Incidental Mutation 'IGL02813:Cyp2a22'
ID 360655
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2a22
Ensembl Gene ENSMUSG00000091867
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms EG233005
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL02813
Quality Score
Status
Chromosome 7
Chromosomal Location 26631056-26638809 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 26635859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 235 (Q235K)
Ref Sequence ENSEMBL: ENSMUSP00000128030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170227]
AlphaFold B2RXZ2
Predicted Effect probably benign
Transcript: ENSMUST00000170227
AA Change: Q235K

PolyPhen 2 Score 0.186 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: Q235K

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:p450 33 489 7.4e-148 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206638
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206957
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 C A 11: 7,096,591 (GRCm39) Q660K possibly damaging Het
Arhgap5 A C 12: 52,563,748 (GRCm39) T240P probably benign Het
Arhgef7 C T 8: 11,850,767 (GRCm39) probably benign Het
Cttnbp2 C A 6: 18,367,537 (GRCm39) V1594F possibly damaging Het
Dennd11 C T 6: 40,395,473 (GRCm39) V212I probably benign Het
Dynlt5 A G 4: 102,849,769 (GRCm39) N64S probably damaging Het
Ecm1 G A 3: 95,644,098 (GRCm39) P169S probably damaging Het
Emilin3 G A 2: 160,750,649 (GRCm39) Q320* probably null Het
Ern1 T C 11: 106,314,251 (GRCm39) D183G probably damaging Het
Gpat2 T C 2: 127,276,375 (GRCm39) V635A possibly damaging Het
Gria1 A G 11: 57,174,410 (GRCm39) N564S probably damaging Het
Grtp1 A C 8: 13,236,945 (GRCm39) I173S possibly damaging Het
Hsd17b4 A G 18: 50,261,415 (GRCm39) probably benign Het
Lrp1b T C 2: 40,569,229 (GRCm39) probably null Het
Mark4 A T 7: 19,181,181 (GRCm39) probably null Het
Mphosph9 T C 5: 124,453,691 (GRCm39) D207G probably benign Het
Mrgprd A G 7: 144,875,251 (GRCm39) M41V probably benign Het
Myo1g T C 11: 6,468,743 (GRCm39) *66W probably null Het
Neto2 C A 8: 86,417,515 (GRCm39) D30Y probably benign Het
Nlrp6 A T 7: 140,503,333 (GRCm39) I450F possibly damaging Het
Nup155 T A 15: 8,159,605 (GRCm39) probably benign Het
Or4c11c A G 2: 88,661,495 (GRCm39) I11M probably benign Het
Pcdhb10 T G 18: 37,546,815 (GRCm39) S630R possibly damaging Het
Rwdd4a T C 8: 47,990,396 (GRCm39) probably null Het
Slc12a7 T A 13: 73,961,795 (GRCm39) probably benign Het
Slc22a20 C T 19: 6,034,886 (GRCm39) V192I probably benign Het
Slc9a2 T A 1: 40,781,829 (GRCm39) S353T probably damaging Het
Srgap3 A G 6: 112,708,441 (GRCm39) F753L probably damaging Het
Tcea1 C T 1: 4,956,979 (GRCm39) T93I probably benign Het
Tecpr2 A T 12: 110,899,626 (GRCm39) S665C probably damaging Het
Tor4a C A 2: 25,084,761 (GRCm39) E381* probably null Het
Vdr A G 15: 97,767,562 (GRCm39) Y143H probably benign Het
Vmn2r91 A C 17: 18,356,348 (GRCm39) T672P possibly damaging Het
Wdr41 A G 13: 95,131,753 (GRCm39) probably null Het
Other mutations in Cyp2a22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Cyp2a22 APN 7 26,637,163 (GRCm39) missense probably benign 0.09
IGL01111:Cyp2a22 APN 7 26,635,883 (GRCm39) missense probably damaging 1.00
IGL01388:Cyp2a22 APN 7 26,637,217 (GRCm39) missense probably benign 0.02
IGL01449:Cyp2a22 APN 7 26,632,978 (GRCm39) missense probably benign 0.01
IGL01642:Cyp2a22 APN 7 26,638,184 (GRCm39) missense possibly damaging 0.81
IGL02253:Cyp2a22 APN 7 26,637,662 (GRCm39) splice site probably benign
IGL02327:Cyp2a22 APN 7 26,634,206 (GRCm39) missense probably damaging 0.99
IGL02673:Cyp2a22 APN 7 26,637,525 (GRCm39) missense probably benign 0.00
IGL02896:Cyp2a22 APN 7 26,635,886 (GRCm39) missense probably damaging 0.98
IGL03193:Cyp2a22 APN 7 26,635,846 (GRCm39) missense probably benign 0.00
IGL03350:Cyp2a22 APN 7 26,634,279 (GRCm39) missense possibly damaging 0.88
R1648:Cyp2a22 UTSW 7 26,631,793 (GRCm39) missense probably damaging 0.98
R1679:Cyp2a22 UTSW 7 26,635,736 (GRCm39) nonsense probably null
R1733:Cyp2a22 UTSW 7 26,634,187 (GRCm39) missense possibly damaging 0.78
R2001:Cyp2a22 UTSW 7 26,634,197 (GRCm39) missense probably damaging 1.00
R2858:Cyp2a22 UTSW 7 26,633,687 (GRCm39) missense probably damaging 0.99
R3054:Cyp2a22 UTSW 7 26,638,254 (GRCm39) missense probably damaging 1.00
R4528:Cyp2a22 UTSW 7 26,634,194 (GRCm39) missense possibly damaging 0.95
R4623:Cyp2a22 UTSW 7 26,632,916 (GRCm39) missense probably damaging 1.00
R4669:Cyp2a22 UTSW 7 26,637,280 (GRCm39) missense possibly damaging 0.88
R4690:Cyp2a22 UTSW 7 26,638,634 (GRCm39) nonsense probably null
R4840:Cyp2a22 UTSW 7 26,631,949 (GRCm39) missense probably benign 0.13
R4915:Cyp2a22 UTSW 7 26,637,195 (GRCm39) missense probably benign 0.33
R5071:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5072:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5074:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5147:Cyp2a22 UTSW 7 26,635,750 (GRCm39) missense probably damaging 1.00
R5363:Cyp2a22 UTSW 7 26,635,858 (GRCm39) missense probably damaging 0.99
R5705:Cyp2a22 UTSW 7 26,638,640 (GRCm39) missense probably benign 0.05
R6014:Cyp2a22 UTSW 7 26,638,605 (GRCm39) splice site probably null
R6042:Cyp2a22 UTSW 7 26,633,664 (GRCm39) missense probably damaging 1.00
R6253:Cyp2a22 UTSW 7 26,633,657 (GRCm39) missense probably benign 0.18
R6757:Cyp2a22 UTSW 7 26,638,629 (GRCm39) missense probably benign 0.00
R6994:Cyp2a22 UTSW 7 26,638,606 (GRCm39) critical splice donor site probably null
R7581:Cyp2a22 UTSW 7 26,637,573 (GRCm39) missense possibly damaging 0.87
R8212:Cyp2a22 UTSW 7 26,637,205 (GRCm39) missense possibly damaging 0.89
R9225:Cyp2a22 UTSW 7 26,637,202 (GRCm39) missense possibly damaging 0.81
R9749:Cyp2a22 UTSW 7 26,638,715 (GRCm39) missense probably null 0.41
Posted On 2015-12-18