Incidental Mutation 'R0348:Igsf11'
ID 36027
Institutional Source Beutler Lab
Gene Symbol Igsf11
Ensembl Gene ENSMUSG00000022790
Gene Name immunoglobulin superfamily, member 11
Synonyms 1700025L02Rik, BT-IgSF
MMRRC Submission 038555-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0348 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 38713033-38847521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 38829179 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 24 (D24E)
Ref Sequence ENSEMBL: ENSMUSP00000110354 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023478] [ENSMUST00000114706]
AlphaFold P0C673
Predicted Effect probably benign
Transcript: ENSMUST00000023478
AA Change: D83E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000023478
Gene: ENSMUSG00000022790
AA Change: D83E

DomainStartEndE-ValueType
IG 29 143 4.32e-8 SMART
IGc2 156 222 2.54e-5 SMART
transmembrane domain 240 262 N/A INTRINSIC
low complexity region 271 286 N/A INTRINSIC
low complexity region 301 319 N/A INTRINSIC
Blast:DEXDc 355 425 8e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000114706
AA Change: D24E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000110354
Gene: ENSMUSG00000022790
AA Change: D24E

DomainStartEndE-ValueType
IG_like 11 84 3.12e1 SMART
IGc2 97 163 2.54e-5 SMART
transmembrane domain 181 203 N/A INTRINSIC
low complexity region 212 227 N/A INTRINSIC
low complexity region 242 260 N/A INTRINSIC
Blast:DEXDc 296 366 5e-14 BLAST
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit disrupted synaptic transmission and plasticity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921536K21Rik T C 11: 3,844,987 (GRCm39) D34G probably benign Het
Adam6a T C 12: 113,508,337 (GRCm39) S237P probably damaging Het
Adamts13 A C 2: 26,871,092 (GRCm39) D235A probably benign Het
Adgb T A 10: 10,233,623 (GRCm39) M1259L probably benign Het
Apbb1 T C 7: 105,214,510 (GRCm39) Q529R probably damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Camta1 T C 4: 151,670,888 (GRCm39) T96A possibly damaging Het
Ccdc148 A T 2: 58,894,084 (GRCm39) probably null Het
Cep170b T C 12: 112,703,240 (GRCm39) Y568H probably damaging Het
Clca4b A T 3: 144,627,741 (GRCm39) I410N probably damaging Het
Cnot10 G A 9: 114,427,838 (GRCm39) T592I probably benign Het
Col6a3 C T 1: 90,755,771 (GRCm39) A173T probably damaging Het
Ctcf T A 8: 106,402,789 (GRCm39) C560* probably null Het
Daglb G A 5: 143,472,951 (GRCm39) V369I probably benign Het
Defb19 G A 2: 152,422,146 (GRCm39) L8F unknown Het
Emcn G T 3: 137,078,608 (GRCm39) E65* probably null Het
Etl4 G T 2: 20,782,940 (GRCm39) R753L probably damaging Het
Fam151b T C 13: 92,586,689 (GRCm39) Y248C probably benign Het
Fmo1 T C 1: 162,663,704 (GRCm39) D275G probably benign Het
Gjd4 A G 18: 9,280,964 (GRCm39) V38A possibly damaging Het
Hivep1 T C 13: 42,311,855 (GRCm39) V1365A possibly damaging Het
Hivep2 T C 10: 14,005,702 (GRCm39) S767P possibly damaging Het
Hoxa6 T C 6: 52,183,548 (GRCm39) T166A possibly damaging Het
Ift80 G T 3: 68,843,232 (GRCm39) L367I probably benign Het
Igf2bp1 T C 11: 95,859,719 (GRCm39) N369S possibly damaging Het
Ints5 C T 19: 8,873,114 (GRCm39) L358F probably damaging Het
Kbtbd3 A G 9: 4,330,519 (GRCm39) T298A possibly damaging Het
Kif28 C A 1: 179,558,818 (GRCm39) V297F probably damaging Het
Krt12 T C 11: 99,308,771 (GRCm39) Y422C probably damaging Het
Lig1 T A 7: 13,043,122 (GRCm39) W856R probably damaging Het
Liph C T 16: 21,786,730 (GRCm39) probably null Het
Lrig3 T A 10: 125,849,317 (GRCm39) C1012* probably null Het
Lrit1 A G 14: 36,782,182 (GRCm39) E285G probably damaging Het
Lrrc31 A G 3: 30,743,377 (GRCm39) V196A probably benign Het
Lrrn4 T C 2: 132,712,363 (GRCm39) T487A probably benign Het
Mllt10 T C 2: 18,167,424 (GRCm39) Y372H probably damaging Het
Mrpl50 A T 4: 49,514,515 (GRCm39) V52E probably damaging Het
Mthfd1l T C 10: 4,006,766 (GRCm39) V676A probably damaging Het
Ncl C T 1: 86,284,362 (GRCm39) D245N possibly damaging Het
Neil1 A T 9: 57,054,065 (GRCm39) probably null Het
Nfatc3 A G 8: 106,818,827 (GRCm39) E515G probably damaging Het
Nlrp4b A G 7: 10,449,108 (GRCm39) E70G possibly damaging Het
Nme3 A T 17: 25,115,491 (GRCm39) I2F possibly damaging Het
Nup210 G A 6: 91,051,292 (GRCm39) H364Y probably benign Het
Nxpe3 T A 16: 55,686,898 (GRCm39) T37S probably benign Het
Olfm1 T A 2: 28,102,554 (GRCm39) M76K probably benign Het
Pgbd5 A T 8: 125,160,771 (GRCm39) V32E probably damaging Het
Plcb4 T C 2: 135,810,339 (GRCm39) M646T probably damaging Het
Plekha7 G A 7: 115,757,255 (GRCm39) P565L probably damaging Het
Poc5 A G 13: 96,535,374 (GRCm39) D213G probably null Het
Poli A G 18: 70,656,452 (GRCm39) I125T probably benign Het
Ppm1f T C 16: 16,721,254 (GRCm39) M1T probably null Het
Psmd7 T C 8: 108,307,523 (GRCm39) K320R unknown Het
Rabggtb A G 3: 153,615,954 (GRCm39) V128A probably damaging Het
Rasa2 A T 9: 96,454,012 (GRCm39) L308H probably damaging Het
Serpina1d C T 12: 103,730,034 (GRCm39) V383M probably benign Het
Sipa1l1 T C 12: 82,431,530 (GRCm39) probably null Het
Sos1 T C 17: 80,715,740 (GRCm39) T1006A probably benign Het
Sugp1 T A 8: 70,522,658 (GRCm39) Y453N probably damaging Het
Taf3 A T 2: 10,047,455 (GRCm39) D64E probably benign Het
Tcf19 A T 17: 35,826,801 (GRCm39) probably null Het
Trim60 T A 8: 65,453,868 (GRCm39) H127L probably damaging Het
Tubb4a C T 17: 57,387,770 (GRCm39) V419M probably damaging Het
Vmn2r22 G T 6: 123,614,684 (GRCm39) T302K probably damaging Het
Vmn2r68 T G 7: 84,870,884 (GRCm39) T800P possibly damaging Het
Zfhx2 A C 14: 55,300,965 (GRCm39) V2262G probably damaging Het
Other mutations in Igsf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Igsf11 APN 16 38,829,279 (GRCm39) missense probably damaging 1.00
R0139:Igsf11 UTSW 16 38,829,240 (GRCm39) missense probably damaging 1.00
R1268:Igsf11 UTSW 16 38,845,216 (GRCm39) missense probably benign 0.01
R4494:Igsf11 UTSW 16 38,831,703 (GRCm39) missense possibly damaging 0.46
R4791:Igsf11 UTSW 16 38,845,226 (GRCm39) missense probably damaging 0.99
R5387:Igsf11 UTSW 16 38,842,785 (GRCm39) missense probably damaging 1.00
R5572:Igsf11 UTSW 16 38,845,294 (GRCm39) missense probably damaging 0.97
R6150:Igsf11 UTSW 16 38,843,711 (GRCm39) missense probably damaging 0.96
R6340:Igsf11 UTSW 16 38,829,336 (GRCm39) missense probably benign
R6815:Igsf11 UTSW 16 38,829,243 (GRCm39) missense probably benign 0.02
R7521:Igsf11 UTSW 16 38,829,274 (GRCm39) missense probably damaging 1.00
R7533:Igsf11 UTSW 16 38,829,236 (GRCm39) missense probably benign 0.07
R7732:Igsf11 UTSW 16 38,829,160 (GRCm39) missense probably damaging 0.99
R7838:Igsf11 UTSW 16 38,827,565 (GRCm39) missense possibly damaging 0.65
R8305:Igsf11 UTSW 16 38,827,586 (GRCm39) missense probably damaging 1.00
R8842:Igsf11 UTSW 16 38,829,243 (GRCm39) missense probably benign 0.02
R9732:Igsf11 UTSW 16 38,843,652 (GRCm39) missense probably benign 0.16
X0026:Igsf11 UTSW 16 38,827,648 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- AGTGATCTGTCATTCGAGCAATGCC -3'
(R):5'- GGACTTGACTGCCACTCACCTAAC -3'

Sequencing Primer
(F):5'- ATGCTCACAGATGGGCTG -3'
(R):5'- TAACACTGTGAGGCCAGTGAC -3'
Posted On 2013-05-09