
15: 76,231,767 (GRCm39) |
D314V |
probably damaging |
Het |
| Slc14a2 |
A |
T |
18: 78,198,796 (GRCm39) |
L778Q |
probably damaging |
Het |
| Slc29a3 |
A |
G |
10: 60,552,105 (GRCm39) |
V313A |
probably benign |
Het |
| Slc4a11 |
C |
A |
2: 130,532,787 (GRCm39) |
R222L |
probably damaging |
Het |
| Slc7a10 |
C |
T |
7: 34,900,187 (GRCm39) |
P502S |
probably damaging |
Het |
| Sort1 |
T |
G |
3: 108,263,639 (GRCm39) |
Y812* |
probably null |
Het |
| Spata31d1b |
G |
A |
13: 59,866,172 (GRCm39) |
V1107M |
probably damaging |
Het |
| Tcp10b |
G |
A |
17: 13,289,832 (GRCm39) |
|
probably null |
Het |
| Tnc |
T |
C |
4: 63,913,876 (GRCm39) |
D1312G |
possibly damaging |
Het |
| Tomm40l |
G |
A |
1: 171,047,131 (GRCm39) |
R296* |
probably null |
Het |
| Topors |
A |
T |
4: 40,261,015 (GRCm39) |
S756R |
unknown |
Het |
| Trim9 |
T |
C |
12: 70,295,047 (GRCm39) |
N688D |
probably damaging |
Het |
| Ube2o |
T |
C |
11: 116,432,734 (GRCm39) |
D744G |
probably benign |
Het |
| Vmn1r224 |
A |
G |
17: 20,640,013 (GRCm39) |
I197V |
probably benign |
Het |
| Zc3h18 |
A |
T |
8: 123,110,382 (GRCm39) |
D77V |
probably damaging |
Het |
|
| Other mutations in Gcn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00869:Gcn1
|
APN |
5 |
115,726,202 (GRCm39) |
splice site |
probably benign |
|
|
IGL00974:Gcn1
|
APN |
5 |
115,751,852 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01566:Gcn1
|
APN |
5 |
115,749,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Gcn1
|
APN |
5 |
115,757,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01885:Gcn1
|
APN |
5 |
115,714,174 (GRCm39) |
splice site |
probably null |
|
|
IGL02081:Gcn1
|
APN |
5 |
115,723,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Gcn1
|
APN |
5 |
115,748,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02150:Gcn1
|
APN |
5 |
115,747,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02190:Gcn1
|
APN |
5 |
115,752,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02219:Gcn1
|
APN |
5 |
115,751,826 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02507:Gcn1
|
APN |
5 |
115,723,940 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02644:Gcn1
|
APN |
5 |
115,713,250 (GRCm39) |
missense |
probably benign |
|
|
IGL02678:Gcn1
|
APN |
5 |
115,751,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02748:Gcn1
|
APN |
5 |
115,748,859 (GRCm39) |
splice site |
probably null |
|
|
IGL02755:Gcn1
|
APN |
5 |
115,742,065 (GRCm39) |
splice site |
probably null |
|
|
IGL02896:Gcn1
|
APN |
5 |
115,757,707 (GRCm39) |
splice site |
probably benign |
|
|
cusp
|
UTSW |
5 |
115,749,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
farthing
|
UTSW |
5 |
115,714,167 (GRCm39) |
splice site |
probably benign |
|
|
IGL03147:Gcn1
|
UTSW |
5 |
115,748,917 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0362:Gcn1
|
UTSW |
5 |
115,714,167 (GRCm39) |
splice site |
probably benign |
|
|
R0540:Gcn1
|
UTSW |
5 |
115,727,015 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0569:Gcn1
|
UTSW |
5 |
115,733,118 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0570:Gcn1
|
UTSW |
5 |
115,730,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0584:Gcn1
|
UTSW |
5 |
115,733,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Gcn1
|
UTSW |
5 |
115,719,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0656:Gcn1
|
UTSW |
5 |
115,727,362 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0801:Gcn1
|
UTSW |
5 |
115,729,065 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0890:Gcn1
|
UTSW |
5 |
115,717,852 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1400:Gcn1
|
UTSW |
5 |
115,752,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1485:Gcn1
|
UTSW |
5 |
115,712,676 (GRCm39) |
missense |
probably benign |
|
|
R1574:Gcn1
|
UTSW |
5 |
115,753,611 (GRCm39) |
missense |
probably benign |
|
|
R1574:Gcn1
|
UTSW |
5 |
115,753,611 (GRCm39) |
missense |
probably benign |
|
|
R1673:Gcn1
|
UTSW |
5 |
115,720,356 (GRCm39) |
missense |
probably benign |
|
|
R1894:Gcn1
|
UTSW |
5 |
115,727,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2114:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2116:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2117:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2152:Gcn1
|
UTSW |
5 |
115,747,888 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2162:Gcn1
|
UTSW |
5 |
115,730,191 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2216:Gcn1
|
UTSW |
5 |
115,731,720 (GRCm39) |
missense |
probably benign |
|
|
R2218:Gcn1
|
UTSW |
5 |
115,757,720 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2278:Gcn1
|
UTSW |
5 |
115,749,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Gcn1
|
UTSW |
5 |
115,750,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3719:Gcn1
|
UTSW |
5 |
115,717,876 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3729:Gcn1
|
UTSW |
5 |
115,721,453 (GRCm39) |
splice site |
probably benign |
|
|
R3833:Gcn1
|
UTSW |
5 |
115,730,191 (GRCm39) |
missense |
probably benign |
0.18 |
|
R3932:Gcn1
|
UTSW |
5 |
115,725,893 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4067:Gcn1
|
UTSW |
5 |
115,737,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4152:Gcn1
|
UTSW |
5 |
115,751,413 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4179:Gcn1
|
UTSW |
5 |
115,726,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4292:Gcn1
|
UTSW |
5 |
115,714,207 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4350:Gcn1
|
UTSW |
5 |
115,741,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Gcn1
|
UTSW |
5 |
115,732,203 (GRCm39) |
missense |
probably benign |
|
|
R4672:Gcn1
|
UTSW |
5 |
115,744,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4753:Gcn1
|
UTSW |
5 |
115,754,537 (GRCm39) |
missense |
probably benign |
|
|
R4826:Gcn1
|
UTSW |
5 |
115,731,752 (GRCm39) |
missense |
probably benign |
|
|
R4873:Gcn1
|
UTSW |
5 |
115,714,229 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4875:Gcn1
|
UTSW |
5 |
115,714,229 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4932:Gcn1
|
UTSW |
5 |
115,730,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4992:Gcn1
|
UTSW |
5 |
115,737,225 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5049:Gcn1
|
UTSW |
5 |
115,744,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5211:Gcn1
|
UTSW |
5 |
115,757,371 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5226:Gcn1
|
UTSW |
5 |
115,726,126 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5338:Gcn1
|
UTSW |
5 |
115,721,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5914:Gcn1
|
UTSW |
5 |
115,748,194 (GRCm39) |
synonymous |
silent |
|
|
R5932:Gcn1
|
UTSW |
5 |
115,730,435 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6422:Gcn1
|
UTSW |
5 |
115,747,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Gcn1
|
UTSW |
5 |
115,749,081 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6607:Gcn1
|
UTSW |
5 |
115,747,537 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6724:Gcn1
|
UTSW |
5 |
115,747,217 (GRCm39) |
splice site |
probably null |
|
|
R6861:Gcn1
|
UTSW |
5 |
115,749,108 (GRCm39) |
missense |
probably benign |
|
|
R6875:Gcn1
|
UTSW |
5 |
115,726,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6910:Gcn1
|
UTSW |
5 |
115,744,597 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6975:Gcn1
|
UTSW |
5 |
115,751,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Gcn1
|
UTSW |
5 |
115,754,605 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7038:Gcn1
|
UTSW |
5 |
115,749,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7171:Gcn1
|
UTSW |
5 |
115,728,352 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7276:Gcn1
|
UTSW |
5 |
115,749,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7456:Gcn1
|
UTSW |
5 |
115,743,005 (GRCm39) |
nonsense |
probably null |
|
|
R7473:Gcn1
|
UTSW |
5 |
115,719,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7517:Gcn1
|
UTSW |
5 |
115,757,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7714:Gcn1
|
UTSW |
5 |
115,733,359 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7752:Gcn1
|
UTSW |
5 |
115,753,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Gcn1
|
UTSW |
5 |
115,731,751 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7922:Gcn1
|
UTSW |
5 |
115,752,527 (GRCm39) |
missense |
probably benign |
|
|
R8070:Gcn1
|
UTSW |
5 |
115,727,057 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8218:Gcn1
|
UTSW |
5 |
115,719,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8329:Gcn1
|
UTSW |
5 |
115,747,921 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8413:Gcn1
|
UTSW |
5 |
115,717,698 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8795:Gcn1
|
UTSW |
5 |
115,752,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8802:Gcn1
|
UTSW |
5 |
115,747,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8899:Gcn1
|
UTSW |
5 |
115,717,220 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8946:Gcn1
|
UTSW |
5 |
115,733,404 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8963:Gcn1
|
UTSW |
5 |
115,727,153 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9006:Gcn1
|
UTSW |
5 |
115,719,566 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9163:Gcn1
|
UTSW |
5 |
115,742,944 (GRCm39) |
missense |
probably benign |
|
|
R9177:Gcn1
|
UTSW |
5 |
115,719,867 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9187:Gcn1
|
UTSW |
5 |
115,752,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9411:Gcn1
|
UTSW |
5 |
115,733,098 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9541:Gcn1
|
UTSW |
5 |
115,754,416 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9574:Gcn1
|
UTSW |
5 |
115,713,341 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9630:Gcn1
|
UTSW |
5 |
115,741,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9651:Gcn1
|
UTSW |
5 |
115,747,665 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9761:Gcn1
|
UTSW |
5 |
115,729,064 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9765:Gcn1
|
UTSW |
5 |
115,735,131 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Gcn1
|
UTSW |
5 |
115,752,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1191:Gcn1
|
UTSW |
5 |
115,713,352 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGAAGGAGAAGCTTGGGACTC -3'
(R):5'- GTGATGGCATTGAGAGCGTC -3'
Sequencing Primer
(F):5'- TCCAGACGAGCAGCTGGTATG -3'
(R):5'- CATTGAGAGCGTCCCAGC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation