Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02809:Tlr13'

360528

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tlr13

Ensembl Gene

ENSMUSG00000033777

Gene Name

toll-like receptor 13

Synonyms

LOC279572

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02809

Quality Score

Status

Chromosome

Chromosomal Location

105186881-105204099 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 105200297 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000043101 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040065]

AlphaFold

Q6R5N8

Predicted Effect

probably benign
Transcript: ENSMUST00000040065

SMART Domains

Protein: ENSMUSP00000043101
Gene: ENSMUSG00000033777

Domain	Start	End	E-Value	Type
LRR	106	125	5.12e1	SMART
LRR_TYP	126	149	8.81e-2	SMART
LRR	150	172	1.45e1	SMART
LRR_TYP	173	196	5.67e-5	SMART
LRR	197	219	1.49e1	SMART
LRR	223	245	3.76e1	SMART
LRR	246	269	1.33e1	SMART
LRR	395	418	4.7e0	SMART
LRR_TYP	419	442	8.47e-4	SMART
LRR	443	466	1.16e-1	SMART
LRR	467	490	6.06e1	SMART
LRR_TYP	491	514	2.09e-3	SMART
LRR_TYP	515	538	3.39e-3	SMART
LRR_TYP	539	562	6.23e-2	SMART
LRR	563	586	1.97e2	SMART
LRR	592	617	3.36e2	SMART
LRR_TYP	670	693	3.58e-2	SMART
LRR	694	717	8.26e1	SMART
TIR	833	978	1.8e-29	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Macrophages isolated from mice carrying an ENU-induced mutation respond normally to known TLR ligands and can contain various viral infections; however, mice carrying this allele have not been tested for immune responses in vivo. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Camkmt	A	T	17: 85,702,076 (GRCm39)	N180I	probably damaging	Het
Card9	A	G	2: 26,246,876 (GRCm39)	M324T	probably benign	Het
Cenpf	T	C	1: 189,414,555 (GRCm39)		probably benign	Het
Cerkl	A	G	2: 79,172,546 (GRCm39)	S349P	possibly damaging	Het
Ctsj	C	T	13: 61,150,974 (GRCm39)	S162N	probably damaging	Het
Fancm	A	G	12: 65,168,441 (GRCm39)	I1601M	possibly damaging	Het
Fpr-rs3	T	A	17: 20,844,225 (GRCm39)	R305S	probably damaging	Het
Gpatch8	A	G	11: 102,378,416 (GRCm39)	V178A	unknown	Het
Itga4	A	G	2: 79,110,921 (GRCm39)	Y253C	probably damaging	Het
Kntc1	T	C	5: 123,914,645 (GRCm39)	F655S	probably damaging	Het
Manba	A	G	3: 135,253,321 (GRCm39)	D414G	probably damaging	Het
Nfkbid	C	T	7: 30,124,660 (GRCm39)	T7I	possibly damaging	Het
Ngly1	G	T	14: 16,281,791 (GRCm38)	C349F	probably damaging	Het
Palld	T	C	8: 61,968,281 (GRCm39)	N1095S	probably damaging	Het
Sp100	C	T	1: 85,608,845 (GRCm39)	R325W	probably damaging	Het
Stxbp4	A	G	11: 90,491,010 (GRCm39)		probably null	Het
Tle2	C	A	10: 81,422,196 (GRCm39)		probably null	Het
Ttc32	G	A	12: 9,085,879 (GRCm39)	R142Q	possibly damaging	Het
Ubap2l	G	A	3: 89,928,553 (GRCm39)	T526M	probably damaging	Het
Uggt2	T	C	14: 119,328,150 (GRCm39)	E124G	probably benign	Het
Vmn1r72	A	G	7: 11,403,930 (GRCm39)	F173L	probably benign	Het
Xab2	T	C	8: 3,660,175 (GRCm39)	S851G	probably benign	Het
Zfp808	A	G	13: 62,320,994 (GRCm39)	K741R	probably benign	Het

Other mutations in Tlr13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02044:Tlr13	APN	X	105,200,703 (GRCm39)	missense	probably damaging	1.00
IGL02644:Tlr13	APN	X	105,200,503 (GRCm39)	missense	probably benign	0.12
Tlr13rev1	UTSW	X	105,200,983 (GRCm39)	missense	probably benign
X0024:Tlr13	UTSW	X	105,200,334 (GRCm39)	missense	probably benign
X0028:Tlr13	UTSW	X	105,200,928 (GRCm39)	missense	probably benign	0.04
X0067:Tlr13	UTSW	X	105,200,839 (GRCm39)	missense	probably benign	0.00

Posted On

2015-12-18