Incidental Mutation 'IGL02807:Or8b36'
ID 360452
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b36
Ensembl Gene ENSMUSG00000094461
Gene Name olfactory receptor family 8 subfamily B member 36
Synonyms MOR162-6, Olfr883, GA_x6K02T2PVTD-31705144-31706073
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL02807
Quality Score
Status
Chromosome 9
Chromosomal Location 37937104-37938033 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 37937485 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 128 (P128S)
Ref Sequence ENSEMBL: ENSMUSP00000072741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072974]
AlphaFold Q8VF64
Predicted Effect probably damaging
Transcript: ENSMUST00000072974
AA Change: P128S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072741
Gene: ENSMUSG00000094461
AA Change: P128S

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.6e-48 PFAM
Pfam:7tm_1 41 288 3.7e-24 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 C A 13: 70,886,897 (GRCm39) probably null Het
Ankra2 T C 13: 98,408,250 (GRCm39) L73P probably damaging Het
Ankrd63 G T 2: 118,533,789 (GRCm39) probably benign Het
Cars1 A T 7: 143,123,209 (GRCm39) I469N possibly damaging Het
Chn2 A G 6: 54,272,898 (GRCm39) E183G possibly damaging Het
Fstl4 A T 11: 53,077,501 (GRCm39) T753S probably benign Het
Igf2r G T 17: 12,938,770 (GRCm39) N511K probably damaging Het
Il12rb2 A T 6: 67,328,300 (GRCm39) I310N probably damaging Het
Kcnc3 C A 7: 44,245,381 (GRCm39) P557Q probably damaging Het
Mrps36 A G 13: 100,877,674 (GRCm39) probably null Het
Mug1 A G 6: 121,863,531 (GRCm39) T1410A probably damaging Het
Nme8 C A 13: 19,860,001 (GRCm39) probably benign Het
Or1l4 A C 2: 37,091,586 (GRCm39) N111T probably damaging Het
Or4d11 A G 19: 12,013,648 (GRCm39) F153L probably benign Het
Or51v14 A T 7: 103,261,198 (GRCm39) S121T probably benign Het
Pcm1 A G 8: 41,783,919 (GRCm39) E2005G probably damaging Het
Phtf1 T G 3: 103,904,869 (GRCm39) S506A probably benign Het
Plpp5 G T 8: 26,211,192 (GRCm39) probably benign Het
Rapgef4 G T 2: 72,035,993 (GRCm39) probably benign Het
Syt15 G A 14: 33,944,870 (GRCm39) G139D probably benign Het
Trpm8 T C 1: 88,275,830 (GRCm39) L476P probably damaging Het
Virma G A 4: 11,507,079 (GRCm39) probably benign Het
Vmn1r170 T A 7: 23,305,760 (GRCm39) I54N probably damaging Het
Vmn2r98 G A 17: 19,301,283 (GRCm39) A762T probably damaging Het
Other mutations in Or8b36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00980:Or8b36 APN 9 37,937,107 (GRCm39) missense probably benign 0.02
IGL02092:Or8b36 APN 9 37,937,917 (GRCm39) missense possibly damaging 0.80
IGL02351:Or8b36 APN 9 37,937,332 (GRCm39) missense possibly damaging 0.78
IGL02358:Or8b36 APN 9 37,937,332 (GRCm39) missense possibly damaging 0.78
R0972:Or8b36 UTSW 9 37,937,856 (GRCm39) missense possibly damaging 0.88
R1016:Or8b36 UTSW 9 37,937,987 (GRCm39) missense probably damaging 0.98
R1818:Or8b36 UTSW 9 37,937,803 (GRCm39) missense probably damaging 1.00
R4466:Or8b36 UTSW 9 37,937,479 (GRCm39) missense probably damaging 0.99
R4871:Or8b36 UTSW 9 37,937,822 (GRCm39) missense probably damaging 1.00
R5977:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R5979:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6026:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6027:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6029:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6035:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6035:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6053:Or8b36 UTSW 9 37,937,837 (GRCm39) frame shift probably null
R6092:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6106:Or8b36 UTSW 9 37,937,762 (GRCm39) missense probably damaging 1.00
R6131:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6132:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6133:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6134:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6153:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6251:Or8b36 UTSW 9 37,937,842 (GRCm39) frame shift probably null
R6251:Or8b36 UTSW 9 37,937,841 (GRCm39) frame shift probably null
R6251:Or8b36 UTSW 9 37,937,833 (GRCm39) frame shift probably null
R6251:Or8b36 UTSW 9 37,937,844 (GRCm39) frame shift probably null
R6300:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6301:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6305:Or8b36 UTSW 9 37,937,838 (GRCm39) frame shift probably null
R6305:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6307:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6312:Or8b36 UTSW 9 37,937,842 (GRCm39) frame shift probably null
R6312:Or8b36 UTSW 9 37,937,837 (GRCm39) frame shift probably null
R6312:Or8b36 UTSW 9 37,937,836 (GRCm39) frame shift probably null
R6312:Or8b36 UTSW 9 37,937,845 (GRCm39) frame shift probably null
R6312:Or8b36 UTSW 9 37,937,843 (GRCm39) nonsense probably null
R6813:Or8b36 UTSW 9 37,937,129 (GRCm39) missense probably damaging 1.00
R7134:Or8b36 UTSW 9 37,937,795 (GRCm39) missense probably benign 0.00
R7775:Or8b36 UTSW 9 37,937,963 (GRCm39) missense probably damaging 1.00
R7778:Or8b36 UTSW 9 37,937,963 (GRCm39) missense probably damaging 1.00
R7984:Or8b36 UTSW 9 37,937,155 (GRCm39) missense probably damaging 1.00
R8326:Or8b36 UTSW 9 37,938,014 (GRCm39) missense probably benign 0.00
R9154:Or8b36 UTSW 9 37,937,690 (GRCm39) nonsense probably null
Posted On 2015-12-18