Incidental Mutation 'R4741:Npy6r'
ID358110
Institutional Source Beutler Lab
Gene Symbol Npy6r
Ensembl Gene ENSMUSG00000038071
Gene Nameneuropeptide Y receptor Y6
Synonyms
MMRRC Submission 042026-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R4741 (G1)
Quality Score225
Status Not validated
Chromosome18
Chromosomal Location44270127-44277700 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 44275724 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 71 (T71S)
Ref Sequence ENSEMBL: ENSMUSP00000040797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042747]
Predicted Effect probably damaging
Transcript: ENSMUST00000042747
AA Change: T71S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040797
Gene: ENSMUSG00000038071
AA Change: T71S

DomainStartEndE-ValueType
low complexity region 33 41 N/A INTRINSIC
Pfam:7tm_1 52 318 3.5e-51 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit enhanced performance on the rotarod test. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 36,942,375 T1079A probably damaging Het
Angptl2 T C 2: 33,246,188 Y462H probably benign Het
Arhgef12 A G 9: 42,972,153 I1360T possibly damaging Het
Armc10 T G 5: 21,651,836 L111R probably damaging Het
Atm T C 9: 53,453,607 K2628E probably benign Het
Best3 A T 10: 117,023,996 N387I probably benign Het
Brpf3 T C 17: 28,817,784 F721S possibly damaging Het
Cacna1c A G 6: 118,613,310 S1411P probably damaging Het
Cldn8 G A 16: 88,562,408 H210Y probably benign Het
Clip2 T A 5: 134,516,269 T344S probably benign Het
Csmd1 A C 8: 15,910,447 W3323G probably damaging Het
Doc2a A T 7: 126,851,445 T298S possibly damaging Het
Dpp9 T C 17: 56,205,286 N234S probably benign Het
Dtx2 C T 5: 136,026,517 R353C probably benign Het
Epm2aip1 A G 9: 111,272,613 H218R probably benign Het
F2rl1 G A 13: 95,514,143 T77M probably damaging Het
Fsd2 A G 7: 81,551,895 probably null Het
Grin2a T C 16: 9,663,512 Y475C probably damaging Het
H2-Ob T A 17: 34,242,571 S95T possibly damaging Het
Hddc3 A G 7: 80,345,716 T160A probably benign Het
Hp A T 8: 109,575,472 C281* probably null Het
Ighg1 T C 12: 113,326,558 probably benign Het
Ints7 A G 1: 191,619,635 I819V probably benign Het
Jam2 G A 16: 84,812,952 V151M probably damaging Het
Jmjd1c A G 10: 67,224,939 I737V possibly damaging Het
Krt74 C T 15: 101,761,441 noncoding transcript Het
Lnpep T C 17: 17,571,658 Y407C probably damaging Het
Lrp4 T G 2: 91,511,567 C1842G probably damaging Het
Mug2 T A 6: 122,079,613 N1172K probably benign Het
Nsd3 A T 8: 25,673,366 I591F probably damaging Het
Oog2 A C 4: 144,195,145 E208D possibly damaging Het
Otogl A G 10: 107,779,260 I1928T probably benign Het
Papss1 T C 3: 131,619,099 L418P probably damaging Het
Pcdhb13 T A 18: 37,443,518 D316E probably benign Het
Pcdhgb2 T A 18: 37,691,684 probably null Het
Ptcd3 T A 6: 71,902,949 L108F probably damaging Het
Ralgps1 T C 2: 33,336,587 S31G probably benign Het
Rnf225 A T 7: 12,927,930 H12L probably benign Het
Ryr3 T A 2: 112,803,268 M2047L probably damaging Het
Secisbp2l C T 2: 125,740,737 G933D possibly damaging Het
Serpinb3b G T 1: 107,154,470 Q355K probably benign Het
Slc8a2 T A 7: 16,134,308 F155Y probably damaging Het
Taf1c A G 8: 119,603,395 probably benign Het
Tln2 A G 9: 67,386,555 probably null Het
Tmpo A G 10: 91,162,644 V427A probably benign Het
Vmn1r17 A T 6: 57,361,352 Y9* probably null Het
Vmn2r63 C T 7: 42,928,120 M331I probably benign Het
Zdhhc1 CGGGGG CGGGGGG 8: 105,483,744 probably null Het
Zfand5 C T 19: 21,276,481 T16I probably damaging Het
Zfp352 A T 4: 90,224,940 K439M possibly damaging Het
Zfp786 G A 6: 47,820,691 H438Y probably damaging Het
Zfp808 T A 13: 62,171,949 C331S probably damaging Het
Other mutations in Npy6r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Npy6r APN 18 44276444 missense probably damaging 1.00
IGL00767:Npy6r APN 18 44276318 missense probably benign 0.01
IGL01103:Npy6r APN 18 44275518 missense probably benign 0.15
IGL02085:Npy6r APN 18 44275931 missense probably damaging 1.00
IGL02653:Npy6r APN 18 44276627 makesense probably null
IGL03305:Npy6r APN 18 44275854 missense probably damaging 1.00
R0588:Npy6r UTSW 18 44275821 missense possibly damaging 0.94
R1993:Npy6r UTSW 18 44276508 missense probably damaging 1.00
R2039:Npy6r UTSW 18 44276003 missense probably benign
R2567:Npy6r UTSW 18 44275821 missense possibly damaging 0.68
R4572:Npy6r UTSW 18 44275917 missense probably benign 0.03
R4584:Npy6r UTSW 18 44276195 missense probably damaging 1.00
R4611:Npy6r UTSW 18 44276401 missense probably damaging 1.00
R5145:Npy6r UTSW 18 44276619 missense probably benign 0.04
R5603:Npy6r UTSW 18 44276585 missense probably damaging 1.00
R5610:Npy6r UTSW 18 44275994 missense probably benign
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6083:Npy6r UTSW 18 44276492 missense probably damaging 0.99
R6364:Npy6r UTSW 18 44276511 missense possibly damaging 0.86
R7146:Npy6r UTSW 18 44275721 missense probably benign 0.30
R7178:Npy6r UTSW 18 44276484 missense probably damaging 1.00
R7180:Npy6r UTSW 18 44276156 missense probably benign
R7203:Npy6r UTSW 18 44275932 missense probably damaging 1.00
R7448:Npy6r UTSW 18 44276193 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGAAGTGCTCACAAACCAG -3'
(R):5'- TCGTTCAATAGCAATCAACACAAGG -3'

Sequencing Primer
(F):5'- CTAATAAAACCAGTGGCAAGAGC -3'
(R):5'- TCAACACAAGGGAGAATATGGACAC -3'
Posted On2015-11-11