Incidental Mutation 'R4734:Vmn2r102'
ID 359198
Institutional Source Beutler Lab
Gene Symbol Vmn2r102
Ensembl Gene ENSMUSG00000095961
Gene Name vomeronasal 2, receptor 102
Synonyms EG224572
MMRRC Submission 041961-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4734 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 19880661-19915010 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19897795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 270 (V270E)
Ref Sequence ENSEMBL: ENSMUSP00000126559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171741]
AlphaFold L7N279
Predicted Effect probably damaging
Transcript: ENSMUST00000171741
AA Change: V270E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: V270E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 448 5.2e-38 PFAM
Pfam:NCD3G 509 562 1.1e-21 PFAM
Pfam:7tm_3 595 830 1.8e-53 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,603,961 (GRCm39) M1V probably null Het
Abcb11 T A 2: 69,154,306 (GRCm39) T87S possibly damaging Het
Arap3 A G 18: 38,129,328 (GRCm39) V210A probably benign Het
Avl9 T C 6: 56,713,479 (GRCm39) S246P probably damaging Het
Ccdc88a A G 11: 29,432,720 (GRCm39) K222R probably benign Het
Cdhr18 T C 14: 13,845,292 (GRCm38) N540S probably benign Het
Cfap96 A T 8: 46,423,454 (GRCm39) M86K possibly damaging Het
Chsy3 C A 18: 59,312,485 (GRCm39) F319L probably benign Het
Coro2b T C 9: 62,333,860 (GRCm39) T345A probably benign Het
Cpb1 A G 3: 20,317,876 (GRCm39) V216A probably benign Het
Cyp2c65 A G 19: 39,060,778 (GRCm39) I213V probably benign Het
Dcaf15 A G 8: 84,824,357 (GRCm39) C586R probably benign Het
Ddr2 T A 1: 169,825,657 (GRCm39) E314D probably benign Het
Dennd5a C T 7: 109,495,543 (GRCm39) R1196H probably damaging Het
Dnah9 G A 11: 65,724,941 (GRCm39) A4404V probably damaging Het
Dpf2 A G 19: 5,957,027 (GRCm39) probably null Het
Eif2ak4 A T 2: 118,252,568 (GRCm39) H302L probably damaging Het
Eif2d G T 1: 131,092,889 (GRCm39) R399L probably damaging Het
Fat2 A G 11: 55,202,294 (GRCm39) V260A probably benign Het
Fhod3 T A 18: 25,161,192 (GRCm39) Y575N probably benign Het
Fscb T C 12: 64,521,244 (GRCm39) E74G possibly damaging Het
Gdpd2 G A X: 99,777,799 (GRCm39) M243I possibly damaging Het
Glra1 C A 11: 55,427,210 (GRCm39) D42Y probably damaging Het
Gnl2 T C 4: 124,934,811 (GRCm39) F156L probably benign Het
Gpr37 C A 6: 25,689,085 (GRCm39) R4L possibly damaging Het
Hectd4 A T 5: 121,480,040 (GRCm39) H2892L possibly damaging Het
Helb T C 10: 119,920,754 (GRCm39) D1063G probably benign Het
Htr2c A G X: 145,976,793 (GRCm39) T163A probably benign Het
Impact T A 18: 13,118,346 (GRCm39) H188Q probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lnx2 C T 5: 146,965,947 (GRCm39) G391R probably damaging Het
Lrrc19 T C 4: 94,526,586 (GRCm39) I324V probably benign Het
Lrrcc1 G T 3: 14,627,345 (GRCm39) Q458H probably damaging Het
Maml3 A T 3: 51,597,296 (GRCm39) D483E probably damaging Het
Mef2c T A 13: 83,810,748 (GRCm39) *467R probably null Het
Mms19 T A 19: 41,932,997 (GRCm39) S1031C probably damaging Het
Myt1l T C 12: 29,969,925 (GRCm39) I143T possibly damaging Het
Nuggc T C 14: 65,860,679 (GRCm39) Y426H probably damaging Het
Oit3 A T 10: 59,259,904 (GRCm39) C500S probably damaging Het
Oog2 T C 4: 143,923,021 (GRCm39) S429P probably benign Het
Or4d1 T A 11: 87,805,016 (GRCm39) T239S probably damaging Het
Or51f1 A G 7: 102,506,186 (GRCm39) I101T probably damaging Het
Or5p1 A T 7: 107,916,959 (GRCm39) N286I probably damaging Het
Or5p51 T C 7: 107,444,635 (GRCm39) I102V probably benign Het
Pcnt T C 10: 76,273,040 (GRCm39) D93G probably benign Het
Pdia5 A T 16: 35,276,883 (GRCm39) M95K probably benign Het
Pdzrn4 A T 15: 92,668,133 (GRCm39) R762* probably null Het
Piezo1 G T 8: 123,224,945 (GRCm39) Q654K probably damaging Het
Ppil3 A G 1: 58,470,428 (GRCm39) Y141H probably benign Het
Prb1c T A 6: 132,338,891 (GRCm39) N109I unknown Het
Rassf8 G T 6: 145,761,266 (GRCm39) K197N probably benign Het
Ryr2 T C 13: 11,752,639 (GRCm39) Q1894R probably damaging Het
Ryr3 T A 2: 112,740,847 (GRCm39) N487Y probably damaging Het
Scn5a T C 9: 119,368,604 (GRCm39) Y307C probably damaging Het
Sdad1 C T 5: 92,452,836 (GRCm39) R134Q possibly damaging Het
Shroom1 C T 11: 53,356,060 (GRCm39) S370F probably damaging Het
Slc29a3 A G 10: 60,552,105 (GRCm39) V313A probably benign Het
Slc2a9 C A 5: 38,539,442 (GRCm39) G353C probably damaging Het
Snx33 T A 9: 56,833,185 (GRCm39) T295S possibly damaging Het
Spata31d1b G A 13: 59,866,172 (GRCm39) V1107M probably damaging Het
Supt6 T C 11: 78,115,509 (GRCm39) D761G probably benign Het
Tfeb T C 17: 48,096,787 (GRCm39) V18A probably benign Het
Thap12 G T 7: 98,365,161 (GRCm39) C443F probably damaging Het
Thap12 T A 7: 98,365,162 (GRCm39) C443* probably null Het
Tmem67 T C 4: 12,063,158 (GRCm39) D496G probably benign Het
Trappc8 G A 18: 20,974,629 (GRCm39) R900* probably null Het
Trim9 T C 12: 70,295,047 (GRCm39) N688D probably damaging Het
Trmt1l A T 1: 151,318,388 (GRCm39) I80L probably benign Het
Trpm5 C A 7: 142,636,522 (GRCm39) V472L probably benign Het
Tspear C T 10: 77,700,529 (GRCm39) L120F probably damaging Het
Ttc9b G A 7: 27,355,443 (GRCm39) V238M probably benign Het
Usp20 A G 2: 30,909,836 (GRCm39) I819V probably benign Het
Vmn2r63 C T 7: 42,577,544 (GRCm39) M331I probably benign Het
Zc3h18 A T 8: 123,110,382 (GRCm39) D77V probably damaging Het
Zdhhc1 CGGGGG CGGGGGG 8: 106,210,376 (GRCm39) probably null Het
Other mutations in Vmn2r102
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Vmn2r102 APN 17 19,899,154 (GRCm39) missense probably damaging 1.00
IGL00974:Vmn2r102 APN 17 19,897,771 (GRCm39) missense possibly damaging 0.93
IGL00978:Vmn2r102 APN 17 19,899,185 (GRCm39) splice site probably null
IGL01589:Vmn2r102 APN 17 19,899,066 (GRCm39) missense probably benign
IGL01738:Vmn2r102 APN 17 19,898,020 (GRCm39) missense probably damaging 1.00
IGL01994:Vmn2r102 APN 17 19,880,731 (GRCm39) missense probably benign 0.00
IGL02066:Vmn2r102 APN 17 19,914,191 (GRCm39) missense probably benign 0.01
IGL02525:Vmn2r102 APN 17 19,901,447 (GRCm39) missense probably benign
IGL02589:Vmn2r102 APN 17 19,901,480 (GRCm39) missense probably damaging 1.00
IGL02814:Vmn2r102 APN 17 19,898,170 (GRCm39) missense probably damaging 1.00
IGL03028:Vmn2r102 APN 17 19,914,328 (GRCm39) missense possibly damaging 0.92
IGL03162:Vmn2r102 APN 17 19,914,286 (GRCm39) missense probably damaging 1.00
PIT4431001:Vmn2r102 UTSW 17 19,896,958 (GRCm39) missense possibly damaging 0.68
R0042:Vmn2r102 UTSW 17 19,880,851 (GRCm39) missense probably damaging 0.98
R0131:Vmn2r102 UTSW 17 19,899,025 (GRCm39) missense probably benign 0.42
R0131:Vmn2r102 UTSW 17 19,899,025 (GRCm39) missense probably benign 0.42
R0132:Vmn2r102 UTSW 17 19,899,025 (GRCm39) missense probably benign 0.42
R0268:Vmn2r102 UTSW 17 19,898,112 (GRCm39) missense probably benign 0.00
R0441:Vmn2r102 UTSW 17 19,914,630 (GRCm39) missense probably damaging 1.00
R0583:Vmn2r102 UTSW 17 19,897,043 (GRCm39) missense probably benign 0.01
R0600:Vmn2r102 UTSW 17 19,898,277 (GRCm39) missense probably benign 0.00
R0606:Vmn2r102 UTSW 17 19,899,106 (GRCm39) missense possibly damaging 0.93
R0674:Vmn2r102 UTSW 17 19,898,129 (GRCm39) missense probably benign 0.00
R0709:Vmn2r102 UTSW 17 19,897,881 (GRCm39) missense probably benign 0.01
R0879:Vmn2r102 UTSW 17 19,914,454 (GRCm39) missense probably damaging 1.00
R1349:Vmn2r102 UTSW 17 19,880,887 (GRCm39) splice site probably benign
R1473:Vmn2r102 UTSW 17 19,914,843 (GRCm39) missense probably benign 0.00
R1630:Vmn2r102 UTSW 17 19,899,032 (GRCm39) missense possibly damaging 0.60
R1727:Vmn2r102 UTSW 17 19,897,770 (GRCm39) missense probably damaging 0.99
R1759:Vmn2r102 UTSW 17 19,914,755 (GRCm39) missense probably damaging 1.00
R1809:Vmn2r102 UTSW 17 19,897,881 (GRCm39) missense probably benign 0.01
R2013:Vmn2r102 UTSW 17 19,897,006 (GRCm39) missense probably benign 0.03
R2086:Vmn2r102 UTSW 17 19,896,949 (GRCm39) missense probably damaging 1.00
R2241:Vmn2r102 UTSW 17 19,897,003 (GRCm39) missense probably benign 0.00
R2378:Vmn2r102 UTSW 17 19,914,930 (GRCm39) missense probably damaging 1.00
R3814:Vmn2r102 UTSW 17 19,899,093 (GRCm39) missense probably damaging 0.98
R3827:Vmn2r102 UTSW 17 19,914,787 (GRCm39) missense probably damaging 1.00
R4159:Vmn2r102 UTSW 17 19,898,088 (GRCm39) missense probably damaging 1.00
R4505:Vmn2r102 UTSW 17 19,880,845 (GRCm39) missense probably benign 0.00
R4515:Vmn2r102 UTSW 17 19,901,475 (GRCm39) missense probably damaging 1.00
R4517:Vmn2r102 UTSW 17 19,901,475 (GRCm39) missense probably damaging 1.00
R4534:Vmn2r102 UTSW 17 19,914,975 (GRCm39) missense probably benign
R4535:Vmn2r102 UTSW 17 19,914,975 (GRCm39) missense probably benign
R4662:Vmn2r102 UTSW 17 19,901,424 (GRCm39) missense probably damaging 1.00
R4708:Vmn2r102 UTSW 17 19,914,576 (GRCm39) missense probably benign 0.00
R4834:Vmn2r102 UTSW 17 19,898,203 (GRCm39) missense probably damaging 0.99
R4927:Vmn2r102 UTSW 17 19,880,661 (GRCm39) start codon destroyed probably benign 0.00
R5077:Vmn2r102 UTSW 17 19,897,834 (GRCm39) missense probably benign 0.20
R5181:Vmn2r102 UTSW 17 19,897,003 (GRCm39) missense probably benign 0.00
R5277:Vmn2r102 UTSW 17 19,914,393 (GRCm39) missense possibly damaging 0.49
R5418:Vmn2r102 UTSW 17 19,914,415 (GRCm39) missense probably damaging 1.00
R5810:Vmn2r102 UTSW 17 19,897,804 (GRCm39) missense probably benign 0.20
R5864:Vmn2r102 UTSW 17 19,914,943 (GRCm39) missense possibly damaging 0.55
R6168:Vmn2r102 UTSW 17 19,914,402 (GRCm39) missense possibly damaging 0.83
R6266:Vmn2r102 UTSW 17 19,899,007 (GRCm39) missense probably benign
R6432:Vmn2r102 UTSW 17 19,901,483 (GRCm39) missense possibly damaging 0.61
R6487:Vmn2r102 UTSW 17 19,898,169 (GRCm39) missense probably damaging 1.00
R6597:Vmn2r102 UTSW 17 19,914,450 (GRCm39) missense probably damaging 0.99
R6797:Vmn2r102 UTSW 17 19,880,694 (GRCm39) nonsense probably null
R7009:Vmn2r102 UTSW 17 19,914,456 (GRCm39) missense probably damaging 0.99
R7098:Vmn2r102 UTSW 17 19,914,670 (GRCm39) missense probably damaging 1.00
R7134:Vmn2r102 UTSW 17 19,897,749 (GRCm39) missense probably benign 0.01
R7463:Vmn2r102 UTSW 17 19,896,886 (GRCm39) missense probably damaging 1.00
R7511:Vmn2r102 UTSW 17 19,901,405 (GRCm39) missense probably damaging 1.00
R7512:Vmn2r102 UTSW 17 19,914,363 (GRCm39) missense probably damaging 1.00
R7556:Vmn2r102 UTSW 17 19,898,093 (GRCm39) missense probably benign
R8126:Vmn2r102 UTSW 17 19,880,712 (GRCm39) missense probably benign 0.02
R8385:Vmn2r102 UTSW 17 19,914,088 (GRCm39) missense possibly damaging 0.89
R8410:Vmn2r102 UTSW 17 19,898,196 (GRCm39) missense possibly damaging 0.85
R9045:Vmn2r102 UTSW 17 19,880,841 (GRCm39) missense probably benign 0.00
R9267:Vmn2r102 UTSW 17 19,896,928 (GRCm39) missense probably damaging 1.00
R9325:Vmn2r102 UTSW 17 19,897,558 (GRCm39) missense probably damaging 1.00
R9363:Vmn2r102 UTSW 17 19,897,614 (GRCm39) missense probably benign 0.04
R9524:Vmn2r102 UTSW 17 19,897,564 (GRCm39) missense possibly damaging 0.74
R9747:Vmn2r102 UTSW 17 19,898,129 (GRCm39) missense probably benign 0.00
Z1176:Vmn2r102 UTSW 17 19,914,305 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATGGGTTGGTCTCATACTCCC -3'
(R):5'- GCCACAGCTTAGGAAGATAAATGTC -3'

Sequencing Primer
(F):5'- GGTTGGTCTCATACTCCCTGATGAC -3'
(R):5'- ACTCAAAATTCTCTCTATAACTGTGC -3'
Posted On 2015-11-11