Mutagenetix > Incidental Mutation

Incidental Mutation 'R4742:Vmn1r5'

358125

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r5

Ensembl Gene

ENSMUSG00000090346

Gene Name

vomeronasal 1 receptor 5

Synonyms

V1rc19

MMRRC Submission

041966-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R4742 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

56947320-56963335 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 56963236 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 304 (K304*)

Ref Sequence

ENSEMBL: ENSMUSP00000154081 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164307] [ENSMUST00000226130] [ENSMUST00000228276]

AlphaFold

B2RQT2

Predicted Effect

probably null
Transcript: ENSMUST00000164307
AA Change: K304*

SMART Domains

Protein: ENSMUSP00000131092
Gene: ENSMUSG00000090346
AA Change: K304*

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-53	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226130
AA Change: K304*

Predicted Effect

probably null
Transcript: ENSMUST00000228276
AA Change: K304*

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.8%
20x: 93.9%

Validation Efficiency

94% (51/54)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
8030423J24Rik	G	T	13: 71,031,644 (GRCm39)	R17L	unknown	Het
Acan	T	C	7: 78,750,517 (GRCm39)	F1763L	probably benign	Het
Adgrb1	T	A	15: 74,401,328 (GRCm39)	L108*	probably null	Het
Anapc2	T	A	2: 25,163,555 (GRCm39)		probably null	Het
Apbb1ip	A	G	2: 22,716,928 (GRCm39)	K177E	unknown	Het
Azgp1	T	A	5: 137,987,888 (GRCm39)	Y223*	probably null	Het
Cfap44	T	G	16: 44,269,615 (GRCm39)		probably null	Het
Chfr	C	T	5: 110,291,464 (GRCm39)	T94I	probably benign	Het
Chrna10	T	G	7: 101,762,344 (GRCm39)	Q282P	probably damaging	Het
Col9a3	G	T	2: 180,245,180 (GRCm39)	G130W	unknown	Het
Dcaf1	A	G	9: 106,735,754 (GRCm39)	T901A	probably benign	Het
Dock2	T	G	11: 34,244,170 (GRCm39)		probably null	Het
Dysf	C	A	6: 84,074,697 (GRCm39)	D499E	probably damaging	Het
Fdxacb1	A	G	9: 50,679,968 (GRCm39)		probably benign	Het
Fhip1b	A	G	7: 105,033,518 (GRCm39)	V566A	probably damaging	Het
Il31ra	G	T	13: 112,660,501 (GRCm39)	S615*	probably null	Het
Itgam	C	T	7: 127,712,245 (GRCm39)	S827F	probably damaging	Het
Mapkbp1	T	A	2: 119,847,299 (GRCm39)	V512E	probably damaging	Het
Myo1c	C	T	11: 75,560,856 (GRCm39)	R770*	probably null	Het
Nab2	T	C	10: 127,498,696 (GRCm39)	T458A	probably benign	Het
Nadsyn1	A	G	7: 143,352,367 (GRCm39)		probably benign	Het
Nek10	A	G	14: 14,861,624 (GRCm38)	D560G	probably null	Het
Or2ag13	A	T	7: 106,472,635 (GRCm39)	N272K	probably damaging	Het
Or2ak6	A	G	11: 58,592,685 (GRCm39)	R53G	probably benign	Het
Or8b46	T	C	9: 38,450,952 (GRCm39)	S254P	probably damaging	Het
Pou1f1	C	A	16: 65,320,367 (GRCm39)	P19T	probably benign	Het
Prdm9	A	T	17: 15,773,783 (GRCm39)	D329E	probably damaging	Het
Prkn	T	A	17: 11,456,591 (GRCm39)		probably null	Het
Ptprm	A	C	17: 67,051,746 (GRCm39)	Y962*	probably null	Het
Rad9a	G	A	19: 4,250,560 (GRCm39)	R85C	probably damaging	Het
Rhox2c	A	C	X: 36,635,351 (GRCm39)	Q4H	probably benign	Het
Rlig1	T	C	10: 100,414,243 (GRCm39)	I139V	probably benign	Het
Rtkn2	A	G	10: 67,839,144 (GRCm39)	T154A	possibly damaging	Het
Slitrk3	T	C	3: 72,955,898 (GRCm39)	D958G	probably benign	Het
Spata31d1b	C	A	13: 59,864,426 (GRCm39)	H525N	probably damaging	Het
Tacc2	A	G	7: 130,227,697 (GRCm39)	R1461G	probably benign	Het
Tas2r105	G	A	6: 131,663,814 (GRCm39)	H205Y	probably damaging	Het
Tenm4	A	G	7: 96,446,691 (GRCm39)	N809D	probably damaging	Het
Thoc2l	A	T	5: 104,666,723 (GRCm39)	N415I	probably benign	Het
Tns1	A	G	1: 74,163,449 (GRCm39)		probably null	Het
Top1	A	G	2: 160,545,490 (GRCm39)		probably null	Het
Traf3ip2	C	T	10: 39,515,256 (GRCm39)	P345S	possibly damaging	Het
Ttn	T	A	2: 76,585,168 (GRCm39)	I22042F	probably damaging	Het
Txndc9	T	C	1: 38,026,765 (GRCm39)	D135G	possibly damaging	Het
Usp3	A	G	9: 66,427,959 (GRCm39)	Y339H	probably damaging	Het
Vmn2r92	A	G	17: 18,387,119 (GRCm39)	T153A	probably benign	Het
Xkr5	A	T	8: 18,998,746 (GRCm39)	*55K	probably null	Het

Other mutations in Vmn1r5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01674:Vmn1r5	APN	6	56,962,911 (GRCm39)	missense	probably damaging	0.98
IGL02027:Vmn1r5	APN	6	56,962,640 (GRCm39)	missense	probably damaging	0.97
IGL03133:Vmn1r5	APN	6	56,962,600 (GRCm39)	missense	probably benign	0.10
IGL03412:Vmn1r5	APN	6	56,962,918 (GRCm39)	missense	possibly damaging	0.90
R0316:Vmn1r5	UTSW	6	56,962,784 (GRCm39)	missense	probably benign	0.27
R0378:Vmn1r5	UTSW	6	56,962,570 (GRCm39)	missense	probably benign	0.00
R0946:Vmn1r5	UTSW	6	56,963,150 (GRCm39)	missense	possibly damaging	0.64
R1511:Vmn1r5	UTSW	6	56,962,771 (GRCm39)	missense	probably benign	0.02
R1553:Vmn1r5	UTSW	6	56,962,483 (GRCm39)	missense	probably benign	0.00
R1823:Vmn1r5	UTSW	6	56,962,580 (GRCm39)	missense	probably damaging	0.98
R3980:Vmn1r5	UTSW	6	56,962,636 (GRCm39)	missense	probably damaging	1.00
R4473:Vmn1r5	UTSW	6	56,962,633 (GRCm39)	missense	probably benign	0.01
R5321:Vmn1r5	UTSW	6	56,962,592 (GRCm39)	missense	probably damaging	1.00
R5364:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R6102:Vmn1r5	UTSW	6	56,963,099 (GRCm39)	missense	probably damaging	0.96
R6581:Vmn1r5	UTSW	6	56,962,366 (GRCm39)	missense	probably benign
R6885:Vmn1r5	UTSW	6	56,963,042 (GRCm39)	missense	possibly damaging	0.89
R7297:Vmn1r5	UTSW	6	56,963,204 (GRCm39)	missense	possibly damaging	0.94
R8063:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R8766:Vmn1r5	UTSW	6	56,963,100 (GRCm39)	missense	possibly damaging	0.76
R8968:Vmn1r5	UTSW	6	56,963,182 (GRCm39)	nonsense	probably null
R9440:Vmn1r5	UTSW	6	56,962,415 (GRCm39)	missense	possibly damaging	0.67
R9460:Vmn1r5	UTSW	6	56,962,829 (GRCm39)	missense
Z1176:Vmn1r5	UTSW	6	56,962,933 (GRCm39)	missense	possibly damaging	0.75

Predicted Primers

PCR Primer
(F):5'- AGACCATCTTGCTGCTGGTG -3'
(R):5'- AGGACTCTCTACTGTTTGACAAC -3'

Sequencing Primer
(F):5'- GGTCATGTATTGGGTAGACTTAATC -3'
(R):5'- ACTGTTGCTACACAGGACGATTC -3'

Posted On

2015-11-11