Incidental Mutation 'R4737:Pappa2'
| ID |
359304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
PAPP-A2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PLAC3, Pappe |
| MMRRC Submission |
042024-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4737 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158539297-158788019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 158784582 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 143
(R143G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159861
AA Change: R143G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: R143G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159892
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177789
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
100% (94/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430110L20Rik |
A |
G |
1: 181,055,384 (GRCm39) |
|
noncoding transcript |
Het |
| Acp2 |
A |
T |
2: 91,041,068 (GRCm39) |
R419W |
probably benign |
Het |
| Actr5 |
A |
G |
2: 158,469,991 (GRCm39) |
N207S |
probably damaging |
Het |
| Afap1 |
G |
A |
5: 36,119,126 (GRCm39) |
V254M |
probably benign |
Het |
| Arfgef1 |
A |
T |
1: 10,259,836 (GRCm39) |
M544K |
possibly damaging |
Het |
| Arhgap5 |
A |
T |
12: 52,565,860 (GRCm39) |
M944L |
probably benign |
Het |
| Bnip3l-ps |
G |
A |
12: 18,266,773 (GRCm39) |
|
noncoding transcript |
Het |
| Carf |
A |
G |
1: 60,148,477 (GRCm39) |
T58A |
probably benign |
Het |
| Carns1 |
A |
G |
19: 4,220,927 (GRCm39) |
|
probably benign |
Het |
| Ccp110 |
T |
A |
7: 118,323,771 (GRCm39) |
I670K |
possibly damaging |
Het |
| Cftr |
T |
A |
6: 18,299,882 (GRCm39) |
D1218E |
probably benign |
Het |
| Chrna9 |
A |
T |
5: 66,125,214 (GRCm39) |
T52S |
probably damaging |
Het |
| Chst9 |
T |
C |
18: 15,585,834 (GRCm39) |
Y243C |
probably damaging |
Het |
| Ciao3 |
A |
T |
17: 26,000,283 (GRCm39) |
H322L |
probably damaging |
Het |
| Cilk1 |
A |
G |
9: 78,057,936 (GRCm39) |
T162A |
probably damaging |
Het |
| Clk2 |
A |
T |
3: 89,076,016 (GRCm39) |
H62L |
probably benign |
Het |
| Cntnap2 |
A |
T |
6: 45,037,251 (GRCm39) |
R10W |
possibly damaging |
Het |
| Cpt1b |
C |
T |
15: 89,305,609 (GRCm39) |
D369N |
probably benign |
Het |
| Crhr2 |
G |
T |
6: 55,068,290 (GRCm39) |
H423Q |
probably damaging |
Het |
| D8Ertd738e |
T |
A |
8: 84,976,150 (GRCm39) |
I33F |
probably damaging |
Het |
| Dbt |
T |
C |
3: 116,332,781 (GRCm39) |
I200T |
probably damaging |
Het |
| Ddhd1 |
A |
T |
14: 45,866,278 (GRCm39) |
|
probably benign |
Het |
| Ddx27 |
A |
G |
2: 166,871,219 (GRCm39) |
I480V |
probably benign |
Het |
| Dpp9 |
A |
C |
17: 56,505,970 (GRCm39) |
|
probably null |
Het |
| Dpy19l3 |
A |
T |
7: 35,402,926 (GRCm39) |
M562K |
probably damaging |
Het |
| Dus3l |
T |
C |
17: 57,074,868 (GRCm39) |
L330P |
probably damaging |
Het |
| Efcab7 |
C |
T |
4: 99,719,805 (GRCm39) |
Q96* |
probably null |
Het |
| Egfr |
T |
C |
11: 16,819,231 (GRCm39) |
F254L |
probably damaging |
Het |
| Eml5 |
C |
T |
12: 98,765,111 (GRCm39) |
V1566M |
probably damaging |
Het |
| Entpd7 |
T |
A |
19: 43,679,634 (GRCm39) |
Y62* |
probably null |
Het |
| Erbb4 |
T |
C |
1: 68,383,059 (GRCm39) |
M313V |
probably damaging |
Het |
| Gm5528 |
A |
G |
1: 72,043,711 (GRCm39) |
|
noncoding transcript |
Het |
| H2-M9 |
G |
T |
17: 36,951,631 (GRCm39) |
Y281* |
probably null |
Het |
| Hmcn1 |
T |
G |
1: 150,565,346 (GRCm39) |
K2260N |
possibly damaging |
Het |
| Hnf4a |
A |
G |
2: 163,406,139 (GRCm39) |
I259V |
probably benign |
Het |
| Insm1 |
A |
T |
2: 146,064,822 (GRCm39) |
T213S |
probably benign |
Het |
| Iqca1 |
T |
C |
1: 90,005,544 (GRCm39) |
D488G |
probably damaging |
Het |
| Kdm5a |
T |
A |
6: 120,382,976 (GRCm39) |
|
probably benign |
Het |
| Kdm7a |
G |
C |
6: 39,129,773 (GRCm39) |
L468V |
possibly damaging |
Het |
| Lck |
G |
A |
4: 129,449,777 (GRCm39) |
T229I |
possibly damaging |
Het |
| Lig3 |
T |
C |
11: 82,678,553 (GRCm39) |
L265P |
probably damaging |
Het |
| Lipa |
T |
A |
19: 34,479,034 (GRCm39) |
K229* |
probably null |
Het |
| Lrrk1 |
C |
T |
7: 65,956,621 (GRCm39) |
S418N |
probably benign |
Het |
| Mark2 |
A |
G |
19: 7,258,597 (GRCm39) |
V126A |
probably damaging |
Het |
| Met |
T |
C |
6: 17,491,540 (GRCm39) |
C101R |
probably damaging |
Het |
| Mkln1 |
A |
T |
6: 31,403,734 (GRCm39) |
K85M |
probably damaging |
Het |
| Mst1 |
A |
G |
9: 107,957,720 (GRCm39) |
R15G |
probably benign |
Het |
| Muc6 |
T |
G |
7: 141,226,426 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
G |
T |
7: 141,218,685 (GRCm39) |
T1996N |
possibly damaging |
Het |
| Myo7b |
T |
C |
18: 32,131,655 (GRCm39) |
S514G |
probably damaging |
Het |
| Nars1 |
T |
C |
18: 64,649,498 (GRCm39) |
E11G |
probably benign |
Het |
| Ogdh |
T |
A |
11: 6,247,044 (GRCm39) |
F23I |
probably benign |
Het |
| Or10g9 |
A |
T |
9: 39,911,718 (GRCm39) |
D268E |
probably damaging |
Het |
| Or12e9 |
T |
C |
2: 87,202,665 (GRCm39) |
I263T |
probably damaging |
Het |
| Or4a39 |
C |
T |
2: 89,236,830 (GRCm39) |
V198I |
probably benign |
Het |
| Or4b1b |
A |
G |
2: 90,112,725 (GRCm39) |
S65P |
probably damaging |
Het |
| Or4c100 |
C |
T |
2: 88,356,569 (GRCm39) |
S214F |
probably damaging |
Het |
| Or52r1c |
C |
T |
7: 102,735,121 (GRCm39) |
A127V |
probably damaging |
Het |
| Or9k2 |
T |
A |
10: 129,998,707 (GRCm39) |
T163S |
probably benign |
Het |
| Otub2 |
T |
A |
12: 103,359,103 (GRCm39) |
L64Q |
probably benign |
Het |
| Patl2 |
T |
A |
2: 121,955,787 (GRCm39) |
T250S |
probably damaging |
Het |
| Pcdhac2 |
C |
T |
18: 37,278,952 (GRCm39) |
T644I |
possibly damaging |
Het |
| Pi4kb |
C |
T |
3: 94,911,649 (GRCm39) |
T690I |
probably damaging |
Het |
| Pla2g4d |
T |
C |
2: 120,097,271 (GRCm39) |
Y776C |
probably benign |
Het |
| Plekhh2 |
C |
T |
17: 84,871,387 (GRCm39) |
S215L |
probably benign |
Het |
| Psmd2 |
T |
G |
16: 20,478,565 (GRCm39) |
|
probably benign |
Het |
| Ptpn21 |
T |
C |
12: 98,675,103 (GRCm39) |
E183G |
probably benign |
Het |
| Ptprg |
T |
A |
14: 12,226,314 (GRCm38) |
D527E |
probably damaging |
Het |
| Rhobtb1 |
T |
A |
10: 69,115,327 (GRCm39) |
|
probably null |
Het |
| Scel |
T |
A |
14: 103,809,473 (GRCm39) |
M271K |
possibly damaging |
Het |
| Senp3 |
A |
T |
11: 69,569,655 (GRCm39) |
C310* |
probably null |
Het |
| Slc25a3 |
T |
C |
10: 90,958,050 (GRCm39) |
T97A |
possibly damaging |
Het |
| Srsf11 |
A |
T |
3: 157,732,369 (GRCm39) |
Y82* |
probably null |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tbkbp1 |
T |
C |
11: 97,039,474 (GRCm39) |
E145G |
probably damaging |
Het |
| Tln1 |
T |
C |
4: 43,540,588 (GRCm39) |
N1471S |
probably benign |
Het |
| Tnn |
T |
G |
1: 159,973,659 (GRCm39) |
D236A |
probably damaging |
Het |
| Trmt2a |
C |
T |
16: 18,069,150 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubxn10 |
G |
A |
4: 138,463,259 (GRCm39) |
|
probably benign |
Het |
| Ulk4 |
G |
A |
9: 120,902,938 (GRCm39) |
Q1180* |
probably null |
Het |
| Usp43 |
T |
A |
11: 67,746,331 (GRCm39) |
K1120N |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,131,149 (GRCm39) |
L244Q |
possibly damaging |
Het |
| Vmn1r32 |
T |
C |
6: 66,530,629 (GRCm39) |
H49R |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,317,384 (GRCm39) |
D118G |
probably damaging |
Het |
| Vwce |
A |
G |
19: 10,627,943 (GRCm39) |
I468V |
probably benign |
Het |
| Zbtb7c |
G |
T |
18: 76,279,225 (GRCm39) |
R561L |
probably benign |
Het |
| Zfp956 |
T |
C |
6: 47,939,476 (GRCm39) |
S175P |
probably damaging |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,684,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,592,674 (GRCm39) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,642,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,684,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,764,089 (GRCm39) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,611,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,672,695 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,589,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,542,571 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,764,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,678,786 (GRCm39) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,764,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,609,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,678,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,764,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,682,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,592,637 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,682,419 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,592,671 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,675,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,590,628 (GRCm39) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,590,625 (GRCm39) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,660,343 (GRCm39) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,544,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,672,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,764,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,784,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,784,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,590,720 (GRCm39) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,641,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,684,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,631,073 (GRCm39) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,578,133 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,662,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,784,214 (GRCm39) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,684,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,592,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,763,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,642,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4738:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4739:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4788:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,684,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,666,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,784,703 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,589,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,642,355 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,666,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,784,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,675,615 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,544,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,763,820 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,542,567 (GRCm39) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,699,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,662,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,764,438 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,675,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,784,753 (GRCm39) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,590,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,784,096 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,764,456 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,642,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,678,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,764,010 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,589,131 (GRCm39) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,609,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,675,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,764,126 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,763,555 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,764,234 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,682,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,592,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,764,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,678,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,764,518 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,763,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,763,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,684,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,763,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,672,614 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,764,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,784,542 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,642,029 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,784,817 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,609,818 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,675,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,611,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,641,967 (GRCm39) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,764,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,784,503 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGAAACCTTGAGGGGTATTC -3'
(R):5'- GCAGCAAACCCTGTATGCAG -3'
Sequencing Primer
(F):5'- GGGGTCTCCAGTCATGTCTTC -3'
(R):5'- CCCTGTATGCAGAATGGAGTC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation