Incidental Mutation 'R4742:Tas2r105'
ID 358127
Institutional Source Beutler Lab
Gene Symbol Tas2r105
Ensembl Gene ENSMUSG00000051153
Gene Name taste receptor, type 2, member 105
Synonyms T2r5, T2R05, mGR05, T2R9, mt2r5, Tas2r5
MMRRC Submission 041966-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R4742 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 131663524-131664426 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 131663814 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 205 (H205Y)
Ref Sequence ENSEMBL: ENSMUSP00000058006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
AlphaFold Q9JKT4
Predicted Effect probably damaging
Transcript: ENSMUST00000053652
AA Change: H205Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153
AA Change: H205Y

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072404
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080619
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Meta Mutation Damage Score 0.6644 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 94% (51/54)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation respond normally to a variety of bitter, sweet, umami, salty and sour stimuli but show a striking and selective impairement in their ability to taste cycloheximide (a bitter tastant). In addition, homozygotes are no longer behaviorally averse to cycloheximide. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
8030423J24Rik G T 13: 71,031,644 (GRCm39) R17L unknown Het
Acan T C 7: 78,750,517 (GRCm39) F1763L probably benign Het
Adgrb1 T A 15: 74,401,328 (GRCm39) L108* probably null Het
Anapc2 T A 2: 25,163,555 (GRCm39) probably null Het
Apbb1ip A G 2: 22,716,928 (GRCm39) K177E unknown Het
Azgp1 T A 5: 137,987,888 (GRCm39) Y223* probably null Het
Cfap44 T G 16: 44,269,615 (GRCm39) probably null Het
Chfr C T 5: 110,291,464 (GRCm39) T94I probably benign Het
Chrna10 T G 7: 101,762,344 (GRCm39) Q282P probably damaging Het
Col9a3 G T 2: 180,245,180 (GRCm39) G130W unknown Het
Dcaf1 A G 9: 106,735,754 (GRCm39) T901A probably benign Het
Dock2 T G 11: 34,244,170 (GRCm39) probably null Het
Dysf C A 6: 84,074,697 (GRCm39) D499E probably damaging Het
Fdxacb1 A G 9: 50,679,968 (GRCm39) probably benign Het
Fhip1b A G 7: 105,033,518 (GRCm39) V566A probably damaging Het
Il31ra G T 13: 112,660,501 (GRCm39) S615* probably null Het
Itgam C T 7: 127,712,245 (GRCm39) S827F probably damaging Het
Mapkbp1 T A 2: 119,847,299 (GRCm39) V512E probably damaging Het
Myo1c C T 11: 75,560,856 (GRCm39) R770* probably null Het
Nab2 T C 10: 127,498,696 (GRCm39) T458A probably benign Het
Nadsyn1 A G 7: 143,352,367 (GRCm39) probably benign Het
Nek10 A G 14: 14,861,624 (GRCm38) D560G probably null Het
Or2ag13 A T 7: 106,472,635 (GRCm39) N272K probably damaging Het
Or2ak6 A G 11: 58,592,685 (GRCm39) R53G probably benign Het
Or8b46 T C 9: 38,450,952 (GRCm39) S254P probably damaging Het
Pou1f1 C A 16: 65,320,367 (GRCm39) P19T probably benign Het
Prdm9 A T 17: 15,773,783 (GRCm39) D329E probably damaging Het
Prkn T A 17: 11,456,591 (GRCm39) probably null Het
Ptprm A C 17: 67,051,746 (GRCm39) Y962* probably null Het
Rad9a G A 19: 4,250,560 (GRCm39) R85C probably damaging Het
Rhox2c A C X: 36,635,351 (GRCm39) Q4H probably benign Het
Rlig1 T C 10: 100,414,243 (GRCm39) I139V probably benign Het
Rtkn2 A G 10: 67,839,144 (GRCm39) T154A possibly damaging Het
Slitrk3 T C 3: 72,955,898 (GRCm39) D958G probably benign Het
Spata31d1b C A 13: 59,864,426 (GRCm39) H525N probably damaging Het
Tacc2 A G 7: 130,227,697 (GRCm39) R1461G probably benign Het
Tenm4 A G 7: 96,446,691 (GRCm39) N809D probably damaging Het
Thoc2l A T 5: 104,666,723 (GRCm39) N415I probably benign Het
Tns1 A G 1: 74,163,449 (GRCm39) probably null Het
Top1 A G 2: 160,545,490 (GRCm39) probably null Het
Traf3ip2 C T 10: 39,515,256 (GRCm39) P345S possibly damaging Het
Ttn T A 2: 76,585,168 (GRCm39) I22042F probably damaging Het
Txndc9 T C 1: 38,026,765 (GRCm39) D135G possibly damaging Het
Usp3 A G 9: 66,427,959 (GRCm39) Y339H probably damaging Het
Vmn1r5 A T 6: 56,963,236 (GRCm39) K304* probably null Het
Vmn2r92 A G 17: 18,387,119 (GRCm39) T153A probably benign Het
Xkr5 A T 8: 18,998,746 (GRCm39) *55K probably null Het
Other mutations in Tas2r105
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01107:Tas2r105 APN 6 131,664,074 (GRCm39) missense probably benign 0.02
IGL01148:Tas2r105 APN 6 131,663,815 (GRCm39) missense probably damaging 1.00
IGL02882:Tas2r105 APN 6 131,664,143 (GRCm39) missense possibly damaging 0.95
R0833:Tas2r105 UTSW 6 131,664,393 (GRCm39) missense probably benign 0.01
R0836:Tas2r105 UTSW 6 131,664,393 (GRCm39) missense probably benign 0.01
R1429:Tas2r105 UTSW 6 131,663,904 (GRCm39) missense probably benign 0.01
R2010:Tas2r105 UTSW 6 131,664,365 (GRCm39) missense probably benign 0.41
R2418:Tas2r105 UTSW 6 131,664,410 (GRCm39) missense probably damaging 1.00
R4023:Tas2r105 UTSW 6 131,663,789 (GRCm39) missense probably benign 0.02
R4026:Tas2r105 UTSW 6 131,663,789 (GRCm39) missense probably benign 0.02
R5497:Tas2r105 UTSW 6 131,663,805 (GRCm39) splice site probably null
R5812:Tas2r105 UTSW 6 131,663,836 (GRCm39) missense possibly damaging 0.95
R7191:Tas2r105 UTSW 6 131,663,945 (GRCm39) missense probably damaging 0.99
R7236:Tas2r105 UTSW 6 131,663,723 (GRCm39) missense probably damaging 1.00
R7482:Tas2r105 UTSW 6 131,663,972 (GRCm39) missense probably benign 0.10
R8783:Tas2r105 UTSW 6 131,663,732 (GRCm39) missense possibly damaging 0.92
R8986:Tas2r105 UTSW 6 131,663,913 (GRCm39) nonsense probably null
R9250:Tas2r105 UTSW 6 131,663,951 (GRCm39) missense probably benign 0.00
R9580:Tas2r105 UTSW 6 131,663,699 (GRCm39) missense probably damaging 0.97
X0067:Tas2r105 UTSW 6 131,664,233 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- AAAGGCTTGCTTTAGCTGGC -3'
(R):5'- TTGCTAACTTCATGGGTAATCTCC -3'

Sequencing Primer
(F):5'- ATATGGATGCAGTTGTGAAACC -3'
(R):5'- ATGGGTAATCTCCTTCTCATTTGTTG -3'
Posted On 2015-11-11