Incidental Mutation 'R0349:Adgrl3'
| ID |
36064 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl3
|
| Ensembl Gene |
ENSMUSG00000037605 |
| Gene Name |
adhesion G protein-coupled receptor L3 |
| Synonyms |
lectomedin 3, D130075K09Rik, 5430402I23Rik, Lphn3, LEC3 |
| MMRRC Submission |
038556-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0349 (G1)
|
| Quality Score |
224 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
81167985-81972980 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 81919491 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1192
(T1192A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113208
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000118078]
[ENSMUST00000120673]
[ENSMUST00000120144]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000118442]
[ENSMUST00000120292]
[ENSMUST00000119385]
[ENSMUST00000120445]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000121641]
[ENSMUST00000122356]
[ENSMUST00000132375]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000036068
AA Change: T1260A
PolyPhen 2
Score 0.877 (Sensitivity: 0.83; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000045342
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072521
AA Change: T1260A
PolyPhen 2
Score 0.214 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000072336
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
|
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117253
AA Change: T1183A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112470
Gene: ENSMUSG00000037605
AA Change: T1183A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117407
AA Change: T1251A
PolyPhen 2
Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000112388
Gene: ENSMUSG00000037605
AA Change: T1251A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117985
AA Change: T1192A
PolyPhen 2
Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000113950
Gene: ENSMUSG00000037605
AA Change: T1192A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000118034
AA Change: T1183A
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000113534
Gene: ENSMUSG00000037605
AA Change: T1183A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118078
AA Change: T1183A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112731
Gene: ENSMUSG00000037605
AA Change: T1183A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120673
AA Change: T1260A
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000113482
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120144
AA Change: T1183A
PolyPhen 2
Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000113619
Gene: ENSMUSG00000037605
AA Change: T1183A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000119788
AA Change: T1260A
PolyPhen 2
Score 0.877 (Sensitivity: 0.83; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000114067
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
|
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120128
AA Change: T1192A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113208
Gene: ENSMUSG00000037605
AA Change: T1192A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118442
AA Change: T1260A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113836
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120292
AA Change: T1192A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112548
Gene: ENSMUSG00000037605
AA Change: T1192A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119385
AA Change: T1251A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113243
Gene: ENSMUSG00000037605
AA Change: T1251A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120445
AA Change: T1260A
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000113249
Gene: ENSMUSG00000037605
AA Change: T1260A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121707
AA Change: T1251A
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000112823
Gene: ENSMUSG00000037605
AA Change: T1251A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122037
AA Change: T1183A
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000113374
Gene: ENSMUSG00000037605
AA Change: T1183A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000121641
AA Change: T1251A
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000113694
Gene: ENSMUSG00000037605
AA Change: T1251A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000124117
AA Change: T595A
|
| SMART Domains |
Protein: ENSMUSP00000118882
Gene: ENSMUSG00000037605
AA Change: T595A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GAIN
|
2 |
201 |
1.8e-51 |
PFAM |
|
GPS
|
227 |
279 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
287 |
523 |
9.1e-75 |
PFAM |
|
Pfam:Latrophilin
|
543 |
610 |
7.2e-35 |
PFAM |
|
Pfam:Latrophilin
|
607 |
873 |
1.8e-89 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122356
AA Change: T1251A
PolyPhen 2
Score 0.437 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000113600
Gene: ENSMUSG00000037605
AA Change: T1251A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
|
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132375
|
| SMART Domains |
Protein: ENSMUSP00000117211
Gene: ENSMUSG00000037605
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148830
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153264
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
A |
T |
19: 31,910,062 (GRCm39) |
S285C |
possibly damaging |
Het |
| Abcc9 |
A |
T |
6: 142,610,351 (GRCm39) |
N604K |
probably benign |
Het |
| Acsbg3 |
T |
A |
17: 57,192,169 (GRCm39) |
Y577* |
probably null |
Het |
| Aldh1l2 |
A |
T |
10: 83,326,478 (GRCm39) |
Y800N |
probably damaging |
Het |
| Ano3 |
A |
T |
2: 110,491,832 (GRCm39) |
V865D |
probably damaging |
Het |
| App |
A |
T |
16: 84,810,568 (GRCm39) |
L545Q |
probably damaging |
Het |
| Atp10a |
A |
G |
7: 58,453,215 (GRCm39) |
D798G |
probably damaging |
Het |
| B3galnt2 |
T |
C |
13: 14,166,059 (GRCm39) |
V318A |
probably benign |
Het |
| Clcn3 |
T |
A |
8: 61,394,382 (GRCm39) |
D49V |
possibly damaging |
Het |
| Clcn6 |
T |
A |
4: 148,108,651 (GRCm39) |
K126M |
possibly damaging |
Het |
| Cntln |
T |
A |
4: 84,914,722 (GRCm39) |
S510T |
probably damaging |
Het |
| Csk |
A |
C |
9: 57,535,477 (GRCm39) |
C290W |
probably damaging |
Het |
| Dmxl1 |
T |
A |
18: 50,012,349 (GRCm39) |
M1502K |
probably damaging |
Het |
| Dpy19l2 |
T |
A |
9: 24,607,218 (GRCm39) |
N81I |
possibly damaging |
Het |
| Dpyd |
T |
A |
3: 118,710,748 (GRCm39) |
C385* |
probably null |
Het |
| Dst |
G |
A |
1: 34,238,634 (GRCm39) |
V1765I |
probably benign |
Het |
| Eif5b |
A |
G |
1: 38,071,447 (GRCm39) |
S459G |
probably benign |
Het |
| Fam83d |
A |
G |
2: 158,621,768 (GRCm39) |
I160V |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 15,942,476 (GRCm39) |
F1299L |
probably damaging |
Het |
| Fmn1 |
A |
G |
2: 113,196,141 (GRCm39) |
I614V |
unknown |
Het |
| Fsd1l |
T |
A |
4: 53,679,854 (GRCm39) |
V184E |
probably damaging |
Het |
| Fyco1 |
A |
G |
9: 123,626,727 (GRCm39) |
V1328A |
probably damaging |
Het |
| Ganab |
T |
A |
19: 8,889,016 (GRCm39) |
N572K |
probably null |
Het |
| Gbp10 |
T |
A |
5: 105,368,942 (GRCm39) |
D299V |
possibly damaging |
Het |
| Gpr83 |
T |
G |
9: 14,779,563 (GRCm39) |
L205R |
probably damaging |
Het |
| Hapln2 |
G |
A |
3: 87,930,936 (GRCm39) |
P152S |
probably damaging |
Het |
| Htatip2 |
T |
C |
7: 49,423,140 (GRCm39) |
Y232H |
probably benign |
Het |
| Itga2b |
C |
T |
11: 102,358,252 (GRCm39) |
V158I |
probably damaging |
Het |
| Kansl3 |
T |
C |
1: 36,390,864 (GRCm39) |
D390G |
probably damaging |
Het |
| Kcnh2 |
T |
C |
5: 24,556,235 (GRCm39) |
D16G |
probably benign |
Het |
| Kctd8 |
A |
T |
5: 69,498,353 (GRCm39) |
F98I |
probably damaging |
Het |
| Kif21b |
A |
T |
1: 136,077,049 (GRCm39) |
E357V |
probably damaging |
Het |
| Kmt5c |
C |
T |
7: 4,749,594 (GRCm39) |
R371C |
probably damaging |
Het |
| Kndc1 |
T |
C |
7: 139,490,220 (GRCm39) |
F241L |
probably benign |
Het |
| Lrba |
A |
G |
3: 86,447,312 (GRCm39) |
D2052G |
probably damaging |
Het |
| Lsr |
T |
A |
7: 30,658,698 (GRCm39) |
I54F |
probably damaging |
Het |
| Matk |
G |
T |
10: 81,094,328 (GRCm39) |
L28F |
probably benign |
Het |
| Mdn1 |
T |
C |
4: 32,750,318 (GRCm39) |
L4429P |
probably damaging |
Het |
| Med29 |
CCTGCTGCTGCTGCTGC |
CCTGCTGCTGCTGC |
7: 28,091,935 (GRCm39) |
|
probably benign |
Het |
| Msln |
G |
T |
17: 25,969,250 (GRCm39) |
Q407K |
possibly damaging |
Het |
| Msr1 |
C |
T |
8: 40,034,868 (GRCm39) |
G428R |
probably damaging |
Het |
| Myof |
A |
G |
19: 37,899,417 (GRCm39) |
I1040T |
probably damaging |
Het |
| Nckap5 |
A |
G |
1: 125,954,171 (GRCm39) |
S794P |
probably benign |
Het |
| Nfkbiz |
C |
T |
16: 55,639,354 (GRCm39) |
|
probably null |
Het |
| Nr2c1 |
C |
T |
10: 94,031,044 (GRCm39) |
S535L |
probably damaging |
Het |
| Opn3 |
A |
C |
1: 175,519,870 (GRCm39) |
L78R |
probably damaging |
Het |
| Or11h4b |
G |
A |
14: 50,918,711 (GRCm39) |
R127C |
probably benign |
Het |
| Or52n3 |
A |
T |
7: 104,530,199 (GRCm39) |
D95V |
possibly damaging |
Het |
| Or5b12 |
A |
T |
19: 12,897,299 (GRCm39) |
C125S |
probably damaging |
Het |
| Otulinl |
T |
A |
15: 27,664,876 (GRCm39) |
I27L |
probably benign |
Het |
| Pcdhb9 |
A |
G |
18: 37,535,632 (GRCm39) |
N542S |
probably damaging |
Het |
| Pdc |
T |
A |
1: 150,209,178 (GRCm39) |
N220K |
probably benign |
Het |
| Pde6c |
A |
T |
19: 38,150,797 (GRCm39) |
N569Y |
probably damaging |
Het |
| Pgm1 |
A |
T |
4: 99,820,814 (GRCm39) |
K219M |
probably damaging |
Het |
| Pitpnb |
C |
T |
5: 111,494,992 (GRCm39) |
T99M |
possibly damaging |
Het |
| Pou6f2 |
T |
A |
13: 18,326,589 (GRCm39) |
Q71L |
probably damaging |
Het |
| Pramel24 |
T |
G |
4: 143,453,629 (GRCm39) |
W246G |
probably benign |
Het |
| Prkd1 |
C |
A |
12: 50,413,139 (GRCm39) |
L677F |
probably damaging |
Het |
| Ranbp17 |
T |
C |
11: 33,450,689 (GRCm39) |
I78V |
probably benign |
Het |
| Rnft2 |
T |
A |
5: 118,339,450 (GRCm39) |
K362M |
possibly damaging |
Het |
| Rprd1a |
T |
A |
18: 24,639,904 (GRCm39) |
E259V |
possibly damaging |
Het |
| Scara3 |
A |
T |
14: 66,169,230 (GRCm39) |
I129N |
probably damaging |
Het |
| Scgb1a1 |
A |
T |
19: 9,062,753 (GRCm39) |
|
probably null |
Het |
| Sec16b |
A |
T |
1: 157,359,746 (GRCm39) |
|
probably null |
Het |
| Slc18a1 |
A |
T |
8: 69,524,753 (GRCm39) |
M167K |
probably damaging |
Het |
| Slc6a15 |
C |
T |
10: 103,254,086 (GRCm39) |
A674V |
probably benign |
Het |
| Slc6a3 |
T |
C |
13: 73,715,676 (GRCm39) |
F437S |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Stag1 |
T |
A |
9: 100,658,837 (GRCm39) |
N141K |
probably damaging |
Het |
| Sun2 |
T |
C |
15: 79,614,433 (GRCm39) |
E321G |
probably damaging |
Het |
| Taar2 |
C |
A |
10: 23,817,327 (GRCm39) |
T289K |
possibly damaging |
Het |
| Taar2 |
T |
C |
10: 23,817,407 (GRCm39) |
Y316H |
probably benign |
Het |
| Tbcd |
T |
A |
11: 121,493,809 (GRCm39) |
|
probably null |
Het |
| Tecr |
G |
A |
8: 84,298,904 (GRCm39) |
T106I |
probably damaging |
Het |
| Thoc2l |
T |
C |
5: 104,667,842 (GRCm39) |
L788P |
possibly damaging |
Het |
| Tmem60 |
T |
G |
5: 21,091,628 (GRCm39) |
V131G |
probably benign |
Het |
| Uimc1 |
A |
G |
13: 55,223,804 (GRCm39) |
V156A |
probably benign |
Het |
| Usp28 |
G |
A |
9: 48,921,581 (GRCm39) |
W266* |
probably null |
Het |
| Vmn2r17 |
T |
A |
5: 109,576,202 (GRCm39) |
S358T |
probably damaging |
Het |
| Wwc2 |
T |
A |
8: 48,321,701 (GRCm39) |
Y471F |
unknown |
Het |
| Ythdc1 |
C |
T |
5: 86,983,579 (GRCm39) |
R675C |
probably damaging |
Het |
| Zfp30 |
T |
C |
7: 29,493,029 (GRCm39) |
S428P |
probably damaging |
Het |
| Zfp462 |
T |
A |
4: 55,008,768 (GRCm39) |
C245S |
probably benign |
Het |
| Zscan30 |
T |
C |
18: 24,104,455 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Adgrl3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00391:Adgrl3
|
APN |
5 |
81,872,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00596:Adgrl3
|
APN |
5 |
81,794,314 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00766:Adgrl3
|
APN |
5 |
81,942,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00787:Adgrl3
|
APN |
5 |
81,841,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00917:Adgrl3
|
APN |
5 |
81,841,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01155:Adgrl3
|
APN |
5 |
81,708,740 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01348:Adgrl3
|
APN |
5 |
81,874,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Adgrl3
|
APN |
5 |
81,836,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01443:Adgrl3
|
APN |
5 |
81,613,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01532:Adgrl3
|
APN |
5 |
81,842,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01779:Adgrl3
|
APN |
5 |
81,535,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01920:Adgrl3
|
APN |
5 |
81,613,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02065:Adgrl3
|
APN |
5 |
81,660,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02365:Adgrl3
|
APN |
5 |
81,660,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02879:Adgrl3
|
APN |
5 |
81,659,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0010:Adgrl3
|
UTSW |
5 |
81,940,250 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0077:Adgrl3
|
UTSW |
5 |
81,919,532 (GRCm39) |
splice site |
probably benign |
|
|
R0103:Adgrl3
|
UTSW |
5 |
81,940,194 (GRCm39) |
intron |
probably benign |
|
|
R0138:Adgrl3
|
UTSW |
5 |
81,841,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0361:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0522:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0610:Adgrl3
|
UTSW |
5 |
81,841,563 (GRCm39) |
splice site |
probably benign |
|
|
R0658:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0671:Adgrl3
|
UTSW |
5 |
81,708,752 (GRCm39) |
missense |
probably benign |
0.45 |
|
R0679:Adgrl3
|
UTSW |
5 |
81,942,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1444:Adgrl3
|
UTSW |
5 |
81,660,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1738:Adgrl3
|
UTSW |
5 |
81,535,826 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1744:Adgrl3
|
UTSW |
5 |
81,942,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1803:Adgrl3
|
UTSW |
5 |
81,919,464 (GRCm39) |
nonsense |
probably null |
|
|
R1891:Adgrl3
|
UTSW |
5 |
81,659,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Adgrl3
|
UTSW |
5 |
81,836,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2126:Adgrl3
|
UTSW |
5 |
81,660,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Adgrl3
|
UTSW |
5 |
81,660,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2171:Adgrl3
|
UTSW |
5 |
81,660,362 (GRCm39) |
nonsense |
probably null |
|
|
R2891:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3508:Adgrl3
|
UTSW |
5 |
81,872,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3733:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3982:Adgrl3
|
UTSW |
5 |
81,842,373 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4085:Adgrl3
|
UTSW |
5 |
81,660,391 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4462:Adgrl3
|
UTSW |
5 |
81,836,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Adgrl3
|
UTSW |
5 |
81,914,052 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4726:Adgrl3
|
UTSW |
5 |
81,794,425 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4781:Adgrl3
|
UTSW |
5 |
81,908,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4837:Adgrl3
|
UTSW |
5 |
81,914,081 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4841:Adgrl3
|
UTSW |
5 |
81,942,118 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4883:Adgrl3
|
UTSW |
5 |
81,837,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Adgrl3
|
UTSW |
5 |
81,659,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4945:Adgrl3
|
UTSW |
5 |
81,659,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5055:Adgrl3
|
UTSW |
5 |
81,794,398 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5313:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5385:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5447:Adgrl3
|
UTSW |
5 |
81,613,188 (GRCm39) |
intron |
probably benign |
|
|
R5482:Adgrl3
|
UTSW |
5 |
81,942,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Adgrl3
|
UTSW |
5 |
81,871,994 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5637:Adgrl3
|
UTSW |
5 |
81,841,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5919:Adgrl3
|
UTSW |
5 |
81,794,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6090:Adgrl3
|
UTSW |
5 |
81,660,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Adgrl3
|
UTSW |
5 |
81,794,369 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6107:Adgrl3
|
UTSW |
5 |
81,836,410 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6245:Adgrl3
|
UTSW |
5 |
81,836,403 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6426:Adgrl3
|
UTSW |
5 |
81,874,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6440:Adgrl3
|
UTSW |
5 |
81,942,341 (GRCm39) |
nonsense |
probably null |
|
|
R6516:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6527:Adgrl3
|
UTSW |
5 |
81,935,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6622:Adgrl3
|
UTSW |
5 |
81,942,606 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6842:Adgrl3
|
UTSW |
5 |
81,888,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Adgrl3
|
UTSW |
5 |
81,837,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6921:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7201:Adgrl3
|
UTSW |
5 |
81,872,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7207:Adgrl3
|
UTSW |
5 |
81,457,874 (GRCm39) |
start codon destroyed |
probably null |
0.33 |
|
R7215:Adgrl3
|
UTSW |
5 |
81,841,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7376:Adgrl3
|
UTSW |
5 |
81,942,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7441:Adgrl3
|
UTSW |
5 |
81,871,987 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7582:Adgrl3
|
UTSW |
5 |
81,841,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7682:Adgrl3
|
UTSW |
5 |
81,942,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7863:Adgrl3
|
UTSW |
5 |
81,660,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7877:Adgrl3
|
UTSW |
5 |
81,842,467 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8051:Adgrl3
|
UTSW |
5 |
81,613,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Adgrl3
|
UTSW |
5 |
81,935,408 (GRCm39) |
frame shift |
probably null |
|
|
R8390:Adgrl3
|
UTSW |
5 |
81,914,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8392:Adgrl3
|
UTSW |
5 |
81,794,397 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8475:Adgrl3
|
UTSW |
5 |
81,871,976 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8478:Adgrl3
|
UTSW |
5 |
81,942,348 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8550:Adgrl3
|
UTSW |
5 |
81,942,599 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8685:Adgrl3
|
UTSW |
5 |
81,874,708 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8792:Adgrl3
|
UTSW |
5 |
81,836,522 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8851:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8868:Adgrl3
|
UTSW |
5 |
81,794,451 (GRCm39) |
missense |
probably benign |
|
|
R8889:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Adgrl3
|
UTSW |
5 |
81,796,568 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9023:Adgrl3
|
UTSW |
5 |
81,613,065 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9089:Adgrl3
|
UTSW |
5 |
81,808,291 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9100:Adgrl3
|
UTSW |
5 |
81,842,299 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9104:Adgrl3
|
UTSW |
5 |
81,457,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9172:Adgrl3
|
UTSW |
5 |
81,922,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9284:Adgrl3
|
UTSW |
5 |
81,657,568 (GRCm39) |
splice site |
probably benign |
|
|
R9286:Adgrl3
|
UTSW |
5 |
81,794,413 (GRCm39) |
missense |
probably benign |
|
|
R9644:Adgrl3
|
UTSW |
5 |
81,872,036 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Adgrl3
|
UTSW |
5 |
81,942,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9757:Adgrl3
|
UTSW |
5 |
81,613,086 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9795:Adgrl3
|
UTSW |
5 |
81,837,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrl3
|
UTSW |
5 |
81,660,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrl3
|
UTSW |
5 |
81,477,729 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGCAACAGCCTCCTCTAGCTTTG -3'
(R):5'- AATTTTACCAGGCAGCATCCTCCC -3'
Sequencing Primer
(F):5'- CCTCCTCTAGCTTTGAGAGAAAC -3'
(R):5'- TTCATACCTGGGACAATTGGAGC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation