Incidental Mutation 'R4755:Trp53bp1'
| ID |
357877 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trp53bp1
|
| Ensembl Gene |
ENSMUSG00000043909 |
| Gene Name |
transformation related protein 53 binding protein 1 |
| Synonyms |
53BP1, p53BP1 |
| MMRRC Submission |
042033-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4755 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
121023762-121101888 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 121059087 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 179
(R179*)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110647]
[ENSMUST00000110648]
[ENSMUST00000131245]
|
| AlphaFold |
P70399 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000110647
AA Change: R925*
|
| SMART Domains |
Protein: ENSMUSP00000106277
Gene: ENSMUSG00000043909
AA Change: R925*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1430 |
1551 |
2.5e-80 |
PFAM |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
BRCT
|
1673 |
1785 |
7.13e-1 |
SMART |
|
BRCT
|
1813 |
1901 |
1.03e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110648
AA Change: R925*
|
| SMART Domains |
Protein: ENSMUSP00000106278
Gene: ENSMUSG00000043909
AA Change: R925*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
low complexity region
|
1389 |
1409 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1480 |
1601 |
1.5e-80 |
PFAM |
|
low complexity region
|
1631 |
1651 |
N/A |
INTRINSIC |
|
BRCT
|
1723 |
1835 |
7.13e-1 |
SMART |
|
BRCT
|
1863 |
1951 |
1.03e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124031
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131245
|
| SMART Domains |
Protein: ENSMUSP00000114457
Gene: ENSMUSG00000043909
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000142400
AA Change: R73*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000147540
AA Change: R179*
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
96% (112/117) |
| MGI Phenotype |
PHENOTYPE: Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930449A18Rik |
T |
A |
3: 59,733,280 (GRCm39) |
|
noncoding transcript |
Het |
| Aadacl2fm1 |
C |
T |
3: 59,843,735 (GRCm39) |
A143V |
probably benign |
Het |
| Accs |
T |
C |
2: 93,671,682 (GRCm39) |
E236G |
probably damaging |
Het |
| Agrn |
C |
T |
4: 156,257,979 (GRCm39) |
|
probably benign |
Het |
| Ahi1 |
A |
G |
10: 20,930,946 (GRCm39) |
I929V |
possibly damaging |
Het |
| Akap5 |
C |
A |
12: 76,374,581 (GRCm39) |
C4* |
probably null |
Het |
| Amotl2 |
A |
T |
9: 102,597,679 (GRCm39) |
H146L |
probably damaging |
Het |
| Ank1 |
A |
G |
8: 23,594,990 (GRCm39) |
N666S |
probably damaging |
Het |
| Atp10d |
A |
T |
5: 72,403,509 (GRCm39) |
T373S |
probably benign |
Het |
| Bpifb9b |
T |
A |
2: 154,161,614 (GRCm39) |
M582K |
probably benign |
Het |
| Brca2 |
T |
A |
5: 150,483,452 (GRCm39) |
|
probably null |
Het |
| Ccdc149 |
A |
G |
5: 52,561,493 (GRCm39) |
V229A |
probably damaging |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Cdk5rap2 |
A |
G |
4: 70,156,662 (GRCm39) |
S1617P |
probably damaging |
Het |
| Cenpk |
A |
T |
13: 104,367,379 (GRCm39) |
M37L |
probably benign |
Het |
| Cenpk |
A |
T |
13: 104,386,020 (GRCm39) |
H305L |
probably benign |
Het |
| Ces5a |
C |
A |
8: 94,262,305 (GRCm39) |
A11S |
probably benign |
Het |
| Cfap65 |
T |
C |
1: 74,967,520 (GRCm39) |
E186G |
probably damaging |
Het |
| Cfh |
T |
A |
1: 140,016,546 (GRCm39) |
I593F |
probably damaging |
Het |
| Clstn2 |
C |
T |
9: 97,327,726 (GRCm39) |
V961I |
probably benign |
Het |
| Cog5 |
T |
A |
12: 31,919,405 (GRCm39) |
|
probably null |
Het |
| Col4a4 |
T |
C |
1: 82,518,895 (GRCm39) |
D100G |
unknown |
Het |
| Cyp3a41a |
T |
C |
5: 145,652,316 (GRCm39) |
D61G |
probably damaging |
Het |
| Dnah10 |
A |
G |
5: 124,824,809 (GRCm39) |
N655S |
probably benign |
Het |
| Dnai1 |
C |
G |
4: 41,610,269 (GRCm39) |
T295R |
probably damaging |
Het |
| Dnajc6 |
C |
T |
4: 101,407,996 (GRCm39) |
A44V |
probably damaging |
Het |
| Eif4enif1 |
A |
T |
11: 3,194,016 (GRCm39) |
D960V |
probably damaging |
Het |
| Fam167b |
C |
T |
4: 129,472,135 (GRCm39) |
G12R |
probably damaging |
Het |
| Fam20b |
A |
T |
1: 156,515,066 (GRCm39) |
Y266* |
probably null |
Het |
| Fer1l6 |
T |
A |
15: 58,512,060 (GRCm39) |
V1509D |
probably benign |
Het |
| Fhad1 |
A |
T |
4: 141,655,794 (GRCm39) |
I105N |
probably damaging |
Het |
| Fmo2 |
T |
C |
1: 162,716,374 (GRCm39) |
D71G |
probably damaging |
Het |
| Folr2 |
T |
C |
7: 101,493,006 (GRCm39) |
T6A |
possibly damaging |
Het |
| Fry |
A |
C |
5: 150,321,719 (GRCm39) |
E1018A |
probably damaging |
Het |
| Gas2l2 |
A |
G |
11: 83,320,193 (GRCm39) |
I21T |
probably damaging |
Het |
| Gfra1 |
T |
C |
19: 58,441,676 (GRCm39) |
Y85C |
probably damaging |
Het |
| Gpld1 |
A |
T |
13: 25,163,671 (GRCm39) |
Y43F |
probably benign |
Het |
| Gpld1 |
T |
A |
13: 25,163,675 (GRCm39) |
Y44* |
probably null |
Het |
| Grid2 |
A |
G |
6: 63,885,972 (GRCm39) |
T123A |
probably benign |
Het |
| Grina |
T |
C |
15: 76,133,442 (GRCm39) |
L305P |
probably damaging |
Het |
| Gucy1a1 |
G |
A |
3: 82,002,102 (GRCm39) |
A659V |
probably benign |
Het |
| H2-T10 |
T |
A |
17: 36,429,837 (GRCm39) |
K319* |
probably null |
Het |
| Hey2 |
A |
T |
10: 30,710,300 (GRCm39) |
V151E |
probably benign |
Het |
| Ighv1-69 |
G |
A |
12: 115,587,178 (GRCm39) |
T13I |
probably benign |
Het |
| Il1rap |
C |
A |
16: 26,541,532 (GRCm39) |
A591E |
probably benign |
Het |
| Ildr1 |
T |
C |
16: 36,542,383 (GRCm39) |
L261P |
probably benign |
Het |
| Jak1 |
A |
G |
4: 101,031,354 (GRCm39) |
Y463H |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 41,159,285 (GRCm39) |
I1666V |
probably benign |
Het |
| Lrp1b |
T |
A |
2: 41,361,028 (GRCm39) |
T592S |
probably benign |
Het |
| Lrrc36 |
A |
G |
8: 106,178,776 (GRCm39) |
T445A |
possibly damaging |
Het |
| Ly9 |
G |
A |
1: 171,434,806 (GRCm39) |
S29F |
probably damaging |
Het |
| Mapk7 |
A |
C |
11: 61,381,669 (GRCm39) |
C32W |
probably damaging |
Het |
| Marchf10 |
C |
T |
11: 105,255,302 (GRCm39) |
|
probably benign |
Het |
| Mier2 |
A |
T |
10: 79,385,031 (GRCm39) |
M119K |
probably damaging |
Het |
| Mpv17 |
A |
T |
5: 31,303,326 (GRCm39) |
C59* |
probably null |
Het |
| Mrpl27 |
G |
A |
11: 94,544,659 (GRCm39) |
|
probably benign |
Het |
| Myo18b |
G |
A |
5: 113,022,340 (GRCm39) |
Q351* |
probably null |
Het |
| Myo1a |
A |
G |
10: 127,551,557 (GRCm39) |
I704M |
probably damaging |
Het |
| Nadsyn1 |
A |
G |
7: 143,360,650 (GRCm39) |
C373R |
probably damaging |
Het |
| Nckipsd |
C |
A |
9: 108,691,938 (GRCm39) |
A513E |
probably benign |
Het |
| Neb |
T |
C |
2: 52,110,221 (GRCm39) |
D209G |
probably damaging |
Het |
| Nkapl |
T |
A |
13: 21,652,457 (GRCm39) |
Q52L |
unknown |
Het |
| Nptx2 |
G |
A |
5: 144,483,250 (GRCm39) |
S126N |
probably benign |
Het |
| Or2a7 |
G |
A |
6: 43,150,977 (GRCm39) |
S19N |
probably benign |
Het |
| Or52d3 |
T |
A |
7: 104,229,268 (GRCm39) |
Y138* |
probably null |
Het |
| Or7g17 |
A |
T |
9: 18,768,476 (GRCm39) |
H185L |
probably benign |
Het |
| Or8b52 |
A |
G |
9: 38,577,128 (GRCm39) |
V4A |
probably benign |
Het |
| Pclo |
A |
T |
5: 14,764,362 (GRCm39) |
R4278S |
unknown |
Het |
| Pcnx1 |
T |
G |
12: 81,997,068 (GRCm39) |
L988R |
probably damaging |
Het |
| Prl2c5 |
C |
A |
13: 13,363,970 (GRCm39) |
N75K |
probably benign |
Het |
| Prpf19 |
T |
G |
19: 10,875,154 (GRCm39) |
|
probably benign |
Het |
| Ralgapa1 |
A |
G |
12: 55,759,533 (GRCm39) |
S997P |
probably damaging |
Het |
| Rangap1 |
T |
C |
15: 81,597,118 (GRCm39) |
T226A |
probably benign |
Het |
| Rimklb |
G |
A |
6: 122,433,365 (GRCm39) |
L262F |
probably damaging |
Het |
| Rnf169 |
A |
G |
7: 99,574,930 (GRCm39) |
M555T |
probably benign |
Het |
| Rp1l1 |
A |
T |
14: 64,267,519 (GRCm39) |
D1035V |
probably benign |
Het |
| Rps23rg1 |
A |
T |
8: 3,633,922 (GRCm39) |
S8C |
probably damaging |
Het |
| Scd2 |
T |
A |
19: 44,289,791 (GRCm39) |
L262Q |
probably damaging |
Het |
| Scgb2b12 |
T |
A |
7: 32,024,956 (GRCm39) |
M84L |
probably benign |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Sipa1l1 |
G |
A |
12: 82,419,160 (GRCm39) |
V613I |
possibly damaging |
Het |
| Slc25a23 |
T |
A |
17: 57,359,794 (GRCm39) |
D67V |
possibly damaging |
Het |
| Slc25a39 |
C |
T |
11: 102,297,492 (GRCm39) |
|
probably benign |
Het |
| Slc4a10 |
T |
A |
2: 62,127,332 (GRCm39) |
F895Y |
probably damaging |
Het |
| Slc5a4a |
A |
C |
10: 76,022,398 (GRCm39) |
K578Q |
probably benign |
Het |
| Slc6a13 |
G |
A |
6: 121,302,008 (GRCm39) |
G197S |
probably damaging |
Het |
| Smarca2 |
A |
T |
19: 26,631,883 (GRCm39) |
E566V |
possibly damaging |
Het |
| Sorbs3 |
A |
T |
14: 70,421,548 (GRCm39) |
N594K |
probably benign |
Het |
| Spata22 |
A |
T |
11: 73,236,582 (GRCm39) |
D296V |
probably damaging |
Het |
| Sphk2 |
G |
A |
7: 45,363,058 (GRCm39) |
A11V |
possibly damaging |
Het |
| Spp1 |
A |
T |
5: 104,583,081 (GRCm39) |
|
probably benign |
Het |
| Strn3 |
T |
A |
12: 51,656,999 (GRCm39) |
I760L |
possibly damaging |
Het |
| Syk |
A |
T |
13: 52,796,022 (GRCm39) |
Y539F |
probably benign |
Het |
| Tdpoz9-ps1 |
T |
C |
3: 93,846,093 (GRCm39) |
|
probably null |
Het |
| Thsd7b |
T |
A |
1: 130,138,001 (GRCm39) |
Y1560N |
probably benign |
Het |
| Tmod2 |
C |
A |
9: 75,504,494 (GRCm39) |
E42* |
probably null |
Het |
| Tom1l1 |
T |
C |
11: 90,575,942 (GRCm39) |
E30G |
probably damaging |
Het |
| Trav10 |
G |
A |
14: 53,743,518 (GRCm39) |
A40T |
probably benign |
Het |
| Trav14-2 |
G |
A |
14: 53,878,237 (GRCm39) |
|
probably benign |
Het |
| Tril |
T |
A |
6: 53,795,449 (GRCm39) |
E591V |
probably damaging |
Het |
| Tspoap1 |
A |
T |
11: 87,662,489 (GRCm39) |
D562V |
possibly damaging |
Het |
| Usp44 |
A |
T |
10: 93,682,768 (GRCm39) |
H406L |
probably damaging |
Het |
| Vangl1 |
A |
G |
3: 102,065,608 (GRCm39) |
I509T |
probably benign |
Het |
| Vax2 |
T |
G |
6: 83,688,379 (GRCm39) |
L34W |
probably damaging |
Het |
| Vmn1r55 |
A |
T |
7: 5,150,025 (GRCm39) |
C133S |
probably damaging |
Het |
| Vmn2r8 |
T |
A |
5: 108,949,566 (GRCm39) |
D427V |
probably benign |
Het |
| Vwde |
A |
G |
6: 13,205,851 (GRCm39) |
I232T |
possibly damaging |
Het |
| Wnk1 |
C |
A |
6: 119,940,431 (GRCm39) |
A769S |
probably damaging |
Het |
| Xpo4 |
A |
C |
14: 57,855,638 (GRCm39) |
S264A |
probably benign |
Het |
| Zfp330 |
A |
T |
8: 83,496,015 (GRCm39) |
C75* |
probably null |
Het |
| Zfp526 |
T |
A |
7: 24,925,064 (GRCm39) |
L441Q |
probably benign |
Het |
| Zfp607b |
T |
G |
7: 27,402,930 (GRCm39) |
L462R |
probably damaging |
Het |
| Zfp719 |
T |
A |
7: 43,240,217 (GRCm39) |
F602I |
probably damaging |
Het |
|
| Other mutations in Trp53bp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Trp53bp1
|
APN |
2 |
121,087,060 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL00690:Trp53bp1
|
APN |
2 |
121,066,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00922:Trp53bp1
|
APN |
2 |
121,038,963 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01475:Trp53bp1
|
APN |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
IGL01639:Trp53bp1
|
APN |
2 |
121,033,173 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01662:Trp53bp1
|
APN |
2 |
121,066,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01757:Trp53bp1
|
APN |
2 |
121,041,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01829:Trp53bp1
|
APN |
2 |
121,046,377 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02247:Trp53bp1
|
APN |
2 |
121,067,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Trp53bp1
|
APN |
2 |
121,029,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Trp53bp1
|
APN |
2 |
121,033,191 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
chives
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
concur
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
confirmation
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Infra
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
Legume
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
lentil
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
lentil2
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Profundus
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
split_pea
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
verily
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Trp53bp1
|
UTSW |
2 |
121,101,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0045:Trp53bp1
|
UTSW |
2 |
121,034,978 (GRCm39) |
missense |
probably benign |
|
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0281:Trp53bp1
|
UTSW |
2 |
121,100,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Trp53bp1
|
UTSW |
2 |
121,035,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Trp53bp1
|
UTSW |
2 |
121,066,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trp53bp1
|
UTSW |
2 |
121,100,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0522:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0523:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0525:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0543:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0559:Trp53bp1
|
UTSW |
2 |
121,058,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Trp53bp1
|
UTSW |
2 |
121,058,653 (GRCm39) |
splice site |
probably benign |
|
|
R0593:Trp53bp1
|
UTSW |
2 |
121,101,009 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0648:Trp53bp1
|
UTSW |
2 |
121,066,188 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0680:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0732:Trp53bp1
|
UTSW |
2 |
121,078,745 (GRCm39) |
missense |
probably null |
0.96 |
|
R0905:Trp53bp1
|
UTSW |
2 |
121,034,799 (GRCm39) |
splice site |
probably benign |
|
|
R1377:Trp53bp1
|
UTSW |
2 |
121,101,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Trp53bp1
|
UTSW |
2 |
121,066,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Trp53bp1
|
UTSW |
2 |
121,082,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1971:Trp53bp1
|
UTSW |
2 |
121,035,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Trp53bp1
|
UTSW |
2 |
121,034,964 (GRCm39) |
missense |
probably benign |
|
|
R2143:Trp53bp1
|
UTSW |
2 |
121,046,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2282:Trp53bp1
|
UTSW |
2 |
121,100,754 (GRCm39) |
nonsense |
probably null |
|
|
R2296:Trp53bp1
|
UTSW |
2 |
121,039,728 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3106:Trp53bp1
|
UTSW |
2 |
121,067,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3793:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Trp53bp1
|
UTSW |
2 |
121,059,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4001:Trp53bp1
|
UTSW |
2 |
121,035,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4327:Trp53bp1
|
UTSW |
2 |
121,087,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Trp53bp1
|
UTSW |
2 |
121,038,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Trp53bp1
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4744:Trp53bp1
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4751:Trp53bp1
|
UTSW |
2 |
121,058,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Trp53bp1
|
UTSW |
2 |
121,038,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850:Trp53bp1
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4870:Trp53bp1
|
UTSW |
2 |
121,087,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Trp53bp1
|
UTSW |
2 |
121,033,084 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4924:Trp53bp1
|
UTSW |
2 |
121,051,701 (GRCm39) |
nonsense |
probably null |
|
|
R4962:Trp53bp1
|
UTSW |
2 |
121,101,027 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5019:Trp53bp1
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
R5111:Trp53bp1
|
UTSW |
2 |
121,041,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5149:Trp53bp1
|
UTSW |
2 |
121,046,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5252:Trp53bp1
|
UTSW |
2 |
121,074,464 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5533:Trp53bp1
|
UTSW |
2 |
121,038,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Trp53bp1
|
UTSW |
2 |
121,067,143 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5773:Trp53bp1
|
UTSW |
2 |
121,074,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5819:Trp53bp1
|
UTSW |
2 |
121,038,873 (GRCm39) |
nonsense |
probably null |
|
|
R5886:Trp53bp1
|
UTSW |
2 |
121,035,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5908:Trp53bp1
|
UTSW |
2 |
121,067,304 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Trp53bp1
|
UTSW |
2 |
121,087,083 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6351:Trp53bp1
|
UTSW |
2 |
121,100,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Trp53bp1
|
UTSW |
2 |
121,101,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6575:Trp53bp1
|
UTSW |
2 |
121,059,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6619:Trp53bp1
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6626:Trp53bp1
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6754:Trp53bp1
|
UTSW |
2 |
121,101,057 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6765:Trp53bp1
|
UTSW |
2 |
121,039,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6806:Trp53bp1
|
UTSW |
2 |
121,059,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6860:Trp53bp1
|
UTSW |
2 |
121,029,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6991:Trp53bp1
|
UTSW |
2 |
121,038,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7278:Trp53bp1
|
UTSW |
2 |
121,029,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Trp53bp1
|
UTSW |
2 |
121,066,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7357:Trp53bp1
|
UTSW |
2 |
121,041,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Trp53bp1
|
UTSW |
2 |
121,066,827 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7577:Trp53bp1
|
UTSW |
2 |
121,067,119 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7643:Trp53bp1
|
UTSW |
2 |
121,078,295 (GRCm39) |
splice site |
probably null |
|
|
R7728:Trp53bp1
|
UTSW |
2 |
121,038,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Trp53bp1
|
UTSW |
2 |
121,035,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7955:Trp53bp1
|
UTSW |
2 |
121,066,225 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8099:Trp53bp1
|
UTSW |
2 |
121,030,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8200:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8282:Trp53bp1
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9136:Trp53bp1
|
UTSW |
2 |
121,067,092 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9152:Trp53bp1
|
UTSW |
2 |
121,029,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9292:Trp53bp1
|
UTSW |
2 |
121,046,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9340:Trp53bp1
|
UTSW |
2 |
121,100,460 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9475:Trp53bp1
|
UTSW |
2 |
121,039,761 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9616:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9675:Trp53bp1
|
UTSW |
2 |
121,087,089 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9779:Trp53bp1
|
UTSW |
2 |
121,066,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF046:Trp53bp1
|
UTSW |
2 |
121,046,482 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Trp53bp1
|
UTSW |
2 |
121,084,126 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1177:Trp53bp1
|
UTSW |
2 |
121,074,541 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGAGGTCAAACCCTGCTG -3'
(R):5'- GGCTGTGAAGCTGATAGGAC -3'
Sequencing Primer
(F):5'- GTCAAACCCTGCTGCTCCAC -3'
(R):5'- GAAGGTGATATTATCCCACCA -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation