Incidental Mutation 'R4739:Pappa2'
| ID |
359480 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
PAPP-A2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PLAC3, Pappe |
| MMRRC Submission |
042025-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4739 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158539297-158788019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 158784572 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Alanine
at position 146
(D146A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159861
AA Change: D146A
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: D146A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159892
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177789
|
| Meta Mutation Damage Score |
0.0625 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.5%
|
| Validation Efficiency |
96% (102/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
C |
T |
1: 158,796,904 (GRCm39) |
|
noncoding transcript |
Het |
| 2300002M23Rik |
A |
G |
17: 35,878,403 (GRCm39) |
|
probably benign |
Het |
| Aadat |
T |
C |
8: 60,993,140 (GRCm39) |
V360A |
probably benign |
Het |
| Abcc5 |
T |
A |
16: 20,218,376 (GRCm39) |
D283V |
probably damaging |
Het |
| Abraxas1 |
T |
A |
5: 100,959,886 (GRCm39) |
K155N |
probably damaging |
Het |
| Acot3 |
T |
C |
12: 84,105,364 (GRCm39) |
I277T |
probably benign |
Het |
| Ankrd45 |
G |
A |
1: 160,982,960 (GRCm39) |
C157Y |
probably damaging |
Het |
| Apol10a |
C |
T |
15: 77,372,841 (GRCm39) |
T159I |
possibly damaging |
Het |
| Arhgef11 |
G |
A |
3: 87,605,306 (GRCm39) |
V214M |
possibly damaging |
Het |
| Ash1l |
A |
C |
3: 88,890,152 (GRCm39) |
N677T |
probably benign |
Het |
| Atg13 |
A |
G |
2: 91,515,040 (GRCm39) |
S254P |
probably damaging |
Het |
| Atg16l2 |
A |
G |
7: 100,946,385 (GRCm39) |
L129P |
probably damaging |
Het |
| Avl9 |
T |
A |
6: 56,703,294 (GRCm39) |
V120D |
probably damaging |
Het |
| Castor1 |
A |
G |
11: 4,169,004 (GRCm39) |
E57G |
possibly damaging |
Het |
| Cc2d1b |
T |
C |
4: 108,485,239 (GRCm39) |
V527A |
probably benign |
Het |
| Ccnl1 |
A |
G |
3: 65,854,092 (GRCm39) |
|
probably benign |
Het |
| Cenpl |
T |
A |
1: 160,910,837 (GRCm39) |
D261E |
probably damaging |
Het |
| Cep192 |
T |
G |
18: 67,984,803 (GRCm39) |
I1604M |
probably benign |
Het |
| Cep95 |
A |
G |
11: 106,706,560 (GRCm39) |
I573V |
probably benign |
Het |
| Cfap100 |
A |
G |
6: 90,389,825 (GRCm39) |
|
probably null |
Het |
| Ciao3 |
A |
T |
17: 26,000,283 (GRCm39) |
H322L |
probably damaging |
Het |
| Cmc1 |
T |
A |
9: 117,904,245 (GRCm39) |
M49L |
probably benign |
Het |
| Cyfip2 |
G |
T |
11: 46,170,820 (GRCm39) |
N176K |
probably damaging |
Het |
| Cyp2w1 |
T |
C |
5: 139,342,430 (GRCm39) |
F408L |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,172,971 (GRCm39) |
S399F |
possibly damaging |
Het |
| Dcbld2 |
T |
A |
16: 58,281,339 (GRCm39) |
L528Q |
probably damaging |
Het |
| Dip2b |
T |
C |
15: 100,105,658 (GRCm39) |
V1138A |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,583,375 (GRCm39) |
L119Q |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,677,169 (GRCm39) |
D444G |
possibly damaging |
Het |
| Dsg1c |
A |
T |
18: 20,408,246 (GRCm39) |
N432Y |
possibly damaging |
Het |
| Dst |
T |
A |
1: 34,230,228 (GRCm39) |
I2785N |
probably benign |
Het |
| Dynap |
A |
T |
18: 70,374,296 (GRCm39) |
Y77N |
possibly damaging |
Het |
| Eif4g3 |
T |
C |
4: 137,910,510 (GRCm39) |
L1330P |
possibly damaging |
Het |
| Eif4g3 |
T |
A |
4: 137,925,408 (GRCm39) |
S1584T |
probably benign |
Het |
| Enpp1 |
A |
T |
10: 24,555,146 (GRCm39) |
C67S |
probably null |
Het |
| Enpp5 |
C |
T |
17: 44,392,027 (GRCm39) |
T152I |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,383,059 (GRCm39) |
M313V |
probably damaging |
Het |
| Erc2 |
T |
G |
14: 27,498,838 (GRCm39) |
L238R |
probably damaging |
Het |
| Eya3 |
T |
A |
4: 132,448,698 (GRCm39) |
|
probably benign |
Het |
| Farp1 |
T |
C |
14: 121,476,199 (GRCm39) |
F339L |
probably damaging |
Het |
| Fsip2 |
A |
C |
2: 82,805,697 (GRCm39) |
D672A |
possibly damaging |
Het |
| Gap43 |
G |
T |
16: 42,112,581 (GRCm39) |
P60Q |
probably benign |
Het |
| Gpr37l1 |
T |
A |
1: 135,094,783 (GRCm39) |
I154F |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,746,329 (GRCm39) |
S1314P |
probably damaging |
Het |
| Hectd4 |
A |
T |
5: 121,486,505 (GRCm39) |
M3167L |
probably benign |
Het |
| Hps3 |
C |
T |
3: 20,084,574 (GRCm39) |
|
probably null |
Het |
| Hps5 |
A |
G |
7: 46,436,013 (GRCm39) |
C178R |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,297,384 (GRCm39) |
|
probably benign |
Het |
| Impdh2-ps |
A |
G |
8: 100,757,839 (GRCm39) |
|
noncoding transcript |
Het |
| Josd2 |
T |
A |
7: 44,120,678 (GRCm39) |
N138K |
probably damaging |
Het |
| Mtmr6 |
T |
G |
14: 60,529,546 (GRCm39) |
M315R |
probably damaging |
Het |
| Mtrf1 |
G |
A |
14: 79,650,520 (GRCm39) |
V323M |
probably damaging |
Het |
| Myo16 |
G |
T |
8: 10,423,527 (GRCm39) |
G288W |
probably damaging |
Het |
| Myo18a |
T |
C |
11: 77,714,149 (GRCm39) |
Y748H |
probably damaging |
Het |
| Nek1 |
A |
T |
8: 61,551,545 (GRCm39) |
N853I |
probably benign |
Het |
| Npnt |
T |
G |
3: 132,610,452 (GRCm39) |
T272P |
possibly damaging |
Het |
| Obi1 |
C |
T |
14: 104,747,819 (GRCm39) |
D43N |
probably damaging |
Het |
| Or2ag1b |
C |
A |
7: 106,288,351 (GRCm39) |
E196* |
probably null |
Het |
| Or2b6 |
T |
A |
13: 21,823,340 (GRCm39) |
M118L |
possibly damaging |
Het |
| Or2y17 |
G |
A |
11: 49,232,148 (GRCm39) |
G263D |
probably benign |
Het |
| Or51e1 |
T |
A |
7: 102,359,378 (GRCm39) |
I304N |
probably damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,017 (GRCm39) |
T318I |
possibly damaging |
Het |
| Or5a1 |
A |
G |
19: 12,097,234 (GRCm39) |
Y269H |
possibly damaging |
Het |
| Pcsk9 |
C |
T |
4: 106,304,353 (GRCm39) |
G496R |
probably damaging |
Het |
| Pes1 |
A |
G |
11: 3,914,058 (GRCm39) |
K8E |
probably damaging |
Het |
| Phlpp2 |
G |
A |
8: 110,667,052 (GRCm39) |
G1194S |
probably damaging |
Het |
| Pkn1 |
A |
C |
8: 84,398,378 (GRCm39) |
V763G |
probably damaging |
Het |
| Pkp2 |
C |
A |
16: 16,048,588 (GRCm39) |
A331E |
probably damaging |
Het |
| Plb1 |
T |
A |
5: 32,507,023 (GRCm39) |
|
probably null |
Het |
| Plxna1 |
A |
T |
6: 89,309,657 (GRCm39) |
|
probably null |
Het |
| Polq |
C |
T |
16: 36,862,109 (GRCm39) |
T264M |
probably damaging |
Het |
| Prkag3 |
T |
C |
1: 74,779,864 (GRCm39) |
*490W |
probably null |
Het |
| Prl2c1 |
T |
C |
13: 28,041,661 (GRCm39) |
C228R |
probably damaging |
Het |
| Pus7l |
T |
C |
15: 94,438,591 (GRCm39) |
S85G |
probably benign |
Het |
| Rfc3 |
A |
C |
5: 151,568,241 (GRCm39) |
|
probably benign |
Het |
| Riox2 |
A |
G |
16: 59,309,732 (GRCm39) |
N362S |
probably benign |
Het |
| Scaper |
A |
T |
9: 55,650,932 (GRCm39) |
D904E |
probably damaging |
Het |
| Scn11a |
T |
C |
9: 119,583,627 (GRCm39) |
M1663V |
probably benign |
Het |
| Slc13a3 |
A |
T |
2: 165,272,209 (GRCm39) |
I278N |
possibly damaging |
Het |
| Slc22a7 |
T |
C |
17: 46,745,923 (GRCm39) |
E278G |
probably damaging |
Het |
| Snrnp48 |
T |
A |
13: 38,393,893 (GRCm39) |
M66K |
probably damaging |
Het |
| Styk1 |
T |
G |
6: 131,277,429 (GRCm39) |
E404A |
probably damaging |
Het |
| Synj1 |
T |
A |
16: 90,752,307 (GRCm39) |
H1016L |
probably benign |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tjp2 |
T |
C |
19: 24,097,475 (GRCm39) |
|
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,190,518 (GRCm39) |
|
probably null |
Het |
| Trappc9 |
T |
G |
15: 72,808,909 (GRCm39) |
Y718S |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
| Ugt2a3 |
C |
T |
5: 87,475,054 (GRCm39) |
G397R |
probably damaging |
Het |
| Wdr33 |
T |
A |
18: 32,019,139 (GRCm39) |
M454K |
probably benign |
Het |
| Wdtc1 |
G |
T |
4: 133,029,110 (GRCm39) |
N325K |
possibly damaging |
Het |
| Whrn |
T |
C |
4: 63,336,402 (GRCm39) |
H720R |
probably damaging |
Het |
| Xirp2 |
A |
T |
2: 67,349,609 (GRCm39) |
D3268V |
probably damaging |
Het |
| Zc3h7a |
A |
T |
16: 10,959,573 (GRCm39) |
H793Q |
probably damaging |
Het |
| Zfp518b |
C |
T |
5: 38,831,841 (GRCm39) |
A55T |
possibly damaging |
Het |
| Zmynd8 |
G |
A |
2: 165,647,249 (GRCm39) |
T901M |
probably damaging |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,684,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,592,674 (GRCm39) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,642,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,684,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,764,089 (GRCm39) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,611,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,672,695 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,589,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,542,571 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,764,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,678,786 (GRCm39) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,764,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,609,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,678,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,764,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,682,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,592,637 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,682,419 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,592,671 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,675,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,590,628 (GRCm39) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,590,625 (GRCm39) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,660,343 (GRCm39) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,544,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,672,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,764,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,784,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,784,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,590,720 (GRCm39) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,641,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,684,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,631,073 (GRCm39) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,578,133 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,662,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,784,214 (GRCm39) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,684,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,592,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,763,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,642,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4788:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,684,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,666,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,784,703 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,589,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,642,355 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,666,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,784,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,675,615 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,544,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,763,820 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,542,567 (GRCm39) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,699,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,662,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,764,438 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,675,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,784,753 (GRCm39) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,590,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,784,096 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,764,456 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,642,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,678,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,764,010 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,589,131 (GRCm39) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,609,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,675,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,764,126 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,763,555 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,764,234 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,682,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,592,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,764,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,678,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,764,518 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,763,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,763,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,684,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,763,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,672,614 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,764,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,784,542 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,642,029 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,784,817 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,609,818 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,675,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,611,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,641,967 (GRCm39) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,764,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,784,503 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTCTCCAGTCATGTCTTCTG -3'
(R):5'- ACCCAAGGTCCTATCCTGTG -3'
Sequencing Primer
(F):5'- AGTCATGTCTTCTGCCTGC -3'
(R):5'- GACACAGCAGCAAACCCTGTATG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation