Incidental Mutation 'IGL02813:Nlrp6'
| ID |
360679 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Nlrp6
|
| Ensembl Gene |
ENSMUSG00000038745 |
| Gene Name |
NLR family, pyrin domain containing 6 |
| Synonyms |
Nalp6 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL02813
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
140500815-140509105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 140503333 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 450
(I450F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139357
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106045]
[ENSMUST00000183845]
[ENSMUST00000184560]
|
| AlphaFold |
Q91WS2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106045
AA Change: I450F
PolyPhen 2
Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000101660
Gene: ENSMUSG00000038745
AA Change: I450F
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
15 |
96 |
5.44e-27 |
SMART |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
194 |
363 |
8.6e-44 |
PFAM |
|
coiled coil region
|
590 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
675 |
697 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
715 |
763 |
9.43e-6 |
PROSPERO |
|
internal_repeat_1
|
828 |
876 |
9.43e-6 |
PROSPERO |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183761
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000183845
AA Change: I450F
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139357
Gene: ENSMUSG00000038745
AA Change: I450F
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
15 |
96 |
5.44e-27 |
SMART |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
194 |
363 |
5.5e-43 |
PFAM |
|
coiled coil region
|
590 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
694 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
702 |
750 |
1.26e-5 |
PROSPERO |
|
internal_repeat_1
|
815 |
863 |
1.26e-5 |
PROSPERO |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000184560
AA Change: I480F
PolyPhen 2
Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139170
Gene: ENSMUSG00000038745
AA Change: I480F
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
45 |
126 |
5.44e-27 |
SMART |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
224 |
393 |
8.2e-43 |
PFAM |
|
coiled coil region
|
620 |
647 |
N/A |
INTRINSIC |
|
low complexity region
|
710 |
724 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
732 |
780 |
1.55e-5 |
PROSPERO |
|
internal_repeat_1
|
845 |
893 |
1.55e-5 |
PROSPERO |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]
PHENOTYPE: Nullizygous mutations lead to altered colonic microbiota, increased susceptibility to induced colitis and/or inflammation-associated colon tumorigenesis. Homozygotes for a null allele show lower blood pressure and sex-specific changes in urine concentrating ability, cognition, and anxiety behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy1 |
C |
A |
11: 7,096,591 (GRCm39) |
Q660K |
possibly damaging |
Het |
| Arhgap5 |
A |
C |
12: 52,563,748 (GRCm39) |
T240P |
probably benign |
Het |
| Arhgef7 |
C |
T |
8: 11,850,767 (GRCm39) |
|
probably benign |
Het |
| Cttnbp2 |
C |
A |
6: 18,367,537 (GRCm39) |
V1594F |
possibly damaging |
Het |
| Cyp2a22 |
G |
T |
7: 26,635,859 (GRCm39) |
Q235K |
probably benign |
Het |
| Dennd11 |
C |
T |
6: 40,395,473 (GRCm39) |
V212I |
probably benign |
Het |
| Dynlt5 |
A |
G |
4: 102,849,769 (GRCm39) |
N64S |
probably damaging |
Het |
| Ecm1 |
G |
A |
3: 95,644,098 (GRCm39) |
P169S |
probably damaging |
Het |
| Emilin3 |
G |
A |
2: 160,750,649 (GRCm39) |
Q320* |
probably null |
Het |
| Ern1 |
T |
C |
11: 106,314,251 (GRCm39) |
D183G |
probably damaging |
Het |
| Gpat2 |
T |
C |
2: 127,276,375 (GRCm39) |
V635A |
possibly damaging |
Het |
| Gria1 |
A |
G |
11: 57,174,410 (GRCm39) |
N564S |
probably damaging |
Het |
| Grtp1 |
A |
C |
8: 13,236,945 (GRCm39) |
I173S |
possibly damaging |
Het |
| Hsd17b4 |
A |
G |
18: 50,261,415 (GRCm39) |
|
probably benign |
Het |
| Lrp1b |
T |
C |
2: 40,569,229 (GRCm39) |
|
probably null |
Het |
| Mark4 |
A |
T |
7: 19,181,181 (GRCm39) |
|
probably null |
Het |
| Mphosph9 |
T |
C |
5: 124,453,691 (GRCm39) |
D207G |
probably benign |
Het |
| Mrgprd |
A |
G |
7: 144,875,251 (GRCm39) |
M41V |
probably benign |
Het |
| Myo1g |
T |
C |
11: 6,468,743 (GRCm39) |
*66W |
probably null |
Het |
| Neto2 |
C |
A |
8: 86,417,515 (GRCm39) |
D30Y |
probably benign |
Het |
| Nup155 |
T |
A |
15: 8,159,605 (GRCm39) |
|
probably benign |
Het |
| Or4c11c |
A |
G |
2: 88,661,495 (GRCm39) |
I11M |
probably benign |
Het |
| Pcdhb10 |
T |
G |
18: 37,546,815 (GRCm39) |
S630R |
possibly damaging |
Het |
| Rwdd4a |
T |
C |
8: 47,990,396 (GRCm39) |
|
probably null |
Het |
| Slc12a7 |
T |
A |
13: 73,961,795 (GRCm39) |
|
probably benign |
Het |
| Slc22a20 |
C |
T |
19: 6,034,886 (GRCm39) |
V192I |
probably benign |
Het |
| Slc9a2 |
T |
A |
1: 40,781,829 (GRCm39) |
S353T |
probably damaging |
Het |
| Srgap3 |
A |
G |
6: 112,708,441 (GRCm39) |
F753L |
probably damaging |
Het |
| Tcea1 |
C |
T |
1: 4,956,979 (GRCm39) |
T93I |
probably benign |
Het |
| Tecpr2 |
A |
T |
12: 110,899,626 (GRCm39) |
S665C |
probably damaging |
Het |
| Tor4a |
C |
A |
2: 25,084,761 (GRCm39) |
E381* |
probably null |
Het |
| Vdr |
A |
G |
15: 97,767,562 (GRCm39) |
Y143H |
probably benign |
Het |
| Vmn2r91 |
A |
C |
17: 18,356,348 (GRCm39) |
T672P |
possibly damaging |
Het |
| Wdr41 |
A |
G |
13: 95,131,753 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Nlrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Nlrp6
|
APN |
7 |
140,503,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01066:Nlrp6
|
APN |
7 |
140,501,709 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01966:Nlrp6
|
APN |
7 |
140,505,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02625:Nlrp6
|
APN |
7 |
140,503,413 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02792:Nlrp6
|
APN |
7 |
140,502,348 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03140:Nlrp6
|
APN |
7 |
140,507,400 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0608:Nlrp6
|
UTSW |
7 |
140,503,399 (GRCm39) |
nonsense |
probably null |
|
|
R1404:Nlrp6
|
UTSW |
7 |
140,504,026 (GRCm39) |
small deletion |
probably benign |
|
|
R1404:Nlrp6
|
UTSW |
7 |
140,504,026 (GRCm39) |
small deletion |
probably benign |
|
|
R1472:Nlrp6
|
UTSW |
7 |
140,503,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1587:Nlrp6
|
UTSW |
7 |
140,502,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Nlrp6
|
UTSW |
7 |
140,503,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Nlrp6
|
UTSW |
7 |
140,504,026 (GRCm39) |
small deletion |
probably benign |
|
|
R2097:Nlrp6
|
UTSW |
7 |
140,503,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2118:Nlrp6
|
UTSW |
7 |
140,506,357 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2119:Nlrp6
|
UTSW |
7 |
140,506,357 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2120:Nlrp6
|
UTSW |
7 |
140,506,357 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2121:Nlrp6
|
UTSW |
7 |
140,506,357 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2290:Nlrp6
|
UTSW |
7 |
140,502,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3546:Nlrp6
|
UTSW |
7 |
140,506,682 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3547:Nlrp6
|
UTSW |
7 |
140,506,682 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3970:Nlrp6
|
UTSW |
7 |
140,501,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4483:Nlrp6
|
UTSW |
7 |
140,501,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4484:Nlrp6
|
UTSW |
7 |
140,501,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4869:Nlrp6
|
UTSW |
7 |
140,504,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4962:Nlrp6
|
UTSW |
7 |
140,503,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5436:Nlrp6
|
UTSW |
7 |
140,502,630 (GRCm39) |
nonsense |
probably null |
|
|
R5442:Nlrp6
|
UTSW |
7 |
140,502,103 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5924:Nlrp6
|
UTSW |
7 |
140,503,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Nlrp6
|
UTSW |
7 |
140,502,725 (GRCm39) |
nonsense |
probably null |
|
|
R6124:Nlrp6
|
UTSW |
7 |
140,503,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6455:Nlrp6
|
UTSW |
7 |
140,507,422 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6480:Nlrp6
|
UTSW |
7 |
140,507,356 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6873:Nlrp6
|
UTSW |
7 |
140,503,433 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7061:Nlrp6
|
UTSW |
7 |
140,502,780 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7350:Nlrp6
|
UTSW |
7 |
140,501,191 (GRCm39) |
start gained |
probably benign |
|
|
R7532:Nlrp6
|
UTSW |
7 |
140,505,097 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7752:Nlrp6
|
UTSW |
7 |
140,507,353 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7901:Nlrp6
|
UTSW |
7 |
140,507,353 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8098:Nlrp6
|
UTSW |
7 |
140,503,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8381:Nlrp6
|
UTSW |
7 |
140,503,754 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8513:Nlrp6
|
UTSW |
7 |
140,502,743 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9114:Nlrp6
|
UTSW |
7 |
140,506,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7732:Nlrp6
|
UTSW |
7 |
140,506,561 (GRCm39) |
splice site |
probably benign |
|
|
Z1176:Nlrp6
|
UTSW |
7 |
140,502,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-12-18 |
Incidental Mutation