Incidental Mutation 'R4739:Erbb4'
| ID |
359477 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
042025-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4739 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 68383059 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 313
(M313V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119142
AA Change: M313V
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121473
AA Change: M313V
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: M313V
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Meta Mutation Damage Score |
0.0983 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.5%
|
| Validation Efficiency |
96% (102/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
C |
T |
1: 158,796,904 (GRCm39) |
|
noncoding transcript |
Het |
| 2300002M23Rik |
A |
G |
17: 35,878,403 (GRCm39) |
|
probably benign |
Het |
| Aadat |
T |
C |
8: 60,993,140 (GRCm39) |
V360A |
probably benign |
Het |
| Abcc5 |
T |
A |
16: 20,218,376 (GRCm39) |
D283V |
probably damaging |
Het |
| Abraxas1 |
T |
A |
5: 100,959,886 (GRCm39) |
K155N |
probably damaging |
Het |
| Acot3 |
T |
C |
12: 84,105,364 (GRCm39) |
I277T |
probably benign |
Het |
| Ankrd45 |
G |
A |
1: 160,982,960 (GRCm39) |
C157Y |
probably damaging |
Het |
| Apol10a |
C |
T |
15: 77,372,841 (GRCm39) |
T159I |
possibly damaging |
Het |
| Arhgef11 |
G |
A |
3: 87,605,306 (GRCm39) |
V214M |
possibly damaging |
Het |
| Ash1l |
A |
C |
3: 88,890,152 (GRCm39) |
N677T |
probably benign |
Het |
| Atg13 |
A |
G |
2: 91,515,040 (GRCm39) |
S254P |
probably damaging |
Het |
| Atg16l2 |
A |
G |
7: 100,946,385 (GRCm39) |
L129P |
probably damaging |
Het |
| Avl9 |
T |
A |
6: 56,703,294 (GRCm39) |
V120D |
probably damaging |
Het |
| Castor1 |
A |
G |
11: 4,169,004 (GRCm39) |
E57G |
possibly damaging |
Het |
| Cc2d1b |
T |
C |
4: 108,485,239 (GRCm39) |
V527A |
probably benign |
Het |
| Ccnl1 |
A |
G |
3: 65,854,092 (GRCm39) |
|
probably benign |
Het |
| Cenpl |
T |
A |
1: 160,910,837 (GRCm39) |
D261E |
probably damaging |
Het |
| Cep192 |
T |
G |
18: 67,984,803 (GRCm39) |
I1604M |
probably benign |
Het |
| Cep95 |
A |
G |
11: 106,706,560 (GRCm39) |
I573V |
probably benign |
Het |
| Cfap100 |
A |
G |
6: 90,389,825 (GRCm39) |
|
probably null |
Het |
| Ciao3 |
A |
T |
17: 26,000,283 (GRCm39) |
H322L |
probably damaging |
Het |
| Cmc1 |
T |
A |
9: 117,904,245 (GRCm39) |
M49L |
probably benign |
Het |
| Cyfip2 |
G |
T |
11: 46,170,820 (GRCm39) |
N176K |
probably damaging |
Het |
| Cyp2w1 |
T |
C |
5: 139,342,430 (GRCm39) |
F408L |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,172,971 (GRCm39) |
S399F |
possibly damaging |
Het |
| Dcbld2 |
T |
A |
16: 58,281,339 (GRCm39) |
L528Q |
probably damaging |
Het |
| Dip2b |
T |
C |
15: 100,105,658 (GRCm39) |
V1138A |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,583,375 (GRCm39) |
L119Q |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,677,169 (GRCm39) |
D444G |
possibly damaging |
Het |
| Dsg1c |
A |
T |
18: 20,408,246 (GRCm39) |
N432Y |
possibly damaging |
Het |
| Dst |
T |
A |
1: 34,230,228 (GRCm39) |
I2785N |
probably benign |
Het |
| Dynap |
A |
T |
18: 70,374,296 (GRCm39) |
Y77N |
possibly damaging |
Het |
| Eif4g3 |
T |
C |
4: 137,910,510 (GRCm39) |
L1330P |
possibly damaging |
Het |
| Eif4g3 |
T |
A |
4: 137,925,408 (GRCm39) |
S1584T |
probably benign |
Het |
| Enpp1 |
A |
T |
10: 24,555,146 (GRCm39) |
C67S |
probably null |
Het |
| Enpp5 |
C |
T |
17: 44,392,027 (GRCm39) |
T152I |
probably damaging |
Het |
| Erc2 |
T |
G |
14: 27,498,838 (GRCm39) |
L238R |
probably damaging |
Het |
| Eya3 |
T |
A |
4: 132,448,698 (GRCm39) |
|
probably benign |
Het |
| Farp1 |
T |
C |
14: 121,476,199 (GRCm39) |
F339L |
probably damaging |
Het |
| Fsip2 |
A |
C |
2: 82,805,697 (GRCm39) |
D672A |
possibly damaging |
Het |
| Gap43 |
G |
T |
16: 42,112,581 (GRCm39) |
P60Q |
probably benign |
Het |
| Gpr37l1 |
T |
A |
1: 135,094,783 (GRCm39) |
I154F |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,746,329 (GRCm39) |
S1314P |
probably damaging |
Het |
| Hectd4 |
A |
T |
5: 121,486,505 (GRCm39) |
M3167L |
probably benign |
Het |
| Hps3 |
C |
T |
3: 20,084,574 (GRCm39) |
|
probably null |
Het |
| Hps5 |
A |
G |
7: 46,436,013 (GRCm39) |
C178R |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,297,384 (GRCm39) |
|
probably benign |
Het |
| Impdh2-ps |
A |
G |
8: 100,757,839 (GRCm39) |
|
noncoding transcript |
Het |
| Josd2 |
T |
A |
7: 44,120,678 (GRCm39) |
N138K |
probably damaging |
Het |
| Mtmr6 |
T |
G |
14: 60,529,546 (GRCm39) |
M315R |
probably damaging |
Het |
| Mtrf1 |
G |
A |
14: 79,650,520 (GRCm39) |
V323M |
probably damaging |
Het |
| Myo16 |
G |
T |
8: 10,423,527 (GRCm39) |
G288W |
probably damaging |
Het |
| Myo18a |
T |
C |
11: 77,714,149 (GRCm39) |
Y748H |
probably damaging |
Het |
| Nek1 |
A |
T |
8: 61,551,545 (GRCm39) |
N853I |
probably benign |
Het |
| Npnt |
T |
G |
3: 132,610,452 (GRCm39) |
T272P |
possibly damaging |
Het |
| Obi1 |
C |
T |
14: 104,747,819 (GRCm39) |
D43N |
probably damaging |
Het |
| Or2ag1b |
C |
A |
7: 106,288,351 (GRCm39) |
E196* |
probably null |
Het |
| Or2b6 |
T |
A |
13: 21,823,340 (GRCm39) |
M118L |
possibly damaging |
Het |
| Or2y17 |
G |
A |
11: 49,232,148 (GRCm39) |
G263D |
probably benign |
Het |
| Or51e1 |
T |
A |
7: 102,359,378 (GRCm39) |
I304N |
probably damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,017 (GRCm39) |
T318I |
possibly damaging |
Het |
| Or5a1 |
A |
G |
19: 12,097,234 (GRCm39) |
Y269H |
possibly damaging |
Het |
| Pappa2 |
T |
C |
1: 158,784,582 (GRCm39) |
R143G |
probably benign |
Het |
| Pappa2 |
T |
G |
1: 158,784,572 (GRCm39) |
D146A |
probably damaging |
Het |
| Pcsk9 |
C |
T |
4: 106,304,353 (GRCm39) |
G496R |
probably damaging |
Het |
| Pes1 |
A |
G |
11: 3,914,058 (GRCm39) |
K8E |
probably damaging |
Het |
| Phlpp2 |
G |
A |
8: 110,667,052 (GRCm39) |
G1194S |
probably damaging |
Het |
| Pkn1 |
A |
C |
8: 84,398,378 (GRCm39) |
V763G |
probably damaging |
Het |
| Pkp2 |
C |
A |
16: 16,048,588 (GRCm39) |
A331E |
probably damaging |
Het |
| Plb1 |
T |
A |
5: 32,507,023 (GRCm39) |
|
probably null |
Het |
| Plxna1 |
A |
T |
6: 89,309,657 (GRCm39) |
|
probably null |
Het |
| Polq |
C |
T |
16: 36,862,109 (GRCm39) |
T264M |
probably damaging |
Het |
| Prkag3 |
T |
C |
1: 74,779,864 (GRCm39) |
*490W |
probably null |
Het |
| Prl2c1 |
T |
C |
13: 28,041,661 (GRCm39) |
C228R |
probably damaging |
Het |
| Pus7l |
T |
C |
15: 94,438,591 (GRCm39) |
S85G |
probably benign |
Het |
| Rfc3 |
A |
C |
5: 151,568,241 (GRCm39) |
|
probably benign |
Het |
| Riox2 |
A |
G |
16: 59,309,732 (GRCm39) |
N362S |
probably benign |
Het |
| Scaper |
A |
T |
9: 55,650,932 (GRCm39) |
D904E |
probably damaging |
Het |
| Scn11a |
T |
C |
9: 119,583,627 (GRCm39) |
M1663V |
probably benign |
Het |
| Slc13a3 |
A |
T |
2: 165,272,209 (GRCm39) |
I278N |
possibly damaging |
Het |
| Slc22a7 |
T |
C |
17: 46,745,923 (GRCm39) |
E278G |
probably damaging |
Het |
| Snrnp48 |
T |
A |
13: 38,393,893 (GRCm39) |
M66K |
probably damaging |
Het |
| Styk1 |
T |
G |
6: 131,277,429 (GRCm39) |
E404A |
probably damaging |
Het |
| Synj1 |
T |
A |
16: 90,752,307 (GRCm39) |
H1016L |
probably benign |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tjp2 |
T |
C |
19: 24,097,475 (GRCm39) |
|
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,190,518 (GRCm39) |
|
probably null |
Het |
| Trappc9 |
T |
G |
15: 72,808,909 (GRCm39) |
Y718S |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
| Ugt2a3 |
C |
T |
5: 87,475,054 (GRCm39) |
G397R |
probably damaging |
Het |
| Wdr33 |
T |
A |
18: 32,019,139 (GRCm39) |
M454K |
probably benign |
Het |
| Wdtc1 |
G |
T |
4: 133,029,110 (GRCm39) |
N325K |
possibly damaging |
Het |
| Whrn |
T |
C |
4: 63,336,402 (GRCm39) |
H720R |
probably damaging |
Het |
| Xirp2 |
A |
T |
2: 67,349,609 (GRCm39) |
D3268V |
probably damaging |
Het |
| Zc3h7a |
A |
T |
16: 10,959,573 (GRCm39) |
H793Q |
probably damaging |
Het |
| Zfp518b |
C |
T |
5: 38,831,841 (GRCm39) |
A55T |
possibly damaging |
Het |
| Zmynd8 |
G |
A |
2: 165,647,249 (GRCm39) |
T901M |
probably damaging |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTAGCTAATCCCACTGGC -3'
(R):5'- ATGTATGTGGTTCAGAGGAAGAGTC -3'
Sequencing Primer
(F):5'- CTAGACCAGACTGTTCTAGAGTTCG -3'
(R):5'- TGTGGTTCAGAGGAAGAGTCATAAAC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation