Incidental Mutation 'IGL02803:Csnk2a1'
ID 360331
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csnk2a1
Ensembl Gene ENSMUSG00000074698
Gene Name casein kinase 2, alpha 1 polypeptide
Synonyms CK2, Csnk2a1-rs4
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02803
Quality Score
Status
Chromosome 2
Chromosomal Location 152068759-152123772 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 152116005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000096829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099224]
AlphaFold Q60737
Predicted Effect probably benign
Transcript: ENSMUST00000099224
SMART Domains Protein: ENSMUSP00000096829
Gene: ENSMUSG00000074698

DomainStartEndE-ValueType
S_TKc 39 324 1.88e-78 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136063
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agmo C T 12: 37,302,480 (GRCm39) L106F probably benign Het
Appl1 A G 14: 26,673,473 (GRCm39) I208T possibly damaging Het
Arap2 G T 5: 62,906,452 (GRCm39) A189D probably benign Het
Arhgef12 T C 9: 42,883,324 (GRCm39) K1402E possibly damaging Het
C7 A C 15: 5,079,042 (GRCm39) F89V probably damaging Het
Camsap2 G A 1: 136,208,861 (GRCm39) T877I probably damaging Het
Cpt2 T C 4: 107,764,583 (GRCm39) T394A probably benign Het
Dnah10 C A 5: 124,875,078 (GRCm39) T2528N probably damaging Het
Entpd8 G T 2: 24,975,151 (GRCm39) W494L probably damaging Het
Fam114a1 T A 5: 65,163,135 (GRCm39) probably benign Het
Fat4 T C 3: 38,943,444 (GRCm39) V779A probably damaging Het
Gckr T C 5: 31,455,548 (GRCm39) S34P probably damaging Het
Golga4 T C 9: 118,364,528 (GRCm39) V297A probably benign Het
Gpr65 T C 12: 98,241,469 (GRCm39) S41P probably damaging Het
Gps1 G T 11: 120,677,649 (GRCm39) A221S probably damaging Het
Heatr1 T A 13: 12,448,867 (GRCm39) S1861T probably damaging Het
Hmces A G 6: 87,902,711 (GRCm39) E184G probably damaging Het
Itfg1 T C 8: 86,452,140 (GRCm39) probably null Het
Mrtfb C T 16: 13,221,020 (GRCm39) T743I possibly damaging Het
Nfe2l3 A G 6: 51,434,291 (GRCm39) S284G possibly damaging Het
Nlrp2 C A 7: 5,331,317 (GRCm39) A360S probably damaging Het
Nop9 A G 14: 55,987,533 (GRCm39) H298R probably benign Het
Or5an1 A T 19: 12,261,347 (GRCm39) S312C possibly damaging Het
Or5h17 T A 16: 58,820,321 (GRCm39) V91E probably benign Het
Or6ae1 T C 7: 139,742,287 (GRCm39) D192G possibly damaging Het
Osgin1 A G 8: 120,170,006 (GRCm39) M158V probably benign Het
Patj C A 4: 98,314,301 (GRCm39) Q374K probably damaging Het
Pck1 G T 2: 172,997,797 (GRCm39) G289W probably damaging Het
Phkg1 T G 5: 129,894,895 (GRCm39) I219L possibly damaging Het
Ppp1r15b G A 1: 133,061,081 (GRCm39) A533T probably damaging Het
Ppwd1 T C 13: 104,350,192 (GRCm39) I398V probably benign Het
Prkdc A G 16: 15,651,530 (GRCm39) probably benign Het
Psg25 G A 7: 18,260,212 (GRCm39) L229F possibly damaging Het
Rps6ka1 T A 4: 133,608,265 (GRCm39) Q24L probably benign Het
Sgk3 T C 1: 9,949,273 (GRCm39) I147T possibly damaging Het
Slc25a24 T A 3: 109,062,387 (GRCm39) I159N probably damaging Het
Slc26a4 T C 12: 31,572,526 (GRCm39) probably null Het
Slc35f4 T C 14: 49,541,714 (GRCm39) I347V probably benign Het
Spag17 A T 3: 100,016,713 (GRCm39) M2163L probably benign Het
Stab2 C T 10: 86,786,133 (GRCm39) probably benign Het
Sult2a8 G A 7: 14,145,630 (GRCm39) probably benign Het
Syne2 T C 12: 76,078,320 (GRCm39) L4718P probably damaging Het
Timd4 G T 11: 46,706,521 (GRCm39) G108W probably damaging Het
Timm9 T C 12: 71,173,148 (GRCm39) probably benign Het
Vmn2r98 G A 17: 19,286,275 (GRCm39) V258I probably benign Het
Zcchc9 C T 13: 91,949,000 (GRCm39) V174I probably benign Het
Zdbf2 T C 1: 63,342,236 (GRCm39) V205A possibly damaging Het
Other mutations in Csnk2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Csnk2a1 APN 2 152,117,326 (GRCm39) missense probably damaging 1.00
IGL02003:Csnk2a1 APN 2 152,118,890 (GRCm39) nonsense probably null
IGL02043:Csnk2a1 APN 2 152,116,070 (GRCm39) missense probably damaging 1.00
IGL02815:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
IGL02818:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
IGL02819:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
R1454:Csnk2a1 UTSW 2 152,099,347 (GRCm39) missense probably damaging 1.00
R1725:Csnk2a1 UTSW 2 152,099,892 (GRCm39) missense probably damaging 0.98
R2086:Csnk2a1 UTSW 2 152,096,201 (GRCm39) missense probably benign 0.01
R3113:Csnk2a1 UTSW 2 152,105,134 (GRCm39) missense probably damaging 1.00
R4003:Csnk2a1 UTSW 2 152,092,495 (GRCm39) missense probably damaging 0.97
R4021:Csnk2a1 UTSW 2 152,100,609 (GRCm39) missense probably damaging 0.96
R6702:Csnk2a1 UTSW 2 152,100,608 (GRCm39) missense probably benign 0.35
R6703:Csnk2a1 UTSW 2 152,100,608 (GRCm39) missense probably benign 0.35
R6849:Csnk2a1 UTSW 2 152,092,484 (GRCm39) missense probably benign
R7021:Csnk2a1 UTSW 2 152,102,732 (GRCm39) missense probably damaging 1.00
R7061:Csnk2a1 UTSW 2 152,116,091 (GRCm39) missense probably benign 0.08
R7381:Csnk2a1 UTSW 2 152,100,614 (GRCm39) missense probably benign 0.05
R8799:Csnk2a1 UTSW 2 152,099,886 (GRCm39) missense probably damaging 1.00
R8990:Csnk2a1 UTSW 2 152,096,177 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18