Mutagenetix > Incidental Mutation

Incidental Mutation 'R4741:Vmn1r17'

358073

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r17

Ensembl Gene

ENSMUSG00000115644

Gene Name

vomeronasal 1 receptor 17

Synonyms

V1rc16

MMRRC Submission

042026-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.218) question?

Stock #

R4741 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57337452-57338363 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 57338337 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 9 (Y9*)

Ref Sequence

ENSEMBL: ENSMUSP00000154129 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176395] [ENSMUST00000227186] [ENSMUST00000227966] [ENSMUST00000228156] [ENSMUST00000228294] [ENSMUST00000228342]

AlphaFold

Q8R2D8

Predicted Effect

probably null
Transcript: ENSMUST00000176395
AA Change: Y9*

SMART Domains

Protein: ENSMUSP00000135746
Gene: ENSMUSG00000093411
AA Change: Y9*

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.4e-53	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000227186
AA Change: Y9*

Predicted Effect

probably null
Transcript: ENSMUST00000227966
AA Change: Y9*

Predicted Effect

probably benign
Transcript: ENSMUST00000228156

Predicted Effect

probably benign
Transcript: ENSMUST00000228294

Predicted Effect

probably null
Transcript: ENSMUST00000228342
AA Change: Y9*

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angptl2	T	C	2: 33,136,200 (GRCm39)	Y462H	probably benign	Het
Arhgef12	A	G	9: 42,883,449 (GRCm39)	I1360T	possibly damaging	Het
Armc10	T	G	5: 21,856,834 (GRCm39)	L111R	probably damaging	Het
Atm	T	C	9: 53,364,907 (GRCm39)	K2628E	probably benign	Het
Best3	A	T	10: 116,859,901 (GRCm39)	N387I	probably benign	Het
Bltp1	A	G	3: 36,996,524 (GRCm39)	T1079A	probably damaging	Het
Brpf3	T	C	17: 29,036,758 (GRCm39)	F721S	possibly damaging	Het
Cacna1c	A	G	6: 118,590,271 (GRCm39)	S1411P	probably damaging	Het
Cldn8	G	A	16: 88,359,296 (GRCm39)	H210Y	probably benign	Het
Clip2	T	A	5: 134,545,123 (GRCm39)	T344S	probably benign	Het
Csmd1	A	C	8: 15,960,447 (GRCm39)	W3323G	probably damaging	Het
Doc2a	A	T	7: 126,450,617 (GRCm39)	T298S	possibly damaging	Het
Dpp9	T	C	17: 56,512,286 (GRCm39)	N234S	probably benign	Het
Dtx2	C	T	5: 136,055,371 (GRCm39)	R353C	probably benign	Het
Epm2aip1	A	G	9: 111,101,681 (GRCm39)	H218R	probably benign	Het
F2rl1	G	A	13: 95,650,651 (GRCm39)	T77M	probably damaging	Het
Fsd2	A	G	7: 81,201,643 (GRCm39)		probably null	Het
Grin2a	T	C	16: 9,481,376 (GRCm39)	Y475C	probably damaging	Het
H2-Ob	T	A	17: 34,461,545 (GRCm39)	S95T	possibly damaging	Het
Hddc3	A	G	7: 79,995,464 (GRCm39)	T160A	probably benign	Het
Hp	A	T	8: 110,302,104 (GRCm39)	C281*	probably null	Het
Ighg1	T	C	12: 113,290,178 (GRCm39)		probably benign	Het
Ints7	A	G	1: 191,351,747 (GRCm39)	I819V	probably benign	Het
Jam2	G	A	16: 84,609,840 (GRCm39)	V151M	probably damaging	Het
Jmjd1c	A	G	10: 67,060,718 (GRCm39)	I737V	possibly damaging	Het
Krt74	C	T	15: 101,669,876 (GRCm39)		noncoding transcript	Het
Lnpep	T	C	17: 17,791,920 (GRCm39)	Y407C	probably damaging	Het
Lrp4	T	G	2: 91,341,912 (GRCm39)	C1842G	probably damaging	Het
Mug2	T	A	6: 122,056,572 (GRCm39)	N1172K	probably benign	Het
Npy6r	A	T	18: 44,408,791 (GRCm39)	T71S	probably damaging	Het
Nsd3	A	T	8: 26,163,382 (GRCm39)	I591F	probably damaging	Het
Oog2	A	C	4: 143,921,715 (GRCm39)	E208D	possibly damaging	Het
Otogl	A	G	10: 107,615,121 (GRCm39)	I1928T	probably benign	Het
Papss1	T	C	3: 131,324,860 (GRCm39)	L418P	probably damaging	Het
Pcdhb13	T	A	18: 37,576,571 (GRCm39)	D316E	probably benign	Het
Pcdhgb2	T	A	18: 37,824,737 (GRCm39)		probably null	Het
Ptcd3	T	A	6: 71,879,933 (GRCm39)	L108F	probably damaging	Het
Ralgps1	T	C	2: 33,226,599 (GRCm39)	S31G	probably benign	Het
Rnf225	A	T	7: 12,661,857 (GRCm39)	H12L	probably benign	Het
Ryr3	T	A	2: 112,633,613 (GRCm39)	M2047L	probably damaging	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Serpinb3b	G	T	1: 107,082,200 (GRCm39)	Q355K	probably benign	Het
Slc8a2	T	A	7: 15,868,233 (GRCm39)	F155Y	probably damaging	Het
Taf1c	A	G	8: 120,330,134 (GRCm39)		probably benign	Het
Tln2	A	G	9: 67,293,837 (GRCm39)		probably null	Het
Tmpo	A	G	10: 90,998,506 (GRCm39)	V427A	probably benign	Het
Vmn2r63	C	T	7: 42,577,544 (GRCm39)	M331I	probably benign	Het
Zdhhc1	CGGGGG	CGGGGGG	8: 106,210,376 (GRCm39)		probably null	Het
Zfand5	C	T	19: 21,253,845 (GRCm39)	T16I	probably damaging	Het
Zfp352	A	T	4: 90,113,177 (GRCm39)	K439M	possibly damaging	Het
Zfp786	G	A	6: 47,797,625 (GRCm39)	H438Y	probably damaging	Het
Zfp808	T	A	13: 62,319,763 (GRCm39)	C331S	probably damaging	Het

Other mutations in Vmn1r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00943:Vmn1r17	APN	6	57,338,185 (GRCm39)	missense	possibly damaging	0.48
IGL02073:Vmn1r17	APN	6	57,337,787 (GRCm39)	missense	probably benign	0.00
IGL03117:Vmn1r17	APN	6	57,337,501 (GRCm39)	missense	probably benign	0.08
IGL03168:Vmn1r17	APN	6	57,337,583 (GRCm39)	missense	probably benign	0.01
R0472:Vmn1r17	UTSW	6	57,338,304 (GRCm39)	missense	probably benign
R0590:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R0648:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	probably damaging	0.98
R1025:Vmn1r17	UTSW	6	57,338,240 (GRCm39)	missense	probably benign	0.05
R1545:Vmn1r17	UTSW	6	57,338,317 (GRCm39)	missense	probably benign	0.01
R2035:Vmn1r17	UTSW	6	57,337,573 (GRCm39)	missense	probably benign	0.13
R2507:Vmn1r17	UTSW	6	57,338,244 (GRCm39)	missense	probably damaging	0.99
R2508:Vmn1r17	UTSW	6	57,337,855 (GRCm39)	missense	possibly damaging	0.76
R3084:Vmn1r17	UTSW	6	57,337,768 (GRCm39)	missense	probably damaging	0.99
R3688:Vmn1r17	UTSW	6	57,337,544 (GRCm39)	missense	probably damaging	0.99
R3696:Vmn1r17	UTSW	6	57,337,523 (GRCm39)	missense	possibly damaging	0.74
R4436:Vmn1r17	UTSW	6	57,337,719 (GRCm39)	missense	possibly damaging	0.91
R4989:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	possibly damaging	0.47
R5013:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5133:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5134:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5162:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5184:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5185:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5831:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R6487:Vmn1r17	UTSW	6	57,338,209 (GRCm39)	missense	possibly damaging	0.94
R7436:Vmn1r17	UTSW	6	57,337,862 (GRCm39)	missense	probably benign	0.03
R7600:Vmn1r17	UTSW	6	57,337,906 (GRCm39)	missense	probably benign	0.01
R8944:Vmn1r17	UTSW	6	57,338,142 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CACACTCAGGAGGCAAGTAGTAC -3'
(R):5'- AGAGACAAGGCAATCTTCAACTAG -3'

Sequencing Primer
(F):5'- AGAGGCCTCTTGTCACCCTG -3'
(R):5'- CAAGGCAATCTTCAACTAGTAAGG -3'

Posted On

2015-11-11