Incidental Mutation 'R0306:Stk35'
ID 35783
Institutional Source Beutler Lab
Gene Symbol Stk35
Ensembl Gene ENSMUSG00000037885
Gene Name serine/threonine kinase 35
Synonyms CLP-36 interacting kinase, CLIK1, 1700054C12Rik
MMRRC Submission 038517-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0306 (G1)
Quality Score 157
Status Validated
Chromosome 2
Chromosomal Location 129642437-129674207 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 129643683 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 222 (Y222*)
Ref Sequence ENSEMBL: ENSMUSP00000132862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165413] [ENSMUST00000166282]
AlphaFold Q80ZW0
Predicted Effect probably null
Transcript: ENSMUST00000165413
AA Change: Y222*
SMART Domains Protein: ENSMUSP00000126541
Gene: ENSMUSG00000037885
AA Change: Y222*

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 295 2e-6 PFAM
Pfam:Pkinase 207 531 8.6e-51 PFAM
Pfam:Pkinase_Tyr 304 532 2.1e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000166282
AA Change: Y222*
SMART Domains Protein: ENSMUSP00000132862
Gene: ENSMUSG00000037885
AA Change: Y222*

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 300 5.9e-7 PFAM
Pfam:Pkinase 207 311 1e-9 PFAM
Meta Mutation Damage Score 0.9591 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 94% (61/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1l1 T C 6: 48,953,020 (GRCm39) V315A probably damaging Het
BC028528 C T 3: 95,797,132 (GRCm39) probably benign Het
Bspry T C 4: 62,414,394 (GRCm39) F329S probably damaging Het
Cd209a A G 8: 3,795,535 (GRCm39) Y120H probably benign Het
Ces1f T C 8: 94,003,172 (GRCm39) probably benign Het
Cfap52 T C 11: 67,844,896 (GRCm39) N58D probably benign Het
Cfap74 G A 4: 155,549,896 (GRCm39) probably benign Het
Chst8 T C 7: 34,374,723 (GRCm39) E372G probably benign Het
Cplane1 T C 15: 8,209,373 (GRCm39) V270A probably damaging Het
Ddx49 A G 8: 70,747,322 (GRCm39) probably benign Het
Ddx52 G T 11: 83,835,474 (GRCm39) L133F probably benign Het
Defb26 T A 2: 152,349,888 (GRCm39) I131F unknown Het
Dip2c T A 13: 9,654,635 (GRCm39) S719T probably benign Het
Dnmt3a A G 12: 3,916,096 (GRCm39) S94G possibly damaging Het
Dytn G A 1: 63,724,272 (GRCm39) P3S possibly damaging Het
Fmn2 T C 1: 174,437,050 (GRCm39) probably benign Het
Gal3st1 T A 11: 3,948,546 (GRCm39) L251Q probably damaging Het
Gm19684 A T 17: 36,438,300 (GRCm39) probably benign Het
Il15 T A 8: 83,061,083 (GRCm39) probably benign Het
Jag1 C T 2: 136,927,855 (GRCm39) G852D probably damaging Het
Kbtbd4 A G 2: 90,744,530 (GRCm39) probably benign Het
Kdm3b C A 18: 34,937,070 (GRCm39) Q451K probably benign Het
Lrfn2 A T 17: 49,403,283 (GRCm39) I469F probably damaging Het
Mep1a A T 17: 43,813,534 (GRCm39) probably benign Het
Morn5 T C 2: 35,944,986 (GRCm39) F70S probably damaging Het
Nav2 C A 7: 49,195,651 (GRCm39) P1009Q probably benign Het
Noc3l T C 19: 38,796,094 (GRCm39) Y334C probably damaging Het
Nsun4 A T 4: 115,910,019 (GRCm39) Y180* probably null Het
Nup210l T C 3: 90,114,675 (GRCm39) I1750T probably benign Het
Or51s1 A T 7: 102,559,010 (GRCm39) I12N probably benign Het
Or5p53 A T 7: 107,532,907 (GRCm39) Y60F probably damaging Het
Or8u9 T A 2: 86,002,060 (GRCm39) I34F possibly damaging Het
Parp14 A G 16: 35,676,944 (GRCm39) L1008P probably benign Het
Paxbp1 A G 16: 90,819,003 (GRCm39) V759A possibly damaging Het
Prdm10 C A 9: 31,227,520 (GRCm39) Q42K probably damaging Het
Prkcsh T C 9: 21,917,822 (GRCm39) probably benign Het
Psmg1 A G 16: 95,788,540 (GRCm39) C138R probably damaging Het
Ptprb T C 10: 116,179,893 (GRCm39) M1437T probably benign Het
Ryr3 A G 2: 112,606,000 (GRCm39) probably null Het
Serpinf1 T C 11: 75,304,761 (GRCm39) Y200C probably damaging Het
Shox2 T C 3: 66,881,167 (GRCm39) H130R probably damaging Het
Slc22a1 A G 17: 12,881,485 (GRCm39) F335L probably benign Het
Slc44a5 A G 3: 153,975,638 (GRCm39) N683S probably damaging Het
Slc9a9 A T 9: 95,019,987 (GRCm39) T519S probably benign Het
Smarca2 T A 19: 26,618,013 (GRCm39) L348Q probably damaging Het
Sorbs1 T C 19: 40,332,855 (GRCm39) D521G possibly damaging Het
Sorbs2 A T 8: 46,248,767 (GRCm39) T593S probably benign Het
Srp19 T C 18: 34,467,629 (GRCm39) probably benign Het
Syt10 T G 15: 89,711,191 (GRCm39) K114T probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Trpc4ap A G 2: 155,478,180 (GRCm39) V662A probably benign Het
Ttll4 G A 1: 74,735,916 (GRCm39) R1066Q probably benign Het
Tulp2 C T 7: 45,168,000 (GRCm39) probably benign Het
Unc5b C A 10: 60,615,437 (GRCm39) probably benign Het
Vmn1r230 T A 17: 21,066,895 (GRCm39) I28K possibly damaging Het
Vmn2r118 A C 17: 55,915,616 (GRCm39) F445V possibly damaging Het
Zfp142 C T 1: 74,609,341 (GRCm39) E1485K probably damaging Het
Zfp819 C A 7: 43,266,621 (GRCm39) A292E possibly damaging Het
Other mutations in Stk35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00850:Stk35 APN 2 129,643,912 (GRCm39) missense probably damaging 1.00
IGL02609:Stk35 APN 2 129,643,721 (GRCm39) missense probably damaging 1.00
fingernails UTSW 2 129,652,855 (GRCm39) missense probably damaging 1.00
R2256_Stk35_331 UTSW 2 129,652,427 (GRCm39) nonsense probably null
skinned UTSW 2 129,653,155 (GRCm39) intron probably benign
R0045:Stk35 UTSW 2 129,642,488 (GRCm39) nonsense probably null
R0784:Stk35 UTSW 2 129,652,722 (GRCm39) nonsense probably null
R1536:Stk35 UTSW 2 129,653,155 (GRCm39) intron probably benign
R2256:Stk35 UTSW 2 129,652,427 (GRCm39) nonsense probably null
R2507:Stk35 UTSW 2 129,643,435 (GRCm39) missense probably damaging 0.97
R2508:Stk35 UTSW 2 129,643,435 (GRCm39) missense probably damaging 0.97
R3848:Stk35 UTSW 2 129,642,656 (GRCm39) missense probably benign 0.13
R3872:Stk35 UTSW 2 129,652,495 (GRCm39) missense possibly damaging 0.82
R4466:Stk35 UTSW 2 129,643,436 (GRCm39) missense probably damaging 0.99
R5144:Stk35 UTSW 2 129,652,855 (GRCm39) missense probably damaging 1.00
R6267:Stk35 UTSW 2 129,652,808 (GRCm39) nonsense probably null
R6296:Stk35 UTSW 2 129,652,808 (GRCm39) nonsense probably null
R6480:Stk35 UTSW 2 129,652,607 (GRCm39) missense possibly damaging 0.95
R6807:Stk35 UTSW 2 129,643,573 (GRCm39) missense probably damaging 0.97
R7203:Stk35 UTSW 2 129,643,513 (GRCm39) missense probably benign
R7476:Stk35 UTSW 2 129,652,645 (GRCm39) missense probably damaging 1.00
R8505:Stk35 UTSW 2 129,643,649 (GRCm39) missense probably damaging 0.99
R8998:Stk35 UTSW 2 129,652,509 (GRCm39) missense probably damaging 1.00
R8999:Stk35 UTSW 2 129,652,509 (GRCm39) missense probably damaging 1.00
R9224:Stk35 UTSW 2 129,652,491 (GRCm39) missense probably damaging 1.00
R9760:Stk35 UTSW 2 129,642,605 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCTCGCCCTTAGATCACCATCCAAG -3'
(R):5'- CTGTAGGACGCACTCCTCAAACTG -3'

Sequencing Primer
(F):5'- AGTCCAGCGGGTACTGTG -3'
(R):5'- CTCAAACTGCACGATATTCTGGTG -3'
Posted On 2013-05-09